Details for: MPHOSPH10

Gene ID: 10199

Symbol: MPHOSPH10

Ensembl ID: ENSG00000124383

Description: M-phase phosphoprotein 10

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.65
    Marker Score: 2,366
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,252
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.43
    Marker Score: 817
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.43
    Marker Score: 1,525
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.4
    Marker Score: 2,486
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.36
    Marker Score: 925
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.35
    Marker Score: 390
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.29
    Marker Score: 11,141
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.28
    Marker Score: 1,606
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.21
    Marker Score: 1,776
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2
    Marker Score: 13,526
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.19
    Marker Score: 2,709
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.17
    Marker Score: 2,882
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.15
    Marker Score: 4,519
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.1
    Marker Score: 544
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.09
    Marker Score: 1,099
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.09
    Marker Score: 4,450
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.08
    Marker Score: 2,255
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.07
    Marker Score: 1,136
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.06
    Marker Score: 3,938
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.06
    Marker Score: 509
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.05
    Marker Score: 298
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.05
    Marker Score: 303
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.04
    Marker Score: 1,102
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.04
    Marker Score: 1,760
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.03
    Marker Score: 1,411
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.03
    Marker Score: 618
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34,741
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.02
    Marker Score: 681
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.02
    Marker Score: 305
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1
    Marker Score: 1,082
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1
    Marker Score: 936
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1
    Marker Score: 499
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1
    Marker Score: 834
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,614
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,839
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.99
    Marker Score: 676
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.99
    Marker Score: 741
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.98
    Marker Score: 619
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,375
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.98
    Marker Score: 620
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.98
    Marker Score: 486
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.97
    Marker Score: 1,040
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.97
    Marker Score: 1,291
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.95
    Marker Score: 1,070
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.95
    Marker Score: 650
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.94
    Marker Score: 233
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.94
    Marker Score: 7,355
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14,696
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.94
    Marker Score: 405
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.94
    Marker Score: 224
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.94
    Marker Score: 516
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,377
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.93
    Marker Score: 52,249
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.93
    Marker Score: 623
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.93
    Marker Score: 9,412
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.92
    Marker Score: 1,737
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.92
    Marker Score: 12,172
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.92
    Marker Score: 285
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.92
    Marker Score: 5,966
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.91
    Marker Score: 470
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.91
    Marker Score: 943
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.91
    Marker Score: 1,170
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 428
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9
    Marker Score: 3,878
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,124
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9
    Marker Score: 944
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2,669
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.89
    Marker Score: 1,372
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.89
    Marker Score: 315
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.89
    Marker Score: 328
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.89
    Marker Score: 208
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.88
    Marker Score: 810
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.88
    Marker Score: 868
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.88
    Marker Score: 232
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.87
    Marker Score: 1,020
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.87
    Marker Score: 634
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.87
    Marker Score: 190
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 397
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.86
    Marker Score: 633
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.86
    Marker Score: 2,345
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.86
    Marker Score: 674
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.86
    Marker Score: 212
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.86
    Marker Score: 486
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.85
    Marker Score: 770
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.85
    Marker Score: 8,783
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.85
    Marker Score: 29,442
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.85
    Marker Score: 225
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.85
    Marker Score: 1,689
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.84
    Marker Score: 794
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.84
    Marker Score: 170
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.84
    Marker Score: 349
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.84
    Marker Score: 907
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.84
    Marker Score: 1,976
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.84
    Marker Score: 254
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.84
    Marker Score: 445
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.83
    Marker Score: 838
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.83
    Marker Score: 407

