Details for: ALYREF

Gene ID: 10189

Symbol: ALYREF

Ensembl ID: ENSG00000183684

Description: Aly/REF export factor

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 6.61
    Marker Score: 9,494
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.95
    Marker Score: 4,803
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.88
    Marker Score: 1,273
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.52
    Marker Score: 5,642
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.45
    Marker Score: 49,275
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.33
    Marker Score: 13,443
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.25
    Marker Score: 1,837
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.19
    Marker Score: 714
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.17
    Marker Score: 294
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.15
    Marker Score: 1,437
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1
    Marker Score: 38,026
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.08
    Marker Score: 5,309
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.07
    Marker Score: 1,002
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.07
    Marker Score: 379
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.04
    Marker Score: 369
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.03
    Marker Score: 1,105
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.03
    Marker Score: 1,248
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.02
    Marker Score: 1,689
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.02
    Marker Score: 1,070
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.01
    Marker Score: 993
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,723
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,948
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.99
    Marker Score: 300
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.97
    Marker Score: 470
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.97
    Marker Score: 811
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.97
    Marker Score: 661
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,397
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.93
    Marker Score: 988
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.93
    Marker Score: 1,330
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,703
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9
    Marker Score: 10,150
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,119
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.87
    Marker Score: 252
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,241
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.86
    Marker Score: 1,966
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.86
    Marker Score: 930
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.85
    Marker Score: 664
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.85
    Marker Score: 2,371
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.84
    Marker Score: 434
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.84
    Marker Score: 290
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.83
    Marker Score: 1,762
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.82
    Marker Score: 236
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.81
    Marker Score: 806
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.8
    Marker Score: 533
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.78
    Marker Score: 445
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.77
    Marker Score: 651
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.76
    Marker Score: 556
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.76
    Marker Score: 370
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.76
    Marker Score: 326
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.76
    Marker Score: 885
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.74
    Marker Score: 2,027
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.73
    Marker Score: 418
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.73
    Marker Score: 241
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.73
    Marker Score: 742
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.72
    Marker Score: 238
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.72
    Marker Score: 273
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.72
    Marker Score: 4,576
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.71
    Marker Score: 357
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7
    Marker Score: 696
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.69
    Marker Score: 1,745
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.69
    Marker Score: 1,222
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.69
    Marker Score: 976
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.69
    Marker Score: 220
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.69
    Marker Score: 213
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.69
    Marker Score: 784
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.68
    Marker Score: 430
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.68
    Marker Score: 218
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 611
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.66
    Marker Score: 274
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,754
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.64
    Marker Score: 193
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.64
    Marker Score: 1,902
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.64
    Marker Score: 3,871
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.64
    Marker Score: 660
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.63
    Marker Score: 1,268
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.63
    Marker Score: 682
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.63
    Marker Score: 401
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.63
    Marker Score: 217
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.63
    Marker Score: 1,489
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.63
    Marker Score: 1,421
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.6
    Marker Score: 377
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 399
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.6
    Marker Score: 426
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.58
    Marker Score: 174
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.58
    Marker Score: 889
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.57
    Marker Score: 263
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.56
    Marker Score: 278
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.56
    Marker Score: 1,500
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.56
    Marker Score: 527
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 741

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Aly/REF is a multifunctional protein that interacts with various RNA-binding proteins (RBPs) and other cellular factors to regulate RNA transport and processing. Its primary function is to facilitate the export of mature mRNAs from the nucleus to the cytoplasm, where they can be translated into proteins. Aly/REF is also involved in the regulation of alternative splicing, chromatin remodeling, and transcriptional regulation. Its expression is widespread, with significant levels detected in various cell types, including respiratory basal cells, glandular epithelial cells, and hematopoietic cells. **Pathways and Functions:** Aly/REF is integral to several key pathways, including: 1. **RNA Export Complex:** Aly/REF interacts with the exportin-1 (XPO1) complex to facilitate the transport of mature mRNAs from the nucleus to the cytoplasm. 2. **Splicing and Processing:** Aly/REF regulates alternative splicing by interacting with RBPs and other splicing factors, ensuring the correct processing and export of mRNAs. 3. **Transcription and Termination:** Aly/REF influences transcriptional regulation by modulating the activity of RNA polymerase II and the termination of transcription. 4. **Chromatin Remodeling:** Aly/REF interacts with chromatin-modifying enzymes to regulate chromatin structure and accessibility, affecting gene expression. **Clinical Significance:** Dysregulation of Aly/REF has been implicated in various diseases, including: 1. **Cancer:** Altered expression of Aly/REF has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. 2. **Neurological Disorders:** Aly/REF has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation may contribute to RNA transport and processing defects. 3. **Immune System Dysregulation:** Aly/REF expression has been altered in immune cells, such as B cells and T cells, suggesting its potential role in immune system dysfunction. In conclusion, the Aly/REF export factor is a crucial component of the RNA export machinery, playing a vital role in regulating gene expression and cellular processes. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further studies are needed to fully elucidate the mechanisms of Aly/REF and its role in human diseases.

Genular Protein ID: 3389934674

Symbol: THOC4_HUMAN

Name: THO complex subunit 4

UniProtKB Accession Codes:

Q86V81 O43672

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 1 EPD 1 GO 20 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 UniProtKB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9952027

Title: Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus.

PubMed ID: 9952027

DOI: 10.1016/s0198-8859(98)00085-8

PubMed ID: 12176931

Title: Large-scale proteomic analysis of the human spliceosome.

