Details for: CDH16

Gene ID: 1014

Symbol: CDH16

Ensembl ID: ENSG00000166589

Description: cadherin 16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8278
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.22
    Marker Score: 10637
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6844
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.71
    Marker Score: 3931
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.27
    Marker Score: 8767
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 3.15
    Marker Score: 4456
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.7
    Marker Score: 4483
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.91
    Marker Score: 1471
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.56
    Marker Score: 367
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.56
    Marker Score: 5554
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.49
    Marker Score: 1515
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.41
    Marker Score: 752
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.26
    Marker Score: 1056
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19434
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.17
    Marker Score: 614
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.07
    Marker Score: 715
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.03
    Marker Score: 430
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 451
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.92
    Marker Score: 180
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.88
    Marker Score: 841
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.87
    Marker Score: 1681
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.84
    Marker Score: 1967
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.83
    Marker Score: 896
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3195
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.74
    Marker Score: 149
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.72
    Marker Score: 6245
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1150
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.72
    Marker Score: 758
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.72
    Marker Score: 1104
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.66
    Marker Score: 425
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 498
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 288
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.6
    Marker Score: 346
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.58
    Marker Score: 2412.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.58
    Marker Score: 497
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.56
    Marker Score: 395
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 951
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.48
    Marker Score: 994
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.42
    Marker Score: 3287.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.38
    Marker Score: 295
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 752
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.37
    Marker Score: 134
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.32
    Marker Score: 82
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.25
    Marker Score: 623
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 199
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.21
    Marker Score: 68
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.19
    Marker Score: 133
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.19
    Marker Score: 337
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.18
    Marker Score: 74.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.15
    Marker Score: 97
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.15
    Marker Score: 154
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 137
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 186
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 154
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.08
    Marker Score: 553
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.08
    Marker Score: 2792
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 19

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Other Information

**Key characteristics:** - CDH16 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in oligodendrocyte precursor cells, kidney cells, and endothelial cells. - It is also expressed in low levels in epithelial cells in various tissues. - CDH16 is a homophilic protein, meaning that it binds to other cadherins. **Pathways and functions:** - CDH16 is involved in cell-cell adhesion by binding to cadherins on neighboring cells. - It is also involved in calcium-dependent cell-cell adhesion, which is a process that is essential for the formation and maintenance of tissues and organs. - CDH16 is a key regulator of cell migration, proliferation, and differentiation. - It is also involved in the regulation of angiogenesis, cell migration, and tissue remodeling. **Clinical significance:** - Mutations in CDH16 have been linked to several human diseases, including cerebral palsy, kidney disease, and cancer. - CDH16 is a promising target for cancer immunotherapy, as it is frequently expressed on tumor cells and is involved in their adhesion to neighboring cells. - Drugs that block CDH16 have been shown to be effective in inhibiting tumor growth and metastasis.

Genular Protein ID: 464922807

Symbol: CAD16_HUMAN

Name: Cadherin-16

UniProtKB Accession Codes:

O75309 B4DPA8 H3BPD3 Q6UW93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9721215

Title: cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin.

PubMed ID: 9721215

DOI: 10.1006/geno.1998.5402

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 829
  • Mass: 89923
  • Checksum: 41966915E4BFC891
  • Sequence:
    • MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD 
SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN 
DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF 
QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS 
LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA 
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA 
EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM 
DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE 
PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG 
PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL 
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP 
PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT 
LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM 
PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.