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MPHOSPH10 is a phosphoprotein that is specifically expressed in certain cell types, indicating its potential role in cell-specific functions. The protein is involved in the regulation of RNA processing, which is essential for the proper translation of mRNAs into proteins. The MPHOSPH10 protein is also part of the MPP10 complex, which is a ribonucleoprotein complex that contains various RNA-binding proteins. This complex is involved in the maturation of ssu-RNA and the modification of RNA in the nucleus and cytosol. **Pathways and Functions:** The MPHOSPH10 protein is involved in several RNA processing pathways, including: 1. **Chromatin remodeling:** MPHOSPH10 is involved in the remodeling of chromatin structure, which is essential for the proper expression of genes. 2. **RNA maturation:** MPHOSPH10 is involved in the maturation of ssu-RNA, which is essential for the proper translation of mRNAs into proteins. 3. **RNA modification:** MPHOSPH10 is involved in the modification of RNA in the nucleus and cytosol, which is essential for the proper regulation of gene expression. 4. **Ribosomal biogenesis:** MPHOSPH10 is involved in the biogenesis of the small subunit processome, a complex involved in the maturation of ssu-RNA. **Clinical Significance:** The MPHOSPH10 gene has significant implications for immunological research, particularly in the context of cancer and autoimmune diseases. The protein's involvement in RNA processing and modification suggests that it may play a role in the regulation of gene expression, which is essential for the proper functioning of the immune system. Abnormal expression of MPHOSPH10 has been observed in various cancers, including breast and esophageal cancer, suggesting that it may be a potential biomarker for these diseases. Additionally, MPHOSPH10 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis, due to its involvement in the regulation of gene expression. In conclusion, MPHOSPH10 is a gene that plays a critical role in RNA processing and modification, which is essential for the proper functioning of the immune system. Further research is needed to fully understand the implications of MPHOSPH10 in immunological research and its potential role in various diseases. **Potential Research Directions:** 1. **Investigating the role of MPHOSPH10 in cancer:** Further research is needed to understand the role of MPHOSPH10 in the development and progression of cancer. 2. **Examining the relationship between MPHOSPH10 and autoimmune diseases:** MPHOSPH10 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis. 3. **Investigating the potential of MPHOSPH10 as a biomarker for disease:** MPHOSPH10 may be a potential biomarker for various diseases, including cancer and autoimmune diseases. Overall, MPHOSPH10 is a gene that plays a critical role in RNA processing and modification, which has significant implications for immunological research. Further research is needed to fully understand the implications of MPHOSPH10 and its potential role in various diseases.

Genular Protein ID: 1129112547

Symbol: MPP10_HUMAN

Name: U3 small nucleolar ribonucleoprotein protein MPP10

UniProtKB Accession Codes:

O00566 A0AVJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8885239

Title: Identification of novel M phase phosphoproteins by expression cloning.

PubMed ID: 8885239

DOI: 10.1091/mbc.7.9.1455

PubMed ID: 9450966

Title: M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component.

PubMed ID: 9450966

DOI: 10.1091/mbc.9.2.437

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 12655004

Title: The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes.

PubMed ID: 12655004

DOI: 10.1093/nar/gkg300

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 681
  • Mass: 78864
  • Checksum: EDF27859D735D4E2
  • Sequence:
    • MAPQVWRRRT LERCLTEVGK ATGRPECFLT IQEGLASKFT SLTKVLYDFN KILENGRIHG 
SPLQKLVIEN FDDEQIWQQL ELQNEPILQY FQNAVSETIN DEDISLLPES EEQEREEDGS 
EIEADDKEDL EDLEEEEVSD MGNDDPEMGE RAENSSKSDL RKSPVFSDED SDLDFDISKL 
EQQSKVQNKG QGKPREKSIV DDKFFKLSEM EAYLENIEKE EERKDDNDEE EEDIDFFEDI 
DSDEDEGGLF GSKKLKSGKS SRNLKYKDFF DPVESDEDIT NVHDDELDSN KEDDEIAEEE 
AEELSISETD EDDDLQENED NKQHKESLKR VTFALPDDAE TEDTGVLNVK KNSDEVKSSF 
EKRQEKMNEK IASLEKELLE KKPWQLQGEV TAQKRPENSL LEETLHFDHA VRMAPVITEE 
TTLQLEDIIK QRIRDQAWDD VVRKEKPKED AYEYKKRLTL DHEKSKLSLA EIYEQEYIKL 
NQQKTAEEEN PEHVEIQKMM DSLFLKLDAL SNFHFIPKPP VPEIKVVSNL PAITMEEVAP 
VSVSDAALLA PEEIKEKNKA GDIKTAAEKT ATDKKRERRK KKYQKRMKIK EKEKRRKLLE 
KSSVDQAGKY SKTVASEKLK QLTKTGKASF IKDEGKDKAL KSSQAFFSKL QDQVKMQIND 
AKKTEKKKKK RQDISVHKLK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.