Details for: FARP1

Gene ID: 10160

Symbol: FARP1

Ensembl ID: ENSG00000152767

Description: FERM, ARH/RhoGEF and pleckstrin domain protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.95
    Marker Score: 123,291
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.75
    Marker Score: 3,244
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.57
    Marker Score: 26,951
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.5
    Marker Score: 18,379
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.26
    Marker Score: 2,514
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.01
    Marker Score: 1,584
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3
    Marker Score: 3,635
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.98
    Marker Score: 63,625
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.97
    Marker Score: 100,354
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.97
    Marker Score: 6,827
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.93
    Marker Score: 2,033
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.87
    Marker Score: 11,959
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.87
    Marker Score: 10,183
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.84
    Marker Score: 2,520
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.78
    Marker Score: 7,439
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.75
    Marker Score: 9,018
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.72
    Marker Score: 5,232
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.7
    Marker Score: 2,574
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.67
    Marker Score: 53,200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.62
    Marker Score: 14,052
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.61
    Marker Score: 3,005
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.57
    Marker Score: 19,726
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.51
    Marker Score: 37,526
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.5
    Marker Score: 909
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.48
    Marker Score: 10,368
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.4
    Marker Score: 1,578
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.34
    Marker Score: 1,212
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.3
    Marker Score: 9,548
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.29
    Marker Score: 10,576
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.27
    Marker Score: 83,582
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.26
    Marker Score: 652
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.26
    Marker Score: 2,288
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.2
    Marker Score: 1,280
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20,362
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.16
    Marker Score: 1,256
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.14
    Marker Score: 8,289
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.07
    Marker Score: 3,478
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2
    Marker Score: 76,126
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2
    Marker Score: 1,508
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.98
    Marker Score: 6,630
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.98
    Marker Score: 2,780
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.97
    Marker Score: 4,479
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.96
    Marker Score: 753
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.95
    Marker Score: 1,694
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.92
    Marker Score: 2,823
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.9
    Marker Score: 1,064
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18,020
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.88
    Marker Score: 1,102
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.87
    Marker Score: 115,048
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.86
    Marker Score: 29,853
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.85
    Marker Score: 629
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.84
    Marker Score: 63,747
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,661
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.82
    Marker Score: 1,965
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.76
    Marker Score: 559
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.75
    Marker Score: 3,106
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.75
    Marker Score: 4,121
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.74
    Marker Score: 18,015
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.72
    Marker Score: 504
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.72
    Marker Score: 1,822
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.7
    Marker Score: 2,051
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.7
    Marker Score: 1,763
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.69
    Marker Score: 813
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.68
    Marker Score: 9,053
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.67
    Marker Score: 780
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.67
    Marker Score: 919
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.66
    Marker Score: 626
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.65
    Marker Score: 2,216
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.63
    Marker Score: 10,479
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2,469
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.59
    Marker Score: 504
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.58
    Marker Score: 6,441
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.57
    Marker Score: 453
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.56
    Marker Score: 6,739
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.56
    Marker Score: 17,558
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.55
    Marker Score: 489
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.55
    Marker Score: 648
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.53
    Marker Score: 1,228
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.52
    Marker Score: 823
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.51
    Marker Score: 880
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5
    Marker Score: 1,003
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.48
    Marker Score: 1,589
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.45
    Marker Score: 606
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.43
    Marker Score: 533
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.42
    Marker Score: 1,711
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.41
    Marker Score: 442
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4
    Marker Score: 692
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.39
    Marker Score: 527
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.39
    Marker Score: 12,091
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.39
    Marker Score: 513
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.38
    Marker Score: 279
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.38
    Marker Score: 823
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.35
    Marker Score: 743
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.35
    Marker Score: 3,395
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.34
    Marker Score: 1,671
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.34
    Marker Score: 2,791
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.33
    Marker Score: 659
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.32
    Marker Score: 2,789
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.31
    Marker Score: 1,620
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.27
    Marker Score: 401

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FARP1 is a 170-kDa protein that contains a FERM (4.1 protein domain, ezrin/radixin/moesin domain), an ARH/RhoGEF (Ras homolog gene family, Rho guanine nucleotide exchange factor) domain, and a pleckstrin domain. The FERM domain is responsible for binding to the cytoskeleton, while the ARH/RhoGEF domain catalyzes the exchange of GDP for GTP in Rho GTPases, activating them and promoting downstream signaling. The pleckstrin domain is involved in binding to phospholipids and modulating protein-protein interactions. **Pathways and Functions:** FARP1 is involved in several signaling pathways, including: 1. **Cdc42 gtpase cycle:** FARP1 regulates the activity of Cdc42, a small GTPase involved in cell migration, adhesion, and cytoskeletal reorganization. 2. **Rac1 gtpase cycle:** FARP1 modulates the activity of Rac1, a small GTPase involved in cell growth, differentiation, and cytoskeletal organization. 3. **RhoA gtpase cycle:** FARP1 regulates the activity of RhoA, a small GTPase involved in cell contraction, cytoskeletal reorganization, and cell migration. 4. **Synaptic plasticity:** FARP1 is involved in the regulation of synaptic plasticity, including the formation and maintenance of dendritic spines, and the regulation of neurotransmitter release. 5. **Cytoskeletal protein binding:** FARP1 binds to various cytoskeletal proteins, including actin, myosin, and tubulin, modulating their activity and cytoskeletal dynamics. **Clinical Significance:** FARP1 has been implicated in various neurological and psychiatric disorders, including: 1. **Neurodegenerative diseases:** FARP1 has been shown to be reduced in Alzheimer's disease, Parkinson's disease, and Huntington's disease, suggesting its potential role in neurodegeneration. 2. **Mental health disorders:** FARP1 has been implicated in the pathophysiology of depression, anxiety disorders, and schizophrenia, suggesting its potential role in mood regulation and synaptic plasticity. 3. **Cancer:** FARP1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis and metastasis. In conclusion, FARP1 is a critical regulator of cytoskeletal dynamics and synaptic plasticity, and its dysregulation has been implicated in various neurological and psychiatric disorders. Further research is needed to fully elucidate the functions and clinical significance of FARP1.

Genular Protein ID: 3164801336

Symbol: FARP1_HUMAN

Name: FERM, ARHGEF and pleckstrin domain-containing protein 1

UniProtKB Accession Codes:

Q9Y4F1 Q5JVI9 Q6IQ29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 5 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SAM 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9425278

Title: Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of rho guanine nucleotide exchange factors.

PubMed ID: 9425278

DOI: 10.1006/bbrc.1997.7826

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23375260

Title: Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.

PubMed ID: 23375260

DOI: 10.1016/j.str.2013.01.001

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1045
  • Mass: 118633
  • Checksum: 0E8B2D61C0F58417
  • Sequence:
    • MGEIEQRPTP GSRLGAPENS GISTLERGQK PPPTPSGKLV SIKIQMLDDT QEAFEVPQRA 
PGKVLLDAVC NHLNLVEGDY FGLEFPDHKK ITVWLDLLKP IVKQIRRPKH VVVKFVVKFF 
PPDHTQLQEE LTRYLFALQV KQDLAQGRLT CNDTSAALLI SHIVQSEIGD FDEALDREHL 
AKNKYIPQQD ALEDKIVEFH HNHIGQTPAE SDFQLLEIAR RLEMYGIRLH PAKDREGTKI 
NLAVANTGIL VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDANSAYQD TLEFLMASRD 
FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY VKEGGHKKVQ 
FERKHSKIHS IRSLASQPTE LNSEVLEQSQ QSTSLTFGEG AESPGGQSCR RGKEPKVSAG 
EPGSHPSPAP RRSPAGNKQA DGAASAPTEE EEEVVKDRTQ QSKPQPPQPS TGSLTGSPHL 
SELSVNSQGG VAPANVTLSP NLSPDTKQAS PLISPLLNDQ ACPRTDDEDE GRRKRFPTDK 
AYFIAKEVST TERTYLKDLE VITSWFQSTV SKEDAMPEAL KSLIFPNFEP LHKFHTNFLK 
EIEQRLALWE GRSNAQIRDY QRIGDVMLKN IQGMKHLAAH LWKHSEALEA LENGIKSSRR 
LENFCRDFEL QKVCYLPLNT FLLRPLHRLM HYKQVLERLC KHHPPSHADF RDCRAALAEI 
TEMVAQLHGT MIKMENFQKL HELKKDLIGI DNLVVPGREF IRLGSLSKLS GKGLQQRMFF 
LFNDVLLYTS RGLTASNQFK VHGQLPLYGM TIEESEDEWG VPHCLTLRGQ RQSIIVAASS 
RSEMEKWVED IQMAIDLAEK SSSPAPEFLA SSPPDNKSPD EATAADQESE DDLSASRTSL 
ERQAPHRGNT MVHVCWHRNT SVSMVDFSIA VENQLSGNLL RKFKNSNGWQ KLWVVFTNFC 
LFFYKSHQDN HPLASLPLLG YSLTIPSESE NIQKDYVFKL HFKSHVYYFR AESEYTFERW 
MEVIRSATSS ASRPHVLSHK ESLVY

Genular Protein ID: 2309244832

Symbol: C9JME2_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JME2

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 5 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 3 GO 3 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 16 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 7 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 5 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1076
  • Mass: 122095
  • Checksum: 34B31A3B5AA0A043
  • Sequence:
    • MGEIEQRPTP GSRLGAPENS GISTLERGQK PPPTPSGKLV SIKIQMLDDT QEAFEVPQRA 
PGKVLLDAVC NHLNLVEGDY FGLEFPDHKK ITVWLDLLKP IVKQIRRPKH VVVKFVVKFF 
PPDHTQLQEE LTRYLFALQV KQDLAQGRLT CNDTSAALLI SHIVQSEIGD FDEALDREHL 
AKNKYIPQQD ALEDKIVEFH HNHIGQTPAE SDFQLLEIAR RLEMYGIRLH PAKDREGTKI 
NLAVANTGIL VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDANSAYQD TLEFLMASRD 
FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY VKEGGHKKVQ 
FERKHSKIHS IRSLASQPTE LNSEVLEQSQ QSTSLTFGEG AESPGGQSCR RGKEPKVSAG 
EPGSHPSPAP RRSPAGNKQA DGAASAPTEE EEEVVKDRTQ QSKPQPPQPS TGSLTGSPHL 
SELSVNSQGG VAPANVTLSP NLSPDTKQAS PLISPLLNDQ ACPRTDDEDE GRRKRFPTDK 
AYFIAKEVST TERTYLKDLE VITSWFQSTV SKEDAMPEAL KSLIFPNFEP LHKFHTNFLK 
EIEQRLALWE GRSNAQIRDY QRIGDVMLKN IQGMKHLAAH LWKHSEALEA LENGIKSSRR 
LENFCRDFEL QKVCYLPLNT FLLRPLHRLM HYKQVLERLC KHHPPSHADF RDCRAALAEI 
TEMVAQLHGT MIKMENFQKL HELKKDLIGI DNLVVPGRPG SFSLIRTPHL GQARRIPCAP 
ERRPLLLVKE FIRLGSLSKL SGKGLQQRMF FLFNDVLLYT SRGLTASNQF KVHGQLPLYG 
MTIEESEDEW GVPHCLTLRG QRQSIIVAAS SRSEMEKWVE DIQMAIDLAE KSSSPAPEFL 
ASSPPDNKSP DEATAADQES EDDLSASRTS LERQAPHRGN TMVHVCWHRN TSVSMVDFSI 
AVENQLSGNL LRKFKNSNGW QKLWVVFTNF CLFFYKSHQD NHPLASLPLL GYSLTIPSES 
ENIQKDYVFK LHFKSHVYYF RAESEYTFER WMEVIRSATS SASRPHVLSH KESLVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.