Details for: FRY

Gene ID: 10129

Symbol: FRY

Ensembl ID: ENSG00000073910

Description: FRY microtubule binding protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.67
    Marker Score: 104,298
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.36
    Marker Score: 10,019
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.99
    Marker Score: 134,758
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.53
    Marker Score: 7,746
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.39
    Marker Score: 3,234
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.35
    Marker Score: 1,817
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.3
    Marker Score: 17,711
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.26
    Marker Score: 4,713
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.24
    Marker Score: 24,430
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.1
    Marker Score: 14,356
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.08
    Marker Score: 3,733
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.91
    Marker Score: 3,911
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.86
    Marker Score: 10,173
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.81
    Marker Score: 41,986
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.71
    Marker Score: 20,766
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.7
    Marker Score: 9,052
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.63
    Marker Score: 1,530
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.59
    Marker Score: 13,565
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.56
    Marker Score: 97,162
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.52
    Marker Score: 1,938
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.43
    Marker Score: 1,016
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.42
    Marker Score: 10,024
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.39
    Marker Score: 2,749
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.31
    Marker Score: 2,881
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.31
    Marker Score: 733
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.3
    Marker Score: 45,670
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.26
    Marker Score: 3,788
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2
    Marker Score: 8,508
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.19
    Marker Score: 80,860
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.16
    Marker Score: 1,265
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125,740
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.04
    Marker Score: 3,922
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.03
    Marker Score: 782
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.03
    Marker Score: 19,081
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.96
    Marker Score: 7,964
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.95
    Marker Score: 20,167
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.9
    Marker Score: 915
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.9
    Marker Score: 1,104
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,838
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.86
    Marker Score: 676
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,906
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.85
    Marker Score: 505
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.81
    Marker Score: 1,081
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.79
    Marker Score: 1,975
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.78
    Marker Score: 2,207
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.76
    Marker Score: 5,033
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.74
    Marker Score: 909
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.73
    Marker Score: 7,194
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,516
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.6
    Marker Score: 1,382
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.56
    Marker Score: 577
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.49
    Marker Score: 1,611
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.47
    Marker Score: 2,062
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.42
    Marker Score: 2,067
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.36
    Marker Score: 11,904
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20,560
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.29
    Marker Score: 984
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.27
    Marker Score: 256
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.22
    Marker Score: 459
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.22
    Marker Score: 1,046
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.2
    Marker Score: 673
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.19
    Marker Score: 19,149
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.17
    Marker Score: 2,969
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.15
    Marker Score: 361
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.14
    Marker Score: 291
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.12
    Marker Score: 2,640
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.11
    Marker Score: 414
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.09
    Marker Score: 23,342
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.06
    Marker Score: 1,557
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.05
    Marker Score: 750
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.05
    Marker Score: 1,307
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.03
    Marker Score: 1,461
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.02
    Marker Score: 6,541
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.01
    Marker Score: 878
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,746
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,972
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.99
    Marker Score: 513
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.98
    Marker Score: 283
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 662
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.95
    Marker Score: 301
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1,931
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.95
    Marker Score: 1,655
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.92
    Marker Score: 195
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.92
    Marker Score: 1,860
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.91
    Marker Score: 436
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,726
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3,925
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.91
    Marker Score: 1,812
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.9
    Marker Score: 425
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.89
    Marker Score: 215
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.89
    Marker Score: 232
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.89
    Marker Score: 897
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.89
    Marker Score: 5,343
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.88
    Marker Score: 786
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.87
    Marker Score: 432

