Details for: PDIA6

Gene ID: 10130

Symbol: PDIA6

Ensembl ID: ENSG00000143870

Description: protein disulfide isomerase family A member 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.36
    Marker Score: 2,858
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.31
    Marker Score: 43,680
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.08
    Marker Score: 54,675
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.96
    Marker Score: 6,743
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.93
    Marker Score: 101,474
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.9
    Marker Score: 2,044
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.87
    Marker Score: 790
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.78
    Marker Score: 3,351
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.77
    Marker Score: 6,757
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.73
    Marker Score: 4,203
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.73
    Marker Score: 17,752
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.72
    Marker Score: 11,744
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.64
    Marker Score: 5,506
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.59
    Marker Score: 29,210
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.58
    Marker Score: 6,510
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.54
    Marker Score: 668
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.53
    Marker Score: 6,774
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.51
    Marker Score: 18,680
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.47
    Marker Score: 6,818
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.45
    Marker Score: 2,309
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.45
    Marker Score: 1,917
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.42
    Marker Score: 4,120
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.42
    Marker Score: 1,382
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.41
    Marker Score: 3,868
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.4
    Marker Score: 6,521
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.37
    Marker Score: 1,585
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.36
    Marker Score: 2,104
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.36
    Marker Score: 757
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.32
    Marker Score: 2,476
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.32
    Marker Score: 1,455
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.31
    Marker Score: 1,038
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.29
    Marker Score: 3,142
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.27
    Marker Score: 4,028
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.27
    Marker Score: 5,149
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.27
    Marker Score: 1,281
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.26
    Marker Score: 5,314
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.25
    Marker Score: 638
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.24
    Marker Score: 2,272
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.24
    Marker Score: 894
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.23
    Marker Score: 1,149
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.23
    Marker Score: 10,957
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.23
    Marker Score: 22,573
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.22
    Marker Score: 2,543
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8,733
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.21
    Marker Score: 2,086
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.21
    Marker Score: 926
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.2
    Marker Score: 915
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.2
    Marker Score: 525
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.19
    Marker Score: 14,027
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.19
    Marker Score: 8,427
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.17
    Marker Score: 2,169
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.15
    Marker Score: 3,093
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.14
    Marker Score: 1,689
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.14
    Marker Score: 1,001
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.14
    Marker Score: 5,610
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.14
    Marker Score: 2,763
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8,761
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.14
    Marker Score: 3,900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.13
    Marker Score: 18,400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.13
    Marker Score: 21,473
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.13
    Marker Score: 616
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.13
    Marker Score: 2,254
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.09
    Marker Score: 3,473
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.09
    Marker Score: 1,216
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.08
    Marker Score: 4,948
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.08
    Marker Score: 1,740
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.07
    Marker Score: 2,088
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.07
    Marker Score: 2,752
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.06
    Marker Score: 2,216
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.06
    Marker Score: 499
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.05
    Marker Score: 69,896
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.05
    Marker Score: 974
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.05
    Marker Score: 1,467
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.05
    Marker Score: 1,292
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.04
    Marker Score: 2,172
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.04
    Marker Score: 3,247
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.03
    Marker Score: 2,114
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.03
    Marker Score: 884
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.02
    Marker Score: 2,863
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.02
    Marker Score: 20,020
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.02
    Marker Score: 17,700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.01
    Marker Score: 7,439
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.01
    Marker Score: 11,903
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.01
    Marker Score: 2,162
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2
    Marker Score: 1,461
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2
    Marker Score: 2,344
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2
    Marker Score: 1,101
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.99
    Marker Score: 1,098
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.99
    Marker Score: 496
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.98
    Marker Score: 1,691
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.98
    Marker Score: 3,250
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.98
    Marker Score: 12,913
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.98
    Marker Score: 496
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.97
    Marker Score: 3,939
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.97
    Marker Score: 2,904
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.97
    Marker Score: 1,766
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.97
    Marker Score: 1,897
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.96
    Marker Score: 4,144
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.96
    Marker Score: 12,491
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.94
    Marker Score: 5,281

