CALCRL | ENSG00000064989 | NCBI 10203

Details for: CALCRL

Gene ID: 10203

Symbol: CALCRL

Ensembl ID: ENSG00000064989

Description: calcitonin receptor like receptor

Associated with

Calcitonin-like ligand receptors
(R-HSA-419812)
Class b/2 (secretin family receptors)
(R-HSA-373080)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adrenomedullin binding
(GO:1990409)
Adrenomedullin receptor activity
(GO:0001605)
Adrenomedullin receptor complex
(GO:1903143)
Adrenomedullin receptor signaling pathway
(GO:1990410)
Angiogenesis
(GO:0001525)
Calcitonin gene-related peptide receptor activity
(GO:0001635)
Calcitonin gene-related peptide receptor signaling pathway
(GO:1990408)
Calcitonin receptor activity
(GO:0004948)
Calcium ion transport
(GO:0006816)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to sucrose stimulus
(GO:0071329)
Cgrp receptor complex
(GO:1990406)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Heart development
(GO:0007507)
Lysosome
(GO:0005764)
Plasma membrane
(GO:0005886)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Receptor internalization
(GO:0031623)
Vascular associated smooth muscle cell proliferation
(GO:1990874)

Other Information

Proteins

Calcitonin receptor-like receptor

Genular Protein ID: 2038004129

Symbol: CALRL_HUMAN

Name: Calcitonin receptor-like receptor

UniProtKB Accession Codes:

Q16602 A8K6G5 A8KAD3 Q53S02 Q53TS5

Database IDs:

Citations:

PubMed ID: 8626685

Title: A cDNA encoding the calcitonin gene-related peptide type 1 receptor.

PubMed ID: 8626685

DOI: 10.1074/jbc.271.19.11325

PubMed ID: 7818539

Title: A human orphan calcitonin receptor-like structure.

PubMed ID: 7818539

DOI: 10.1006/bbrc.1995.1047

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 30115739

Title: hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.

PubMed ID: 30115739

DOI: 10.1084/jem.20180528

PubMed ID: 20826335

Title: Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.

PubMed ID: 20826335

DOI: 10.1016/j.str.2010.05.014

PubMed ID: 22102369

Title: Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.

PubMed ID: 22102369

DOI: 10.1002/pro.2003

Sequence Information:

Length: 461
Mass: 52979
Checksum: DAD6253283088CB4
Sequence:

MEKKCTLYFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA 
EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT 
WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL 
FFSFVCNSVV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL 
IVVAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA 
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI 
AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS 
YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CALCRL

Associated with

Other Information

A cDNA encoding the calcitonin gene-related peptide type 1 receptor. PubMed ID: 8626685

A human orphan calcitonin receptor-like structure. PubMed ID: 7818539

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. PubMed ID: 30115739

Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. PubMed ID: 20826335

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. PubMed ID: 22102369