Details for: CDH18

Gene ID: 1016

Symbol: CDH18

Ensembl ID: ENSG00000145526

Description: cadherin 18

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 7.6
    Marker Score: 3,407
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.19
    Marker Score: 54,236
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 6.94
    Marker Score: 37,302
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.53
    Marker Score: 220,417
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.77
    Marker Score: 5,242
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.68
    Marker Score: 53,308
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.61
    Marker Score: 7,445
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.6
    Marker Score: 38,881
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.56
    Marker Score: 13,447
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.49
    Marker Score: 1,309
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.45
    Marker Score: 93,187
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.4
    Marker Score: 792
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.39
    Marker Score: 9,897
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.33
    Marker Score: 977
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.32
    Marker Score: 8,972
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.31
    Marker Score: 85,148
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,660
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.19
    Marker Score: 3,685
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.15
    Marker Score: 16,458
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.1
    Marker Score: 2,597
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127,381
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,325
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.92
    Marker Score: 7,809
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.89
    Marker Score: 19,567
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,112
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.84
    Marker Score: 502
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.77
    Marker Score: 3,601
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.73
    Marker Score: 8,004
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,543
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.64
    Marker Score: 988
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.47
    Marker Score: 3,380
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.37
    Marker Score: 417
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.37
    Marker Score: 1,710
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.35
    Marker Score: 518
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.25
    Marker Score: 1,437
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.21
    Marker Score: 553
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.2
    Marker Score: 579
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.18
    Marker Score: 3,942
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,190
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.1
    Marker Score: 656
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.09
    Marker Score: 23,266
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.08
    Marker Score: 337
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,766
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,991
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1
    Marker Score: 558
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.97
    Marker Score: 2,281
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,307
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.92
    Marker Score: 1,011
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.91
    Marker Score: 1,094
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.9
    Marker Score: 429
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.88
    Marker Score: 829
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.85
    Marker Score: 1,865
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.84
    Marker Score: 218
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.83
    Marker Score: 3,482
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.81
    Marker Score: 1,471
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.78
    Marker Score: 5,176
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 510
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.74
    Marker Score: 431
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.73
    Marker Score: 480
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.73
    Marker Score: 304
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.66
    Marker Score: 6,702
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.66
    Marker Score: 290
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.61
    Marker Score: 214
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.6
    Marker Score: 1,026
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.58
    Marker Score: 500
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.57
    Marker Score: 630
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.56
    Marker Score: 676
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.52
    Marker Score: 188
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.51
    Marker Score: 1,466
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3,043
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.51
    Marker Score: 1,029
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.5
    Marker Score: 261
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.48
    Marker Score: 152
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.47
    Marker Score: 609
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.46
    Marker Score: 1,636
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.46
    Marker Score: 313
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.46
    Marker Score: 120
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.43
    Marker Score: 253
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.43
    Marker Score: 122
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 243
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 408
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.41
    Marker Score: 168
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 369
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.41
    Marker Score: 82
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.4
    Marker Score: 164
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.39
    Marker Score: 227
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.38
    Marker Score: 920

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDH18 is a type-1 transmembrane cadherin that is characterized by its ability to mediate homophilic cell-cell adhesion via its extracellular domain. The extracellular domain of CDH18 contains a calcium-binding site, which is essential for its function in cell-cell adhesion. The cytoplasmic domain of CDH18 interacts with the cytoplasmic domain of the catenin protein, β-catenin, to form a complex that is involved in the organization of adherens junctions. CDH18 has been shown to be involved in the development and maintenance of various tissues, including the lung, brain, and heart. **Pathways and Functions** CDH18 plays a critical role in several biological pathways, including: 1. Adherens junction organization: CDH18 is involved in the formation and maintenance of adherens junctions, which are critical for maintaining tissue structure and organization. 2. Cell-cell adhesion mediated by cadherin: CDH18 mediates homophilic cell-cell adhesion via its extracellular domain. 3. Calcium-dependent cell-cell adhesion: CDH18 requires calcium ions to function properly, which is essential for its role in cell-cell adhesion. 4. Cell junction assembly: CDH18 is involved in the assembly of cell junctions, including adherens junctions and desmosomes. 5. Cell morphogenesis: CDH18 is involved in the development and maintenance of tissue structure and organization. **Clinical Significance** CDH18 has been implicated in several diseases, including: 1. Lung cancer: CDH18 has been shown to be downregulated in lung cancer, suggesting that it may play a role in the development of this disease. 2. Brain disorders: CDH18 has been implicated in several brain disorders, including Alzheimer's disease and schizophrenia. 3. Cardiovascular disease: CDH18 has been shown to be involved in the development of cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 4. Neurological disorders: CDH18 has been implicated in several neurological disorders, including Parkinson's disease and multiple sclerosis. In conclusion, CDH18 is an important gene that plays a critical role in maintaining tissue structure and organization, as well as in the development and function of various cell types. Further studies are needed to fully understand the role of CDH18 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3127589255

Symbol: CAD18_HUMAN

Name: Cadherin-18

UniProtKB Accession Codes:

Q13634 A8K0I2 B4DHG6 Q8N5Z2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 17 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9030594

Title: Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.

PubMed ID: 9030594

DOI: 10.1074/jbc.272.8.5236

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 790
  • Mass: 88073
  • Checksum: 5C7BDEB229B6EDCA
  • Sequence:
    • MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF 
FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ 
KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ 
VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD 
MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN 
ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH 
LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF 
INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD 
VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK 
DNEDNTASIL TRRRRFSRTV QDVYYLPIMI SDGGIPSLSS SSTLTIRVCA CERDGRVRTC 
HAEAFLSSAG LSTGALIAIL LCVLILLAIV VLFITLRRSK KEPLIISEED VRENVVTYDD 
EGGGEEDTEA FDITALRNPS AAEELKYRRD IRPEVKLTPR HQTSSTLESI DVQEFIKQRL 
AEADLDPSVP PYDSLQTYAY EGQRSEAGSI SSLDSATTQS DQDYHYLGDW GPEFKKLAEL 
YGEIESERTT

Genular Protein ID: 3286615849

Symbol: D6RER2_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RER2

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 6 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 575
  • Mass: 63748
  • Checksum: 4E285F073DFC606B
  • Sequence:
    • MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF 
FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ 
KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ 
VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD 
MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN 
ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH 
LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF 
INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD 
VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK 
DNEAAAAPSP SGFVHAREMG VCGPAMQKPS CPRLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.