CDK4 | ENSG00000135446 | NCBI 1019

Details for: CDK4

Gene ID: 1019

Symbol: CDK4

Ensembl ID: ENSG00000135446

Description: cyclin dependent kinase 4

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Adipogenesis
(R-HSA-9843745)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of cellular response to stress
(R-HSA-9675132)
Diseases of cellular senescence
(R-HSA-9630747)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4
(R-HSA-9630791)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9630794)
Evasion of oncogene induced senescence due to p16ink4a defects
(R-HSA-9630750)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4
(R-HSA-9632697)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9632700)
Evasion of oxidative stress induced senescence due to p16ink4a defects
(R-HSA-9632693)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Reproduction
(R-HSA-1474165)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
S phase
(R-HSA-69242)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Atp binding
(GO:0005524)
Bicellular tight junction
(GO:0005923)
Cell division
(GO:0051301)
Cellular response to interleukin-4
(GO:0071353)
Cellular response to ionomycin
(GO:1904637)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to phorbol 13-acetate 12-myristate
(GO:1904628)
Chromatin
(GO:0000785)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin binding
(GO:0030332)
Cyclin d1-cdk4 complex
(GO:0097128)
Cyclin d2-cdk4 complex
(GO:0097129)
Cyclin d3-cdk4 complex
(GO:0097130)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of cell cycle
(GO:0051726)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of transcription initiation by rna polymerase ii
(GO:0060260)
Regulation of type b pancreatic cell proliferation
(GO:0061469)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Transcription regulator complex
(GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 183.4997
Cell Significance Index: -28.5400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 100.6924
Cell Significance Index: -41.4800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 89.8900
Cell Significance Index: -22.8000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 86.1852
Cell Significance Index: -40.6900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 85.5862
Cell Significance Index: -34.7700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 36.9419
Cell Significance Index: -35.2700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.2907
Cell Significance Index: -38.5800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.5684
Cell Significance Index: -30.9900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.3040
Cell Significance Index: -40.6600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 5.8411
Cell Significance Index: 63.5000
Cell Name: kidney cell (CL1000497)
Fold Change: 3.8639
Cell Significance Index: 30.8500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.7137
Cell Significance Index: 47.5600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.6691
Cell Significance Index: 76.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.1577
Cell Significance Index: 109.7300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.3721
Cell Significance Index: 142.4100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.9642
Cell Significance Index: 228.9100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.9486
Cell Significance Index: 52.1300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8842
Cell Significance Index: 258.7500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.8773
Cell Significance Index: 305.3300
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.7222
Cell Significance Index: 10.6600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.4454
Cell Significance Index: 50.7900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.3965
Cell Significance Index: 11.7300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2447
Cell Significance Index: 33.8800
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.1538
Cell Significance Index: 30.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0424
Cell Significance Index: 29.8800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9792
Cell Significance Index: 115.4700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9256
Cell Significance Index: 505.4800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8736
Cell Significance Index: 41.0600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8651
Cell Significance Index: 382.5000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8519
Cell Significance Index: 58.9200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8293
Cell Significance Index: 58.6500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.7753
Cell Significance Index: 100.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7428
Cell Significance Index: 91.3400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7192
Cell Significance Index: 142.7300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.6968
Cell Significance Index: 18.6700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6297
Cell Significance Index: 29.3600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6060
Cell Significance Index: 77.6900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5681
Cell Significance Index: 42.3400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.5519
Cell Significance Index: 6.2700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5191
Cell Significance Index: 93.5800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4845
Cell Significance Index: 6.6100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4595
Cell Significance Index: 87.4400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3974
Cell Significance Index: 358.8500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3929
Cell Significance Index: 25.3500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3573
Cell Significance Index: 18.6100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3361
Cell Significance Index: 17.4600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2300
Cell Significance Index: 39.2700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1509
Cell Significance Index: 3.2700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1182
Cell Significance Index: 23.7100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1022
Cell Significance Index: 1.7100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0875
Cell Significance Index: 66.2100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0829
Cell Significance Index: 8.2000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0638
Cell Significance Index: 2.8900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0611
Cell Significance Index: 42.2800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0439
