Details for: CDK5

Gene ID: 1020

Symbol: CDK5

Ensembl ID: ENSG00000164885

Description: cyclin dependent kinase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.1498
    Cell Significance Index: -16.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.7188
    Cell Significance Index: -14.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.5410
    Cell Significance Index: -13.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.3469
    Cell Significance Index: -15.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.9723
    Cell Significance Index: -13.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.7231
    Cell Significance Index: -16.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7352
    Cell Significance Index: -12.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3360
    Cell Significance Index: -17.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9788
    Cell Significance Index: 883.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8059
    Cell Significance Index: 48.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6486
    Cell Significance Index: 105.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4932
    Cell Significance Index: 25.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4042
    Cell Significance Index: 39.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4021
    Cell Significance Index: 11.8100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3734
    Cell Significance Index: 5.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2622
    Cell Significance Index: 18.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2546
    Cell Significance Index: 5.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2278
    Cell Significance Index: 124.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2274
    Cell Significance Index: 11.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2129
    Cell Significance Index: 42.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1901
    Cell Significance Index: 11.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1779
    Cell Significance Index: 123.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1688
    Cell Significance Index: 7.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1685
    Cell Significance Index: 21.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1681
    Cell Significance Index: 7.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1445
    Cell Significance Index: 9.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1409
    Cell Significance Index: 17.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1262
    Cell Significance Index: 22.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1194
    Cell Significance Index: 3.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1073
    Cell Significance Index: 47.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0985
    Cell Significance Index: 5.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0924
    Cell Significance Index: 17.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0853
    Cell Significance Index: 30.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0792
    Cell Significance Index: 1.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0561
    Cell Significance Index: 3.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0399
    Cell Significance Index: 4.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0328
    Cell Significance Index: 0.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0293
    Cell Significance Index: 0.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0249
    Cell Significance Index: 0.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0249
    Cell Significance Index: 3.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0139
    Cell Significance Index: 1.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0034
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0081
    Cell Significance Index: -15.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0098
    Cell Significance Index: -7.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0132
    Cell Significance Index: -24.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0159
    Cell Significance Index: -24.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0161
    Cell Significance Index: -1.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0175
    Cell Significance Index: -3.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -25.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0216
    Cell Significance Index: -13.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0219
    Cell Significance Index: -16.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0262
    Cell Significance Index: -14.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0309
    Cell Significance Index: -19.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0375
    Cell Significance Index: -17.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0380
    Cell Significance Index: -2.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0433
    Cell Significance Index: -12.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0501
    Cell Significance Index: -1.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0506
    Cell Significance Index: -1.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0594
    Cell Significance Index: -2.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0594
    Cell Significance Index: -1.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0607
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0661
    Cell Significance Index: -11.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0774
    Cell Significance Index: -9.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0851
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0953
    Cell Significance Index: -20.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0963
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0970
    Cell Significance Index: -11.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1056
    Cell Significance Index: -15.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1212
    Cell Significance Index: -8.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1224
    Cell Significance Index: -3.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1262
    Cell Significance Index: -5.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1316
    Cell Significance Index: -3.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1601
    Cell Significance Index: -12.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1640
    Cell Significance Index: -17.0800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1665
    Cell Significance Index: -2.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1705
    Cell Significance Index: -10.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1850
    Cell Significance Index: -3.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1939
    Cell Significance Index: -5.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2124
    Cell Significance Index: -3.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2287
    Cell Significance Index: -3.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2322
    Cell Significance Index: -17.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2642
    Cell Significance Index: -7.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2643
    Cell Significance Index: -14.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2709
    Cell Significance Index: -7.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2935
    Cell Significance Index: -7.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3064
    Cell Significance Index: -7.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3182
    Cell Significance Index: -8.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3203
    Cell Significance Index: -2.9500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3219
    Cell Significance Index: -2.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3233
    Cell Significance Index: -14.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3250
    Cell Significance Index: -4.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3442
    Cell Significance Index: -3.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3544
    Cell Significance Index: -5.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3751
    Cell Significance Index: -13.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3784
    Cell Significance Index: -12.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3797
    Cell Significance Index: -13.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3842
    Cell Significance Index: -14.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3947
    Cell Significance Index: -12.5700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4127
    Cell Significance Index: -2.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDK5 is a member of the cyclin-dependent kinase family and is unique in its ability to phosphorylate specific substrates, including tau protein, which is implicated in neurodegenerative diseases. CDK5 is composed of two subunits, CDK5α and CDK5β, which are encoded by separate genes. The CDK5α subunit is the catalytic subunit, while the CDK5β subunit is involved in the regulation of CDK5 activity. CDK5 is highly expressed in the CNS, particularly in neurons, and is also present in other cell types, including osteoclasts and cardiac muscle cells. **Pathways and Functions** CDK5 is involved in various signaling pathways, including: 1. **Axon guidance**: CDK5 regulates the extension and guidance of axons during neuronal development. 2. **Synaptic plasticity**: CDK5 is involved in the regulation of synaptic transmission and plasticity, including long-term potentiation (LTP) and long-term depression (LTD). 3. **Neurodegenerative diseases**: CDK5 has been implicated in the pathogenesis of Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. 4. **Cell cycle regulation**: CDK5 regulates the cell cycle, particularly in the CNS, where it ensures proper neuronal development and maintenance. CDK5's functions can be broadly categorized into the following: 1. **Phosphorylation**: CDK5 phosphorylates specific substrates, including tau protein, which is implicated in neurodegenerative diseases. 2. **Regulation of protein localization**: CDK5 regulates the localization of proteins, including tau protein, to specific compartments within the cell. 3. **Regulation of gene expression**: CDK5 regulates gene expression, particularly in the CNS, where it ensures proper neuronal development and maintenance. **Clinical Significance** CDK5's dysregulation has been implicated in several neurodegenerative diseases, including: 1. **Alzheimer's disease**: CDK5 has been shown to contribute to the pathogenesis of Alzheimer's disease, particularly through its dysregulation of tau protein. 2. **Parkinson's disease**: CDK5 has been implicated in the pathogenesis of Parkinson's disease, particularly through its dysregulation of dopamine signaling. 3. **Other neurodegenerative diseases**: CDK5 has also been implicated in the pathogenesis of other neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington's disease. In addition to its role in neurodegenerative diseases, CDK5 has also been implicated in other clinical conditions, including: 1. **Cerebral palsy**: CDK5 has been shown to contribute to the pathogenesis of cerebral palsy, particularly through its dysregulation of neuronal development and synaptic plasticity. 2. **Autism spectrum disorder**: CDK5 has been implicated in the pathogenesis of autism spectrum disorder, particularly through its dysregulation of synaptic plasticity and gene expression. In conclusion, CDK5 is a crucial regulator of the CNS, involved in various cellular processes, including cell cycle regulation, neuronal development, and synaptic plasticity. Its dysregulation has been implicated in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and other conditions. Further research is needed to fully understand the role of CDK5 in human disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 1589642958

