Details for: TOB1

Gene ID: 10140

Symbol: TOB1

Ensembl ID: ENSG00000141232

Description: transducer of ERBB2, 1

Associated with

  • Ccr4-not complex
    (GO:0030014)
  • Cytoplasm
    (GO:0005737)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of nuclear-transcribed mrna poly(a) tail shortening
    (GO:0060212)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of translation
    (GO:0017148)
  • Nucleus
    (GO:0005634)
  • Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
    (GO:1900153)
  • Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
    (GO:0060213)
  • Protein binding
    (GO:0005515)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of smad protein signal transduction
    (GO:0060390)
  • Smad binding
    (GO:0046332)
  • Transcription corepressor activity
    (GO:0003714)

Other Information

Genular Protein ID: 422833013

Symbol: TOB1_HUMAN

Name: Protein Tob1

UniProtKB Accession Codes:

P50616 B2R9T0 D3DTY3 Q4KMQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8632892

Title: Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

PubMed ID: 8632892

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21336257

Title: Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.

PubMed ID: 21336257

DOI: 10.1038/emboj.2011.37

PubMed ID: 23236473

Title: The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

PubMed ID: 23236473

DOI: 10.1371/journal.pone.0051331

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19276069

Title: Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.

PubMed ID: 19276069

DOI: 10.1074/jbc.m809250200

Sequence Information:

  • Length: 345
  • Mass: 38155
  • Checksum: 3C8AC51B49E1E69F
  • Sequence:
    • MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY KGSGFRCIHI 
GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS YQIGEKGPVK VLYVDDNNEN 
GCELDKEIKN SFNPEAQVFM PISDPASSVS SSPSPPFGHS AAVSPTFMPR STQPLTFTTA 
TFAATKFGST KMKNSGRSNK VARTSPINLG LNVNDLLKQK AISSSMHSLY GLGLGSQQQP 
QQQQQPAQPP PPPPPPQQQQ QQKTSALSPN AKEFIFPNMQ GQGSSTNGMF PGDSPLNLSP 
LQYSNAFDVF AAYGGLNEKS FVDGLNFSLN NMQYSNQQFQ PVMAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.