Details for: CDH18

Gene ID: 1016

Symbol: CDH18

Ensembl ID: ENSG00000145526

Description: cadherin 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 17.0140
    Cell Significance Index: 291.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 10.2695
    Cell Significance Index: 224.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.2418
    Cell Significance Index: 352.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9804
    Cell Significance Index: -10.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.5903
    Cell Significance Index: 1646.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.7293
    Cell Significance Index: 141.2200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 3.5097
    Cell Significance Index: 36.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.3371
    Cell Significance Index: 669.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.0662
    Cell Significance Index: 87.5000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.9964
    Cell Significance Index: 37.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6496
    Cell Significance Index: 117.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1714
    Cell Significance Index: 1501.8100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.7482
    Cell Significance Index: 23.3200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 1.6224
    Cell Significance Index: 17.9000
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.0123
    Cell Significance Index: 11.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.7145
    Cell Significance Index: 8.9100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.5752
    Cell Significance Index: 7.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2158
    Cell Significance Index: 11.3300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1745
    Cell Significance Index: 1.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1387
    Cell Significance Index: 4.5400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.1062
    Cell Significance Index: 1.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0228
    Cell Significance Index: 35.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0197
    Cell Significance Index: 8.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0132
    Cell Significance Index: -0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -24.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0221
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0379
    Cell Significance Index: -28.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0450
    Cell Significance Index: -1.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0498
    Cell Significance Index: -31.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0520
    Cell Significance Index: -38.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0551
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0639
    Cell Significance Index: -36.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0742
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0763
    Cell Significance Index: -47.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0819
    Cell Significance Index: -2.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1239
    Cell Significance Index: -35.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1463
    Cell Significance Index: -29.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1572
    Cell Significance Index: -22.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1669
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1708
    Cell Significance Index: -29.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1816
    Cell Significance Index: -2.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1968
    Cell Significance Index: -35.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1993
    Cell Significance Index: -41.9700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2231
    Cell Significance Index: -4.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2573
    Cell Significance Index: -11.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3021
    Cell Significance Index: -41.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3119
    Cell Significance Index: -38.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3152
    Cell Significance Index: -8.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3327
    Cell Significance Index: -8.3000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3583
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4030
    Cell Significance Index: -46.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4109
    Cell Significance Index: -5.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4163
    Cell Significance Index: -48.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4207
    Cell Significance Index: -43.8100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4536
    Cell Significance Index: -4.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5030
    Cell Significance Index: -38.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5112
    Cell Significance Index: -40.4900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5477
    Cell Significance Index: -6.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6497
    Cell Significance Index: -36.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6563
    Cell Significance Index: -14.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6694
    Cell Significance Index: -23.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7864
    Cell Significance Index: -40.9700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7887
    Cell Significance Index: -6.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7974
    Cell Significance Index: -50.2600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8094
    Cell Significance Index: -9.6800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8555
    Cell Significance Index: -17.8600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.8703
    Cell Significance Index: -6.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8743
    Cell Significance Index: -41.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8799
    Cell Significance Index: -13.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9388
    Cell Significance Index: -43.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0428
    Cell Significance Index: -54.1700
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -1.0530
    Cell Significance Index: -10.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0913
    Cell Significance Index: -40.0600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.1215
    Cell Significance Index: -14.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.1574
    Cell Significance Index: -40.6700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.1630
    Cell Significance Index: -22.8900
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -1.1943
    Cell Significance Index: -12.8400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.2061
    Cell Significance Index: -24.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.2878
    Cell Significance Index: -40.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.3088
    Cell Significance Index: -22.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3318
    Cell Significance Index: -35.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3379
    Cell Significance Index: -34.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3693
    Cell Significance Index: -34.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.4088
    Cell Significance Index: -40.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4205
    Cell Significance Index: -41.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5408
    Cell Significance Index: -10.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5454
    Cell Significance Index: -44.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5571
    Cell Significance Index: -30.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5585
    Cell Significance Index: -41.6200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.5756
    Cell Significance Index: -32.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.6005
    Cell Significance Index: -34.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6218
    Cell Significance Index: -40.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.6383
    Cell Significance Index: -41.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.6730
    Cell Significance Index: -41.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7025
    Cell Significance Index: -45.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.7078
    Cell Significance Index: -41.6700
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.7175
    Cell Significance Index: -13.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.8033
    Cell Significance Index: -48.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDH18 is a type-1 transmembrane cadherin that is characterized by its ability to mediate homophilic cell-cell adhesion via its extracellular domain. The extracellular domain of CDH18 contains a calcium-binding site, which is essential for its function in cell-cell adhesion. The cytoplasmic domain of CDH18 interacts with the cytoplasmic domain of the catenin protein, β-catenin, to form a complex that is involved in the organization of adherens junctions. CDH18 has been shown to be involved in the development and maintenance of various tissues, including the lung, brain, and heart. **Pathways and Functions** CDH18 plays a critical role in several biological pathways, including: 1. Adherens junction organization: CDH18 is involved in the formation and maintenance of adherens junctions, which are critical for maintaining tissue structure and organization. 2. Cell-cell adhesion mediated by cadherin: CDH18 mediates homophilic cell-cell adhesion via its extracellular domain. 3. Calcium-dependent cell-cell adhesion: CDH18 requires calcium ions to function properly, which is essential for its role in cell-cell adhesion. 4. Cell junction assembly: CDH18 is involved in the assembly of cell junctions, including adherens junctions and desmosomes. 5. Cell morphogenesis: CDH18 is involved in the development and maintenance of tissue structure and organization. **Clinical Significance** CDH18 has been implicated in several diseases, including: 1. Lung cancer: CDH18 has been shown to be downregulated in lung cancer, suggesting that it may play a role in the development of this disease. 2. Brain disorders: CDH18 has been implicated in several brain disorders, including Alzheimer's disease and schizophrenia. 3. Cardiovascular disease: CDH18 has been shown to be involved in the development of cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 4. Neurological disorders: CDH18 has been implicated in several neurological disorders, including Parkinson's disease and multiple sclerosis. In conclusion, CDH18 is an important gene that plays a critical role in maintaining tissue structure and organization, as well as in the development and function of various cell types. Further studies are needed to fully understand the role of CDH18 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3127589255

