Details for: ZNF263

Gene ID: 10127

Symbol: ZNF263

Ensembl ID: ENSG00000006194

Description: zinc finger protein 263

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16,143
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,738
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,963
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.97
    Marker Score: 313
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.94
    Marker Score: 294
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,712
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.87
    Marker Score: 53,748
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.87
    Marker Score: 8,260
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,936
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1,732
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.81
    Marker Score: 6,940
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.8
    Marker Score: 915
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.79
    Marker Score: 1,224
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.74
    Marker Score: 445
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 560
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.73
    Marker Score: 725
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.73
    Marker Score: 6,878
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,915
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.66
    Marker Score: 3,964
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 600
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.66
    Marker Score: 823
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.65
    Marker Score: 2,506
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.63
    Marker Score: 661
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,460
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 290
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6,217
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.56
    Marker Score: 607
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.55
    Marker Score: 503
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.55
    Marker Score: 18,549
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.54
    Marker Score: 155
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.54
    Marker Score: 296
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 339
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.52
    Marker Score: 553
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.51
    Marker Score: 1,079
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 337
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.51
    Marker Score: 132
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.51
    Marker Score: 177
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5
    Marker Score: 538
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.5
    Marker Score: 617
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.49
    Marker Score: 3,200
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.49
    Marker Score: 199
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.48
    Marker Score: 1,316
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.48
    Marker Score: 1,175
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.47
    Marker Score: 4,742
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.47
    Marker Score: 262
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.47
    Marker Score: 9,315
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.46
    Marker Score: 293
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.46
    Marker Score: 6,878
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 286
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 198
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.45
    Marker Score: 165
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.45
    Marker Score: 302
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.44
    Marker Score: 296
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.44
    Marker Score: 497
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.44
    Marker Score: 567
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.44
    Marker Score: 103
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.44
    Marker Score: 96
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.44
    Marker Score: 455
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.43
    Marker Score: 323
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.43
    Marker Score: 432
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.43
    Marker Score: 149
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.43
    Marker Score: 108
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.42
    Marker Score: 409
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.42
    Marker Score: 90
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.42
    Marker Score: 209
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.42
    Marker Score: 281
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 15,915
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.42
    Marker Score: 874
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.42
    Marker Score: 2,054
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.42
    Marker Score: 278
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.42
    Marker Score: 613
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.42
    Marker Score: 2,462
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.42
    Marker Score: 439
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.41
    Marker Score: 703
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 190
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.41
    Marker Score: 3,163
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.41
    Marker Score: 200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 397
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.41
    Marker Score: 98
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.41
    Marker Score: 1,699
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.4
    Marker Score: 8,612
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.4
    Marker Score: 152
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.4
    Marker Score: 99
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.4
    Marker Score: 110
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.4
    Marker Score: 80

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF263 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain. This protein exhibits both transcriptional repressive and activating properties, depending on the context and target genes. Its expression is widespread in various tissues, including the heart, brain, and intestinal epithelium, highlighting its importance in cellular differentiation and development. Notably, ZNF263 has been implicated in the regulation of gene expression in response to environmental stimuli, such as DNA damage and oxidative stress. **Pathways and Functions:** ZNF263's involvement in transcriptional regulation is mediated through its interaction with RNA polymerase II (RNAPII), a key enzyme responsible for transcribing protein-coding genes. The protein's ability to bind to RNAPII cis-regulatory regions allows it to modulate the expression of target genes, either by repressing or activating transcription. This function is essential for maintaining cellular homeostasis and responding to environmental changes. Furthermore, ZNF263's role in metal ion binding and DNA binding suggests its involvement in transcriptional regulation of genes involved in cellular responses to stress and injury. Its ability to bind specific DNA sequences and interact with transcription factors positions ZNF263 as a key regulator of gene expression in various cellular contexts. **Clinical Significance:** The identification of ZNF263 as a transcriptional regulator with roles in cellular differentiation and development has significant implications for our understanding of human disease. Abnormal expression of ZNF263 has been linked to various cancers, including colorectal and breast cancer, suggesting its potential as a therapeutic target. Additionally, ZNF263's involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlights its importance in regulating gene expression in the brain. Furthermore, the discovery of ZNF263's role in regulating transcription in response to environmental stimuli has implications for our understanding of disease mechanisms and the development of novel therapeutic strategies. For example, the protein's ability to respond to DNA damage and oxidative stress positions it as a potential target for cancer therapy and neuroprotection. In conclusion, ZNF263 is a multifunctional transcriptional regulator with significant implications for our understanding of human disease. Further research is needed to elucidate the protein's mechanisms of action and its potential therapeutic applications.

Genular Protein ID: 1847694174

Symbol: ZN263_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14978 B2R634 O43387 Q96H95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256059

Title: Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains.

PubMed ID: 9256059

DOI: 10.1016/s0167-4781(97)00074-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 32277030

Title: ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.

PubMed ID: 32277030

DOI: 10.1073/pnas.1920880117

PubMed ID: 27231705

Title: Somatic mutations in GLI3 and OFD1 involved in sonic hedgehog signaling cause hypothalamic hamartoma.

PubMed ID: 27231705

DOI: 10.1002/acn3.300

Sequence Information:

  • Length: 683
  • Mass: 77299
  • Checksum: 1E02C862FCE69265
  • Sequence:
    • MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ EAAGPREALS 
RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR VQELHPESGE EAVTLVEDMQ 
RELGRLRQQV TNHGRGTEVL LEEPLPLETA RESPSFKLEP METERSPGPR LQELLGPSPQ 
RDPQAVKERA LSAPWLSLFP PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA 
LSRDTVQESY ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF 
ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE GGMEQALAGA 
SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH AAERLCMGVD CTEIFGGNPR 
FLSLHRAHLG EEAHKCLECG KCFSQNTHLT RHQRTHTGEK PYQCNICGKC FSCNSNLHRH 
QRTHTGEKPY KCPECGEIFA HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH 
ERERLYPFSE CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE 
KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL RTHTGERPYK 
CSECGESFSR SSRLMSHQRT HTG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.