Details for: CDK2

Gene ID: 1017

Symbol: CDK2

Ensembl ID: ENSG00000123374

Description: cyclin dependent kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.0061
    Cell Significance Index: -9.6400
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.6447
    Cell Significance Index: -4.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.7027
    Cell Significance Index: -10.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8897
    Cell Significance Index: -10.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9194
    Cell Significance Index: -11.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1609
    Cell Significance Index: 220.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9506
    Cell Significance Index: 12.9700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.9425
    Cell Significance Index: 13.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9047
    Cell Significance Index: -1.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8520
    Cell Significance Index: 22.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8315
    Cell Significance Index: 9.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7642
    Cell Significance Index: 20.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7007
    Cell Significance Index: 69.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6794
    Cell Significance Index: 12.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6696
    Cell Significance Index: 108.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6656
    Cell Significance Index: 72.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6122
    Cell Significance Index: 31.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6101
    Cell Significance Index: 36.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5531
    Cell Significance Index: 19.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5390
    Cell Significance Index: 13.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5339
    Cell Significance Index: 482.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5274
    Cell Significance Index: 11.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.4995
    Cell Significance Index: 8.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4973
    Cell Significance Index: 57.9500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.4862
    Cell Significance Index: 5.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4156
    Cell Significance Index: 49.0100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.4147
    Cell Significance Index: 0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3825
    Cell Significance Index: 11.0200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2780
    Cell Significance Index: 3.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2550
    Cell Significance Index: 17.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2251
    Cell Significance Index: 5.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2196
    Cell Significance Index: 9.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2040
    Cell Significance Index: 5.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1968
    Cell Significance Index: 35.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1923
    Cell Significance Index: 38.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1908
    Cell Significance Index: 23.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1730
    Cell Significance Index: 22.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1546
    Cell Significance Index: 11.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1500
    Cell Significance Index: 3.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1373
    Cell Significance Index: 1.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1348
    Cell Significance Index: 59.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1225
    Cell Significance Index: 16.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1118
    Cell Significance Index: 2.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1065
    Cell Significance Index: 2.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1007
    Cell Significance Index: 55.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0844
    Cell Significance Index: 10.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0761
    Cell Significance Index: 4.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0692
    Cell Significance Index: 1.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0580
    Cell Significance Index: 1.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0557
    Cell Significance Index: 2.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0448
    Cell Significance Index: 2.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0406
    Cell Significance Index: 0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0262
    Cell Significance Index: 0.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0167
    Cell Significance Index: 0.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0125
    Cell Significance Index: 0.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0083
    Cell Significance Index: 0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0058
    Cell Significance Index: 10.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.6300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0050
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0078
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0133
    Cell Significance Index: -1.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0153
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0158
    Cell Significance Index: -11.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0206
    Cell Significance Index: -11.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0274
    Cell Significance Index: -9.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0293
    Cell Significance Index: -8.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0381
    Cell Significance Index: -6.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0483
    Cell Significance Index: -9.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0500
    Cell Significance Index: -5.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0601
    Cell Significance Index: -12.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0794
    Cell Significance Index: -2.0400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0821
    Cell Significance Index: -0.7800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0856
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0936
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1003
    Cell Significance Index: -10.4400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1128
    Cell Significance Index: -0.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1182
    Cell Significance Index: -9.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1213
    Cell Significance Index: -9.3100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1313
    Cell Significance Index: -1.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1451
    Cell Significance Index: -7.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1485
    Cell Significance Index: -9.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1511
    Cell Significance Index: -9.2900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1527
    Cell Significance Index: -0.9500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1553
    Cell Significance Index: -1.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1647
    Cell Significance Index: -2.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1695
    Cell Significance Index: -11.4000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1761
    Cell Significance Index: -1.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1823
    Cell Significance Index: -9.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1857
    Cell Significance Index: -7.6100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1879
    Cell Significance Index: -1.1800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2045
    Cell Significance Index: -1.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2088
    Cell Significance Index: -6.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell Cycle Regulation**: CDK2 is a key regulator of the cell cycle, particularly during the G1/S and G2/M transitions. 2. **Cyclin-Dependent Kinase Activity**: CDK2 is a cyclin-dependent kinase, which means it phosphorylates and activates or inhibits various substrates to regulate the cell cycle. 3. **Substrate Specificity**: CDK2 is associated with specific cyclins, which determine its substrate specificity and activity. 4. **Cell Cycle Checkpoints**: CDK2 is involved in cell cycle checkpoints, which ensure that cells do not proceed through the cell cycle unless they are in a suitable state. 5. **Cancer Association**: Dysregulation of CDK2 has been implicated in various cancers, including breast, lung, and colon cancer. **Pathways and Functions** 1. **Cell Cycle Regulation**: CDK2 regulates the G1/S and G2/M transitions by phosphorylating and activating or inhibiting key substrates, such as cyclin E, cyclin B, and p53. 2. **DNA Replication**: CDK2 is involved in DNA replication by phosphorylating and activating or inhibiting enzymes involved in DNA synthesis, such as DNA polymerase and topoisomerase II. 3. **Mitosis**: CDK2 regulates mitosis by phosphorylating and activating or inhibiting key substrates, such as centrin and plk1. 4. **Cell Cycle Checkpoints**: CDK2 is involved in cell cycle checkpoints, which ensure that cells do not proceed through the cell cycle unless they are in a suitable state. 5. **Apoptosis**: CDK2 can regulate apoptosis by phosphorylating and activating or inhibiting key substrates, such as Bcl-2 and p53. **Clinical Significance** 1. **Cancer**: Dysregulation of CDK2 has been implicated in various cancers, including breast, lung, and colon cancer. 2. **Aging**: CDK2 is involved in the regulation of telomere length and telomerase activity, which contributes to aging and age-related diseases. 3. **Neurodegenerative Diseases**: CDK2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates the phosphorylation and degradation of tau protein. 4. **Cardiovascular Disease**: CDK2 is involved in the regulation of cardiac myocyte proliferation and differentiation, which contributes to cardiovascular disease. 5. **Reproductive Diseases**: CDK2 is involved in the regulation of reproductive cell cycle, particularly in the development of gametes and the regulation of fertility. In conclusion, CDK2 is a crucial protein kinase involved in the regulation of the cell cycle, particularly during the G1/S and G2/M transitions. Its dysregulation has been implicated in various diseases, including cancer, aging, neurodegenerative diseases, cardiovascular disease, and reproductive diseases. Further research is needed to fully understand the role of CDK2 in human health and disease.

