Details for: LPCAT3

Gene ID: 10162

Symbol: LPCAT3

Ensembl ID: ENSG00000111684

Description: lysophosphatidylcholine acyltransferase 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.81
    Marker Score: 50,621
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.66
    Marker Score: 1,775
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.28
    Marker Score: 2,033
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.61
    Marker Score: 6,316
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.5
    Marker Score: 1,563
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.48
    Marker Score: 1,001
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,820
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.42
    Marker Score: 9,106
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.39
    Marker Score: 1,232
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.37
    Marker Score: 2,012
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.35
    Marker Score: 5,840
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.35
    Marker Score: 7,261
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.29
    Marker Score: 28,785
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.27
    Marker Score: 6,090
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.23
    Marker Score: 856
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.23
    Marker Score: 3,068
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.2
    Marker Score: 1,441
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.19
    Marker Score: 1,919
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.19
    Marker Score: 890
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.17
    Marker Score: 72,063
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.13
    Marker Score: 2,670
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.13
    Marker Score: 2,570
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.13
    Marker Score: 9,666
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.12
    Marker Score: 2,542
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.12
    Marker Score: 616
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.12
    Marker Score: 1,264
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.11
    Marker Score: 7,090
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.09
    Marker Score: 10,330
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.08
    Marker Score: 765
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16,898
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.08
    Marker Score: 1,306
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.07
    Marker Score: 481
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.06
    Marker Score: 310
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.05
    Marker Score: 3,306
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.05
    Marker Score: 1,134
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.03
    Marker Score: 577
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.03
    Marker Score: 2,446
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.02
    Marker Score: 1,582
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.02
    Marker Score: 38,673
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,697
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,921
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.99
    Marker Score: 1,524
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.98
    Marker Score: 514
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.98
    Marker Score: 332
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.97
    Marker Score: 4,060
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.97
    Marker Score: 565
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.96
    Marker Score: 1,199
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.95
    Marker Score: 6,187
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,398
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.94
    Marker Score: 1,079
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.94
    Marker Score: 1,259
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.92
    Marker Score: 964
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,223
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.89
    Marker Score: 6,789
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.88
    Marker Score: 602
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.88
    Marker Score: 513
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.88
    Marker Score: 524
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.87
    Marker Score: 280
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.87
    Marker Score: 885
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.87
    Marker Score: 1,428
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.87
    Marker Score: 582
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.86
    Marker Score: 362
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 950
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.86
    Marker Score: 473
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.86
    Marker Score: 345
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.86
    Marker Score: 1,645
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.85
    Marker Score: 297
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.84
    Marker Score: 1,208
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,358
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.83
    Marker Score: 303
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.83
    Marker Score: 502
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 266
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.82
    Marker Score: 308
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.82
    Marker Score: 199
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.82
    Marker Score: 308
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.82
    Marker Score: 2,005
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.81
    Marker Score: 2,891
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.81
    Marker Score: 17,342
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.8
    Marker Score: 295
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.8
    Marker Score: 1,323
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.79
    Marker Score: 3,049
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.79
    Marker Score: 726
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.79
    Marker Score: 982
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.78
    Marker Score: 1,109
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.78
    Marker Score: 1,968
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.77
    Marker Score: 407
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.77
    Marker Score: 211
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.77
    Marker Score: 323
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.76
    Marker Score: 154
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.76
    Marker Score: 231
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.76
    Marker Score: 1,597
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.75
    Marker Score: 343