Cell Significance Index: 1.2900
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.0399
Cell Significance Index: 0.2500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0274
Cell Significance Index: 9.8300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0273
Cell Significance Index: 0.7300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0039
Cell Significance Index: -7.2900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0042
Cell Significance Index: -3.1400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0081
Cell Significance Index: -0.2600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0081
Cell Significance Index: -5.0600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0169
Cell Significance Index: -26.0800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0176
Cell Significance Index: -32.4100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0190
Cell Significance Index: -0.5300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0206
Cell Significance Index: -15.1000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0248
Cell Significance Index: -2.5300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0281
Cell Significance Index: -38.1700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0382
Cell Significance Index: -1.1000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0444
Cell Significance Index: -28.2000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0481
Cell Significance Index: -27.1300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0744
Cell Significance Index: -33.7900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0755
Cell Significance Index: -1.9300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0806
Cell Significance Index: -16.9700
Cell Name: chondroblast (CL0000058)
Fold Change: -0.1005
Cell Significance Index: -0.5900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1162
Cell Significance Index: -33.4300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1282
Cell Significance Index: -2.7300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1746
Cell Significance Index: -19.9300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1947
Cell Significance Index: -22.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2029
Cell Significance Index: -12.7900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2355
Cell Significance Index: -34.2300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2996
Cell Significance Index: -18.4100
Cell Name: peg cell (CL4033014)
Fold Change: -0.3329
Cell Significance Index: -7.6900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3405
Cell Significance Index: -3.5300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3461
Cell Significance Index: -19.4200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3826
Cell Significance Index: -39.8400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4028
Cell Significance Index: -31.9000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4062
Cell Significance Index: -31.1800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4508
Cell Significance Index: -23.6700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4726
Cell Significance Index: -13.9200
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: -0.4955
Cell Significance Index: -2.4100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5294
Cell Significance Index: -35.6000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6102
Cell Significance Index: -37.4100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6335
Cell Significance Index: -11.2000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6516
Cell Significance Index: -16.7500
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.7099
Cell Significance Index: -4.8100
Cell Name: theca cell (CL0000503)
Fold Change: -0.7932
Cell Significance Index: -4.6600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8100
Cell Significance Index: -35.8300
Cell Name: glioblast (CL0000030)
Fold Change: -0.8997
Cell Significance Index: -5.6500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.9367
Cell Significance Index: -34.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CDK4 is a serine/threonine kinase that is activated by binding to cyclin D1, cyclin D2, or cyclin D3. The kinase then phosphorylates and activates downstream targets, including the retinoblastoma protein (pRb), which is a key regulator of the cell cycle. CDK4 is also involved in the regulation of gene expression, particularly during the G1 phase, and has been shown to interact with various transcription factors, including Runx2. The kinase is ubiquitantly expressed in cells, with highest levels detected in the cytosol. **Pathways and Functions** CDK4 is involved in several key pathways, including: 1. **Cell cycle regulation**: CDK4 is a critical regulator of the G1/S transition, promoting the progression of cells through the cell cycle. 2. **Gene expression regulation**: CDK4 is involved in the regulation of gene expression during the G1 phase, particularly in the context of cellular proliferation. 3. **Cancer development**: Aberrant expression and activity of CDK4 have been implicated in various cancers, including breast, lung, and colon cancer. 4. **Cellular senescence**: CDK4 is also involved in the regulation of cellular senescence, a state of irreversible cell cycle arrest that occurs in response to DNA damage or other forms of cellular stress. **Clinical Significance** CDK4 has been implicated in various diseases, including: 1. **Cancer**: Aberrant expression and activity of CDK4 have been associated with various cancers, including breast, lung, and colon cancer. 2. **Cellular senescence**: CDK4 is involved in the regulation of cellular senescence, a state of irreversible cell cycle arrest that occurs in response to DNA damage or other forms of cellular stress. 3. **Diseases of the mitotic cell cycle**: CDK4 is involved in the regulation of the mitotic cell cycle, and aberrant expression and activity of the kinase have been implicated in various diseases, including mitotic catastrophe and aneuploidy. 4. **Aging and age-related diseases**: CDK4 has been implicated in the regulation of aging and age-related diseases, including age-related macular degeneration and osteoporosis. In conclusion, CDK4 is a critical regulator of the cell cycle, gene expression, and cellular senescence. Aberrant expression and activity of the kinase have been implicated in various diseases, including cancer, cellular senescence, and diseases of the mitotic cell cycle. Further research is needed to fully understand the role of CDK4 in human disease and to develop effective therapeutic strategies for the treatment of CDK4-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-dependent kinase 4

