Details for: ADAM10
Associated with
Other Information
Genular Protein ID: 470821522
Symbol: ADA10_HUMAN
Name: CDw156
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9305925
Title: Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.
PubMed ID: 9305925
PubMed ID: 8694785
Title: Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types.
PubMed ID: 8694785
DOI: 10.1042/bj3170045
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 9016778
Title: Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes.
PubMed ID: 9016778
PubMed ID: 12475894
Title: ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
PubMed ID: 12475894
PubMed ID: 11477090
Title: The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
PubMed ID: 11477090
PubMed ID: 11511685
Title: ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage.
PubMed ID: 11511685
PubMed ID: 11786905
Title: Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells.
PubMed ID: 11786905
DOI: 10.1038/nm0102-41
PubMed ID: 16239146
Title: Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.
PubMed ID: 16239146
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 17557115
Title: The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.
PubMed ID: 17557115
PubMed ID: 19114711
Title: Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis.
PubMed ID: 19114711
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 20164177
Title: Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI.
PubMed ID: 20164177
PubMed ID: 20592283
Title: Junctional adhesion molecule-C is a soluble mediator of angiogenesis.
PubMed ID: 20592283
PubMed ID: 20624979
Title: Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury.
PubMed ID: 20624979
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21288900
Title: Ectodomain shedding and autocleavage of the cardiac membrane protease corin.
PubMed ID: 21288900
PubMed ID: 23676497
Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
PubMed ID: 23676497
DOI: 10.1172/jci65401
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24990881
Title: TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
PubMed ID: 24990881
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26686862
Title: TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.
PubMed ID: 26686862
PubMed ID: 26876177
Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
PubMed ID: 26876177
PubMed ID: 26668317
Title: TspanC8 tetraspanins and A disintegrin and metalloprotease 10 (ADAM10) interact via their extracellular regions: evidence for distinct binding mechanisms for different TspanC8 proteins.
PubMed ID: 26668317
PubMed ID: 30463011
Title: A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity.
PubMed ID: 30463011
PubMed ID: 29430990
Title: The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.
PubMed ID: 29430990
PubMed ID: 30312582
Title: Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth.
PubMed ID: 30312582
PubMed ID: 28600292
Title: ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.
PubMed ID: 28600292
PubMed ID: 31792032
Title: TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life.
PubMed ID: 31792032
PubMed ID: 34739841
Title: Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
PubMed ID: 34739841
PubMed ID: 29224781
Title: Structural basis for regulated proteolysis by the alpha-secretase ADAM10.
PubMed ID: 29224781
PubMed ID: 37516108
Title: Structural basis for membrane-proximal proteolysis of substrates by ADAM10.
PubMed ID: 37516108
PubMed ID: 19608551
Title: Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.
PubMed ID: 19608551
DOI: 10.1093/hmg/ddp323
PubMed ID: 21618342
Title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
PubMed ID: 21618342
DOI: 10.1002/humu.21477
PubMed ID: 23666529
Title: Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease.
PubMed ID: 23666529
DOI: 10.1093/hmg/ddt207
PubMed ID: 24055016
Title: ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function.
PubMed ID: 24055016
Sequence Information:
- Length: 748
- Mass: 84142
- Checksum: 0881E65B17022A71
- Sequence:
MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI DGRFEGFIQT RGGTFYVEPA ERYIKDRTLP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE RMRKYQMTGV EEVTQIPQEE HAANGPELLR KKRTTSAEKN TCQLYIQTDH LFFKYYGTRE AVIAQISSHV KAIDTIYQTT DFSGIRNISF MVKRIRINTT ADEKDPTNPF RFPNIGVEKF LELNSEQNHD DYCLAYVFTD RDFDDGVLGL AWVGAPSGSS GGICEKSKLY SDGKKKSLNT GIITVQNYGS HVPPKVSHIT FAHEVGHNFG SPHDSGTECT PGESKNLGQK ENGNYIMYAR ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN CFVESGQPIC GNGMVEQGEE CDCGYSDQCK DECCFDANQP EGRKCKLKPG KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT ALCPASDPKP NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD VFMRCRLVDA DGPLARLKKA IFSPELYENI AEWIVAHWWA VLLMGIALIM LMAGFIKICS VHTPSSNPKL PPPKPLPGTL KRRRPPQPIQ QPQRQRPRES YQMGHMRR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.