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein Disulfide Isomerase Activity:** PDIA6 is a member of the protein disulfide isomerase family, which catalyzes the formation and rearrangement of disulfide bonds in proteins. 2. **Endoplasmic Reticulum Localization:** PDIA6 is primarily localized to the ER, where it participates in protein folding, quality control, and stress response. 3. **Insulin-Like Growth Factor (IGF) Regulation:** PDIA6 regulates the transport and uptake of IGF by insulin-like growth factor binding proteins (IGFBPs), which is essential for cell growth and survival. 4. **ER Stress Response:** PDIA6 is involved in the unfolded protein response (UPR), which is activated in response to ER stress. The UPR aims to restore ER homeostasis by increasing protein folding capacity and reducing protein synthesis. **Pathways and Functions:** 1. **Protein Folding:** PDIA6 participates in protein folding by catalyzing the formation of disulfide bonds, which is essential for the proper folding of proteins in the ER. 2. **ER Stress Response:** PDIA6 is involved in the UPR, which is activated in response to ER stress. The UPR aims to restore ER homeostasis by increasing protein folding capacity and reducing protein synthesis. 3. **IGF Regulation:** PDIA6 regulates the transport and uptake of IGF by IGFBPs, which is essential for cell growth and survival. 4. **Cellular Stress Response:** PDIA6 is involved in the response to various cellular stresses, including oxidative stress, heat shock, and hypoxia. **Clinical Significance:** 1. **Cancer:** Dysregulation of PDIA6 has been linked to various cancers, including breast, lung, and colon cancer. PDIA6 overexpression has been associated with tumor progression and poor prognosis. 2. **Metabolic Disorders:** PDIA6 has been implicated in the pathogenesis of metabolic disorders, including type 2 diabetes and obesity. Dysregulation of PDIA6 has been linked to insulin resistance and impaired glucose metabolism. 3. **Neurodegenerative Diseases:** PDIA6 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Dysregulation of PDIA6 has been linked to protein misfolding and aggregation. 4. **Immunological Disorders:** PDIA6 has been implicated in the pathogenesis of immunological disorders, including autoimmune diseases and immunodeficiency disorders. Dysregulation of PDIA6 has been linked to impaired immune function and increased susceptibility to infections. In conclusion, PDIA6 is a crucial gene involved in protein folding, ER stress response, and IGF regulation. Its dysregulation has been linked to various diseases, including cancer, metabolic disorders, neurodegenerative diseases, and immunological disorders. Understanding the role of PDIA6 in these processes may provide new insights into the pathogenesis of these diseases and potential therapeutic strategies for their treatment.

Genular Protein ID: 763071678

Symbol: PDIA6_HUMAN

Name: Protein disulfide-isomerase A6

UniProtKB Accession Codes:

Q15084 B3KY95 B5MCQ5 B7Z254 B7Z4M8 F8WA83 Q53RC7 Q6ZSH5 Q99778

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7590364

Title: Cloning and sequencing of the cDNA encoding human P5.

PubMed ID: 7590364

DOI: 10.1016/0378-1119(95)00474-k

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 15466936

Title: A role for the thiol isomerase protein ERP5 in platelet function.

PubMed ID: 15466936

DOI: 10.1182/blood-2004-02-0608

PubMed ID: 12204115

Title: Functional analysis of human P5, a protein disulfide isomerase homologue.

PubMed ID: 12204115

DOI: 10.1093/oxfordjournals.jbchem.a003242

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17495932

Title: Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.

PubMed ID: 17495932

DOI: 10.1038/nature05768

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24508390

Title: Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association.

PubMed ID: 24508390

DOI: 10.1016/j.molcel.2014.01.004

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 440
  • Mass: 48121
  • Checksum: 06895409F0265D7C
  • Sequence:
    • MALLVLGLVS CTFFLAVNGL YSSSDDVIEL TPSNFNREVI QSDSLWLVEF YAPWCGHCQR 
LTPEWKKAAT ALKDVVKVGA VDADKHHSLG GQYGVQGFPT IKIFGSNKNR PEDYQGGRTG 
EAIVDAALSA LRQLVKDRLG GRSGGYSSGK QGRSDSSSKK DVIELTDDSF DKNVLDSEDV 
WMVEFYAPWC GHCKNLEPEW AAAASEVKEQ TKGKVKLAAV DATVNQVLAS RYGIRGFPTI 
KIFQKGESPV DYDGGRTRSD IVSRALDLFS DNAPPPELLE IINEDIAKRT CEEHQLCVVA 
VLPHILDTGA AGRNSYLEVL LKLADKYKKK MWGWLWTEAG AQSELETALG IGGFGYPAMA 
AINARKMKFA LLKGSFSEQG INEFLRELSF GRGSTAPVGG GAFPTIVERE PWDGRDGELP 
VEDDIDLSDV ELDDLGKDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.