Details for: CDK2
Associated with
Other Information
Genular Protein ID: 2328343218
Symbol: CDK2_HUMAN
Name: Cyclin-dependent kinase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1714386
Title: A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
PubMed ID: 1714386
PubMed ID: 1653904
Title: Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
PubMed ID: 1653904
DOI: 10.1038/353174a0
PubMed ID: 1717994
Title: Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.
PubMed ID: 1717994
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1396589
Title: Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.
PubMed ID: 1396589
PubMed ID: 9030781
Title: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
PubMed ID: 9030781
PubMed ID: 10499802
Title: Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.
PubMed ID: 10499802
PubMed ID: 11051553
Title: Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.
PubMed ID: 11051553
PubMed ID: 10995386
Title: NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
PubMed ID: 10995386
DOI: 10.1101/gad.827700
PubMed ID: 10995387
Title: Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
PubMed ID: 10995387
DOI: 10.1101/gad.829500
PubMed ID: 10884347
Title: The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
PubMed ID: 10884347
PubMed ID: 11113184
Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
PubMed ID: 11113184
PubMed ID: 12185076
Title: Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.
PubMed ID: 12185076
PubMed ID: 11980914
Title: Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.
PubMed ID: 11980914
PubMed ID: 12839962
Title: Human Spy1 promotes survival of mammalian cells following DNA damage.
PubMed ID: 12839962
PubMed ID: 12944431
Title: DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.
PubMed ID: 12944431
DOI: 10.1242/dev.00731
PubMed ID: 12972555
Title: Spy1 interacts with p27Kip1 to allow G1/S progression.
PubMed ID: 12972555
PubMed ID: 15178429
Title: NIRF induces G1 arrest and associates with Cdk2.
PubMed ID: 15178429
PubMed ID: 15107404
Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.
PubMed ID: 15107404
DOI: 10.1101/gad.1183304
PubMed ID: 14597612
Title: p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.
PubMed ID: 14597612
PubMed ID: 15611625
Title: Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.
PubMed ID: 15611625
DOI: 10.4161/cc.4.1.1347
PubMed ID: 15800615
Title: CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
PubMed ID: 15800615
DOI: 10.1038/nature03404
PubMed ID: 17373709
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18372919
Title: Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.
PubMed ID: 18372919
DOI: 10.1038/onc.2008.74
PubMed ID: 19829063
Title: Identification and characterization of CAC1 as a novel CDK2-associated cullin.
PubMed ID: 19829063
DOI: 10.4161/cc.8.21.9955
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20147522
Title: Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.
PubMed ID: 20147522
DOI: 10.1210/en.2009-1116
PubMed ID: 20079829
Title: Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle.
PubMed ID: 20079829
PubMed ID: 20360007
Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.
PubMed ID: 20360007
PubMed ID: 20935635
Title: Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.
PubMed ID: 20935635
DOI: 10.1038/ncb2116
PubMed ID: 20195506
Title: Cdk2 is required for p53-independent G2/M checkpoint control.
PubMed ID: 20195506
PubMed ID: 19966300
Title: Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
PubMed ID: 19966300
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406398
Title: Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
PubMed ID: 21406398
PubMed ID: 21262353
Title: Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.
PubMed ID: 21262353
PubMed ID: 21684737
Title: Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.
PubMed ID: 21684737
PubMed ID: 21596315
Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
PubMed ID: 21596315
PubMed ID: 21319273
Title: An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
PubMed ID: 21319273
DOI: 10.1002/stem.620
PubMed ID: 19445729
PubMed ID: 19238148
PubMed ID: 19561645
Title: Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.
PubMed ID: 19561645
DOI: 10.1038/onc.2009.170
PubMed ID: 20713526
Title: Tipping the balance: Cdk2 enables Myc to suppress senescence.
PubMed ID: 20713526
PubMed ID: 21517772
Title: Cyclin dependent kinase 1 inhibitors: a review of recent progress.
PubMed ID: 21517772
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23781148
Title: Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation.
PubMed ID: 23781148
DOI: 10.7150/ijbs.5763
PubMed ID: 29203878
Title: ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.
PubMed ID: 29203878
PubMed ID: 8510751
PubMed ID: 7630397
Title: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
PubMed ID: 7630397
DOI: 10.1038/376313a0
PubMed ID: 8601310
Title: Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
PubMed ID: 8601310
PubMed ID: 8917641
Title: High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
PubMed ID: 8917641
DOI: 10.1021/jm960402a
PubMed ID: 8684460
Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
PubMed ID: 8684460
DOI: 10.1038/382325a0
PubMed ID: 8756328
Title: Structural basis of cyclin-dependent kinase activation by phosphorylation.
PubMed ID: 8756328
DOI: 10.1038/nsb0896-696
PubMed ID: 8610110
Title: Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
PubMed ID: 8610110
PubMed ID: 9334743
Title: Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
PubMed ID: 9334743
DOI: 10.1038/nsb1097-796
PubMed ID: 9677190
Title: Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
PubMed ID: 9677190
PubMed ID: 16325401
Title: Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
PubMed ID: 16325401
PubMed ID: 17570665
Title: Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
PubMed ID: 17570665
PubMed ID: 17495531
Title: Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
PubMed ID: 17495531
DOI: 10.4161/cc.6.11.4278
PubMed ID: 17095507
Title: How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.
PubMed ID: 17095507
PubMed ID: 17937404
Title: Structure-guided discovery of cyclin-dependent kinase inhibitors.
PubMed ID: 17937404
DOI: 10.1002/bip.20868
PubMed ID: 18656911
Title: Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
PubMed ID: 18656911
DOI: 10.1021/jm800382h
PubMed ID: 21565702
Title: Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.
PubMed ID: 21565702
PubMed ID: 28666995
Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
PubMed ID: 28666995
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 23711367
Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.
PubMed ID: 23711367
Sequence Information:
- Length: 298
- Mass: 33930
- Checksum: F90A0F4E70910B51
- Sequence:
MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
Genular Protein ID: 2439212519
Symbol: G3V5T9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 346
- Mass: 39178
- Checksum: EFE068D119CA7637
- Sequence:
MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMHLVG TQHHARCCGE HRRNGRQSLC PLCSYLEVAA SQGWGMTAVS TPYPVTRRAL FPGDSEIDQL FRIFRTLGTP DEVVWPGVTS MPDYKPSFPK WARQDFSKVV PPLDEDGRSL LSQMLHYDPN KRISAKAALA HPFFQDVTKP VPHLRL
Genular Protein ID: 2936554235
Symbol: E7ESI2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 238
- Mass: 27165
- Checksum: 61415DADFE55CFB0
- Sequence:
MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL YLVFEFLHQD LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF GLARAFGVPV RTYTHEVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
Genular Protein ID: 3614439243
Symbol: B4DDL9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 238
- Mass: 27163
- Checksum: 4F04E6E0098F684F
- Sequence:
MENFQKVERI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTL LDVIHTENKL YLVFEFLHQD LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF GLARAFGVPV RTYTHEVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK VVPPLDEDGR SLLSQTLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.