Symbol: CDK5_HUMAN

Name: Cyclin-dependent-like kinase 5

UniProtKB Accession Codes:

Q00535 A1XKG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 3 ELM 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 93 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 19693690

Title: Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling.

PubMed ID: 19693690

DOI: 10.1007/s11033-009-9752-7

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9030781

Title: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

PubMed ID: 9030781

DOI: 10.1111/j.1432-1033.1997.t01-2-00527.x

PubMed ID: 9822744

Title: Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.

PubMed ID: 9822744

DOI: 10.1523/jneurosci.18-23-09858.1998

PubMed ID: 10500146

Title: Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.

PubMed ID: 10500146

DOI: 10.1073/pnas.96.20.11156

PubMed ID: 12393264

Title: Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.

PubMed ID: 12393264

DOI: 10.1016/s0169-328x(02)00409-6

PubMed ID: 14521924

Title: Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.

PubMed ID: 14521924

DOI: 10.1016/j.bbrc.2003.08.143

PubMed ID: 12691662

Title: Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.

PubMed ID: 12691662

DOI: 10.1016/s0896-6273(03)00191-0

PubMed ID: 15992363

Title: Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation.

PubMed ID: 15992363

DOI: 10.1111/j.1471-4159.2005.03301.x

PubMed ID: 17121855

Title: Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.

PubMed ID: 17121855

DOI: 10.1074/jbc.m610541200

PubMed ID: 17009320

Title: cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells.

PubMed ID: 17009320

DOI: 10.1002/jcb.21041

PubMed ID: 17591690

Title: Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.

PubMed ID: 17591690

DOI: 10.1242/jcs.03468

PubMed ID: 18042622

Title: Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin.

PubMed ID: 18042622

DOI: 10.1242/jcs.018218

PubMed ID: 17611284

Title: Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

PubMed ID: 17611284

DOI: 10.1523/jneurosci.1831-07.2007

PubMed ID: 17671990

Title: Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.

