Details for: CDK2

Gene ID: 1017

Symbol: CDK2

Ensembl ID: ENSG00000123374

Description: cyclin dependent kinase 2

Associated with

Other Information

Genular Protein ID: 2328343218

Symbol: CDK2_HUMAN

Name: Cyclin-dependent kinase 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1714386

Title: A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

PubMed ID: 1714386

DOI: 10.1002/j.1460-2075.1991.tb07808.x

PubMed ID: 1653904

Title: Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.

PubMed ID: 1653904

DOI: 10.1038/353174a0

PubMed ID: 1717994

Title: Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

PubMed ID: 1717994

DOI: 10.1073/pnas.88.20.9006

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1396589

Title: Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

PubMed ID: 1396589

DOI: 10.1002/j.1460-2075.1992.tb05493.x

PubMed ID: 9030781

Title: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

PubMed ID: 9030781

DOI: 10.1111/j.1432-1033.1997.t01-2-00527.x

PubMed ID: 10499802

Title: Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.

PubMed ID: 10499802

DOI: 10.1016/s0092-8674(00)81519-6

PubMed ID: 11051553

Title: Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.

PubMed ID: 11051553

DOI: 10.1016/s0092-8674(00)00093-3

PubMed ID: 10995386

Title: NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.

PubMed ID: 10995386

DOI: 10.1101/gad.827700

PubMed ID: 10995387

Title: Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.

PubMed ID: 10995387

DOI: 10.1101/gad.829500

PubMed ID: 10884347

Title: The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

PubMed ID: 10884347

DOI: 10.1006/jmbi.2000.3830

PubMed ID: 11113184

Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.

PubMed ID: 11113184

DOI: 10.1128/mcb.21.1.88-99.2001

PubMed ID: 12185076

Title: Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.

PubMed ID: 12185076

DOI: 10.1074/jbc.m203951200

PubMed ID: 11980914

Title: Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.

PubMed ID: 11980914

DOI: 10.1083/jcb.200109045

PubMed ID: 12839962

Title: Human Spy1 promotes survival of mammalian cells following DNA damage.

PubMed ID: 12839962

PubMed ID: 12944431

Title: DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.

PubMed ID: 12944431

DOI: 10.1242/dev.00731

PubMed ID: 12972555

Title: Spy1 interacts with p27Kip1 to allow G1/S progression.

PubMed ID: 12972555

DOI: 10.1091/mbc.e02-12-0820

PubMed ID: 15178429

Title: NIRF induces G1 arrest and associates with Cdk2.

PubMed ID: 15178429

DOI: 10.1016/j.bbrc.2004.04.190

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 14597612

Title: p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.

PubMed ID: 14597612

DOI: 10.1074/jbc.m309995200

PubMed ID: 15611625

Title: Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

PubMed ID: 15611625

DOI: 10.4161/cc.4.1.1347

PubMed ID: 15800615

Title: CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.

PubMed ID: 15800615

DOI: 10.1038/nature03404

PubMed ID: 17373709

Title: Recognition of Cdk2 by Cdk7.

PubMed ID: 17373709

DOI: 10.1002/prot.21370

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18372919

Title: Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.

PubMed ID: 18372919

DOI: 10.1038/onc.2008.74

PubMed ID: 19829063

Title: Identification and characterization of CAC1 as a novel CDK2-associated cullin.

PubMed ID: 19829063

DOI: 10.4161/cc.8.21.9955

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20147522

Title: Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.

PubMed ID: 20147522

DOI: 10.1210/en.2009-1116

PubMed ID: 20079829

Title: Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle.

PubMed ID: 20079829

DOI: 10.1016/j.freeradbiomed.2010.01.004

PubMed ID: 20360007

Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

PubMed ID: 20360007

DOI: 10.1074/jbc.m109.096552

PubMed ID: 20935635

Title: Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.

PubMed ID: 20935635

DOI: 10.1038/ncb2116

PubMed ID: 20195506

Title: Cdk2 is required for p53-independent G2/M checkpoint control.

PubMed ID: 20195506

DOI: 10.1371/journal.pgen.1000863

PubMed ID: 19966300

Title: Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.

PubMed ID: 19966300

DOI: 10.1073/pnas.0900121106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406398

Title: Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.

PubMed ID: 21406398

DOI: 10.1158/0008-5472.can-10-2684

PubMed ID: 21262353

Title: Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.

PubMed ID: 21262353

DOI: 10.1016/j.cellsig.2011.01.019

PubMed ID: 21684737

Title: Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.

PubMed ID: 21684737

DOI: 10.1016/j.bmcl.2011.05.081

PubMed ID: 21596315

Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

PubMed ID: 21596315

DOI: 10.1016/j.molcel.2011.03.027

PubMed ID: 21319273

Title: An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

PubMed ID: 21319273

DOI: 10.1002/stem.620

PubMed ID: 19445729

Title: A dual role of Cdk2 in DNA damage response.

