Details for: CDH16

Gene ID: 1014

Symbol: CDH16

Ensembl ID: ENSG00000166589

Description: cadherin 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 14.5730
    Cell Significance Index: 55.8000
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 11.8504
    Cell Significance Index: 40.6900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 5.8015
    Cell Significance Index: 49.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4556
    Cell Significance Index: 27.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2690
    Cell Significance Index: 139.1100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.7647
    Cell Significance Index: 18.7500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.6564
    Cell Significance Index: 19.2600
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.2964
    Cell Significance Index: 13.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6714
    Cell Significance Index: 127.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6122
    Cell Significance Index: 14.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4111
    Cell Significance Index: 8.7600
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.3695
    Cell Significance Index: 3.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3618
    Cell Significance Index: 35.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3450
    Cell Significance Index: 252.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3355
    Cell Significance Index: 302.9800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.3119
    Cell Significance Index: 2.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3024
    Cell Significance Index: 4.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2662
    Cell Significance Index: 15.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2418
    Cell Significance Index: 26.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2079
    Cell Significance Index: 33.8200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.1864
    Cell Significance Index: 2.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1489
    Cell Significance Index: 4.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1455
    Cell Significance Index: 10.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1297
    Cell Significance Index: 1.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0946
    Cell Significance Index: 2.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0895
    Cell Significance Index: 7.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0795
    Cell Significance Index: 1.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0750
    Cell Significance Index: 3.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0540
    Cell Significance Index: 1.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0475
    Cell Significance Index: 1.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0303
    Cell Significance Index: 0.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0234
    Cell Significance Index: 4.6500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0196
    Cell Significance Index: 0.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0136
    Cell Significance Index: 0.3200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.0121
    Cell Significance Index: 0.1100
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.0083
    Cell Significance Index: 0.0600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0078
    Cell Significance Index: 0.0600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0050
    Cell Significance Index: 0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0025
    Cell Significance Index: 1.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0031
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0046
    Cell Significance Index: -2.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0048
    Cell Significance Index: -0.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0080
    Cell Significance Index: -0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0082
    Cell Significance Index: -2.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0095
    Cell Significance Index: -6.0600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0096
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0131
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0134
    Cell Significance Index: -1.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0147
    Cell Significance Index: -0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0157
    Cell Significance Index: -3.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0167
    Cell Significance Index: -0.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0173
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0174
    Cell Significance Index: -2.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0198
    Cell Significance Index: -0.5100
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0214
    Cell Significance Index: -0.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0232
    Cell Significance Index: -3.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0238
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0238
    Cell Significance Index: -2.7300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0250
    Cell Significance Index: -0.2900
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0301
    Cell Significance Index: -0.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0337
    Cell Significance Index: -3.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0388
    Cell Significance Index: -2.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0399
    Cell Significance Index: -5.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0427
    Cell Significance Index: -0.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0434
    Cell Significance Index: -3.3300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.0448
    Cell Significance Index: -0.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0474
    Cell Significance Index: -3.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0487
    Cell Significance Index: -0.8400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0541
    Cell Significance Index: -0.8100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0550
    Cell Significance Index: -0.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0564
    Cell Significance Index: -1.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0597
    Cell Significance Index: -2.1900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0646
    Cell Significance Index: -0.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0651
    Cell Significance Index: -3.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0686
    Cell Significance Index: -1.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0695
    Cell Significance Index: -3.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0750
    Cell Significance Index: -3.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0757
    Cell Significance Index: -1.5700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0765
    Cell Significance Index: -0.9600
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0766
    Cell Significance Index: -0.7600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0769
    Cell Significance Index: -0.8600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0783
    Cell Significance Index: -0.7600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0794
    Cell Significance Index: -0.8500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0817
    Cell Significance Index: -1.6300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0851
    Cell Significance Index: -0.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0855
    Cell Significance Index: -3.7800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0856
    Cell Significance Index: -1.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** CDH16 exhibits structural homology with other cadherins, including E-cadherin and N-cadherin, suggesting a conserved mechanism of cell adhesion. 2. **Cell Type-Specific Expression:** CDH16 is significantly expressed in cells of the nervous system, kidney, and colon, highlighting its role in tissue-specific cell-cell interactions. 3. **Calcium-Dependent Adhesion:** CDH16 is calcium-dependent, indicating its reliance on calcium ions to facilitate cell-cell adhesion. 4. **Homophilic Adhesion:** CDH16 exhibits homophilic adhesion, meaning it interacts with itself to mediate cell-cell adhesion. **Pathways and Functions:** 1. **Basolateral Plasma Membrane Adhesion:** CDH16 is involved in the formation of the basolateral plasma membrane, a critical structure for maintaining tissue integrity and function. 2. **Calcium-Dependent Cell-Cell Adhesion:** CDH16 plays a key role in calcium-dependent cell-cell adhesion, regulating the interactions between adjacent cells. 3. **Extracellular Exosome Signaling:** CDH16 is involved in extracellular exosome signaling, which regulates the exchange of molecules between cells and the extracellular matrix. 4. **Protein Binding:** CDH16 binds to various proteins, including those involved in cell signaling and adhesion, modulating its function. **Clinical Significance:** 1. **Neurological Disorders:** CDH16 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where impaired cell-cell adhesion contributes to disease progression. 2. **Kidney Disease:** CDH16 dysfunction has been linked to kidney disease, including nephrotic syndrome and chronic kidney disease, where impaired cell-cell adhesion contributes to tissue damage. 3. **Inflammatory Responses:** CDH16 has been shown to modulate inflammatory responses, suggesting its potential role in regulating immune responses and tissue repair. 4. **Cancer:** CDH16 has been implicated in cancer, including colon cancer, where its expression is often downregulated, leading to impaired cell-cell adhesion and tumor progression. In conclusion, CDH16 is a novel cadherin involved in cell-cell adhesion and tissue homeostasis. Its unique characteristics, pathways, and functions highlight its significance in maintaining tissue integrity and regulating immune responses. Further studies are necessary to elucidate the full extent of CDH16's role in human diseases and its potential as a therapeutic target.

Genular Protein ID: 464922807

Symbol: CAD16_HUMAN

Name: Cadherin-16

UniProtKB Accession Codes:

O75309 B4DPA8 H3BPD3 Q6UW93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9721215

Title: cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin.

PubMed ID: 9721215

DOI: 10.1006/geno.1998.5402

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 829
  • Mass: 89923
  • Checksum: 41966915E4BFC891
  • Sequence:
    • MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD 
SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN 
DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF 
QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS 
LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA 
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA 
EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM 
DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE 
PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG 
PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL 
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP 
PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT 
LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM 
PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.