Details for: CDH17

Gene ID: 1015

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CDH17

Ensembl ID: ENSG00000079112

Description: cadherin 17

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • BEST4+ enteroycte CL4030026
    CSI 38.43
    rCSI 47.8%
    PRS 98.19
  • colon epithelial cell CL0011108
    CSI 31.21
    rCSI 32.69%
    PRS 98.39
  • goblet cell CL0000160
    CSI 31.19
    rCSI 29.47%
    PRS 98.22
  • M cell of gut CL0000682
    CSI 27.18
    rCSI 28.88%
    PRS 98.79
  • intestinal epithelial cell CL0002563
    CSI 26.4
    rCSI 27.6%
    PRS 98.14
  • intestine goblet cell CL0019031
    CSI 22.21
    rCSI 19.72%
    PRS 98.12
  • brush cell CL0002204
    CSI 19.06
    rCSI 37.73%
    PRS 98.32
  • myeloid leukocyte CL0000766
    CSI 17.41
    rCSI 16.06%
    PRS 99.13
  • enterocyte CL0000584
    CSI 15.51
    rCSI 25.01%
    PRS 97.49
  • enteroendocrine cell CL0000164
    CSI 15.02
    rCSI 20.52%
    PRS 97.64
  • stem cell CL0000034
    CSI 13.95
    rCSI 13.45%
    PRS 98.41
  • intestinal tuft cell CL0019032
    CSI 13.93
    rCSI 21.29%
    PRS 98.36
  • type L enteroendocrine cell CL0002279
    CSI 13.24
    rCSI 24.85%
    PRS 98.5
  • colonocyte CL1000347
    CSI 13.23
    rCSI 18.97%
    PRS 98.37
  • transit amplifying cell of colon CL0009011
    CSI 12.18
    rCSI 14.31%
    PRS 99.11
  • transit amplifying cell CL0009010
    CSI 11.49
    rCSI 17.58%
    PRS 99.21
  • enterocyte of epithelium of large intestine CL0002071
    CSI 11.12
    rCSI 58.42%
    PRS 98.97
  • small intestine goblet cell CL1000495
    CSI 10.48
    rCSI 22.96%
    PRS 98.86
  • colon goblet cell CL0009039
    CSI 9.24
    rCSI 21.96%
    PRS 98.86
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 9.02
    rCSI 24.3%
    PRS 99.1
  • melanocyte of skin CL1000458
    CSI 7.81
    rCSI 10.64%
    PRS 85.53
  • tuft cell of colon CL0009041
    CSI 6.81
    rCSI 15.87%
    PRS 98.33
  • transit amplifying cell of small intestine CL0009012
    CSI 6.52
    rCSI 28.64%
    PRS 99.11
  • type EC enteroendocrine cell CL0000577
    CSI 6.41
    rCSI 22.74%
    PRS 98.39
  • enteroendocrine cell of small intestine CL0009006
    CSI 6.11
    rCSI 13.46%
    PRS 98.62
  • pancreatic PP cell CL0002275
    CSI 5.79
    rCSI 23.03%
    PRS 98.31
  • IgA plasma cell CL0000987
    CSI 5.23
    rCSI 5.35%
    PRS 97.05
  • paneth cell of epithelium of small intestine CL1000343
    CSI 3.78
    rCSI 10.59%
    PRS 99.05
  • enterocyte of epithelium of small intestine CL1000334
    CSI 3.5
    rCSI 54.14%
    PRS 98.71
  • enteroendocrine cell of colon CL0009042
    CSI 2.99
    rCSI 14.01%
    PRS 98.4
  • paneth cell of colon CL0009009
    CSI 2.71
    rCSI 26.6%
    PRS 99.02
  • paneth cell CL0000510
    CSI 2.55
    rCSI 3.76%
    PRS 99.34
  • intestinal crypt stem cell of colon CL0009043
    CSI 2.11
    rCSI 15.86%
    PRS 99.45

