CDK4 | ENSG00000135446 | NCBI 1019

Details for: CDK4

Gene ID: 1019

Symbol: CDK4

Ensembl ID: ENSG00000135446

Description: cyclin dependent kinase 4

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of cellular response to stress
(R-HSA-9675132)
Diseases of cellular senescence
(R-HSA-9630747)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4
(R-HSA-9630791)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9630794)
Evasion of oncogene induced senescence due to p16ink4a defects
(R-HSA-9630750)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4
(R-HSA-9632697)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9632700)
Evasion of oxidative stress induced senescence due to p16ink4a defects
(R-HSA-9632693)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Reproduction
(R-HSA-1474165)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
S phase
(R-HSA-69242)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Atp binding
(GO:0005524)
Bicellular tight junction
(GO:0005923)
Cell division
(GO:0051301)
Cellular response to interleukin-4
(GO:0071353)
Cellular response to ionomycin
(GO:1904637)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to phorbol 13-acetate 12-myristate
(GO:1904628)
Chromatin
(GO:0000785)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin binding
(GO:0030332)
Cyclin d1-cdk4 complex
(GO:0097128)
Cyclin d2-cdk4 complex
(GO:0097129)
Cyclin d3-cdk4 complex
(GO:0097130)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of cell cycle
(GO:0051726)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of transcription initiation by rna polymerase ii
(GO:0060260)
Regulation of type b pancreatic cell proliferation
(GO:0061469)
Response to organic substance
(GO:0010033)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Cyclin-dependent kinase 4

Genular Protein ID: 55778198

Symbol: CDK4_HUMAN

Name: Cyclin-dependent kinase 4

UniProtKB Accession Codes:

P11802 B2R9A0 B4DNF9 O00576 Q6FG61

Database IDs:

Citations:

PubMed ID: 9192850

Title: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.

PubMed ID: 9192850

DOI: 10.1006/geno.1997.4727

PubMed ID: 7652577

Title: A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

PubMed ID: 7652577

DOI: 10.1126/science.7652577

PubMed ID: 8528263

Title: Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.

PubMed ID: 8528263

DOI: 10.1038/ng0196-97

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2948189

Title: Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

PubMed ID: 2948189

DOI: 10.1073/pnas.84.2.388

PubMed ID: 8221695

Title: Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

PubMed ID: 8221695

PubMed ID: 9003781

Title: The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

PubMed ID: 9003781

DOI: 10.1002/j.1460-2075.1996.tb01097.x

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 10580009

Title: Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).

PubMed ID: 10580009

DOI: 10.1101/gad.13.22.3027

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 15241418

Title: Cyclin-dependent kinases regulate the antiproliferative function of Smads.

PubMed ID: 15241418

DOI: 10.1038/nature02650

PubMed ID: 15558030

Title: Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.

PubMed ID: 15558030

DOI: 10.1038/sj.onc.1208043

PubMed ID: 16782892

Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.

PubMed ID: 16782892

DOI: 10.1128/mcb.02006-05

PubMed ID: 18827403

Title: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.

PubMed ID: 18827403

DOI: 10.1247/csf.08019

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19075005

Title: p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

PubMed ID: 19075005

DOI: 10.1128/mcb.00898-08

PubMed ID: 19487459

Title: Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.

PubMed ID: 19487459

DOI: 10.1128/mcb.01823-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20399237

Title: TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

PubMed ID: 20399237

DOI: 10.1016/j.bbamcr.2010.04.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 19237565

Title: Crystal structure of human CDK4 in complex with a D-type cyclin.

PubMed ID: 19237565

DOI: 10.1073/pnas.0809645106

PubMed ID: 19237555

Title: The structure of CDK4/cyclin D3 has implications for models of CDK activation.

PubMed ID: 19237555

DOI: 10.1073/pnas.0809674106

PubMed ID: 9311594

Title: Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma.

PubMed ID: 9311594

DOI: 10.1002/(sici)1097-0215(19970904)72:5<780::aid-ijc13>3.0.co;2-d

PubMed ID: 9425228

Title: Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France.

PubMed ID: 9425228

DOI: 10.1093/hmg/7.2.209

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 303
Mass: 33730
Checksum: 0916A0C07403A33A
Sequence:

MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL 
RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL 
MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 
RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 
DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG 
NPE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDK4

Associated with

Other Information

Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. PubMed ID: 9192850

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. PubMed ID: 7652577

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. PubMed ID: 8528263

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. PubMed ID: 2948189

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. PubMed ID: 8221695

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. PubMed ID: 9003781

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). PubMed ID: 10580009

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

Cyclin-dependent kinases regulate the antiproliferative function of Smads. PubMed ID: 15241418

Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. PubMed ID: 15558030

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'. PubMed ID: 16782892

Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. PubMed ID: 18827403

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. PubMed ID: 19124461

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. PubMed ID: 19075005

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. PubMed ID: 19487459

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity. PubMed ID: 20399237

Initial characterization of the human central proteome. PubMed ID: 21269460

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. PubMed ID: 27353360

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. PubMed ID: 29127155

Crystal structure of human CDK4 in complex with a D-type cyclin. PubMed ID: 19237565

The structure of CDK4/cyclin D3 has implications for models of CDK activation. PubMed ID: 19237555

Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. PubMed ID: 9311594

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. PubMed ID: 9425228

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846