Details for: G3BP1
Associated with
Other Information
Genular Protein ID: 1151273719
Symbol: G3BP1_HUMAN
Name: Ras GTPase-activating protein-binding protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8649363
Title: A Ras-GTPase-activating protein SH3-domain-binding protein.
PubMed ID: 8649363
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9889278
Title: Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway.
PubMed ID: 9889278
DOI: 10.1093/nar/27.3.817
PubMed ID: 11604510
Title: RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization.
PubMed ID: 11604510
PubMed ID: 11439350
Title: Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.
PubMed ID: 11439350
PubMed ID: 12642610
Title: The RasGAP-associated endoribonuclease G3BP assembles stress granules.
PubMed ID: 12642610
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17487921
Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
PubMed ID: 17487921
PubMed ID: 17210633
Title: Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs.
PubMed ID: 17210633
DOI: 10.1128/mcb.02300-06
PubMed ID: 17693683
Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
PubMed ID: 17693683
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 18684830
Title: Different types of nsP3-containing protein complexes in Sindbis virus-infected cells.
PubMed ID: 18684830
DOI: 10.1128/jvi.01011-08
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20180778
Title: The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation.
PubMed ID: 20180778
DOI: 10.1042/bj20091383
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23209657
Title: Ataxin-2-like is a regulator of stress granules and processing bodies.
PubMed ID: 23209657
PubMed ID: 23087212
Title: Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection.
PubMed ID: 23087212
PubMed ID: 23953116
Title: Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.
PubMed ID: 23953116
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23279204
Title: Both G3BP1 and G3BP2 contribute to stress granule formation.
PubMed ID: 23279204
DOI: 10.1111/gtc.12023
PubMed ID: 23785203
Title: Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses.
PubMed ID: 23785203
DOI: 10.1128/jvi.03248-12
PubMed ID: 24623412
Title: The C-terminal repeat domains of nsP3 from the Old World alphaviruses bind directly to G3BP.
PubMed ID: 24623412
DOI: 10.1128/jvi.00439-14
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25658430
Title: Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation.
PubMed ID: 25658430
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27022092
Title: G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
PubMed ID: 27022092
PubMed ID: 27383630
Title: Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
PubMed ID: 27383630
DOI: 10.1098/rsob.160078
PubMed ID: 28794026
Title: Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.
PubMed ID: 28794026
DOI: 10.1128/jvi.01298-17
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28592527
Title: Zika virus hijacks stress granule proteins and modulates the host stress response.
PubMed ID: 28592527
DOI: 10.1128/jvi.00474-17
PubMed ID: 30006004
Title: Enterovirus 71 inhibits cytoplasmic stress granule formation during the late stage of infection.
PubMed ID: 30006004
PubMed ID: 30404792
Title: Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation.
PubMed ID: 30404792
DOI: 10.1128/jvi.00922-18
PubMed ID: 30510222
Title: G3BP1 promotes DNA binding and activation of cGAS.
PubMed ID: 30510222
PubMed ID: 30804210
Title: The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance IFN-beta response.
PubMed ID: 30804210
PubMed ID: 32302570
Title: Competing protein-RNA interaction networks control multiphase intracellular organization.
PubMed ID: 32302570
PubMed ID: 32302571
Title: G3BP1 is a tunable switch that triggers phase separation to assemble stress granules.
PubMed ID: 32302571
PubMed ID: 32302572
Title: RNA-Induced conformational switching and clustering of G3BP drive stress granule assembly by condensation.
PubMed ID: 32302572
PubMed ID: 31981475
Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.
PubMed ID: 31981475
PubMed ID: 34739333
Title: Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
PubMed ID: 34739333
PubMed ID: 34779554
Title: The stress granule protein G3BP1 promotes pre-condensation of cGAS to allow rapid responses to DNA.
PubMed ID: 34779554
PubMed ID: 36692217
Title: Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
PubMed ID: 36692217
PubMed ID: 37379838
Title: QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism.
PubMed ID: 37379838
PubMed ID: 24324649
Title: Crystal structures of the human G3BP1 NTF2-like domain visualize FxFG Nup repeat specificity.
PubMed ID: 24324649
PubMed ID: 36183834
Title: Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.
PubMed ID: 36183834
PubMed ID: 36279435
Title: Yin and yang regulation of stress granules by Caprin-1.
PubMed ID: 36279435
Sequence Information:
- Length: 466
- Mass: 52164
- Checksum: 0F9429D78E0C7F59
- Sequence:
MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK PADAVYGQKE IHRKVMSQNF TNCHTKIRHV DAHATLNDGV VVQVMGLLSN NNQALRRFMQ TFVLAPEGSV ANKFYVHNDI FRYQDEVFGG FVTEPQEESE EEVEEPEERQ QTPEVVPDDS GTFYDQAVVS NDMEEHLEEP VAEPEPDPEP EPEQEPVSEI QEEKPEPVLE ETAPEDAQKS SSPAPADIAQ TVQEDLRTFS WASVTSKNLP PSGAVPVTGI PPHVVKVPAS QPRPESKPES QIPPQRPQRD QRVREQRINI PPQRGPRPIR EAGEQGDIEP RRMVRHPDSH QLFIGNLPHE VDKSELKDFF QSYGNVVELR INSGGKLPNF GFVVFDDSEP VQKVLSNRPI MFRGEVRLNV EEKKTRAARE GDRRDNRLRG PGGPRGGLGG GMRGPPRGGM VQKPGFGVGR GLAPRQ
Genular Protein ID: 68659996
Symbol: Q6ZP53_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 307
- Mass: 34576
- Checksum: 02B7A3168AC798DE
- Sequence:
MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK PADAVYGQKE IQEEKPEPVL EETAPDDSGT FYDQAVVSND MEEHLEEPVA EPEPDPEPEP EQEPVSEIQE EKPEPESKPE SQIPPQRPQR DQRVREQRIN IPPQRGPRPI REAGEQGDIE PRRMVRHPDS HQLFIGNLPH EVDKSELKDF FQSYGNVVEL RINSGGKLPN FGFVVFDDSE PVQKVLSNRP IMFRGEVRLN VEEKKTRAAR EGDRRDNRLR GPGGPRGGLG GGMRGPPRGG MVQKPGFGVG RGLAPRQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.