Genular Protein ID: 2328343218

Symbol: CDK2_HUMAN

Name: Cyclin-dependent kinase 2

UniProtKB Accession Codes:

P24941 A8K7C6 O75100

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 4 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 2 ELM 1 EMBL 11 EMDB 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 57 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 27 RefSeq 3 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1714386

Title: A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

PubMed ID: 1714386

DOI: 10.1002/j.1460-2075.1991.tb07808.x

PubMed ID: 1653904

Title: Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.

PubMed ID: 1653904

DOI: 10.1038/353174a0

PubMed ID: 1717994

Title: Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

PubMed ID: 1717994

DOI: 10.1073/pnas.88.20.9006

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1396589

Title: Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

PubMed ID: 1396589

DOI: 10.1002/j.1460-2075.1992.tb05493.x

PubMed ID: 9030781

Title: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

PubMed ID: 9030781

DOI: 10.1111/j.1432-1033.1997.t01-2-00527.x

PubMed ID: 10499802

Title: Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.

PubMed ID: 10499802

DOI: 10.1016/s0092-8674(00)81519-6

PubMed ID: 11051553

Title: Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.

PubMed ID: 11051553

DOI: 10.1016/s0092-8674(00)00093-3

PubMed ID: 10995386

Title: NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.

PubMed ID: 10995386

DOI: 10.1101/gad.827700

PubMed ID: 10995387

Title: Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.

PubMed ID: 10995387

DOI: 10.1101/gad.829500

PubMed ID: 10884347

Title: The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

PubMed ID: 10884347

DOI: 10.1006/jmbi.2000.3830

PubMed ID: 11113184

Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.

