Details for: ALYREF
Associated with
Other Information
Genular Protein ID: 3389934674
Symbol: THOC4_HUMAN
Name: THO complex subunit 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9952027
Title: Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus.
PubMed ID: 9952027
PubMed ID: 12176931
Title: Large-scale proteomic analysis of the human spliceosome.
PubMed ID: 12176931
DOI: 10.1101/gr.473902
PubMed ID: 10488337
Title: A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins.
PubMed ID: 10488337
PubMed ID: 9731529
Title: Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.
PubMed ID: 9731529
DOI: 10.1038/1700
PubMed ID: 11118221
Title: The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.
PubMed ID: 11118221
PubMed ID: 11707413
Title: Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.
PubMed ID: 11707413
PubMed ID: 11675789
Title: Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly.
PubMed ID: 11675789
DOI: 10.1038/35098106
PubMed ID: 11546873
Title: Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.
PubMed ID: 11546873
PubMed ID: 12438613
Title: ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway.
PubMed ID: 12438613
PubMed ID: 11979277
Title: TREX is a conserved complex coupling transcription with messenger RNA export.
PubMed ID: 11979277
DOI: 10.1038/nature746
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 12944400
Title: An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.
PubMed ID: 12944400
PubMed ID: 15782174
Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
PubMed ID: 15782174
DOI: 10.1038/nmeth715
PubMed ID: 14730019
Title: eIF4A3 is a novel component of the exon junction complex.
PubMed ID: 14730019
DOI: 10.1261/rna.5230104
PubMed ID: 15833825
Title: Linking transcriptional elongation and messenger RNA export to metastatic breast cancers.
PubMed ID: 15833825
PubMed ID: 15998806
Title: Recruitment of the human TREX complex to mRNA during splicing.
PubMed ID: 15998806
DOI: 10.1101/gad.1302205
PubMed ID: 16314458
Title: Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
PubMed ID: 16314458
DOI: 10.1261/rna.2155905
PubMed ID: 17190602
Title: Human mRNA export machinery recruited to the 5' end of mRNA.
PubMed ID: 17190602
PubMed ID: 17234882
Title: The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.
PubMed ID: 17234882
DOI: 10.1101/gad.1503107
PubMed ID: 17984224
Title: ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.
PubMed ID: 17984224
DOI: 10.1128/mcb.01341-07
PubMed ID: 18974867
Title: Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.
PubMed ID: 18974867
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18364396
Title: Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.
PubMed ID: 18364396
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19165146
Title: Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.
PubMed ID: 19165146
DOI: 10.1038/emboj.2009.5
PubMed ID: 19586903
Title: The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
PubMed ID: 19586903
PubMed ID: 19324961
Title: Assembly and mobility of exon-exon junction complexes in living cells.
PubMed ID: 19324961
DOI: 10.1261/rna.1387009
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20129943
Title: Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.
PubMed ID: 20129943
DOI: 10.1093/nar/gkq033
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22144908
Title: Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.
PubMed ID: 22144908
PubMed ID: 21253573
Title: Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57.
PubMed ID: 21253573
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22893130
Title: TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.
PubMed ID: 22893130
DOI: 10.1038/ncomms2005
Title:
DOI: 10.1038/ncomms3377
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23222130
Title: Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.
PubMed ID: 23222130
DOI: 10.1093/nar/gks1188
PubMed ID: 23826332
Title: Mapping interactions between mRNA export factors in living cells.
PubMed ID: 23826332
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25662211
Title: Luzp4 defines a new mRNA export pathway in cancer cells.
PubMed ID: 25662211
DOI: 10.1093/nar/gkv070
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28418038
Title: 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.
PubMed ID: 28418038
DOI: 10.1038/cr.2017.55
Sequence Information:
- Length: 257
- Mass: 26888
- Checksum: E2B5021DA579919A
- Sequence:
MADKMDMSLD DIIKLNRSQR GGRGGGRGRG RAGSQGGRGG GAQAAARVNR GGGPIRNRPA IARGAAGGGG RNRPAPYSRP KQLPDKWQHD LFDSGFGGGA GVETGGKLLV SNLDFGVSDA DIQELFAEFG TLKKAAVHYD RSGRSLGTAD VHFERKADAL KAMKQYNGVP LDGRPMNIQL VTSQIDAQRR PAQSVNRGGM TRNRGAGGFG GGGGTRRGTR GGARGRGRGA GRNSKQQLSA EELDAQLDAY NARMDTS
Genular Protein ID: 456920073
Symbol: E9PB61_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15782174
Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
PubMed ID: 15782174
DOI: 10.1038/nmeth715
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 264
- Mass: 27558
- Checksum: 52BEF28686C9EB04
- Sequence:
MPDSAPAMAD KMDMSLDDII KLNRSQRGGR GGGRGRGRAG SQGGRGGGAQ AAARVNRGGG PIRNRPAIAR GAAGGGGRNR PAPYSRPKQL PDKWQHDLFD SGFGGGAGVE TGGKLLVSNL DFGVSDADIQ ELFAEFGTLK KAAVHYDRSG RSLGTADVHF ERKADALKAM KQYNGVPLDG RPMNIQLVTS QIDAQRRPAQ SVNRGGMTRN RGAGGFGGGG GTRRGTRGGA RGRGRGAGRN SKQQLSAEEL DAQLDAYNAR MDTS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.