CDH15 | ENSG00000129910 | NCBI 1013

Details for: CDH15

Gene ID: 1013

Symbol: CDH15

Ensembl ID: ENSG00000129910

Description: cadherin 15

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Developmental biology
(R-HSA-1266738)
Myogenesis
(R-HSA-525793)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Beta-catenin binding
(GO:0008013)
Cadherin binding
(GO:0045296)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Catenin complex
(GO:0016342)
Caveola
(GO:0005901)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction assembly
(GO:0007043)
Cell adhesion
(GO:0007155)
Cell migration
(GO:0016477)
Cell morphogenesis
(GO:0000902)
Extracellular exosome
(GO:0070062)
Golgi apparatus
(GO:0005794)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Neuromuscular junction
(GO:0031594)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 11.4436
Cell Significance Index: -1.7800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 7.0572
Cell Significance Index: -1.7900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 3.9630
Cell Significance Index: -1.6100
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.9431
Cell Significance Index: 26.7100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.8377
Cell Significance Index: 30.8500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.8524
Cell Significance Index: 31.7500
Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.5791
Cell Significance Index: 38.5300
Cell Name: type II muscle cell (CL0002212)
Fold Change: 1.3511
Cell Significance Index: 21.8000
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.2615
Cell Significance Index: 13.1700
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 1.0773
Cell Significance Index: 7.3600
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.4891
Cell Significance Index: 2.7800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 0.4460
Cell Significance Index: -1.7600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3789
Cell Significance Index: 9.7400
Cell Name: tongue muscle cell (CL0002673)
Fold Change: 0.3619
Cell Significance Index: 2.7100
Cell Name: precursor cell (CL0011115)
Fold Change: 0.3218
Cell Significance Index: 2.4400
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.3089
Cell Significance Index: 4.3400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.2784
Cell Significance Index: -0.6100
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.2695
Cell Significance Index: 3.0600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1819
Cell Significance Index: 6.3200
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.1221
Cell Significance Index: 1.5500
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.0756
Cell Significance Index: 0.9900
Cell Name: peg cell (CL4033014)
Fold Change: 0.0515
Cell Significance Index: 1.1900
Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.0408
Cell Significance Index: 0.6100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0370
Cell Significance Index: 0.6200
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0175
Cell Significance Index: 1.7900
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0114
Cell Significance Index: 0.2500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0106
Cell Significance Index: 1.3600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0081
Cell Significance Index: 6.1300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0049
Cell Significance Index: 0.0700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0037
Cell Significance Index: 2.5400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0011
Cell Significance Index: 0.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0011
Cell Significance Index: 0.3800
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.0009
Cell Significance Index: 0.0100
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0005
Cell Significance Index: -0.2500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0005
Cell Significance Index: -0.8700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0009
Cell Significance Index: -1.7400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0009
Cell Significance Index: -1.4500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0013
Cell Significance Index: -1.7500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0017
Cell Significance Index: -0.3100
Cell Name: granule cell (CL0000120)
Fold Change: -0.0018
Cell Significance Index: -0.0200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0023
Cell Significance Index: -1.6600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0025
Cell Significance Index: -1.5800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0025
Cell Significance Index: -1.8600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0026
Cell Significance Index: -0.5300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0034
Cell Significance Index: -1.9100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0038
Cell Significance Index: -1.7300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0039
Cell Significance Index: -1.1300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0046
Cell Significance Index: -0.7900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0047
Cell Significance Index: -0.9400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0048
Cell Significance Index: -0.6600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0067
Cell Significance Index: -0.1400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0091
Cell Significance Index: -1.9200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0097
Cell Significance Index: -1.4100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0112
Cell Significance Index: -1.3100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0113
Cell Significance Index: -1.4000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0139
Cell Significance Index: -0.4100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0141
Cell Significance Index: -1.6100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0151
Cell Significance Index: -1.9500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0170
Cell Significance Index: -1.7700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0190
Cell Significance Index: -2.2400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0210
Cell Significance Index: -1.4100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0211
Cell Significance Index: -0.5100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0220
Cell Significance Index: -1.3500
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0229
Cell Significance Index: -0.3000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0233
Cell Significance Index: -1.2100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0248
Cell Significance Index: -1.9000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0259
Cell Significance Index: -1.5900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0269
Cell Significance Index: -1.7400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0285
Cell Significance Index: -0.8200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0286
Cell Significance Index: -2.1300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0298
Cell Significance Index: -1.5500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0307
Cell Significance Index: -1.4300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0308
Cell Significance Index: -1.7300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0313
Cell Significance Index: -0.8800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0323
Cell Significance Index: -1.5200
Cell Name: osteoblast (CL0000062)
Fold Change: -0.0330
Cell Significance Index: -0.3200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0344
Cell Significance Index: -1.5200
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0346
Cell Significance Index: -0.5700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0350
Cell Significance Index: -1.8400
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0354
Cell Significance Index: -0.7200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0357
Cell Significance Index: -0.3700
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0372
Cell Significance Index: -0.4800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0376
Cell Significance Index: -1.9000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0385
Cell Significance Index: -1.3500
Cell Name: osteoclast (CL0000092)
Fold Change: -0.0402
Cell Significance Index: -0.4100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0403
Cell Significance Index: -1.5300
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.0414
Cell Significance Index: -0.6200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0418
Cell Significance Index: -1.3700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0437
Cell Significance Index: -1.7900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0449
Cell Significance Index: -1.4300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0468
Cell Significance Index: -1.0000
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0476
Cell Significance Index: -0.6600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0478
Cell Significance Index: -1.6800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0484
Cell Significance Index: -1.3800
Cell Name: keratocyte (CL0002363)
Fold Change: -0.0555
Cell Significance Index: -0.8800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0567
Cell Significance Index: -2.0800
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0585
Cell Significance Index: -1.4600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0593
Cell Significance Index: -2.5800
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0593
Cell Significance Index: -0.6500
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0601
Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Cell adhesion molecule**: CDH15 is a type of cadherin, which is a transmembrane glycoprotein that mediates cell-cell adhesion through homophilic interactions. 2. **Expressed in specific cell types**: CDH15 is specifically expressed in cells of skeletal muscle, preosteoblasts, conventional dendritic cells, osteoblasts, skeletal muscle satellite cells, kidney proximal convoluted tubule epithelial cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and intestinal crypt stem cells of the colon. 3. **Homophilic interactions**: CDH15 interacts with itself, forming homophilic adhesions that are essential for maintaining tissue structure and function. 4. **Calcium-dependent**: CDH15 is calcium-dependent, which suggests that calcium ions play a role in regulating its activity. **Pathways and Functions** 1. **Adherens junction organization**: CDH15 is involved in the formation and maintenance of adherens junctions, which are critical for maintaining tissue structure and function. 2. **Cell-cell adhesion**: CDH15 mediates cell-cell adhesion through homophilic interactions, which is essential for maintaining tissue integrity and preventing cell migration. 3. **Cell junction assembly**: CDH15 is involved in the assembly of cell junctions, which is essential for maintaining tissue structure and function. 4. **Cell morphogenesis**: CDH15 plays a role in regulating cell shape and morphology, which is essential for maintaining tissue structure and function. 5. **Caveola formation**: CDH15 is also involved in the formation of caveolae, which are small invaginations of the plasma membrane that play a role in cell signaling and transport. **Clinical Significance** 1. **Muscle disorders**: Mutations in the CDH15 gene have been associated with muscle disorders, such as muscular dystrophy. 2. **Cancer**: CDH15 has been implicated in cancer progression, particularly in the development of osteosarcoma. 3. **Neurological disorders**: CDH15 has been implicated in neurological disorders, such as epilepsy and schizophrenia. 4. **Regenerative medicine**: CDH15 has been identified as a potential target for regenerative medicine, particularly in the development of therapies for muscle and bone disorders. In conclusion, CDH15 is a critical gene that plays a crucial role in maintaining tissue structure and function through its involvement in cell-cell adhesion, cell junction organization, and cell morphogenesis. Its dysregulation has been implicated in various clinical disorders, highlighting the importance of further research into the mechanisms of CDH15 function and its role in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cadherin-15

