Details for: CDH17

Gene ID: 1015

Symbol: CDH17

Ensembl ID: ENSG00000079112

Description: cadherin 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 15.7187
    Cell Significance Index: 119.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 13.5384
    Cell Significance Index: 202.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 10.0418
    Cell Significance Index: 455.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 9.1506
    Cell Significance Index: 198.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 8.8772
    Cell Significance Index: 255.7700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.3038
    Cell Significance Index: -4.2300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 5.2687
    Cell Significance Index: 53.1500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 4.6800
    Cell Significance Index: 50.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 3.9366
    Cell Significance Index: 428.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.6609
    Cell Significance Index: 58.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6425
    Cell Significance Index: -4.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1539
    Cell Significance Index: 27.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9400
    Cell Significance Index: 92.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6807
    Cell Significance Index: 21.8000
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.6657
    Cell Significance Index: 5.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.6400
    Cell Significance Index: 6.6300
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.5891
    Cell Significance Index: 4.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5658
    Cell Significance Index: 107.6800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.5599
    Cell Significance Index: 3.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4284
    Cell Significance Index: 7.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1946
    Cell Significance Index: 31.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1665
    Cell Significance Index: 3.5500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0660
    Cell Significance Index: 0.4800
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.0469
    Cell Significance Index: 0.4600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0403
    Cell Significance Index: 0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0207
    Cell Significance Index: 4.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0035
    Cell Significance Index: 1.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0034
    Cell Significance Index: 3.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0009
    Cell Significance Index: 1.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0007
    Cell Significance Index: 0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0030
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0032
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0045
    Cell Significance Index: -0.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0065
    Cell Significance Index: -3.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0086
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0107
    Cell Significance Index: -1.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0124
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0145
    Cell Significance Index: -1.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0180
    Cell Significance Index: -2.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0194
    Cell Significance Index: -3.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0226
    Cell Significance Index: -0.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0231
    Cell Significance Index: -0.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0268
    Cell Significance Index: -3.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0329
    Cell Significance Index: -1.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0359
    Cell Significance Index: -3.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0384
    Cell Significance Index: -1.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0397
    Cell Significance Index: -2.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0408
    Cell Significance Index: -5.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0471
    Cell Significance Index: -2.8900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0475
    Cell Significance Index: -0.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0478
    Cell Significance Index: -0.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0485
    Cell Significance Index: -3.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0487
    Cell Significance Index: -1.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0492
    Cell Significance Index: -1.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0518
    Cell Significance Index: -2.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0523
    Cell Significance Index: -4.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0543
    Cell Significance Index: -5.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0565
    Cell Significance Index: -3.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0570
    Cell Significance Index: -6.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0697
    Cell Significance Index: -3.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0806
    Cell Significance Index: -0.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0816
    Cell Significance Index: -3.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0884
    Cell Significance Index: -1.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0908
    Cell Significance Index: -3.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0914
    Cell Significance Index: -5.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0926
    Cell Significance Index: -2.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0968
    Cell Significance Index: -1.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0970
    Cell Significance Index: -3.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0982
    Cell Significance Index: -2.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1003
    Cell Significance Index: -1.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1006
    Cell Significance Index: -5.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1008
    Cell Significance Index: -3.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1216
    Cell Significance Index: -3.4700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1300
    Cell Significance Index: -1.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1333
    Cell Significance Index: -6.2700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1374
    Cell Significance Index: -4.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1415
    Cell Significance Index: -3.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1425
    Cell Significance Index: -3.8100
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1440
    Cell Significance Index: -1.5200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1503
    Cell Significance Index: -1.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1509
    Cell Significance Index: -3.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1521
    Cell Significance Index: -4.0000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1524
    Cell Significance Index: -3.1000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1526
    Cell Significance Index: -2.1100
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.1546
    Cell Significance Index: -0.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1589
    Cell Significance Index: -1.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1597
    Cell Significance Index: -4.0800
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1609
    Cell Significance Index: -1.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1626
    Cell Significance Index: -3.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1713
    Cell Significance Index: -4.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDH17 is a type II transmembrane protein that belongs to the cadherin family, which plays a crucial role in cell-cell adhesion. It is expressed in various cell types, including epithelial cells, endothelial cells, mononuclear phagocytes, and stem cells. CDH17 exhibits a unique binding specificity, interacting with other cadherins and catenins to form complexes that regulate cell-cell adhesion and signaling. **Pathways and Functions:** CDH17 is involved in various cellular processes, including: 1. **Cell-cell adhesion**: CDH17 mediates homophilic cell adhesion via the plasma membrane, contributing to the formation and maintenance of adherens junctions. 2. **Cell junction organization**: CDH17 interacts with catenins and other cadherins to regulate the organization and dynamics of cell junctions, influencing cell morphology and signaling. 3. **Immune responses**: CDH17 is expressed in immune cells, such as mononuclear phagocytes and B cells, where it regulates immune cell interactions and signaling. 4. **Cell signaling**: CDH17 interacts with other signaling molecules, including integrins, to regulate cell surface receptor-linked signal transduction and integrin activation. **Clinical Significance:** CDH17 has been implicated in various diseases and disorders, including: 1. **Cancer**: CDH17 is often downregulated in cancer cells, leading to decreased cell-cell adhesion and increased invasion and metastasis. 2. **Autoimmune diseases**: CDH17 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it may contribute to immune cell dysfunction and tissue damage. 3. **Neurological disorders**: CDH17 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuronal cell adhesion and signaling dysregulation. In conclusion, CDH17 is a critical regulator of cell-cell adhesion and immune responses. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the mechanisms and functions of CDH17. As an expert immunologist, I believe that understanding the role of CDH17 in immune regulation and disease can lead to the development of novel therapeutic strategies for treating various human diseases.

Genular Protein ID: 1601485992

Symbol: CAD17_HUMAN

Name: Cadherin-17

UniProtKB Accession Codes:

Q12864 Q15336 Q2M2E0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8153632

Title: Association of intestinal peptide transport with a protein related to the cadherin superfamily.

PubMed ID: 8153632

DOI: 10.1126/science.8153632

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 832
  • Mass: 92219
  • Checksum: 2707547DD2DB4202
  • Sequence:
    • MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF 
ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN 
DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA TDLDDPATPN GQLYYQIVIQ LPMINNVMYF 
QINNKTGAIS LTREGSQELN PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK 
APKPVEMVEN STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ ENERLGNSIG 
TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA GMLQLAKQSL KKQDTPQYNL 
TIEVSDKDFK TLCFVQINVI DINDQIPIFE KSDYGNLTLA EDTNIGSTIL TIQATDADEP 
FTGSSKILYH IIKGDSEGRL GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV 
FGVKYNASSF AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV SEFHLILMDV 
NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG PHFTFSLGSG SLQNDWEVSK 
INGTHARLST RHTEFEEREY VVLIRINDGG RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT 
GIPTVGMAVG ILLTTLLVIG IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.