Gene CDH17 - ENSG00000079112 | NCBI Gene ID: 1015

Details for: CDH17

Gene ID: 1015

Symbol: CDH17

Ensembl ID: ENSG00000079112

Description: cadherin 17

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Basolateral plasma membrane
(GO:0016323)
Cadherin binding
(GO:0045296)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Catenin complex
(GO:0016342)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction assembly
(GO:0007043)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell morphogenesis
(GO:0000902)
Cell surface
(GO:0009986)
Germinal center b cell differentiation
(GO:0002314)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Marginal zone b cell differentiation
(GO:0002315)
Multicellular organism development
(GO:0007275)
Nucleoplasm
(GO:0005654)
Oligopeptide transmembrane transport
(GO:0035672)
Oligopeptide transport
(GO:0006857)
Plasma membrane
(GO:0005886)
Positive regulation of integrin activation by cell surface receptor linked signal transduction
(GO:0033626)
Protein binding
(GO:0005515)
Proton-dependent oligopeptide secondary active transmembrane transporter activity
(GO:0005427)
Spleen development
(GO:0048536)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.19
Marker Score: 10009
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 3.01
Marker Score: 3022
Cell Name: enterocyte (CL0000584)
Fold Change: 2.86
Marker Score: 13708
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.37
Marker Score: 2389
Cell Name: stem cell (CL0000034)
Fold Change: 1.98
Marker Score: 4709
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.94
Marker Score: 1858
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.82
Marker Score: 452
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.81
Marker Score: 2788
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.65
Marker Score: 3407.5
Cell Name: amacrine cell (CL0000561)
Fold Change: 1.64
Marker Score: 5247
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.53
Marker Score: 576.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.47
Marker Score: 1466
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.38
Marker Score: 2622
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.38
Marker Score: 398
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.33
Marker Score: 11248
Cell Name: precursor cell (CL0011115)
Fold Change: 1.33
Marker Score: 322
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.16
Marker Score: 2365
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.12
Marker Score: 17556
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 1.1
Marker Score: 3260.5
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.01
Marker Score: 291
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.98
Marker Score: 1091
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.96
Marker Score: 1551
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: paneth cell (CL0000510)
Fold Change: 0.95
Marker Score: 660
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5354
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.81
Marker Score: 387
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.75
Marker Score: 452
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.73
Marker Score: 190
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 467
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 664
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.71
Marker Score: 285.5
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.7
Marker Score: 186
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2935
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.69
Marker Score: 217
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.66
Marker Score: 190
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.59
Marker Score: 714
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.58
Marker Score: 300
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.57
Marker Score: 123
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.56
Marker Score: 548
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 440
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.53
Marker Score: 387
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.52
Marker Score: 237
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.5
Marker Score: 124
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.46
Marker Score: 133
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.46
Marker Score: 201
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.46
Marker Score: 204
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.45
Marker Score: 187
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.44
Marker Score: 1037
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.44
Marker Score: 111
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.39
Marker Score: 101
Cell Name: oocyte (CL0000023)
Fold Change: 0.37
Marker Score: 92
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.34
Marker Score: 111
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.34
Marker Score: 94
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.34
Marker Score: 322
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.33
Marker Score: 98
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.31
Marker Score: 97
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.31
Marker Score: 304
Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.3
Marker Score: 91
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.3
Marker Score: 133
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.29
Marker Score: 224
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.22
Marker Score: 76
Cell Name: goblet cell (CL0000160)
Fold Change: 0.22
Marker Score: 1463
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.21
Marker Score: 59
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.2
Marker Score: 121
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 0.2
Marker Score: 64
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.2
Marker Score: 61
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.19
Marker Score: 61
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.17
Marker Score: 79
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.16
Marker Score: 54
Cell Name: GIP cell (CL0002278)
Fold Change: 0.16
Marker Score: 51
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.16
Marker Score: 999
Cell Name: plasma cell (CL0000786)
Fold Change: 0.15
Marker Score: 173
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.15
Marker Score: 30
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.15
Marker Score: 99
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.14
Marker Score: 1881
Cell Name: pericyte (CL0000669)
Fold Change: 0.14
Marker Score: 81
Cell Name: podocyte (CL0000653)
Fold Change: 0.14
Marker Score: 50
Cell Name: mast cell (CL0000097)
Fold Change: 0.13
Marker Score: 78
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.13
Marker Score: 50
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.13
Marker Score: 799
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.13
Marker Score: 76
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.13
Marker Score: 26
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.13
Marker Score: 46
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.13
Marker Score: 160
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.13
Marker Score: 28
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.13
Marker Score: 324
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.12
Marker Score: 28
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.12
Marker Score: 66
Cell Name: PP cell (CL0000696)
Fold Change: 0.12
Marker Score: 27
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.12
Marker Score: 102
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.11
Marker Score: 180

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**Key characteristics:** * CDH17 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a glycoprotein that is highly expressed in epithelial cells. * It is involved in cell-cell adhesion, cell junction assembly, and cell migration. **Pathways and functions:** * CDH17 is a key component of adherens junctions, which are cell-cell contacts found in epithelial tissues. * It is involved in the organization and stability of epithelial cell layers. * It is also involved in cell migration and tissue morphogenesis. * CDH17 is a regulator of cell-cell adhesion and signaling pathways. **Clinical significance:** * Mutations in CDH17 have been linked to several human diseases, including colon cancer, breast cancer, and leukemia. * CDH17 is a potential target for cancer immunotherapy. * It is a promising therapeutic target for diseases characterized by abnormal cell adhesion and tissue organization. **Other important points:** * CDH17 is a highly conserved protein, with similar sequences found in organisms from different species. * It is a key regulator of epithelial cell function and tissue homeostasis. * It is a promising target for cancer immunotherapy due to its role in cell adhesion and tumor progression.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cadherin-17

Genular Protein ID: 1601485992

Symbol: CAD17_HUMAN

Name: Cadherin-17

UniProtKB Accession Codes:

Q12864 Q15336 Q2M2E0

Database IDs:

Citations:

PubMed ID: 8153632

Title: Association of intestinal peptide transport with a protein related to the cadherin superfamily.

PubMed ID: 8153632

DOI: 10.1126/science.8153632

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 832
Mass: 92219
Checksum: 2707547DD2DB4202
Sequence:

MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF 
ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN 
DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA TDLDDPATPN GQLYYQIVIQ LPMINNVMYF 
QINNKTGAIS LTREGSQELN PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK 
APKPVEMVEN STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ ENERLGNSIG 
TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA GMLQLAKQSL KKQDTPQYNL 
TIEVSDKDFK TLCFVQINVI DINDQIPIFE KSDYGNLTLA EDTNIGSTIL TIQATDADEP 
FTGSSKILYH IIKGDSEGRL GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV 
FGVKYNASSF AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV SEFHLILMDV 
NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG PHFTFSLGSG SLQNDWEVSK 
INGTHARLST RHTEFEEREY VVLIRINDGG RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT 
GIPTVGMAVG ILLTTLLVIG IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.