Details for: RNF41

Gene ID: 10193

Symbol: RNF41

Ensembl ID: ENSG00000181852

Description: ring finger protein 41

Associated with

Other Information

Genular Protein ID: 1970504260

Symbol: RNF41_HUMAN

Name: E3 ubiquitin-protein ligase NRDP1

UniProtKB Accession Codes:

Q9H4P4 A6NFW0 B2RBT8 O75598

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12411582

Title: Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3.

PubMed ID: 12411582

DOI: 10.1073/pnas.232580999

PubMed ID: 14765125

Title: Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.

PubMed ID: 14765125

DOI: 10.1038/sj.emboj.7600075

PubMed ID: 15314180

Title: Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.

PubMed ID: 15314180

DOI: 10.1128/mcb.24.17.7748-7757.2004

PubMed ID: 15632191

Title: RING finger ubiquitin-protein isopeptide ligase Nrdp1/FLRF regulates parkin stability and activity.

PubMed ID: 15632191

DOI: 10.1074/jbc.m408955200

PubMed ID: 17210635

Title: Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1.

PubMed ID: 17210635

DOI: 10.1128/mcb.01245-06

PubMed ID: 18541373

Title: Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress.

PubMed ID: 18541373

DOI: 10.1016/j.neulet.2008.05.052

PubMed ID: 19483718

Title: The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.

PubMed ID: 19483718

DOI: 10.1038/ni.1742

PubMed ID: 24949970

Title: The diabetes susceptibility gene Clec16a regulates mitophagy.

PubMed ID: 24949970

DOI: 10.1016/j.cell.2014.05.016

PubMed ID: 17035239

Title: Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).

PubMed ID: 17035239

DOI: 10.1074/jbc.m606704200

Sequence Information:

  • Length: 317
  • Mass: 35905
  • Checksum: 46AE87AF8BE1A369
  • Sequence:
    • MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV 
TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC 
GLEMPKDELP NHNCIKHLRS VVQQQQTRIA ELEKTSAEHK HQLAEQKRDI QLLKAYMRAI 
RSVNPNLQNL EETIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA 
SIVNELIENA HERSWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGDDM 
VQEPGLVMIF AHGVEEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.