Genular Protein ID: 1838142683

Symbol: CAD15_HUMAN

Name: Cadherin-15

UniProtKB Accession Codes:

P55291

Database IDs:

Citations:

PubMed ID: 9030594

Title: Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.

PubMed ID: 9030594

DOI: 10.1074/jbc.272.8.5236

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19012874

Title: Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability.

PubMed ID: 19012874

DOI: 10.1016/j.ajhg.2008.10.020

Sequence Information:

Length: 814
Mass: 88916
Checksum: 618A817DBF2B3343
Sequence:

MDAAFLLVLG LLAQSLCLSL GVPGWRRPTT LYPWRRAPAL SRVRRAWVIP PISVSENHKR 
LPYPLVQIKS DKQQLGSVIY SIQGPGVDEE PRGVFSIDKF TGKVFLNAML DREKTDRFRL 
RAFALDLGGS TLEDPTDLEI VVVDQNDNRP AFLQEAFTGR VLEGAVPGTY VTRAEATDAD 
DPETDNAALR FSILQQGSPE LFSIDELTGE IRTVQVGLDR EVVAVYNLTL QVADMSGDGL 
TATASAIITL DDINDNAPEF TRDEFFMEAI EAVSGVDVGR LEVEDRDLPG SPNWVARFTI 
LEGDPDGQFT IRTDPKTNEG VLSIVKALDY ESCEHYELKV SVQNEAPLQA AALRAERGQA 
KVRVHVQDTN EPPVFQENPL RTSLAEGAPP GTLVATFSAR DPDTEQLQRL SYSKDYDPED 
WLQVDAATGR IQTQHVLSPA SPFLKGGWYR AIVLAQDDAS QPRTATGTLS IEILEVNDHA 
PVLAPPPPGS LCSEPHQGPG LLLGATDEDL PPHGAPFHFQ LSPRLPELGR NWSLSQVNVS 
HARLRPRHQV PEGLHRLSLL LRDSGQPPQQ REQPLNVTVC RCGKDGVCLP GAAALLAGGT 
GLSLGALVIV LASALLLLVL VLLVALRARF WKQSRGKGLL HGPQDDLRDN VLNYDEQGGG 
EEDQDAYDIS QLRHPTALSL PLGPPPLRRD APQGRLHPQP PRVLPTSPLD IADFINDGLE 
AADSDPSVPP YDTALIYDYE GDGSVAGTLS SILSSQGDED QDYDYLRDWG PRFARLADMY 
GHPCGLEYGA RWDHQAREGL SPGALLPRHR GRTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.