PubMed ID: 19445729

DOI: 10.1186/1747-1028-4-9

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 19561645

Title: Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

PubMed ID: 19561645

DOI: 10.1038/onc.2009.170

PubMed ID: 20713526

Title: Tipping the balance: Cdk2 enables Myc to suppress senescence.

PubMed ID: 20713526

DOI: 10.1158/0008-5472.can-10-1383

PubMed ID: 21517772

Title: Cyclin dependent kinase 1 inhibitors: a review of recent progress.

PubMed ID: 21517772

DOI: 10.2174/092986711795590110

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23781148

Title: Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation.

PubMed ID: 23781148

DOI: 10.7150/ijbs.5763

PubMed ID: 29203878

Title: ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.

PubMed ID: 29203878

DOI: 10.1038/s41467-017-02114-x

PubMed ID: 8510751

Title: Crystal structure of cyclin-dependent kinase 2.

PubMed ID: 8510751

DOI: 10.1038/363595a0

PubMed ID: 7630397

Title: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.

PubMed ID: 7630397

DOI: 10.1038/376313a0

PubMed ID: 8601310

Title: Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.

PubMed ID: 8601310

DOI: 10.1016/s0092-8674(00)81065-x

PubMed ID: 8917641

Title: High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.

PubMed ID: 8917641

DOI: 10.1021/jm960402a

PubMed ID: 8684460

Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

PubMed ID: 8684460

DOI: 10.1038/382325a0

PubMed ID: 8756328

Title: Structural basis of cyclin-dependent kinase activation by phosphorylation.

PubMed ID: 8756328

DOI: 10.1038/nsb0896-696

PubMed ID: 8610110

Title: Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

PubMed ID: 8610110

DOI: 10.1073/pnas.93.7.2735

PubMed ID: 9334743

Title: Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.

PubMed ID: 9334743

DOI: 10.1038/nsb1097-796

PubMed ID: 9677190

Title: Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

PubMed ID: 9677190

DOI: 10.1126/science.281.5376.533

PubMed ID: 16325401

Title: Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

PubMed ID: 16325401

DOI: 10.1016/j.bmcl.2005.11.048

PubMed ID: 17570665

Title: Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

PubMed ID: 17570665

DOI: 10.1016/j.bmcl.2007.04.110

PubMed ID: 17495531

Title: Cyclin B and cyclin A confer different substrate recognition properties on CDK2.

PubMed ID: 17495531

DOI: 10.4161/cc.6.11.4278

PubMed ID: 17095507

Title: How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

PubMed ID: 17095507

DOI: 10.1074/jbc.m609151200

PubMed ID: 17937404

Title: Structure-guided discovery of cyclin-dependent kinase inhibitors.

PubMed ID: 17937404

DOI: 10.1002/bip.20868

PubMed ID: 18656911

Title: Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

PubMed ID: 18656911

DOI: 10.1021/jm800382h

PubMed ID: 21565702

Title: Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.

PubMed ID: 21565702

DOI: 10.1016/j.str.2011.02.016

PubMed ID: 28666995

Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.

PubMed ID: 28666995

DOI: 10.15252/embj.201796905

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23711367

Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.

PubMed ID: 23711367

DOI: 10.1016/j.febslet.2013.05.037

Sequence Information:

  • Length: 298
  • Mass: 33930
  • Checksum: F90A0F4E70910B51
  • Sequence:
  • MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 
    PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 
    HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 
    STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 
    PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

Genular Protein ID: 2439212519

Symbol: G3V5T9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 346
  • Mass: 39178
  • Checksum: EFE068D119CA7637
  • Sequence:
  • MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 
    PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 
    HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 
    STAVDIWSLG CIFAEMHLVG TQHHARCCGE HRRNGRQSLC PLCSYLEVAA SQGWGMTAVS 
    TPYPVTRRAL FPGDSEIDQL FRIFRTLGTP DEVVWPGVTS MPDYKPSFPK WARQDFSKVV 
    PPLDEDGRSL LSQMLHYDPN KRISAKAALA HPFFQDVTKP VPHLRL

Genular Protein ID: 2936554235

Symbol: E7ESI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 238
  • Mass: 27165
  • Checksum: 61415DADFE55CFB0
  • Sequence:
  • MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL YLVFEFLHQD 
    LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF 
    GLARAFGVPV RTYTHEVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 
    PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

Genular Protein ID: 3614439243

Symbol: B4DDL9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 238
  • Mass: 27163
  • Checksum: 4F04E6E0098F684F
  • Sequence:
  • MENFQKVERI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL YLVFEFLHQD 
    LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF 
    GLARAFGVPV RTYTHEVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 
    PKWARQDFSK VVPPLDEDGR SLLSQTLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.