Details for: RASA4

Gene ID: 10156

Symbol: RASA4

Ensembl ID: ENSG00000105808

Description: RAS p21 protein activator 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.11
    Marker Score: 447
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,003
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.98
    Marker Score: 4,060
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,247
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,725
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.85
    Marker Score: 573
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.82
    Marker Score: 597
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 789
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8
    Marker Score: 564
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.79
    Marker Score: 7,391
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.79
    Marker Score: 16,757
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.74
    Marker Score: 1,253
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.71
    Marker Score: 719
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.7
    Marker Score: 152
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 526
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 275
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.68
    Marker Score: 5,977
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.67
    Marker Score: 25,496
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.66
    Marker Score: 213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.66
    Marker Score: 799
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.66
    Marker Score: 811
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2,724
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.64
    Marker Score: 155
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 993
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.64
    Marker Score: 148
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.63
    Marker Score: 422
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.63
    Marker Score: 38,744
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.62
    Marker Score: 700
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.62
    Marker Score: 132
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.62
    Marker Score: 898
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.61
    Marker Score: 1,225
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.61
    Marker Score: 1,541
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.6
    Marker Score: 22,160
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.59
    Marker Score: 294
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.58
    Marker Score: 215
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.57
    Marker Score: 191
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.57
    Marker Score: 31,691
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.56
    Marker Score: 5,298
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.56
    Marker Score: 502
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.55
    Marker Score: 1,137
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.54
    Marker Score: 938
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.52
    Marker Score: 4,462
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.5
    Marker Score: 3,837
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.49
    Marker Score: 1,157
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.48
    Marker Score: 132
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 309
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.48
    Marker Score: 1,865
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.48
    Marker Score: 117
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.47
    Marker Score: 113
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.46
    Marker Score: 199
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.46
    Marker Score: 6,809
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.44
    Marker Score: 168
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 289
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 174
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.41
    Marker Score: 8,254
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.41
    Marker Score: 166
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.41
    Marker Score: 177
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.4
    Marker Score: 207
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 355
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 124
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.39
    Marker Score: 208
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.39
    Marker Score: 87
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.38
    Marker Score: 198
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.38
    Marker Score: 359
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.38
    Marker Score: 735
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.38
    Marker Score: 1,565
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.37
    Marker Score: 971
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.35
    Marker Score: 279
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.35
    Marker Score: 299
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.34
    Marker Score: 3,839
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.34
    Marker Score: 88
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.34
    Marker Score: 248
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.33
    Marker Score: 77
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.33
    Marker Score: 227
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.32
    Marker Score: 71
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.32
    Marker Score: 346
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.32
    Marker Score: 551
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.31
    Marker Score: 331
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.31
    Marker Score: 1,986
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.3
    Marker Score: 105
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.3
    Marker Score: 326
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3
    Marker Score: 613
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.3
    Marker Score: 68
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 79

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** RASA4 is significantly expressed in various cell types, including type A enteroendocrine cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, chandelier pvalb GABAergic cortical interneurons, intestinal crypt stem cells, tuft cells, BEST4+ intestinal epithelial cells, human, and transit amplifying cells. 2. **Protein Structure:** RASA4 is a protein that interacts with Ras proteins, regulating their GTPase activity and thereby modulating their signaling pathways. 3. **Function:** RASA4 acts as a negative regulator of Ras protein signal transduction, ensuring that Ras proteins are deactivated and their signaling pathways are terminated. **Pathways and Functions:** 1. **Ras Signaling Pathway:** RASA4 is a key component of the Ras signaling pathway, which regulates cell proliferation, differentiation, and survival. The pathway involves the activation of Ras proteins, which then interact with downstream effectors, such as MAPK and PI3K, to regulate various cellular processes. 2. **GTPase Activator Activity:** RASA4 possesses GTPase activator activity, which enables it to stimulate the GTPase activity of Ras proteins, leading to their deactivation and termination of signaling. 3. **Intracellular Signal Transduction:** RASA4 regulates various intracellular signaling pathways, including the MAPK1/3 signaling cascade, the Raf/MAPK cascade, and the regulation of Ras by GTPase-activating proteins (GAPs). **Clinical Significance:** 1. **Cancer:** RASA4 has been implicated in the regulation of Ras protein signaling pathways, which are frequently dysregulated in various cancers, including colorectal cancer, breast cancer, and lung cancer. 2. **Neurological Disorders:** RASA4 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where dysregulation of Ras protein signaling pathways contributes to disease progression. 3. **Immunological Disorders:** RASA4 has been shown to play a role in regulating the activity of immune cells, such as T cells and B cells, which are critical in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, RASA4 is a critical regulator of Ras protein signaling pathways, which are essential for various cellular processes, including cell growth, differentiation, and survival. Dysregulation of RASA4 has been implicated in various diseases, including cancer, neurological disorders, and immunological disorders, highlighting the importance of this gene in maintaining cellular homeostasis.

Genular Protein ID: 2849356773

Symbol: RASL2_HUMAN

Name: Ras GTPase-activating protein 4

UniProtKB Accession Codes:

O43374 O60286 Q14CQ4 Q86UW3 Q96QU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 27 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11448776

Title: CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

PubMed ID: 11448776

DOI: 10.1016/s0960-9822(01)00261-5

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 803
  • Mass: 90458
  • Checksum: 6E70DBF2F8F5D0E9
  • Sequence:
    • MAKRSSLYIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLC PFWGEEYQVH 
LPPTFHAVAF YVMDEDALSR DDVIGKVCLT RDTIASHPKG FSGWAHLTEV DPDEEVQGEI 
HLRLEVWPGA RACRLRCSVL EARDLAPKDR NGTSDPFVRV RYKGRTRETS IVKKSCYPRW 
NETFEFELQE GAMEALCVEA WDWDLVSRND FLGKVVIDVQ RLRVVQQEEG WFRLQPDQSK 
SRRHDEGNLG SLQLEVRLRD ETVLPSSYYQ PLVHLLCHEV KLGMQGPGQL IPLIEETTST 
ECRQDVATNL LKLFLGQGLA KDFLDLLFQL ELSRTSETNT LFRSNSLASK SMESFLKVAG 
MQYLHGVLGP IINKVFEEKK YVELDPSKVE VKDVGCSGLH RPQTEAEVLE QSAQTLRAHL 
GALLSALSRS VRACPAVVRA TFRQLFRRVR ERFPGAQHEN VPFIAVTSFL CLRFFSPAIM 
SPKLFHLRER HADARTSRTL LLLAKAVQNV GNMDTPASRA KEAWMEPLQP TVRQGVAQLK 
DFITKLVDIE EKDELDLQRT LSLQAPPVKE GPLFIHRTKG KGPLMSSSFK KLYFSLTTEA 
LSFAKTPSSK KSALIKLANI RAAEKVEEKS FGGSHVMQVI YTDDAGRPQT AYLQCKCVNE 
LNQWLSALRK VSINNTGLLG SYHPGVFRGD KWSCCHQKEK TGQGCDKTRS RVTLQEWNDP 
LDHDLEAQLI YRHLLGVEAM LWERHRELSG GAEAGTVPTS PGKVPEDSLA RLLRVLQDLR 
EAHSSSPAGS PPSEPNCLLE LQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.