WASF2 | ENSG00000158195 | NCBI 10163

Details for: WASF2

Gene ID: 10163

Symbol: WASF2

Ensembl ID: ENSG00000158195

Description: WASP family member 2

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament-based movement
(GO:0030048)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Ameboidal-type cell migration
(GO:0001667)
Angiogenesis
(GO:0001525)
Arp2/3 complex binding
(GO:0071933)
Basolateral plasma membrane
(GO:0016323)
Cadherin binding
(GO:0045296)
Cell-cell junction
(GO:0005911)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endocytosis
(GO:0006897)
Extracellular exosome
(GO:0070062)
Lamellipodium
(GO:0030027)
Lamellipodium assembly
(GO:0030032)
Lamellipodium morphogenesis
(GO:0072673)
Megakaryocyte development
(GO:0035855)
Negative regulation of stress fiber assembly
(GO:0051497)
Positive regulation of arp2/3 complex-mediated actin nucleation
(GO:2000601)
Positive regulation of lamellipodium assembly
(GO:0010592)
Postsynaptic actin cytoskeleton organization
(GO:0098974)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase a binding
(GO:0051018)
Protein kinase a regulatory subunit binding
(GO:0034237)
Rac protein signal transduction
(GO:0016601)
Ruffle
(GO:0001726)
Scar complex
(GO:0031209)
Sh3 domain binding
(GO:0017124)
Synapse
(GO:0045202)

Other Information

Proteins

Protein WAVE-2

Genular Protein ID: 4048201967

Symbol: WASF2_HUMAN

Name: Protein WAVE-2

UniProtKB Accession Codes:

Q9Y6W5 B4DZN0 O60794 Q9UDY7

Database IDs:

Citations:

PubMed ID: 10381382

Title: Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

PubMed ID: 10381382

DOI: 10.1006/bbrc.1999.0894

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11130076

Title: IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

PubMed ID: 11130076

DOI: 10.1038/35047107

PubMed ID: 15070726

Title: Purification and architecture of the ubiquitous Wave complex.

PubMed ID: 15070726

DOI: 10.1073/pnas.0400628101

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 19798448

Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

PubMed ID: 19798448

DOI: 10.1371/journal.pgen.1000675

PubMed ID: 21107423

Title: Structure and control of the actin regulatory WAVE complex.

PubMed ID: 21107423

DOI: 10.1038/nature09623

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25121749

Title: HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.

PubMed ID: 25121749

DOI: 10.1016/j.chom.2014.07.005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30250061

Title: Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

PubMed ID: 30250061

DOI: 10.1038/s41556-018-0198-9

PubMed ID: 16275905

Title: Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.

PubMed ID: 16275905

DOI: 10.1073/pnas.0507021102

Sequence Information:

Length: 498
Mass: 54284
Checksum: C737CE963016DE94
Sequence:

MPLVTRNIEP RHLCRQTLPS VRSELECVTN ITLANVIRQL GSLSKYAEDI FGELFTQANT 
FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF RSSTIQDQKL FDRNSLPVPV 
LETYNTCDTP PPLNNLTPYR DDGKEALKFY TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK 
EKKDNPNRGN VNPRKIKTRK EEWEKMKMGQ EFVESKEKLG TSGYPPTLVY QNGSIGCVEN 
VDASSYPPPP QSDSASSPSP SFSEDNLPPP PAEFSYPVDN QRGSGLAGPK RSSVVSPSHP 
PPAPPLGSPP GPKPGFAPPP APPPPPPPMI GIPPPPPPVG FGSPGTPPPP SPPSFPPHPD 
FAAPPPPPPP PAADYPTLPP PPLSQPTGGA PPPPPPPPPP GPPPPPFTGA DGQPAIPPPL 
SDTTKPKSSL PAVSDARSDL LSAIRQGFQL RRVEEQREQE KRDVVGNDVA TILSRRIAVE 
YSDSEDDSSE FDEDDWSD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WASF2

Associated with

Other Information

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. PubMed ID: 10381382

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. PubMed ID: 11130076

Purification and architecture of the ubiquitous Wave complex. PubMed ID: 15070726

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PubMed ID: 16417406

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PubMed ID: 19798448

Structure and control of the actin regulatory WAVE complex. PubMed ID: 21107423

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. PubMed ID: 25121749

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. PubMed ID: 30250061

Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. PubMed ID: 16275905