TRIM13 | ENSG00000204977 | NCBI 10206

Details for: TRIM13

Gene ID: 10206

Symbol: TRIM13

Ensembl ID: ENSG00000204977

Description: tripartite motif containing 13

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Calnexin/calreticulin cycle
(R-HSA-901042)
Er quality control compartment (erqc)
(R-HSA-901032)
Metabolism of proteins
(R-HSA-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Post-translational protein modification
(R-HSA-597592)
Anatomical structure morphogenesis
(GO:0009653)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum membrane
(GO:0005789)
Erad pathway
(GO:0036503)
Innate immune response
(GO:0045087)
Negative regulation of viral transcription
(GO:0032897)
Perinuclear endoplasmic reticulum
(GO:0097038)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Suppression of viral release by host
(GO:0044790)
Transcription coactivator activity
(GO:0003713)
Ubiquitin-like protein ligase activity
(GO:0061659)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase TRIM13
L7MTJ6_HUMAN

Genular Protein ID: 925850530

Symbol: TRI13_HUMAN

Name: E3 ubiquitin-protein ligase TRIM13

UniProtKB Accession Codes:

O60858 B2RB49 Q5UBW0 Q5W0U8 Q5W0U9 Q9BQ47 Q9C021

Database IDs:

Citations:

PubMed ID: 9599022

Title: A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5.

PubMed ID: 9599022

DOI: 10.1016/s0014-5793(98)00357-3

PubMed ID: 11264177

Title: Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.

PubMed ID: 11264177

DOI: 10.1182/blood.v97.7.2098

PubMed ID: 11331580

Title: The tripartite motif family identifies cell compartments.

PubMed ID: 11331580

DOI: 10.1093/emboj/20.9.2140

PubMed ID: 14499696

Title: RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia.

PubMed ID: 14499696

DOI: 10.1016/s0165-4608(03)00126-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17314412

Title: The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.

PubMed ID: 17314412

DOI: 10.1091/mbc.e06-03-0248

PubMed ID: 21333377

Title: Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.

PubMed ID: 21333377

DOI: 10.1016/j.ejcb.2010.12.001

PubMed ID: 22178386

Title: TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.

PubMed ID: 22178386

DOI: 10.1016/j.bbamcr.2011.11.015

PubMed ID: 25152375

Title: TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-kappaB activation.

PubMed ID: 25152375

DOI: 10.1016/j.cellsig.2014.08.008

PubMed ID: 25088585

Title: Participation of the E3-ligase TRIM13 in NF-kappaB p65 activation and NFAT-dependent activation of c-Rel upon T-cell receptor engagement.

PubMed ID: 25088585

DOI: 10.1016/j.biocel.2014.07.012

PubMed ID: 28087809

Title: Trim13 potentiates toll-like receptor 2-mediated nuclear factor kappaB activation via K29-linked polyubiquitination of tumor necrosis factor receptor-associated factor 6.

PubMed ID: 28087809

DOI: 10.1124/mol.116.106716

Sequence Information:

Length: 407
Mass: 46988
Checksum: 94B624345124AEBF
Sequence:

MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE 
TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR 
GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD 
KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK 
DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP 
QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFSSYLTK 
TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL

Genular Protein ID: 1917817445

Symbol: L7MTJ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

L7MTJ6

Database IDs:

Sequence Information:

Length: 216
Mass: 24791
Checksum: 1C6DC5158A3F1B2C
Sequence:

GGRMSSQELV TLNVGGKIFT TRFSTIKQFP ASRLARMLDG RDQEFKMVGG QIFVDRDGDL 
FSFILDFLRT HQLLLPTEFS DYLRLQREAL FYELRSLVDL LNPYLLQPRP ALVEVHFLSR 
NTQAFFRVFG SCSKTIEMLT GRITVFTEQP SAPTWNGNFF PPQMTLLPLP PQRPSYHDLV 
FQCGSDSTTD NQTGVRYFVL CSISLVYQFV MFSLKT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIM13

Associated with

Other Information

A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5. PubMed ID: 9599022

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. PubMed ID: 11264177

The tripartite motif family identifies cell compartments. PubMed ID: 11331580

RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia. PubMed ID: 14499696

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. PubMed ID: 17314412

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. PubMed ID: 21333377

TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells. PubMed ID: 22178386

TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-kappaB activation. PubMed ID: 25152375

Participation of the E3-ligase TRIM13 in NF-kappaB p65 activation and NFAT-dependent activation of c-Rel upon T-cell receptor engagement. PubMed ID: 25088585

Trim13 potentiates toll-like receptor 2-mediated nuclear factor kappaB activation via K29-linked polyubiquitination of tumor necrosis factor receptor-associated factor 6. PubMed ID: 28087809