Details for: TRIM28
Associated with
Other Information
Genular Protein ID: 3028976037
Symbol: TIF1B_HUMAN
Name: E3 SUMO-protein ligase TRIM28
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8769649
Title: KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
PubMed ID: 8769649
PubMed ID: 9016654
Title: Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.
PubMed ID: 9016654
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17512541
Title: The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain.
PubMed ID: 17512541
PubMed ID: 10330177
Title: KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.
PubMed ID: 10330177
PubMed ID: 10347202
Title: Two novel Kruppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1).
PubMed ID: 10347202
PubMed ID: 11013263
Title: A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.
PubMed ID: 11013263
PubMed ID: 11230151
Title: Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
PubMed ID: 11230151
DOI: 10.1101/gad.869501
PubMed ID: 11959841
Title: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
PubMed ID: 11959841
DOI: 10.1101/gad.973302
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15882967
Title: The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.
PubMed ID: 15882967
PubMed ID: 16107876
Title: MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.
PubMed ID: 16107876
PubMed ID: 17056014
Title: KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction.
PubMed ID: 17056014
PubMed ID: 16792528
Title: The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.
PubMed ID: 16792528
DOI: 10.1042/bj20060194
PubMed ID: 17178852
Title: KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions.
PubMed ID: 17178852
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16862143
Title: Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
PubMed ID: 16862143
DOI: 10.1038/ncb1446
PubMed ID: 17942928
Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.
PubMed ID: 17942928
PubMed ID: 17079232
Title: Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells.
PubMed ID: 17079232
PubMed ID: 17704056
Title: Regulation of E2F1 function by the nuclear corepressor KAP1.
PubMed ID: 17704056
PubMed ID: 17942393
Title: Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression.
PubMed ID: 17942393
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18082607
Title: PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.
PubMed ID: 18082607
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18060868
Title: A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1.
PubMed ID: 18060868
PubMed ID: 18675275
Title: The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS.
PubMed ID: 18675275
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19710015
Title: The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
PubMed ID: 19710015
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20388717
Title: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
PubMed ID: 20388717
PubMed ID: 20858735
Title: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.
PubMed ID: 20858735
PubMed ID: 20864041
Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
PubMed ID: 20864041
PubMed ID: 20562864
Title: Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.
PubMed ID: 20562864
DOI: 10.1038/ncb2075
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 20424263
Title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.
PubMed ID: 20424263
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21940674
Title: Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.
PubMed ID: 21940674
PubMed ID: 21549307
Title: Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
PubMed ID: 21549307
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23034801
Title: SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
PubMed ID: 23034801
DOI: 10.1093/nar/gks868
PubMed ID: 32890405
Title: SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
PubMed ID: 32890405
DOI: 10.1093/nar/gkaa754
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23665872
Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.
PubMed ID: 23665872
PubMed ID: 23543754
Title: Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28.
PubMed ID: 23543754
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23149945
Title: Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
PubMed ID: 23149945
DOI: 10.1128/mcb.01195-12
PubMed ID: 24623306
Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
PubMed ID: 24623306
DOI: 10.7554/elife.02313
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24741090
Title: Kaposi's sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency.
PubMed ID: 24741090
DOI: 10.1128/jvi.00596-14
PubMed ID: 24657165
Title: Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.
PubMed ID: 24657165
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25593309
Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
PubMed ID: 25593309
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 27029610
Title: ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment.
PubMed ID: 27029610
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 31856708
Title: DUF3669, a 'domain of unknown function' within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression.
PubMed ID: 31856708
PubMed ID: 30042493
Title: TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.
PubMed ID: 30042493
PubMed ID: 32051553
Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
PubMed ID: 32051553
PubMed ID: 11226167
Title: Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.
PubMed ID: 11226167
PubMed ID: 18488044
Title: Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing.
PubMed ID: 18488044
DOI: 10.1038/nsmb.1416
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 835
- Mass: 88550
- Checksum: 2027BABB7C94FE20
- Sequence:
MAASAAAASA AAASAASGSP GPGEGSAGGE KRSTAPSAAA SASASAAASS PAGGGAEALE LLEHCGVCRE RLRPEREPRL LPCLHSACSA CLGPAAPAAA NSSGDGGAAG DGTVVDCPVC KQQCFSKDIV ENYFMRDSGS KAATDAQDAN QCCTSCEDNA PATSYCVECS EPLCETCVEA HQRVKYTKDH TVRSTGPAKS RDGERTVYCN VHKHEPLVLF CESCDTLTCR DCQLNAHKDH QYQFLEDAVR NQRKLLASLV KRLGDKHATL QKSTKEVRSS IRQVSDVQKR VQVDVKMAIL QIMKELNKRG RVLVNDAQKV TEGQQERLER QHWTMTKIQK HQEHILRFAS WALESDNNTA LLLSKKLIYF QLHRALKMIV DPVEPHGEMK FQWDLNAWTK SAEAFGKIVA ERPGTNSTGP APMAPPRAPG PLSKQGSGSS QPMEVQEGYG FGSGDDPYSS AEPHVSGVKR SRSGEGEVSG LMRKVPRVSL ERLDLDLTAD SQPPVFKVFP GSTTEDYNLI VIERGAAAAA TGQPGTAPAG TPGAPPLAGM AIVKEEETEA AIGAPPTATE GPETKPVLMA LAEGPGAEGP RLASPSGSTS SGLEVVAPEG TSAPGGGPGT LDDSATICRV CQKPGDLVMC NQCEFCFHLD CHLPALQDVP GEEWSCSLCH VLPDLKEEDG SLSLDGADST GVVAKLSPAN QRKCERVLLA LFCHEPCRPL HQLATDSTFS LDQPGGTLDL TLIRARLQEK LSPPYSSPQE FAQDVGRMFK QFNKLTEDKA DVQSIIGLQR FFETRMNEAF GDTKFSAVLV EPPPMSLPGA GLSSQELSGG PGDGP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.