Genular Protein ID: 55778198

Symbol: CDK4_HUMAN

Name: Cyclin-dependent kinase 4

UniProtKB Accession Codes:

P11802 B2R9A0 B4DNF9 O00576 Q6FG61

Database IDs:

Citations:

PubMed ID: 9192850

Title: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.

PubMed ID: 9192850

DOI: 10.1006/geno.1997.4727

PubMed ID: 7652577

Title: A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

PubMed ID: 7652577

DOI: 10.1126/science.7652577

PubMed ID: 8528263

Title: Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.

PubMed ID: 8528263

DOI: 10.1038/ng0196-97

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2948189

Title: Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

PubMed ID: 2948189

DOI: 10.1073/pnas.84.2.388

PubMed ID: 8221695

Title: Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

PubMed ID: 8221695

PubMed ID: 9003781

Title: The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

PubMed ID: 9003781

DOI: 10.1002/j.1460-2075.1996.tb01097.x

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 10580009

Title: Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).

PubMed ID: 10580009

DOI: 10.1101/gad.13.22.3027

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 15241418

Title: Cyclin-dependent kinases regulate the antiproliferative function of Smads.

PubMed ID: 15241418

DOI: 10.1038/nature02650

PubMed ID: 15558030

Title: Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.

PubMed ID: 15558030

DOI: 10.1038/sj.onc.1208043

PubMed ID: 16782892

Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.

PubMed ID: 16782892

DOI: 10.1128/mcb.02006-05

PubMed ID: 18827403

Title: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.

PubMed ID: 18827403

DOI: 10.1247/csf.08019

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19075005

Title: p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

PubMed ID: 19075005

DOI: 10.1128/mcb.00898-08

PubMed ID: 19487459

Title: Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.

PubMed ID: 19487459

DOI: 10.1128/mcb.01823-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20399237

Title: TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

PubMed ID: 20399237

DOI: 10.1016/j.bbamcr.2010.04.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 19237565

Title: Crystal structure of human CDK4 in complex with a D-type cyclin.

PubMed ID: 19237565

DOI: 10.1073/pnas.0809645106

PubMed ID: 19237555

Title: The structure of CDK4/cyclin D3 has implications for models of CDK activation.

PubMed ID: 19237555

DOI: 10.1073/pnas.0809674106

PubMed ID: 9311594

Title: Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma.

PubMed ID: 9311594

DOI: 10.1002/(sici)1097-0215(19970904)72:5<780::aid-ijc13>3.0.co;2-d

PubMed ID: 9425228

Title: Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France.

PubMed ID: 9425228

DOI: 10.1093/hmg/7.2.209

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 303
Mass: 33730
Checksum: 0916A0C07403A33A
Sequence:

MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL 
RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL 
MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 
RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 
DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG 
NPE

Database document:

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Details for: CDK4

Associated with

Cells (max top 100)

Other Information

Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. PubMed ID: 9192850

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. PubMed ID: 7652577

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. PubMed ID: 8528263

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. PubMed ID: 2948189

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. PubMed ID: 8221695

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. PubMed ID: 9003781

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). PubMed ID: 10580009

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

Cyclin-dependent kinases regulate the antiproliferative function of Smads. PubMed ID: 15241418

Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. PubMed ID: 15558030

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'. PubMed ID: 16782892

Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. PubMed ID: 18827403

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. PubMed ID: 19124461

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. PubMed ID: 19075005

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. PubMed ID: 19487459

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity. PubMed ID: 20399237

Initial characterization of the human central proteome. PubMed ID: 21269460

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. PubMed ID: 27353360

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. PubMed ID: 29127155

Crystal structure of human CDK4 in complex with a D-type cyclin. PubMed ID: 19237565

The structure of CDK4/cyclin D3 has implications for models of CDK activation. PubMed ID: 19237555

Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. PubMed ID: 9311594

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. PubMed ID: 9425228

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846