Details for: LHFPL6

Gene ID: 10186

Symbol: LHFPL6

Ensembl ID: ENSG00000183722

Description: LHFPL tetraspan subfamily member 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 8.64
    Marker Score: 114,891
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 5.53
    Marker Score: 2,996
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.88
    Marker Score: 3,210
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.89
    Marker Score: 86,869
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.75
    Marker Score: 3,579
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.6
    Marker Score: 4,140
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.53
    Marker Score: 3,153
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.43
    Marker Score: 1,665
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.19
    Marker Score: 4,618
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.19
    Marker Score: 1,012
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.99
    Marker Score: 12,525
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.87
    Marker Score: 1,714
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.78
    Marker Score: 5,354
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.72
    Marker Score: 92,704
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.72
    Marker Score: 58,083
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.63
    Marker Score: 9,344
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.46
    Marker Score: 1,618
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.44
    Marker Score: 1,204
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.35
    Marker Score: 1,306
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.28
    Marker Score: 5,972
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.08
    Marker Score: 1,176
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.07
    Marker Score: 5,261
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.06
    Marker Score: 1,153
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.01
    Marker Score: 1,428
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.99
    Marker Score: 122,587
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.97
    Marker Score: 8,492
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.93
    Marker Score: 444
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.86
    Marker Score: 3,777
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.85
    Marker Score: 630
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.84
    Marker Score: 1,320
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.81
    Marker Score: 1,055
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15,435
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.69
    Marker Score: 2,091
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.66
    Marker Score: 2,008
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.66
    Marker Score: 3,639
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.64
    Marker Score: 3,282
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,518
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.62
    Marker Score: 3,047
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,150
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.58
    Marker Score: 1,965
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.57
    Marker Score: 1,033
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.56
    Marker Score: 1,349
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.51
    Marker Score: 2,082
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5
    Marker Score: 9,769
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.5
    Marker Score: 57,014
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.5
    Marker Score: 14,225
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.49
    Marker Score: 2,524
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.48
    Marker Score: 1,396
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.48
    Marker Score: 365
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.48
    Marker Score: 383
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1,461
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.46
    Marker Score: 629
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.45
    Marker Score: 1,236
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.44
    Marker Score: 321
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.43
    Marker Score: 902
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.42
    Marker Score: 1,570
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.42
    Marker Score: 341
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.41
    Marker Score: 825
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.39
    Marker Score: 2,337
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.39
    Marker Score: 1,278
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.39
    Marker Score: 577
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.38
    Marker Score: 520
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2,790
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.37
    Marker Score: 291
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.34
    Marker Score: 1,296
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20,827
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.3
    Marker Score: 412
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.29
    Marker Score: 365
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.29
    Marker Score: 752
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.28
    Marker Score: 14,371
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.26
    Marker Score: 1,363
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.25
    Marker Score: 837
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.23
    Marker Score: 140,564
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.21
    Marker Score: 449
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.2
    Marker Score: 299
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.19
    Marker Score: 299
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.18
    Marker Score: 1,814
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.18
    Marker Score: 2,816
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.17
    Marker Score: 368
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.16
    Marker Score: 425
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.14
    Marker Score: 290
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.13
    Marker Score: 1,642
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.1
    Marker Score: 684
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.08
    Marker Score: 1,348
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.06
    Marker Score: 311
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.06
    Marker Score: 332
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.05
    Marker Score: 6,281
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.04
    Marker Score: 3,856
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,744
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.03
    Marker Score: 926
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.01
    Marker Score: 370
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,765
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,991
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 598
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1
    Marker Score: 892
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.99
    Marker Score: 384
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.97
    Marker Score: 462
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LHFPL6 shares several key characteristics with other tetraspanins. Firstly, it belongs to the LHFPL tetraspan subfamily, which is characterized by the presence of a specific tetraspanin domain. This domain is composed of four transmembrane helices and is thought to play a role in the interaction with other proteins and the regulation of cellular processes. LHFPL6 is also a type II transmembrane protein, meaning that it has a single transmembrane helix and a cytoplasmic tail. This localization is consistent with its role in cell-cell interactions and signal transduction. In addition to its structural characteristics, LHFPL6 exhibits a high degree of tissue-specific expression, with significant levels of mRNA detected in cardiac muscle cells, skeletal muscle fibroblasts, and vascular cells. This tissue specificity suggests that LHFPL6 plays a unique role in the development and function of these tissues. **Pathways and Functions** The pathways and functions of LHFPL6 are not yet fully understood, but several potential mechanisms have been proposed based on its expression profile and structural characteristics. One possibility is that LHFPL6 plays a role in the regulation of cell-cell interactions and adhesion in muscle cells. Tetraspanins, including LHFPL6, have been shown to interact with other proteins and regulate the assembly of adhesion complexes, which are essential for the formation and maintenance of tissue structure. Another potential function of LHFPL6 is its involvement in signal transduction pathways. Tetraspanins, including LHFPL6, have been shown to interact with signaling molecules and regulate the transmission of signals into the cell. This could be important for the development and function of muscle cells, where signal transduction plays a critical role in regulating gene expression and cellular behavior. **Clinical Significance** While the clinical significance of LHFPL6 is not yet fully understood, its expression profile and tissue specificity suggest that it may play a role in the development and function of muscle tissues. Abnormalities in LHFPL6 expression or function may contribute to various diseases, including muscular dystrophy, cardiovascular disease, and cancer. For example, mutations in the LHFPL6 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. Additionally, LHFPL6 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting that it may play a role in tumorigenesis. Further research is needed to fully understand the role of LHFPL6 in human disease and to explore its potential as a therapeutic target. However, its unique expression profile and structural characteristics make it an interesting candidate for further study. In conclusion, LHFPL6 is a member of the LHFPL tetraspan subfamily that plays a critical role in the development and function of muscle tissues. Its unique expression profile and structural characteristics suggest that it may be involved in cell-cell interactions, signal transduction, and tissue structure formation. Further research is needed to fully understand its role in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2233274881

Symbol: LHPL6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y693 B2R7M2 Q53FC0 Q96SH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10329012

Title: LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes.

PubMed ID: 10329012

DOI: 10.1006/geno.1999.5778

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 200
  • Mass: 21598
  • Checksum: 49D1161602966423
  • Sequence:
    • MASSLTCTGV IWALLSFLCA ATSCVGFFMP YWLWGSQLGK PVSFGTFRRC SYPVHDESRQ 
MMVMVEECGR YASFQGIPSA EWRICTIVTG LGCGLLLLVA LTALMGCCVS DLISRTVGRV 
AGGIQFLGGL LIGAGCALYP LGWDSEEVRQ TCGYTSGQFD LGKCEIGWAY YCTGAGATAA 
MLLCTWLACF SGKKQKHYPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.