Gene CDK4 - ENSG00000135446 | NCBI Gene ID: 1019

Details for: CDK4

Gene ID: 1019

Symbol: CDK4

Ensembl ID: ENSG00000135446

Description: cyclin dependent kinase 4

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of cellular response to stress
(R-HSA-9675132)
Diseases of cellular senescence
(R-HSA-9630747)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4
(R-HSA-9630791)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9630794)
Evasion of oncogene induced senescence due to p16ink4a defects
(R-HSA-9630750)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4
(R-HSA-9632697)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9632700)
Evasion of oxidative stress induced senescence due to p16ink4a defects
(R-HSA-9632693)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Reproduction
(R-HSA-1474165)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
S phase
(R-HSA-69242)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Atp binding
(GO:0005524)
Bicellular tight junction
(GO:0005923)
Cell division
(GO:0051301)
Cellular response to interleukin-4
(GO:0071353)
Cellular response to ionomycin
(GO:1904637)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to phorbol 13-acetate 12-myristate
(GO:1904628)
Chromatin
(GO:0000785)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin binding
(GO:0030332)
Cyclin d1-cdk4 complex
(GO:0097128)
Cyclin d2-cdk4 complex
(GO:0097129)
Cyclin d3-cdk4 complex
(GO:0097130)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of cell cycle
(GO:0051726)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of transcription initiation by rna polymerase ii
(GO:0060260)
Regulation of type b pancreatic cell proliferation
(GO:0061469)
Response to organic substance
(GO:0010033)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Transcription regulator complex
(GO:0005667)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.44
Marker Score: 3591
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.7
Marker Score: 35651.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.36
Marker Score: 2219
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.36
Marker Score: 2519
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.34
Marker Score: 15208
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.29
Marker Score: 4772
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.25
Marker Score: 1416
Cell Name: Unknown (CL0002371)
Fold Change: 2.07
Marker Score: 2204.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.07
Marker Score: 8490
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.04
Marker Score: 5559
Cell Name: decidual cell (CL2000002)
Fold Change: 2.01
Marker Score: 8661
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.94
Marker Score: 3296
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.92
Marker Score: 2950
Cell Name: kidney cell (CL1000497)
Fold Change: 1.9
Marker Score: 1265
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.86
Marker Score: 1972
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.86
Marker Score: 6876
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.83
Marker Score: 20630
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.81
Marker Score: 4257.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.8
Marker Score: 1813
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.77
Marker Score: 1908.5
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.72
Marker Score: 2769
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.72
Marker Score: 58580
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.72
Marker Score: 980
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.72
Marker Score: 17283
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.71
Marker Score: 484
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.69
Marker Score: 1148
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.68
Marker Score: 925
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.64
Marker Score: 1230
Cell Name: stem cell (CL0000034)
Fold Change: 1.61
Marker Score: 3816
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.6
Marker Score: 1796
Cell Name: stromal cell (CL0000499)
Fold Change: 1.6
Marker Score: 1870
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.59
Marker Score: 878
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.57
Marker Score: 505
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.57
Marker Score: 2572
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.56
Marker Score: 1131
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.51
Marker Score: 522
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.5
Marker Score: 1130
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 1.48
Marker Score: 472
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.47
Marker Score: 1382.5
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.46
Marker Score: 1829
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.46
Marker Score: 3562
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.43
Marker Score: 5624
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.41
Marker Score: 331
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.41
Marker Score: 494
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.4
Marker Score: 739
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.38
Marker Score: 675
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.37
Marker Score: 1965
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.36
Marker Score: 3687
Cell Name: supporting cell (CL0000630)
Fold Change: 1.35
Marker Score: 2542
Cell Name: Unknown (CL0000548)
Fold Change: 1.35
Marker Score: 985
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.33
Marker Score: 489
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.31
Marker Score: 3900
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.3
Marker Score: 821
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.3
Marker Score: 3396
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.29
Marker Score: 610
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.29
Marker Score: 44692
Cell Name: osteoclast (CL0000092)
Fold Change: 1.29
Marker Score: 641
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.26
Marker Score: 284
Cell Name: plasmablast (CL0000980)
Fold Change: 1.26
Marker Score: 1679
Cell Name: motor neuron (CL0000100)
Fold Change: 1.24
Marker Score: 738
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.24
Marker Score: 440
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.24
Marker Score: 636
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.23
Marker Score: 9169
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.23
Marker Score: 1693
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.21
Marker Score: 646
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.21
Marker Score: 7893
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.21
Marker Score: 5922.5
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.19
Marker Score: 400
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.18
Marker Score: 1255
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.17
Marker Score: 1856
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.16
Marker Score: 1712
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.15
Marker Score: 4435
Cell Name: theca cell (CL0000503)
Fold Change: 1.15
Marker Score: 820.5
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.14
Marker Score: 562
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.13
Marker Score: 222
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.13
Marker Score: 4357.5
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.12
Marker Score: 277
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.1
Marker Score: 737
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.1
Marker Score: 2195.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.1
Marker Score: 1916
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.09
Marker Score: 722
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.08
Marker Score: 687.5
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.08
Marker Score: 6415
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.08
Marker Score: 2534
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.07
Marker Score: 267
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.07
Marker Score: 344
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.07
Marker Score: 402
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.07
Marker Score: 6481
Cell Name: osteoblast (CL0000062)
Fold Change: 1.07
Marker Score: 572
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.06
Marker Score: 267
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.06
Marker Score: 1100
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.04
Marker Score: 252
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.02
Marker Score: 1938
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.02
Marker Score: 425
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.02
Marker Score: 918
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.01
Marker Score: 2293.5
Cell Name: muscle cell (CL0000187)
Fold Change: 1
Marker Score: 283
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1
Marker Score: 1771
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71613.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47837

Hover over a box to see details here...