PubMed ID: 11113184

DOI: 10.1128/mcb.21.1.88-99.2001

PubMed ID: 12185076

Title: Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.

PubMed ID: 12185076

DOI: 10.1074/jbc.m203951200

PubMed ID: 11980914

Title: Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.

PubMed ID: 11980914

DOI: 10.1083/jcb.200109045

PubMed ID: 12839962

Title: Human Spy1 promotes survival of mammalian cells following DNA damage.

PubMed ID: 12839962

PubMed ID: 12944431

Title: DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.

PubMed ID: 12944431

DOI: 10.1242/dev.00731

PubMed ID: 12972555

Title: Spy1 interacts with p27Kip1 to allow G1/S progression.

PubMed ID: 12972555

DOI: 10.1091/mbc.e02-12-0820

PubMed ID: 15178429

Title: NIRF induces G1 arrest and associates with Cdk2.

PubMed ID: 15178429

DOI: 10.1016/j.bbrc.2004.04.190

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 14597612

Title: p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.

PubMed ID: 14597612

DOI: 10.1074/jbc.m309995200

PubMed ID: 15611625

Title: Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

PubMed ID: 15611625

DOI: 10.4161/cc.4.1.1347

PubMed ID: 15800615

Title: CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.

PubMed ID: 15800615

DOI: 10.1038/nature03404

PubMed ID: 17373709

Title: Recognition of Cdk2 by Cdk7.

PubMed ID: 17373709

DOI: 10.1002/prot.21370

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18372919

Title: Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.

PubMed ID: 18372919

DOI: 10.1038/onc.2008.74

PubMed ID: 19829063

Title: Identification and characterization of CAC1 as a novel CDK2-associated cullin.

PubMed ID: 19829063

DOI: 10.4161/cc.8.21.9955

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20147522

Title: Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.

PubMed ID: 20147522

DOI: 10.1210/en.2009-1116

PubMed ID: 20079829

Title: Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle.

PubMed ID: 20079829

DOI: 10.1016/j.freeradbiomed.2010.01.004

PubMed ID: 20360007

Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

PubMed ID: 20360007

DOI: 10.1074/jbc.m109.096552

PubMed ID: 20935635

Title: Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.

PubMed ID: 20935635

DOI: 10.1038/ncb2116

PubMed ID: 20195506

Title: Cdk2 is required for p53-independent G2/M checkpoint control.

PubMed ID: 20195506

DOI: 10.1371/journal.pgen.1000863

PubMed ID: 19966300

Title: Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.

PubMed ID: 19966300

DOI: 10.1073/pnas.0900121106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406398

Title: Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.

PubMed ID: 21406398

DOI: 10.1158/0008-5472.can-10-2684

PubMed ID: 21262353

Title: Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.

PubMed ID: 21262353

DOI: 10.1016/j.cellsig.2011.01.019

PubMed ID: 21684737

Title: Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.

PubMed ID: 21684737

DOI: 10.1016/j.bmcl.2011.05.081

PubMed ID: 21596315

Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

PubMed ID: 21596315

DOI: 10.1016/j.molcel.2011.03.027

PubMed ID: 21319273

Title: An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

PubMed ID: 21319273

DOI: 10.1002/stem.620

PubMed ID: 19445729

Title: A dual role of Cdk2 in DNA damage response.

PubMed ID: 19445729

DOI: 10.1186/1747-1028-4-9

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 19561645

Title: Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

PubMed ID: 19561645

DOI: 10.1038/onc.2009.170

PubMed ID: 20713526

Title: Tipping the balance: Cdk2 enables Myc to suppress senescence.

PubMed ID: 20713526

DOI: 10.1158/0008-5472.can-10-1383

PubMed ID: 21517772

Title: Cyclin dependent kinase 1 inhibitors: a review of recent progress.

PubMed ID: 21517772

DOI: 10.2174/092986711795590110

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23781148

Title: Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation.

PubMed ID: 23781148

DOI: 10.7150/ijbs.5763

PubMed ID: 28216226

Title: NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres.

PubMed ID: 28216226

DOI: 10.1016/j.molcel.2017.01.016

PubMed ID: 29203878

Title: ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.