PubMed ID: 17671990

DOI: 10.1002/jnr.21438

PubMed ID: 17143272

Title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

PubMed ID: 17143272

DOI: 10.1038/nn1811

PubMed ID: 18507738

Title: Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.

PubMed ID: 18507738

DOI: 10.1111/j.1471-4159.2008.05500.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19081376

Title: Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.

PubMed ID: 19081376

DOI: 10.1016/j.neuron.2008.10.015

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20826806

Title: Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.

PubMed ID: 20826806

DOI: 10.1074/jbc.m110.126177

PubMed ID: 20213743

Title: CDK5 phosphorylates eNOS at Ser-113 and regulates NO production.

PubMed ID: 20213743

DOI: 10.1002/jcb.22515

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21144757

Title: Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.

PubMed ID: 21144757

DOI: 10.1016/j.bmc.2010.11.022

PubMed ID: 21442427

Title: Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).

PubMed ID: 21442427

DOI: 10.1007/s00018-011-0638-1

PubMed ID: 21465480

Title: Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.

PubMed ID: 21465480

DOI: 10.1002/jcp.22782

PubMed ID: 21668448

Title: Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity.

PubMed ID: 21668448

DOI: 10.1111/j.1471-4159.2011.07343.x

PubMed ID: 21209322

Title: High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.

PubMed ID: 21209322

DOI: 10.1091/mbc.e10-08-0681

PubMed ID: 21499257

Title: Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.

PubMed ID: 21499257

DOI: 10.1038/ncb2217

PubMed ID: 21220307

Title: Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control.

PubMed ID: 21220307

DOI: 10.1073/pnas.1011275108

PubMed ID: 11584302

Title: A decade of CDK5.

PubMed ID: 11584302

DOI: 10.1038/35096019

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 19782409

Title: Making a neuron: Cdk5 in embryonic and adult neurogenesis.

PubMed ID: 19782409

DOI: 10.1016/j.tins.2009.07.002

PubMed ID: 20061803

Title: Cdk5, the multifunctional surveyor.

PubMed ID: 20061803

DOI: 10.4161/cc.9.2.10466

PubMed ID: 21044075

Title: Regulation and role of cyclin-dependent kinase activity in neuronal survival and death.

PubMed ID: 21044075

DOI: 10.1111/j.1471-4159.2010.07050.x

PubMed ID: 21415596

Title: Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons.

PubMed ID: 21415596

DOI: 10.4161/cc.10.8.15328

PubMed ID: 21600237

Title: Cdk5: Mediator of neuronal development, death and the response to DNA damage.

PubMed ID: 21600237

DOI: 10.1016/j.mad.2011.04.011

PubMed ID: 21473899

Title: Cdk5: multitasking between physiological and pathological conditions.

PubMed ID: 21473899

DOI: 10.1016/j.pneurobio.2011.03.006

PubMed ID: 24235147

Title: Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.

PubMed ID: 24235147

DOI: 10.1074/jbc.m113.494856

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25560765

Title: Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with a loss-of-function mutation in CDK5.

PubMed ID: 25560765

DOI: 10.1007/s00439-014-1522-5

PubMed ID: 11583627

Title: Structure and regulation of the CDK5-p25(nck5a) complex.

PubMed ID: 11583627

DOI: 10.1016/s1097-2765(01)00343-4

PubMed ID: 16039528

Title: Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

PubMed ID: 16039528

DOI: 10.1016/j.chembiol.2005.05.011

PubMed ID: 15689152

Title: Mechanism of CDK5/p25 binding by CDK inhibitors.

PubMed ID: 15689152

DOI: 10.1021/jm049323m

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 292
  • Mass: 33304
  • Checksum: 54D10495F017D527
  • Sequence:
    • MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 
NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 
TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP 
MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

Genular Protein ID: 3562956000

Symbol: A0A0S2Z355_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z355

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 10 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 260
  • Mass: 29544
  • Checksum: 808E46028B657622
  • Sequence:
    • MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKNGELKL ADFGLARAFG 
IPVRCYSAEV VTLWYRPPDV LFGAKLYSTS IDMWSAGCIF AELANAGRPL FPGNDVDDQL 
KRIFRLLGTP TEEQWPSMTK LPDYKPYPMY PATTSLVNVV PKLNATGRDL LQNLLKCNPV 
QRISAEEALQ HPYFSDFCPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.