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The FRY gene encodes a microtubule binding protein that is significantly expressed in various cell types, including cardiac myocytes, macroglial cells, Purkinje cells, and stellate neurons. FRY is characterized by its ability to bind to microtubules, which is essential for maintaining their structural integrity and dynamics. The protein's binding activity is regulated by its interaction with other proteins, such as tubulin deacetylases, which modulate its activity. FRY is also involved in negative regulation of tubulin deacetylation, a process that is crucial for maintaining microtubule stability and dynamics. **Pathways and Functions:** FRY is involved in several cellular pathways, including: 1. **Cell morphogenesis**: FRY plays a crucial role in regulating cell shape and movement by modulating microtubule dynamics. 2. **Neuron projection development**: FRY is essential for the development and maintenance of axonal projections in neurons. 3. **Centrosome organization**: FRY regulates the organization and dynamics of centrosomes, which are essential for cell division and movement. 4. **Negative regulation of tubulin deacetylation**: FRY inhibits the activity of tubulin deacetylases, which is crucial for maintaining microtubule stability and dynamics. **Clinical Significance:** Dysregulation of FRY has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in the FRY gene have been associated with neurological disorders, such as neurodegenerative diseases and developmental disorders. 2. **Cardiac disorders**: FRY has been implicated in cardiac disorders, including heart failure and arrhythmias. 3. **Muscular dystrophy**: FRY has been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. In summary, the FRY microtubule binding protein plays a crucial role in maintaining cellular structure and dynamics, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the function and clinical significance of the FRY gene. **Conclusion:** In conclusion, the FRY microtubule binding protein is a critical component involved in various cellular processes, including cell morphogenesis, neuron projection development, and negative regulation of tubulin deacetylation. Its dysregulation has been implicated in various diseases, including neurological disorders, cardiac disorders, and muscular dystrophy. Further research is needed to fully elucidate the function and clinical significance of the FRY gene and to explore its potential as a therapeutic target for these diseases.

Genular Protein ID: 346498621

Symbol: FRY_HUMAN

Name: Protein furry homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22753416

Title: Furry protein promotes Aurora A-mediated polo-like kinase 1 activation.