PubMed ID: 29203878

DOI: 10.1038/s41467-017-02114-x

PubMed ID: 8510751

Title: Crystal structure of cyclin-dependent kinase 2.

PubMed ID: 8510751

DOI: 10.1038/363595a0

PubMed ID: 7630397

Title: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.

PubMed ID: 7630397

DOI: 10.1038/376313a0

PubMed ID: 8601310

Title: Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.

PubMed ID: 8601310

DOI: 10.1016/s0092-8674(00)81065-x

PubMed ID: 8917641

Title: High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.

PubMed ID: 8917641

DOI: 10.1021/jm960402a

PubMed ID: 8684460

Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

PubMed ID: 8684460

DOI: 10.1038/382325a0

PubMed ID: 8756328

Title: Structural basis of cyclin-dependent kinase activation by phosphorylation.

PubMed ID: 8756328

DOI: 10.1038/nsb0896-696

PubMed ID: 8610110

Title: Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

PubMed ID: 8610110

DOI: 10.1073/pnas.93.7.2735

PubMed ID: 9334743

Title: Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.

PubMed ID: 9334743

DOI: 10.1038/nsb1097-796

PubMed ID: 9677190

Title: Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

PubMed ID: 9677190

DOI: 10.1126/science.281.5376.533

PubMed ID: 16325401

Title: Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

PubMed ID: 16325401

DOI: 10.1016/j.bmcl.2005.11.048

PubMed ID: 17570665

Title: Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

PubMed ID: 17570665

DOI: 10.1016/j.bmcl.2007.04.110

PubMed ID: 17495531

Title: Cyclin B and cyclin A confer different substrate recognition properties on CDK2.

PubMed ID: 17495531

DOI: 10.4161/cc.6.11.4278

PubMed ID: 17095507

Title: How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

PubMed ID: 17095507

DOI: 10.1074/jbc.m609151200

PubMed ID: 17937404

Title: Structure-guided discovery of cyclin-dependent kinase inhibitors.

PubMed ID: 17937404

DOI: 10.1002/bip.20868

PubMed ID: 18656911

Title: Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

PubMed ID: 18656911

DOI: 10.1021/jm800382h

PubMed ID: 21565702

Title: Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.

PubMed ID: 21565702

DOI: 10.1016/j.str.2011.02.016

PubMed ID: 28666995

Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.

PubMed ID: 28666995

DOI: 10.15252/embj.201796905

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23711367

Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.

PubMed ID: 23711367

DOI: 10.1016/j.febslet.2013.05.037

Sequence Information:

  • Length: 298
  • Mass: 33930
  • Checksum: F90A0F4E70910B51
  • Sequence:
    • MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 
PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 
HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 
STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 
PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

Genular Protein ID: 2936554235

Symbol: E7ESI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ESI2

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 238
  • Mass: 27165
  • Checksum: 61415DADFE55CFB0
  • Sequence:
    • MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL YLVFEFLHQD 
LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF 
GLARAFGVPV RTYTHEVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 
PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

Genular Protein ID: 2439212519

Symbol: G3V5T9_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V5T9

Database IDs:

ARBA 16 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 2 GO 7 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 346
  • Mass: 39178
  • Checksum: EFE068D119CA7637
  • Sequence:
    • MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 
PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 
HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 
STAVDIWSLG CIFAEMHLVG TQHHARCCGE HRRNGRQSLC PLCSYLEVAA SQGWGMTAVS 
TPYPVTRRAL FPGDSEIDQL FRIFRTLGTP DEVVWPGVTS MPDYKPSFPK WARQDFSKVV 
PPLDEDGRSL LSQMLHYDPN KRISAKAALA HPFFQDVTKP VPHLRL

Genular Protein ID: 3614439243

Symbol: B4DDL9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDL9

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 12 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 11 Gene3D 1 IntAct 1 InterPro 5 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 6 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 238
  • Mass: 27163
  • Checksum: 4F04E6E0098F684F
  • Sequence:
    • MENFQKVERI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL YLVFEFLHQD 
LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF 
GLARAFGVPV RTYTHEVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 
PKWARQDFSK VVPPLDEDGR SLLSQTLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.