**Key characteristics:** * CDK4 is a protein of the cyclin-dependent kinase family. * It is expressed in proliferating cells throughout the body. * It is involved in the regulation of cell cycle progression. * It is a key regulator of cell proliferation, differentiation, and apoptosis. **Pathways and functions:** * CDK4 is involved in the regulation of cell cycle progression. * It is responsible for the phosphorylation of a number of proteins involved in cell cycle regulation, including CDKIs. * Phosphorylation of these proteins by CDK4 allows them to be degraded, which leads to the progression of the cell cycle. * CDK4 is also involved in the regulation of cell differentiation. * It is expressed in early-stage embryos and is essential for the development of the embryo. * In adult tissues, CDK4 is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. * It is involved in the regulation of cell proliferation, differentiation, and apoptosis. **Clinical significance:** * Mutations in the CDK4 gene have been linked to a number of human cancers. * CDK4 inhibitors are being investigated as a treatment for cancer. * CDK4 is a promising target for the treatment of cancer. **Additional notes:** * CDK4 is a highly conserved protein. It is found in all eukaryotic cells. * CDK4 is a multi-functional protein. It can also regulate the expression of other genes. * CDK4 is a key regulator of cell growth and development.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-dependent kinase 4

Genular Protein ID: 55778198

Symbol: CDK4_HUMAN

Name: Cyclin-dependent kinase 4

UniProtKB Accession Codes:

P11802 B2R9A0 B4DNF9 O00576 Q6FG61

Database IDs:

Citations:

PubMed ID: 9192850

Title: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.

PubMed ID: 9192850

DOI: 10.1006/geno.1997.4727

PubMed ID: 7652577

Title: A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

PubMed ID: 7652577

DOI: 10.1126/science.7652577

PubMed ID: 8528263

Title: Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.

PubMed ID: 8528263

DOI: 10.1038/ng0196-97

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2948189

Title: Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

PubMed ID: 2948189

DOI: 10.1073/pnas.84.2.388

PubMed ID: 8221695

Title: Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

PubMed ID: 8221695

PubMed ID: 9003781

Title: The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

PubMed ID: 9003781

DOI: 10.1002/j.1460-2075.1996.tb01097.x

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 10580009

Title: Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).

PubMed ID: 10580009

DOI: 10.1101/gad.13.22.3027

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 15241418

Title: Cyclin-dependent kinases regulate the antiproliferative function of Smads.

PubMed ID: 15241418

DOI: 10.1038/nature02650

PubMed ID: 15558030

Title: Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.

PubMed ID: 15558030

DOI: 10.1038/sj.onc.1208043

PubMed ID: 16782892

Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.

PubMed ID: 16782892

DOI: 10.1128/mcb.02006-05

PubMed ID: 18827403

Title: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.

PubMed ID: 18827403

DOI: 10.1247/csf.08019

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19075005

Title: p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

PubMed ID: 19075005

DOI: 10.1128/mcb.00898-08

PubMed ID: 19487459

Title: Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.

PubMed ID: 19487459

DOI: 10.1128/mcb.01823-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20399237

Title: TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

PubMed ID: 20399237

DOI: 10.1016/j.bbamcr.2010.04.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 19237565

Title: Crystal structure of human CDK4 in complex with a D-type cyclin.

PubMed ID: 19237565

DOI: 10.1073/pnas.0809645106

PubMed ID: 19237555

Title: The structure of CDK4/cyclin D3 has implications for models of CDK activation.

PubMed ID: 19237555

DOI: 10.1073/pnas.0809674106

PubMed ID: 9311594

Title: Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma.

PubMed ID: 9311594

DOI: 10.1002/(sici)1097-0215(19970904)72:5<780::aid-ijc13>3.0.co;2-d

PubMed ID: 9425228

Title: Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France.

PubMed ID: 9425228

DOI: 10.1093/hmg/7.2.209

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 303
Mass: 33730
Checksum: 0916A0C07403A33A
Sequence:

MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL 
RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL 
MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 
RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 
DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG 
NPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CDK4

Associated with

Cells (max top 100)

Other Information

Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. PubMed ID: 9192850

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. PubMed ID: 7652577

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. PubMed ID: 8528263

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. PubMed ID: 2948189

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. PubMed ID: 8221695

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. PubMed ID: 9003781

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). PubMed ID: 10580009

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

Cyclin-dependent kinases regulate the antiproliferative function of Smads. PubMed ID: 15241418

Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. PubMed ID: 15558030

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'. PubMed ID: 16782892

Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. PubMed ID: 18827403

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. PubMed ID: 19124461

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. PubMed ID: 19075005

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. PubMed ID: 19487459

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity. PubMed ID: 20399237

Initial characterization of the human central proteome. PubMed ID: 21269460

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. PubMed ID: 27353360

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. PubMed ID: 29127155

Crystal structure of human CDK4 in complex with a D-type cyclin. PubMed ID: 19237565

The structure of CDK4/cyclin D3 has implications for models of CDK activation. PubMed ID: 19237555

Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. PubMed ID: 9311594

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. PubMed ID: 9425228

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846