Associated with
Other Information
Genular Protein ID: 3563233245
Symbol: OPTN_HUMAN
Name: Optineurin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9488477
Title: Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains.
PubMed ID: 9488477
PubMed ID: 11834836
Title: Adult-onset primary open-angle glaucoma caused by mutations in optineurin.
PubMed ID: 11834836
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9700202
Title: Huntingtin interacts with a family of WW domain proteins.
PubMed ID: 9700202
DOI: 10.1093/hmg/7.9.1463
PubMed ID: 11137014
Title: FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis.
PubMed ID: 11137014
PubMed ID: 10807909
Title: Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway.
PubMed ID: 10807909
PubMed ID: 10756201
Title: Identification of a transcription factor IIIA-interacting protein.
PubMed ID: 10756201
PubMed ID: 12379221
Title: Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure.
PubMed ID: 12379221
PubMed ID: 12646749
Title: Optineurin gene expression level in human trabecular meshwork does not change in response to pressure elevation.
PubMed ID: 12646749
DOI: 10.1159/000069133
PubMed ID: 15837803
Title: Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.
PubMed ID: 15837803
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20085643
Title: Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.
PubMed ID: 20085643
PubMed ID: 20388642
Title: Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice.
PubMed ID: 20388642
DOI: 10.1093/hmg/ddq146
PubMed ID: 20174559
Title: Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.
PubMed ID: 20174559
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22854040
Title: Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17.
PubMed ID: 22854040
DOI: 10.1242/jcs.102327
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23908376
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24705354
Title: The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
PubMed ID: 24705354
DOI: 10.1093/hmg/ddu137
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27538435
Title: The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing.
PubMed ID: 27538435
PubMed ID: 23805866
Title: Structural basis for phosphorylation-triggered autophagic clearance of Salmonella.
PubMed ID: 23805866
DOI: 10.1042/bj20121907
PubMed ID: 14627677
Title: The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma.
PubMed ID: 14627677
PubMed ID: 12939304
Title: Different optineurin mutation pattern in primary open-angle glaucoma.
PubMed ID: 12939304
DOI: 10.1167/iovs.02-0693
PubMed ID: 14597044
Title: Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma.
PubMed ID: 14597044
PubMed ID: 23357852
Title: M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells.
PubMed ID: 23357852
DOI: 10.4161/auto.23458
PubMed ID: 24752605
Title: E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.
PubMed ID: 24752605
PubMed ID: 23669351
Title: Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.
PubMed ID: 23669351
DOI: 10.1093/hmg/ddt210
PubMed ID: 15498064
Title: Analysis of optineurin (OPTN) gene mutations in subjects with and without glaucoma: the blue mountains eye study.
PubMed ID: 15498064
PubMed ID: 15326130
Title: Defining the pathogenicity of optineurin in juvenile open-angle glaucoma.
PubMed ID: 15326130
DOI: 10.1167/iovs.04-0107
PubMed ID: 15557444
Title: Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.
PubMed ID: 15557444
DOI: 10.1167/iovs.03-1403
PubMed ID: 15226658
Title: Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population.
PubMed ID: 15226658
PubMed ID: 15370540
Title: Clinical relevance of optineurin sequence alterations in Japanese glaucoma patients.
PubMed ID: 15370540
PubMed ID: 17389490
Title: A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.
PubMed ID: 17389490
DOI: 10.1167/iovs.06-0834
PubMed ID: 20428114
Title: Mutations of optineurin in amyotrophic lateral sclerosis.
PubMed ID: 20428114
DOI: 10.1038/nature08971
PubMed ID: 21617041
Title: Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
PubMed ID: 21617041
PubMed ID: 31371777
Title: Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering.
PubMed ID: 31371777
PubMed ID: 32185393
Title: CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.
PubMed ID: 32185393
PubMed ID: 27534431
Title: A novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro.
PubMed ID: 27534431
Sequence Information:
- Length: 577
- Mass: 65922
- Checksum: 2BAF841BA515AAE2
- Sequence:
MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.