Symbol: CAD18_HUMAN

Name: Cadherin-18

UniProtKB Accession Codes:

Q13634 A8K0I2 B4DHG6 Q8N5Z2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 17 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9030594

Title: Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.

PubMed ID: 9030594

DOI: 10.1074/jbc.272.8.5236

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 790
  • Mass: 88073
  • Checksum: 5C7BDEB229B6EDCA
  • Sequence:
    • MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF 
FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ 
KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ 
VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD 
MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN 
ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH 
LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF 
INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD 
VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK 
DNEDNTASIL TRRRRFSRTV QDVYYLPIMI SDGGIPSLSS SSTLTIRVCA CERDGRVRTC 
HAEAFLSSAG LSTGALIAIL LCVLILLAIV VLFITLRRSK KEPLIISEED VRENVVTYDD 
EGGGEEDTEA FDITALRNPS AAEELKYRRD IRPEVKLTPR HQTSSTLESI DVQEFIKQRL 
AEADLDPSVP PYDSLQTYAY EGQRSEAGSI SSLDSATTQS DQDYHYLGDW GPEFKKLAEL 
YGEIESERTT

Genular Protein ID: 3286615849

Symbol: D6RER2_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RER2

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 6 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 575
  • Mass: 63748
  • Checksum: 4E285F073DFC606B
  • Sequence:
    • MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF 
FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ 
KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ 
VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD 
MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN 
ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH 
LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF 
INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD 
VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK 
DNEAAAAPSP SGFVHAREMG VCGPAMQKPS CPRLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.