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LPCAT3 is a member of the lysophosphatidylcholine acyltransferase family, which is characterized by their ability to catalyze the transfer of acyl groups from lysophosphatidylcholine to other phospholipids. LPCAT3 exhibits a broad substrate specificity, allowing it to interact with various phospholipids, including phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. The enzyme is also involved in multiple cellular processes, including lipid metabolism, cell signaling, and membrane remodeling. **Pathways and Functions** LPCAT3 is involved in several key pathways, including: 1. **Glycerophospholipid biosynthesis**: LPCAT3 plays a crucial role in the biosynthesis of phospholipids, which are essential components of cellular membranes. 2. **Acyl chain remodeling**: LPCAT3 is involved in the remodeling of acyl chains in phospholipids, which is essential for maintaining cellular homeostasis and function. 3. **Cholesterol biosynthesis**: LPCAT3 is involved in the regulation of cholesterol biosynthesis, which is critical for maintaining lipid homeostasis in cells. 4. **Intestinal cholesterol absorption**: LPCAT3 is involved in the positive regulation of intestinal cholesterol absorption, which is essential for maintaining lipid homeostasis in the gut. 5. **Triglyceride transport**: LPCAT3 is involved in the positive regulation of triglyceride transport, which is critical for maintaining lipid homeostasis in cells. **Clinical Significance** Dysregulation of LPCAT3 has been implicated in various diseases, including: 1. **Atherosclerosis**: LPCAT3 has been shown to play a role in the development of atherosclerosis, a disease characterized by the accumulation of lipids in the arterial wall. 2. **Metabolic disorders**: LPCAT3 has been implicated in the development of metabolic disorders, including obesity and type 2 diabetes. 3. **Inflammatory diseases**: LPCAT3 has been shown to play a role in the regulation of inflammatory responses, which is essential for maintaining tissue homeostasis. 4. **Cancer**: LPCAT3 has been implicated in the development and progression of various cancers, including breast and prostate cancer. In conclusion, LPCAT3 is a critical enzyme that plays a key role in the biosynthesis and remodeling of phospholipids in various cellular contexts. Its dysregulation has been implicated in various diseases, highlighting the importance of LPCAT3 in maintaining cellular homeostasis and function. Further research is needed to fully understand the role of LPCAT3 in human disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 1569436361

Symbol: MBOA5_HUMAN

Name: Lysophospholipid acyltransferase 5

UniProtKB Accession Codes:

Q6P1A2 B2RDH0 B7Z3N3 Q7KZS1 Q92980 Q9BW40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 100 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 13 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 76 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9074930

Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PubMed ID: 9074930

DOI: 10.1101/gr.7.3.268

PubMed ID: 18782225

Title: Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity.

PubMed ID: 18782225

DOI: 10.1111/j.1365-2443.2008.01212.x

PubMed ID: 18195019

Title: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase.

PubMed ID: 18195019

DOI: 10.1074/jbc.m710422200

PubMed ID: 18772128

Title: Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils.

PubMed ID: 18772128

DOI: 10.1074/jbc.m806194200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 487
  • Mass: 56035
  • Checksum: 429258B54585B4A7
  • Sequence:
    • MASSAEGDEG TVVALAGVLQ SGFQELSLNK LATSLGASEQ ALRLIISIFL GYPFALFYRH 
YLFYKETYLI HLFHTFTGLS IAYFNFGNQL YHSLLCIVLQ FLILRLMGRT ITAVLTTFCF 
QMAYLLAGYY YTATGNYDIK WTMPHCVLTL KLIGLAVDYF DGGKDQNSLS SEQQKYAIRG 
VPSLLEVAGF SYFYGAFLVG PQFSMNHYMK LVQGELIDIP GKIPNSIIPA LKRLSLGLFY 
LVGYTLLSPH ITEDYLLTED YDNHPFWFRC MYMLIWGKFV LYKYVTCWLV TEGVCILTGL 
GFNGFEEKGK AKWDACANMK VWLFETNPRF TGTIASFNIN TNAWVARYIF KRLKFLGNKE 
LSQGLSLLFL ALWHGLHSGY LVCFQMEFLI VIVERQAARL IQESPTLSKL AAITVLQPFY 
YLVQQTIHWL FMGYSMTAFC LFTWDKWLKV YKSIYFLGHI FFLSLLFILP YIHKAMVPRK 
EKLKKME

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.