PubMed ID: 12176931

DOI: 10.1101/gr.473902

PubMed ID: 10488337

Title: A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins.

PubMed ID: 10488337

DOI: 10.1016/s1097-2765(00)80369-x

PubMed ID: 9731529

Title: Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.

PubMed ID: 9731529

DOI: 10.1038/1700

PubMed ID: 11118221

Title: The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.

PubMed ID: 11118221

DOI: 10.1093/emboj/19.24.6860

PubMed ID: 11707413

Title: Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.

PubMed ID: 11707413

DOI: 10.1093/emboj/20.22.6424

PubMed ID: 11675789

Title: Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly.

PubMed ID: 11675789

DOI: 10.1038/35098106

PubMed ID: 11546873

Title: Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.

PubMed ID: 11546873

DOI: 10.1126/science.1062829

PubMed ID: 12438613

Title: ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway.

PubMed ID: 12438613

DOI: 10.1128/jvi.76.24.12877-12889.2002

PubMed ID: 11979277

Title: TREX is a conserved complex coupling transcription with messenger RNA export.

PubMed ID: 11979277

DOI: 10.1038/nature746

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12944400

Title: An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.

PubMed ID: 12944400

DOI: 10.1074/jbc.m306856200

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 14730019

Title: eIF4A3 is a novel component of the exon junction complex.

PubMed ID: 14730019

DOI: 10.1261/rna.5230104

PubMed ID: 15833825

Title: Linking transcriptional elongation and messenger RNA export to metastatic breast cancers.

PubMed ID: 15833825

DOI: 10.1158/0008-5472.can-04-3624

PubMed ID: 15998806

Title: Recruitment of the human TREX complex to mRNA during splicing.

PubMed ID: 15998806

DOI: 10.1101/gad.1302205

PubMed ID: 16314458

Title: Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

PubMed ID: 16314458

DOI: 10.1261/rna.2155905

PubMed ID: 17190602

Title: Human mRNA export machinery recruited to the 5' end of mRNA.

PubMed ID: 17190602

DOI: 10.1016/j.cell.2006.10.044

PubMed ID: 17234882

Title: The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.

PubMed ID: 17234882

DOI: 10.1101/gad.1503107

PubMed ID: 17984224

Title: ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.

PubMed ID: 17984224

DOI: 10.1128/mcb.01341-07

PubMed ID: 18974867

Title: Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.

PubMed ID: 18974867

DOI: 10.1371/journal.ppat.1000194

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18364396

Title: Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.

PubMed ID: 18364396

DOI: 10.1073/pnas.0709167105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19165146

Title: Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.

PubMed ID: 19165146

DOI: 10.1038/emboj.2009.5

PubMed ID: 19586903

Title: The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.

PubMed ID: 19586903

DOI: 10.1074/jbc.m109.040113

PubMed ID: 19324961

Title: Assembly and mobility of exon-exon junction complexes in living cells.

PubMed ID: 19324961

DOI: 10.1261/rna.1387009

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20129943

Title: Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.

PubMed ID: 20129943

DOI: 10.1093/nar/gkq033

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22144908

Title: Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

PubMed ID: 22144908

DOI: 10.1371/journal.pgen.1002386

PubMed ID: 21253573

Title: Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57.

PubMed ID: 21253573

DOI: 10.1371/journal.ppat.1001244

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22893130

Title: TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.

PubMed ID: 22893130

DOI: 10.1038/ncomms2005

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23222130

Title: Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.

PubMed ID: 23222130

DOI: 10.1093/nar/gks1188

PubMed ID: 23826332

Title: Mapping interactions between mRNA export factors in living cells.

PubMed ID: 23826332

DOI: 10.1371/journal.pone.0067676

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25662211

Title: Luzp4 defines a new mRNA export pathway in cancer cells.

PubMed ID: 25662211

DOI: 10.1093/nar/gkv070

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28418038

Title: 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.

PubMed ID: 28418038

DOI: 10.1038/cr.2017.55

Sequence Information:

  • Length: 257
  • Mass: 26888
  • Checksum: E2B5021DA579919A
  • Sequence:
    • MADKMDMSLD DIIKLNRSQR GGRGGGRGRG RAGSQGGRGG GAQAAARVNR GGGPIRNRPA 
IARGAAGGGG RNRPAPYSRP KQLPDKWQHD LFDSGFGGGA GVETGGKLLV SNLDFGVSDA 
DIQELFAEFG TLKKAAVHYD RSGRSLGTAD VHFERKADAL KAMKQYNGVP LDGRPMNIQL 
VTSQIDAQRR PAQSVNRGGM TRNRGAGGFG GGGGTRRGTR GGARGRGRGA GRNSKQQLSA 
EELDAQLDAY NARMDTS

Genular Protein ID: 456920073

Symbol: E9PB61_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PB61

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 264
  • Mass: 27558
  • Checksum: 52BEF28686C9EB04
  • Sequence:
    • MPDSAPAMAD KMDMSLDDII KLNRSQRGGR GGGRGRGRAG SQGGRGGGAQ AAARVNRGGG 
PIRNRPAIAR GAAGGGGRNR PAPYSRPKQL PDKWQHDLFD SGFGGGAGVE TGGKLLVSNL 
DFGVSDADIQ ELFAEFGTLK KAAVHYDRSG RSLGTADVHF ERKADALKAM KQYNGVPLDG 
RPMNIQLVTS QIDAQRRPAQ SVNRGGMTRN RGAGGFGGGG GTRRGTRGGA RGRGRGAGRN 
SKQQLSAEEL DAQLDAYNAR MDTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.