Details for: TNK2

Gene ID: 10188

Symbol: TNK2

Ensembl ID: ENSG00000061938

Description: tyrosine kinase non receptor 2

Associated with

Other Information

Genular Protein ID: 1599003840

Symbol: ACK1_HUMAN

Name: Activated CDC42 kinase 1

UniProtKB Accession Codes:

Q07912 Q6ZMQ0 Q8N6U7 Q96H59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 DrugCentral 1 EC 3 EMBL 5 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 16 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 Rhea 9 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8497321

Title: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.

PubMed ID: 8497321

DOI: 10.1038/363364a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10587647

Title: Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.

PubMed ID: 10587647

DOI: 10.1038/70302

PubMed ID: 10652228

Title: Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation.

PubMed ID: 10652228

DOI: 10.1006/bbrc.2000.2106

PubMed ID: 11278436

Title: The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors.

PubMed ID: 11278436

DOI: 10.1074/jbc.m008795200

PubMed ID: 14733946

Title: Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK.

PubMed ID: 14733946

DOI: 10.1016/j.bbrc.2003.12.137

PubMed ID: 16288044

Title: Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.

PubMed ID: 16288044

DOI: 10.1158/0008-5472.can-05-1127

PubMed ID: 16137687

Title: SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.

PubMed ID: 16137687

DOI: 10.1016/j.febslet.2005.07.093

PubMed ID: 16257963

Title: Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.

PubMed ID: 16257963

DOI: 10.1074/jbc.m506996200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16247015

Title: Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.

PubMed ID: 16247015

DOI: 10.1073/pnas.0508014102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17038317

Title: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.

PubMed ID: 17038317

DOI: 10.1074/jbc.m604342200

PubMed ID: 16472662

Title: Purification and enzyme activity of ACK1.

PubMed ID: 16472662

DOI: 10.1016/s0076-6879(06)06018-6

PubMed ID: 17494760

Title: Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.

PubMed ID: 17494760

DOI: 10.1073/pnas.0700420104

PubMed ID: 18477472

Title: Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct.

PubMed ID: 18477472

DOI: 10.1016/j.bbrc.2008.05.016

PubMed ID: 18435854

Title: TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells.

PubMed ID: 18435854

DOI: 10.1186/bcr2087

PubMed ID: 18262180

Title: Dysregulation of Ack1 inhibits down-regulation of the EGF receptor.

PubMed ID: 18262180

DOI: 10.1016/j.yexcr.2007.12.017

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19144635

Title: Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

PubMed ID: 19144635

DOI: 10.1074/jbc.m806877200

PubMed ID: 19815557

Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

PubMed ID: 19815557

DOI: 10.1074/jbc.m109.072660

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20979614

Title: Regulation of Ack1 localization and activity by the amino-terminal SAM domain.

PubMed ID: 20979614

DOI: 10.1186/1471-2091-11-42

PubMed ID: 20110370

Title: Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.

PubMed ID: 20110370

DOI: 10.1074/jbc.m109.060459

PubMed ID: 20383201

Title: Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases.

PubMed ID: 20383201

DOI: 10.1038/onc.2010.103

PubMed ID: 20333297

Title: Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.

PubMed ID: 20333297

DOI: 10.1371/journal.pone.0009646

PubMed ID: 20623637

Title: Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.

PubMed ID: 20623637

DOI: 10.1002/pros.21163

PubMed ID: 21309750

Title: The Cdc42-associated kinase ACK1 is not auto-inhibited but requires Src for activation.

PubMed ID: 21309750

DOI: 10.1042/bj20102156

PubMed ID: 21169560

Title: Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.

PubMed ID: 21169560

DOI: 10.1091/mbc.e10-07-0637

PubMed ID: 20432460

Title: Shepherding AKT and androgen receptor by Ack1 tyrosine kinase.

PubMed ID: 20432460

DOI: 10.1002/jcp.22162

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10360579

Title: Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.

PubMed ID: 10360579

DOI: 10.1038/20732

PubMed ID: 15308621

Title: Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1.

PubMed ID: 15308621

DOI: 10.1074/jbc.m406703200

PubMed ID: 18993068

Title: Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.

PubMed ID: 18993068

DOI: 10.1016/j.bmcl.2008.10.092

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23686771

Title: Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.