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CDH17](/details-gene/1015), or Cadherin-17, is a protein-coding gene located on chromosome 8q22.1. As a member of the cadherin superfamily, its primary function involves mediating calcium-dependent cell-cell adhesion, a critical process for maintaining tissue architecture. Expression data reveals that [CDH17](/details-gene/1015) is a highly specific marker for the epithelial lining of the gastrointestinal tract, with profound significance in cell types such as `[BEST4+ enteroycte](/details-cell/CL4030026)`, `[colon epithelial cell](/details-cell/CL0011108)`, and `[goblet cell](/details-cell/CL0000160)`. Uniquely, beyond its structural role, [CDH17](/details-gene/1015) is also implicated in oligopeptide transport across the plasma membrane, suggesting a dual function in both maintaining intestinal barrier integrity and facilitating nutrient absorption [Link](https://doi.org/10.1126/science.8153632). ## Cellular Roles and Expression Landscape The expression profile of [CDH17](/details-gene/1015) firmly establishes its identity as a key structural and functional component of the intestinal epithelium. **Overall**, the gene shows its highest significance in a range of specialized cells lining the gut, including `[BEST4+ enteroycte](/details-cell/CL4030026)` (CSI: 38.43), `[colon epithelial cell](/details-cell/CL0011108)` (CSI: 31.21), and `[goblet cell](/details-cell/CL0000160)` (CSI: 31.19). Its high CSI values extend to other critical intestinal cell types such as `[M cell of gut](/details-cell/CL0000682)`, `[enterocyte](/details-cell/CL0000584)`, and `[enteroendocrine cell](/details-cell/CL0000164)`, underscoring its broad importance in this tissue. This expression pattern suggests that [CDH17](/details-gene/1015) is fundamental to the organization and function of the mucosal barrier. The gene's significance in progenitor populations like `[stem cell](/details-cell/CL0000034)` and `[transit amplifying cell of colon](/details-cell/CL0009011)` further indicates a role in the continuous renewal and maintenance of the intestinal lining. The collective data portrays [CDH17](/details-gene/1015) not merely as a passive adhesion molecule, but as an active participant in the diverse physiological activities of the gut epithelium, from absorption to mucosal defense. ## Pathways and Molecular Function The functions of [CDH17](/details-gene/1015) are well-supported by established biological pathways. Its role in tissue structure is highlighted by its involvement in `[Adherens junctions interactions](/details-pathway/R-HSA-418990)` and `[Cell junction organization](/details-pathway/R-HSA-446728)`. These pathways are crucial for the formation of the epithelial barrier, which is consistent with its high expression in intestinal epithelial cells. Gene Ontology annotations corroborate this, pointing to core functions in `[Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules](/details-go/GO0016339)` and its localization to the `[Adherens junction](/details-go/GO0005912)` and `[Basolateral plasma membrane](/details-go/GO0016323)`. At the molecular level, its ability to engage in `[Cadherin binding](/details-go/GO0045296)` and `[Beta-catenin binding](/details-go/GO0008013)` confirms its canonical mechanism within cell-cell junctions. A distinct and functionally significant aspect of [CDH17](/details-gene/1015) is its annotated role in `[Oligopeptide transmembrane transport](/details-go/GO0035672)`. This dual functionality, combining adhesion with transport, is unusual for a cadherin and is supported by early research identifying it as an intestinal peptide transporter [Link](https://doi.org/10.1126/science.8153632). This suggests [CDH17](/details-gene/1015) physically links the structural integrity of the gut lining with its primary physiological duty of nutrient absorption. ## Research Directions The unique characteristics of [CDH17](/details-gene/1015) suggest several avenues for future investigation. Its high specificity for the gut epithelium, combined with its dual functions, makes it a compelling subject in both normal physiology and disease. **Proposed Hypotheses:** 1. **Dual-Function Regulation:** The adhesive and transport functions of [CDH17](/details-gene/1015) may be co-regulated. It is hypothesized that the state of cell-cell adhesion (e.g., cell density or junctional tension) directly modulates the oligopeptide transport activity of [CDH17](/details-gene/1015), providing a mechanism for intestinal cells to couple nutrient absorption rates to tissue integrity and metabolic demand. 2. **Role in Colorectal Cancer:** Dysregulation of cadherins is a hallmark of epithelial-mesenchymal transition (EMT) and cancer progression. We hypothesize that the loss of [CDH17](/details-gene/1015) expression or function in colorectal cancer contributes to tumor cell dissociation, invasion, and metastasis by disrupting adherens junctions. 3. **Host-Microbiome Interaction:** Given its high expression in `[M cell of gut](/details-cell/CL0000682)` and its peptide transport capabilities, [CDH17](/details-gene/1015) may be involved in sampling and transporting bacterial-derived peptides from the gut lumen, thereby playing a role in mucosal immunity and the maintenance of host-microbiome homeostasis. **Experimental Approach:** To test the role of [CDH17](/details-gene/1015) in colorectal cancer (Hypothesis 2), one could employ a CRISPR-Cas9 knockout strategy in a well-differentiated colon adenocarcinoma cell line (e.g., Caco-2). The impact on cell adhesion could be quantified using cell aggregation assays and immunofluorescence staining for junctional proteins like beta-catenin. Cell migratory and invasive capabilities could be measured using Transwell invasion assays. Concurrently, RNA-sequencing of knockout versus control cells would reveal downstream transcriptional changes, particularly in genes associated with EMT and cell signaling pathways. **Therapeutic Potential:** As a cell surface protein with highly restricted expression to the gastrointestinal epithelium, [CDH17](/details-gene/1015) presents a promising therapeutic target, particularly in oncology. If its expression is retained on colorectal tumor cells, it could serve as a target for antibody-drug conjugates (ADCs) or CAR-T cell therapies, enabling specific delivery of cytotoxic agents to the tumor while sparing other tissues. Such a strategy would involve targeting the protein for tumor cell elimination rather than functional inhibition.

Genular Protein ID: 1601485992

Symbol: CAD17_HUMAN

Name: Cadherin-17

UniProtKB Accession Codes:

Q12864 Q15336 Q2M2E0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8153632

Title: Association of intestinal peptide transport with a protein related to the cadherin superfamily.

PubMed ID: 8153632

DOI: 10.1126/science.8153632

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 832
  • Mass: 92219
  • Checksum: 2707547DD2DB4202
  • Sequence:
    • MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF 
ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN 
DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA TDLDDPATPN GQLYYQIVIQ LPMINNVMYF 
QINNKTGAIS LTREGSQELN PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK 
APKPVEMVEN STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ ENERLGNSIG 
TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA GMLQLAKQSL KKQDTPQYNL 
TIEVSDKDFK TLCFVQINVI DINDQIPIFE KSDYGNLTLA EDTNIGSTIL TIQATDADEP 
FTGSSKILYH IIKGDSEGRL GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV 
FGVKYNASSF AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV SEFHLILMDV 
NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG PHFTFSLGSG SLQNDWEVSK 
INGTHARLST RHTEFEEREY VVLIRINDGG RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT 
GIPTVGMAVG ILLTTLLVIG IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS