Details for: LPAR6

Gene ID: 10161

Symbol: LPAR6

Ensembl ID: ENSG00000139679

Description: lysophosphatidic acid receptor 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.41
    Marker Score: 1,233
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.13
    Marker Score: 1,554
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.64
    Marker Score: 2,339
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.48
    Marker Score: 1,988
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.05
    Marker Score: 497
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.9
    Marker Score: 16,389
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.84
    Marker Score: 3,677
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.84
    Marker Score: 4,491
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.74
    Marker Score: 1,967
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.68
    Marker Score: 688
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.57
    Marker Score: 1,239
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.56
    Marker Score: 860
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.55
    Marker Score: 2,279
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.54
    Marker Score: 6,291
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.47
    Marker Score: 1,627
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.46
    Marker Score: 1,675
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.46
    Marker Score: 11,403
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.44
    Marker Score: 3,668
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.43
    Marker Score: 991
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.39
    Marker Score: 442
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.38
    Marker Score: 1,778
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.32
    Marker Score: 786
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.29
    Marker Score: 438
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.26
    Marker Score: 1,056
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.23
    Marker Score: 1,106
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.22
    Marker Score: 1,225
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.22
    Marker Score: 1,101
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.19
    Marker Score: 278
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.18
    Marker Score: 7,554
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.16
    Marker Score: 1,251
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.15
    Marker Score: 278
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.12
    Marker Score: 270
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.07
    Marker Score: 228
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.06
    Marker Score: 1,538
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.04
    Marker Score: 3,846
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,676
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.04
    Marker Score: 1,108
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.03
    Marker Score: 1,491
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.02
    Marker Score: 1,133
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.01
    Marker Score: 1,714
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1
    Marker Score: 2,597
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,697
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,920
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.98
    Marker Score: 493
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.97
    Marker Score: 1,176
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.96
    Marker Score: 640
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.96
    Marker Score: 1,575
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.96
    Marker Score: 903
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.95
    Marker Score: 395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,398
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.92
    Marker Score: 495
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.91
    Marker Score: 954
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.9
    Marker Score: 617
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,705
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.9
    Marker Score: 451
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.9
    Marker Score: 1,054
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.89
    Marker Score: 253
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.89
    Marker Score: 839
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.89
    Marker Score: 950
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.88
    Marker Score: 555
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.88
    Marker Score: 342
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.88
    Marker Score: 192
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.88
    Marker Score: 1,658
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.87
    Marker Score: 281
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.87
    Marker Score: 1,576
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.86
    Marker Score: 614
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.86
    Marker Score: 1,957
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.85
    Marker Score: 1,551
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.85
    Marker Score: 568
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.84
    Marker Score: 724
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,776
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.84
    Marker Score: 4,105
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 334
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.82
    Marker Score: 1,415
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.82
    Marker Score: 425
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.82
    Marker Score: 591
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.81
    Marker Score: 676
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.81
    Marker Score: 233
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.8
    Marker Score: 1,926
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.8
    Marker Score: 252
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.79
    Marker Score: 1,548
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.78
    Marker Score: 197
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.77
    Marker Score: 528
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.77
    Marker Score: 311
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.76
    Marker Score: 5,688
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.76
    Marker Score: 368
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.76
    Marker Score: 39,951
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.75
    Marker Score: 349
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 234
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.74
    Marker Score: 2,612
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.73
    Marker Score: 739
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.73
    Marker Score: 8,518

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LPAR6 is a member of the lysophosphatidic acid receptor family and belongs to the class A/1 rhodopsin-like receptors. It is characterized by its ability to bind lysophosphatidic acid (LPA), a bioactive lipid mediator involved in various cellular processes. LPAR6 is primarily expressed in mature microglial cells, central nervous system macrophages, and epithelial cells of various organs, including the prostate and esophagus. Its expression is also observed in endothelial cells, suggesting a role in vascular homeostasis. **Pathways and Functions:** LPAR6 mediates its effects through Gαq signaling events, which activate phospholipase C (PLC) and lead to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). These second messengers regulate various cellular processes, including: 1. **Inflammation and Immune Response**: LPAR6 activation by LPA promotes the production of pro-inflammatory cytokines and chemokines, contributing to the development of inflammatory responses. 2. **Cell Proliferation and Survival**: LPAR6 signaling regulates cell growth, differentiation, and survival, with implications for tissue repair and homeostasis. 3. **Vascular Homeostasis**: LPAR6 expression in endothelial cells suggests a role in maintaining vascular tone and regulating blood flow. **Clinical Significance:** LPAR6 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: LPAR6 has been shown to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation contributes to neuronal damage and inflammation. 2. **Cancer**: LPAR6 overexpression has been observed in various types of cancer, including prostate, breast, and lung cancer, where it promotes tumor growth, invasion, and metastasis. 3. **Inflammatory Diseases**: LPAR6 activation by LPA contributes to the development of inflammatory diseases, such as atherosclerosis, arthritis, and asthma. In conclusion, LPAR6 is a multifunctional receptor that plays a critical role in immune regulation, inflammation, and cell proliferation. Its dysregulation contributes to various diseases, highlighting the importance of further research into the mechanisms of LPAR6 signaling and its therapeutic potential.

Genular Protein ID: 4214829660

Symbol: LPAR6_HUMAN

Name: Lysophosphatidic acid receptor 6

UniProtKB Accession Codes:

P43657 A4FTW9 B3KVF2 F2YGU4 O15133 Q3KPF5 Q53FA0 Q5VW44 Q7Z3S0 Q7Z3S6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 17 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7902321

Title: Complete genomic sequence of the human retinoblastoma susceptibility gene.

PubMed ID: 7902321

DOI: 10.1006/geno.1993.1368

PubMed ID: 8889552

Title: Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene.

PubMed ID: 8889552

DOI: 10.1101/gr.6.9.858

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11004484

Title: Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.

PubMed ID: 11004484

DOI: 10.1016/s0167-4781(00)00094-4

PubMed ID: 18297070

Title: G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.

PubMed ID: 18297070

DOI: 10.1038/ng.84

PubMed ID: 18692127

Title: Genome-wide linkage analysis of an autosomal recessive hypotrichosis identifies a novel P2RY5 mutation.

PubMed ID: 18692127

DOI: 10.1016/j.ygeno.2008.06.009

PubMed ID: 18461368

Title: Novel mutations in G protein-coupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3).

PubMed ID: 18461368

DOI: 10.1007/s00439-008-0507-7

PubMed ID: 18297072

Title: Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair.

PubMed ID: 18297072

DOI: 10.1038/ng.100

PubMed ID: 19292720

Title: Mutations in the P2RY5 gene underlie autosomal recessive hypotrichosis in 13 Pakistani families.

PubMed ID: 19292720

DOI: 10.1111/j.1365-2133.2009.09046.x

PubMed ID: 21070332

Title: A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp.

PubMed ID: 21070332

DOI: 10.1111/j.1365-2230.2010.03944.x

PubMed ID: 21426374

Title: Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan.

PubMed ID: 21426374

DOI: 10.1111/j.1365-2230.2011.04014.x

PubMed ID: 28425126

Title: Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in consanguineous families.

PubMed ID: 28425126

DOI: 10.1111/cga.12226

PubMed ID: 36173926

Title: Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis.

PubMed ID: 36173926

DOI: 10.1093/hmg/ddac244

Sequence Information:

  • Length: 344
  • Mass: 39392
  • Checksum: 699212F3C1249433
  • Sequence:
    • MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN ETTTYMINLA 
MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY 
PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP AVFVQSTHSQ GNNASEACFE NFPEATWKTY 
LSRIVIFIEI VGFFIPLILN VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF 
CFVPYNINLI LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN 
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA

Genular Protein ID: 4251917588

Symbol: B3KVQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVQ5

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 3 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 344
  • Mass: 39365
  • Checksum: F82B020D21CA9AD3
  • Sequence:
    • MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN ETTTYMINLA 
MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY 
PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP AVFVQSTHSQ GNNASEACFE NFPEATWKTY 
LSRIVIFIEI VGFFIPLILN VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF 
CFVPYSINLI LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN 
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.