PubMed ID: 23686771

DOI: 10.1002/ana.23934

Sequence Information:

  • Length: 1038
  • Mass: 114569
  • Checksum: 74A1980665BC3E6B
  • Sequence:
    • MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 
EAVKRRKALC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK TSPAPGGPAG EGPLQSLTCL 
IGEKDLRLLE KLGDGSFGVV RRGEWDAPSG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 
MHSLDHRNLI RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 
GYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 
SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 
YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 
ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 
RIDELYLGNP MDPPDLLSVE LSTSRPPQHL GGVKKPTYDP VSEDQDPLSS DFKRLGLRKP 
GLPRGLWLAK PSARVPGTKA SRGSGAEVTL IDFGEEPVVP ALRPCAPSLA QLAMDACSLL 
DETPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEICSI NSTLVGAGVP 
AGPSQGQTNY AFVPEQARPP PPLEDNLFLP PQGGGKPPSS AQTAEIFQAL QQECMRQLQA 
PAGSPAPSPS PGGDDKPQVP PRVPIPPRPT RPHVQLSPAP PGEEETSQWP GPASPPRVPP 
REPLSPQGSR TPSPLVPPGS SPLPPRLSSS PGKTMPTTQS FASDPKYATP QVIQAPGPRA 
GPCILPIVRD GKKVSSTHYY LLPERPSYLE RYQRFLREAQ SPEEPTPLPV PLLLPPPSTP 
APAAPTATVR PMPQAALDPK ANFSTNNSNP GARPPPPRAT ARLPQRGCPG DGPEAGRPAD 
KIQMAMVHGV TTEECQAALQ CHGWSVQRAA QYLKVEQLFG LGLRPRGECH KVLEMFDWNL 
EQAGCHLLGS WGPAHHKR

Genular Protein ID: 2796115830

Symbol: B3KXJ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KXJ4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 565
  • Mass: 60546
  • Checksum: 8A360600EA30B108
  • Sequence:
    • MDPPDLLSVE LSTSRPPQHL GGVKREPPPR PPQPAFFTQK PTYDPVSEDQ DPLSSDFKRL 
GLRKPGLPRG LWLAKPSARV PGTKASRGSG AEVTLIDFGE EPVVPALRPC APSLAQLAMD 
ACSLLDETPP QSPTRALPRP LHPTPVVDWD ARPLPPPPAY DDVAQDEDDF EICSINSTLV 
GAGVPAGPSQ GQTNYAFVPE QARPPPPLED NLFLPPQGGG KPPSSAQTAE IFQALQQECM 
RQLQAPAGSP APSPSPGGDD KPQVPPRVPI PPRPTRPHVQ LSPAPPGEEE TSQWPGPASP 
PRVPPREPLS PQGSRTPSPL VPPGSSPLPP RLSSSPGKTM PTTQSFASDP KYATPQVIQA 
PGPRAGPCIL PIVRDGKKVS STHYYLLPER PSYLERYQRF LREAQSPEEP TPLPVPLLLP 
PPSTPAPAAP TATVRPMPQA ALDPKANFST NNSNPGARPP PPRATARLPQ RGCPGDGPEA 
GRPADKIQML QAMVHGVTTE ECQAALQCHG WSVQRAAQYL KVEQLFGLGL RPRGECHKVL 
EMFDWNLEQA GCHLLGSWGP AHHKR

Genular Protein ID: 2489394885

Symbol: C9J1X3_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J1X3

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 11 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1040
  • Mass: 114950
  • Checksum: C2E28B9C4BBCF45F
  • Sequence:
    • MPAARRFPGL ELSFPLLARL RRRLYTRLGG GRMQPEEGTG WLLELLSEVQ LQQYFLRLRD 
DLNVTRLSHF EYVKNEDLEK IGMGRPGQRR LWEAVKRRKA LCKRKSWMSK VFSGKRLEAE 
FPPHHSQSTF RKTSPAPGGP AGEGPLQSLT CLIGEKDLRL LEKLGDGSFG VVRRGEWDAP 
SGKTVSVAVK CLKPDVLSQP EAMDDFIREV NAMHSLDHRN LIRLYGVVLT PPMKMVTELA 
PLGSLLDRLR KHQGHFLLGT LSRYAVQVAE GMGYLESKRF IHRDLAARNL LLATRDLVKI 
GDFGLMRALP QNDDHYVMQE HRKVPFAWCA PESLKTRTFS HASDTWMFGV TLWEMFTYGQ 
EPWIGLNGSQ ILHKIDKEGE RLPRPEDCPQ DIYNVMVQCW AHKPEDRPTF VALRDFLLEA 
QPTDMRALQD FEEPDKLHIQ MNDVITVIEG RAENYWWRGQ NTRTLCVGPF PRNVVTSVAG 
LSAQDISQPL QNSFIHTGHG DSDPRHCWGF PDRIDELYLG NPMDPPDLLS VELSTSRPPQ 
HLGGVKKPTY DPVSEDQDPL SSDFKRLGLR KPGLPRGLWL AKPSARVPGT KASRGSGAEV 
TLIDFGEEPV VPALRPCAPS LAQLAMDACS LLDETPPQSP TRALPRPLHP TPVVDWDARP 
LPPPPAYDDV AQDEDDFEIC SINSTLVGAG VPAGPSQGQT NYAFVPEQAR PPPPLEDNLF 
LPPQGGGKPP SSAQTAEIFQ ALQQECMRQL QAPAGSPAPS PSPGGDDKPQ VPPRVPIPPR 
PTRPHVQLSP APPGEEETSQ WPGPASPPRV PPREPLSPQG SRTPSPLVPP GSSPLPPRLS 
SSPGKTMPTT QSFASDPKYA TPQVIQAPGP RAGPCILPIV RDGKKVSSTH YYLLPERPSY 
LERYQRFLRE AQSPEEPTPL PVPLLLPPPS TPAPAAPTAT VRPMPQAALD PKANFSTNNS 
NPGARPPPPR ATARLPQRGC PGDGPEAGRP ADKIQMVEQL FGLGLRPRGE CHKVLEMFDW 
NLEQAGCHLL GSWGPAHHKR

Genular Protein ID: 1445827110

Symbol: A0A499FJ16_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A499FJ16

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 3 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 HGNC 1 InterPro 11 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 1086
  • Mass: 119349
  • Checksum: 6FC37F9EFDF69D5E
  • Sequence:
    • MLEARPPRTQ GSDAAGAAAG RGLRALLLSL TAAAGIWGSM GERSAYQRLA GGEEGPQRLG 
GGRMQPEEGT GWLLELLSEV QLQQYFLRLR DDLNVTRLSH FEYVKNEDLE KIGMGRPGQR 
RLWEAVKRRK ALCKRKSWMS KVFSGKRLEA EFPPHHSQST FRKTSPAPGG PAGEGPLQSL 
TCLIGEKDLR LLEKLGDGSF GVVRRGEWDA PSGKTVSVAV KCLKPDVLSQ PEAMDDFIRE 
VNAMHSLDHR NLIRLYGVVL TPPMKMVTEL APLGSLLDRL RKHQGHFLLG TLSRYAVQVA 
EGMGYLESKR FIHRDLAARN LLLATRDLVK IGDFGLMRAL PQNDDHYVMQ EHRKVPFAWC 
APESLKTRTF SHASDTWMFG VTLWEMFTYG QEPWIGLNGS QILHKIDKEG ERLPRPEDCP 
QDIYNVMVQC WAHKPEDRPT FVALRDFLLE AQPTDMRALQ DFEEPDKLHI QMNDVITVIE 
GRAENYWWRG QNTRTLCVGP FPRNVVTSVA GLSAQDISQP LQNSFIHTGH GDSDPRHCWG 
FPDRIDELYL GNPMDPPDLL SVELSTSRPP QHLGGVKREP PPRPPQPAFF TQKPTYDPVS 
EDQDPLSSDF KRLGLRKPGL PRGLWLAKPS ARVPGTKASR GSGAEVTLID FGEEPVVPAL 
RPCAPSLAQL AMDACSLLDE TPPQSPTRAL PRPLHPTPVV DWDARPLPPP PAYDDVAQDE 
DDFEICSINS TLVGAGVPAG PSQGQTNYAF VPEQARPPPP LEDNLFLPPQ GGGKPPSSAQ 
TAEIFQALQQ ECMRQLQAPA GSPAPSPSPG GDDKPQVPPR VPIPPRPTRP HVQLSPAPPG 
EEETSQWPGP ASPPRVPPRE PLSPQGSRTP SPLVPPGSSP LPPRLSSSPG KTMPTTQSFA 
SDPKYATPQV IQAPGPRAGP CILPIVRDGK KVSSTHYYLL PERPSYLERY QRFLREAQSP 
EEPTPLPVPL LLPPPSTPAP AAPTATVRPM PQAALDPKAN FSTNNSNPGA RPPPPRATAR 
LPQRGCPGDG PEAGRPADKI QMVEQLFGLG LRPRGECHKV LEMFDWNLEQ AGCHLLGSWG 
PAHHKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.