PubMed ID: 22753416

DOI: 10.1074/jbc.m112.378968

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 3013
  • Mass: 338875
  • Checksum: 2AB5EDB7D2529538
  • Sequence:
  • MASQQDSGFF EISIKYLLKS WSNTSPVGNG YIKPPVPPAS GTHREKGPPT MLPINVDPDS 
    KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR GEDPQFDQVI SSMSSLSEYC 
    LPSILRTLFD WYKRQNGIED ESHEYRPRTS NKSKSDEQQR DYLMERRDLA IDFIFSLVLI 
    EVLKQIPLHP VIDSLIHDVI NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF 
    PAVKKKFMAE LKELRHKEQN PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY 
    FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE LSSRKKHSLA 
    LYPLVTCLLC VSQKQLFLNR WHIFLNNCLS NLKNKDPKMA RVALESLYRL LWVYMIRIKC 
    ESNTATQSRL ITIITTLFPK GSRGVVPRDM PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC 
    VGKPAKAFSL NPERMNIGLR AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK 
    TLTEEEAKMI GMSLYYSQVR KAVDNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP 
    KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG LLVDFSDWRE 
    DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI QTQGKVYEQA NKIRNSELIA 
    NGSSHRIQSE RGPHCSVLHA VEGFALVLLC SFQVATRKLS VLILKEIRAL FIALGQPEDD 
    DRPMIDVMDQ LSSSILESFI HVAVSDSATL PLTHNVDLQW LVEWNAVLVN SHYDVKSPSH 
    VWIFAQSVKD PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPINAK 
    KTSTAGSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG TVSYDNKAIG 
    TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE LVEELHPLMK EALERRPENK 
    KRRERRDLLR LQLLRIFELL ADAGVISDST NGALERDTLA LGALFLEYVD LTRMLLEAEN 
    DKEVEILKDI RAHFSAMVAN LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP 
    LDRYSDRNHQ ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ 
    LGCEVVVLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGSRN YPFDIVTLLN 
    LVLFKASDTN REIYEISMQL MQILEAKLFV YSKKVAEQRP GSILYGTHGP LPPLYSVSLA 
    LLSCELARMY PELTLPLFSE VSQRFPTTHP NGRQIMLTYL LPWLHNIELV DSRLLLPGSS 
    PSSPEDEVKD REGDVTASHG LRGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGPEMENAWN 
    ALANNEKWSN NLRITLQFLI SLCGVSSDTV LLPYIKKVAI YLCRNNTIQT MEELLFELQQ 
    TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQENFPDAE ENKILKESDE 
    RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL TITETKQPQP LPMPCTGGCW 
    APLVDYLPET ITPRGPLHRC NIAVIFMTEM VVDHSVREDW ALHLPLLLHA VFLGLDHYRP 
    EVFEHSKKLL LHLLIALSCN SNFHSIASVL LQTREMGEAK TLTVQPAYQP EYLYTGGFDF 
    LREDQSSPVP DSGLSSSSTS SSISLGGSSG NLPQMTQEVE DVDTAAETDE KANKLIEFLT 
    TRAFGPLWCH EDITPKNQNS KSAEQLTNFL RHVVSVFKDS KSGFHLEHQL SEVALQTALA 
    SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH GDEIQGYVME ALLTLEAAVD 
    NLSDCLKNSD LLTVLSRSSS PDLSSSSKLT ASRKSTGQLN MNPGTTSGNT ATAERSRHQR 
    SFSVPKKFGV IDRSSDPPRS ATLDRIQACT QQGLSSKTRS SSSLKDSLTD PSHINHPTNL 
    LATIFWVTVA LMESDFEFEY LMALRLLSRL LAHMPLDKAE NREKLEKLQA QLKWADFSGL 
    QQLLLKGFTS LTTTDLTLQL FSLLTPVSKI SMVDASHAIG FPLNVLCLLP QLIQHFENPN 
    QFCKDIAERI AQVCLEEKNP KLSNLAHVMT LYKTHSYTRD CATWVNVVCR YLHEAYADIT 
    LNMVTYLAEL LEKGLPSVQQ PLLQVIYSLL SYMDLSVVPV KQFNVEVLKT IEKYVQSVHW 
    REALNILKLV VSRSASLVLP SYQHSDLSKI EIHRVWTSAS KELPGKTLDF HFDISETPII 
    GRRYDELQNS SGRDGKPRAM AVTRSTSSTS SGSNSNVLVP VSWKRPQYSQ KRTKEKLVHV 
    LSLCGQEVGL SKNPSVIFSS CGDLDLLEHQ TSLVSSEDGA REQENMDDTN SEQQFRVFRD 
    FDFLDVELED GEGESMDNFN WGVRRRSLDS LDKCDMQILE ERQLSGSTPS LNKMHHEDSD 
    ESSEEEDLTA SQILEHSDLI MTLSPSEETN PMELLTTACD STPAEPHSFN TRMSSFDASL 
    PDMNNLQISE GSKAEAVREE EDTTVHEDDL SSSINELPAA FECSDSFSLD MTEGEEKGNR 
    ALDQFTLASF GEGDRGVSPP PSPFFSAILA AFQPAACDDA EEAWRSHINQ LMCDSDGSCA 
    VYTFHVFSSL FKNIQKRFCF LTCDAASYLG DNLRGIGSKF VSSSQMLTSC SECPTLFVDA 
    ETLLSCGLLD KLKFSVLELQ EYLDTYNNRK EATLSWLANC KATFAGGSRD GVITCQPGDS 
    EEKQLELCQR LYKLHFQLLL LFQSYCKLIG QVHEVSSMPE LLNMSRELSD LKKHLKEASA 
    VIAADPLYSD GAWSEPTFTS TEAAIQSMLE CLKNNELGKA LRQIRECRSL WPNDIFGSSS 
    DDEVQTLLNI YFRHQTLGQT GTYALVGSNQ SLTEICTKLM ELNMEIRDMI RRAQSYRVLT 
    TFLPDSSVSG TSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.