Details for: CDK5

Gene ID: 1020

Symbol: CDK5

Ensembl ID: ENSG00000164885

Description: cyclin dependent kinase 5

Associated with

Other Information

Genular Protein ID: 1589642958

Symbol: CDK5_HUMAN

Name: Cyclin-dependent-like kinase 5

UniProtKB Accession Codes:

Q00535 A1XKG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 3 ELM 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 94 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 10 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 19693690

Title: Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling.

PubMed ID: 19693690

DOI: 10.1007/s11033-009-9752-7

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9030781

Title: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

PubMed ID: 9030781

DOI: 10.1111/j.1432-1033.1997.t01-2-00527.x

PubMed ID: 9822744

Title: Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.

PubMed ID: 9822744

DOI: 10.1523/jneurosci.18-23-09858.1998

PubMed ID: 10500146

Title: Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.

PubMed ID: 10500146

DOI: 10.1073/pnas.96.20.11156

PubMed ID: 12393264

Title: Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.

PubMed ID: 12393264

DOI: 10.1016/s0169-328x(02)00409-6

PubMed ID: 14521924

Title: Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.

PubMed ID: 14521924

DOI: 10.1016/j.bbrc.2003.08.143

PubMed ID: 12691662

Title: Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.

PubMed ID: 12691662

DOI: 10.1016/s0896-6273(03)00191-0

PubMed ID: 15992363

Title: Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation.

PubMed ID: 15992363

DOI: 10.1111/j.1471-4159.2005.03301.x

PubMed ID: 17121855

Title: Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.

PubMed ID: 17121855

DOI: 10.1074/jbc.m610541200

PubMed ID: 17009320

Title: cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells.

PubMed ID: 17009320

DOI: 10.1002/jcb.21041

PubMed ID: 17591690

Title: Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.

PubMed ID: 17591690

DOI: 10.1242/jcs.03468

PubMed ID: 18042622

Title: Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin.

PubMed ID: 18042622

DOI: 10.1242/jcs.018218

PubMed ID: 17611284

Title: Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

PubMed ID: 17611284

DOI: 10.1523/jneurosci.1831-07.2007

PubMed ID: 17671990

Title: Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.

PubMed ID: 17671990

DOI: 10.1002/jnr.21438

PubMed ID: 17143272

Title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

PubMed ID: 17143272

DOI: 10.1038/nn1811

PubMed ID: 18507738

Title: Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.

PubMed ID: 18507738

DOI: 10.1111/j.1471-4159.2008.05500.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19081376

Title: Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.

PubMed ID: 19081376

DOI: 10.1016/j.neuron.2008.10.015

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20826806

Title: Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.

PubMed ID: 20826806

DOI: 10.1074/jbc.m110.126177

PubMed ID: 20213743

Title: CDK5 phosphorylates eNOS at Ser-113 and regulates NO production.

PubMed ID: 20213743

DOI: 10.1002/jcb.22515

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21144757

Title: Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.

PubMed ID: 21144757

DOI: 10.1016/j.bmc.2010.11.022

PubMed ID: 21442427

Title: Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).

PubMed ID: 21442427

DOI: 10.1007/s00018-011-0638-1

PubMed ID: 21465480

Title: Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.

PubMed ID: 21465480

DOI: 10.1002/jcp.22782

PubMed ID: 21668448

Title: Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity.

PubMed ID: 21668448

DOI: 10.1111/j.1471-4159.2011.07343.x

PubMed ID: 21209322

Title: High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.

PubMed ID: 21209322

DOI: 10.1091/mbc.e10-08-0681

PubMed ID: 21499257

Title: Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.

PubMed ID: 21499257

DOI: 10.1038/ncb2217

PubMed ID: 21220307

Title: Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control.

PubMed ID: 21220307

DOI: 10.1073/pnas.1011275108

PubMed ID: 11584302

Title: A decade of CDK5.

PubMed ID: 11584302

DOI: 10.1038/35096019

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 19782409

Title: Making a neuron: Cdk5 in embryonic and adult neurogenesis.

PubMed ID: 19782409

DOI: 10.1016/j.tins.2009.07.002

PubMed ID: 20061803

Title: Cdk5, the multifunctional surveyor.

PubMed ID: 20061803

DOI: 10.4161/cc.9.2.10466

PubMed ID: 21044075

Title: Regulation and role of cyclin-dependent kinase activity in neuronal survival and death.

PubMed ID: 21044075

DOI: 10.1111/j.1471-4159.2010.07050.x

PubMed ID: 21415596

Title: Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons.

PubMed ID: 21415596

DOI: 10.4161/cc.10.8.15328

PubMed ID: 21600237

Title: Cdk5: Mediator of neuronal development, death and the response to DNA damage.

PubMed ID: 21600237

DOI: 10.1016/j.mad.2011.04.011

PubMed ID: 21473899

Title: Cdk5: multitasking between physiological and pathological conditions.

PubMed ID: 21473899

DOI: 10.1016/j.pneurobio.2011.03.006

PubMed ID: 24235147

Title: Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.

PubMed ID: 24235147

DOI: 10.1074/jbc.m113.494856

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25560765

Title: Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with a loss-of-function mutation in CDK5.

PubMed ID: 25560765

DOI: 10.1007/s00439-014-1522-5

PubMed ID: 11583627

Title: Structure and regulation of the CDK5-p25(nck5a) complex.

PubMed ID: 11583627

DOI: 10.1016/s1097-2765(01)00343-4

PubMed ID: 16039528

Title: Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

PubMed ID: 16039528

DOI: 10.1016/j.chembiol.2005.05.011

PubMed ID: 15689152

Title: Mechanism of CDK5/p25 binding by CDK inhibitors.

PubMed ID: 15689152

DOI: 10.1021/jm049323m

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 292
  • Mass: 33304
  • Checksum: 54D10495F017D527
  • Sequence:
    • MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 
NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 
TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP 
MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

Genular Protein ID: 3562956000

Symbol: A0A0S2Z355_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z355

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 260
  • Mass: 29544
  • Checksum: 808E46028B657622
  • Sequence:
    • MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKNGELKL ADFGLARAFG 
IPVRCYSAEV VTLWYRPPDV LFGAKLYSTS IDMWSAGCIF AELANAGRPL FPGNDVDDQL 
KRIFRLLGTP TEEQWPSMTK LPDYKPYPMY PATTSLVNVV PKLNATGRDL LQNLLKCNPV 
QRISAEEALQ HPYFSDFCPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.