Details for: PATJ

Gene ID: 10207

Symbol: PATJ

Ensembl ID: ENSG00000132849

Description: PATJ crumbs cell polarity complex component

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 10.18
    Marker Score: 135,460
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.52
    Marker Score: 4,892
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.66
    Marker Score: 3,233
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.63
    Marker Score: 5,241
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.37
    Marker Score: 97,592
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 4.29
    Marker Score: 15,245
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.83
    Marker Score: 2,951
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.35
    Marker Score: 1,764
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.3
    Marker Score: 4,437
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.3
    Marker Score: 8,256
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.21
    Marker Score: 13,418
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.14
    Marker Score: 3,803
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.07
    Marker Score: 898
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.02
    Marker Score: 872
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.01
    Marker Score: 1,753
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.93
    Marker Score: 1,421
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.64
    Marker Score: 2,912
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.48
    Marker Score: 1,450
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.48
    Marker Score: 1,038
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.44
    Marker Score: 770
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.31
    Marker Score: 840
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.3
    Marker Score: 2,329
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.29
    Marker Score: 5,035
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.28
    Marker Score: 1,503
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.25
    Marker Score: 981
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.22
    Marker Score: 33,169
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.22
    Marker Score: 7,865
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.17
    Marker Score: 4,173
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.13
    Marker Score: 42,389
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.08
    Marker Score: 76,800
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2
    Marker Score: 7,719
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.97
    Marker Score: 18,519
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.95
    Marker Score: 9,031
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.95
    Marker Score: 1,861
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.94
    Marker Score: 1,299
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119,292
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.94
    Marker Score: 700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.93
    Marker Score: 14,798
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.93
    Marker Score: 73,181
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19,292
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.86
    Marker Score: 507
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.85
    Marker Score: 4,953
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.81
    Marker Score: 17,160
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.77
    Marker Score: 3,140
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15,145
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.75
    Marker Score: 4,423
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.75
    Marker Score: 553
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.74
    Marker Score: 942
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.72
    Marker Score: 1,814
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.72
    Marker Score: 1,170
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.71
    Marker Score: 7,107
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.71
    Marker Score: 542
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.69
    Marker Score: 2,034
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.67
    Marker Score: 35,589
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.66
    Marker Score: 534
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.65
    Marker Score: 3,894
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.64
    Marker Score: 520
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.63
    Marker Score: 1,754
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.59
    Marker Score: 588
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.59
    Marker Score: 404
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,440
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.58
    Marker Score: 2,328
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.58
    Marker Score: 3,601
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.5
    Marker Score: 1,560
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.5
    Marker Score: 1,377
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.5
    Marker Score: 397
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.48
    Marker Score: 299
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.46
    Marker Score: 2,662
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.45
    Marker Score: 809
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.44
    Marker Score: 9,359
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.43
    Marker Score: 938
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5,659
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.37
    Marker Score: 1,435
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.35
    Marker Score: 1,688
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20,801
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.3
    Marker Score: 6,399
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.29
    Marker Score: 439
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.29
    Marker Score: 602
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.28
    Marker Score: 2,154
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.26
    Marker Score: 736
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.24
    Marker Score: 358
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.23
    Marker Score: 6,491
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.23
    Marker Score: 551
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.22
    Marker Score: 317
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.22
    Marker Score: 1,296
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.21
    Marker Score: 378
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.18
    Marker Score: 1,179
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.17
    Marker Score: 291
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.16
    Marker Score: 1,640
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.15
    Marker Score: 3,287
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.14
    Marker Score: 563
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.11
    Marker Score: 2,352
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.11
    Marker Score: 2,649
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1
    Marker Score: 38,161
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.1
    Marker Score: 1,264
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.09
    Marker Score: 654
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.07
    Marker Score: 928
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.05
    Marker Score: 385
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.04
    Marker Score: 1,726
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.03
    Marker Score: 7,681

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PATJ is a PDZ domain-containing protein that interacts with other proteins to form the crumbs complex, a key component of the apical junction complex. This complex plays a crucial role in establishing and maintaining cell polarity, which is essential for proper epithelial function and barrier integrity. PATJ's expression is widespread, with significant levels found in cardiac muscle cells, basal epithelial cells of the prostate, and other epithelial tissues. **Pathways and Functions:** PATJ's primary function is to regulate the establishment and maintenance of apical/basal cell polarity. It interacts with other proteins, such as NHERF1 and PDGFRα, to form the crumbs complex, which in turn regulates the organization of the apical plasma membrane and tight junctions. PATJ's dysregulation has been implicated in various diseases, including those caused by SARS-CoV-2, which targets PDZ proteins in cell-cell junctions. In addition to its role in cell polarity, PATJ has also been implicated in other cellular processes, including intracellular signal transduction and protein binding. Its expression has been found in various cell types, including cardiac muscle cells, renal principal cells, and skeletal muscle fibers. **Clinical Significance:** The dysregulation of PATJ has been implicated in several diseases, including those caused by SARS-CoV-2. The virus targets PDZ proteins in cell-cell junctions, leading to the disruption of apical/basal cell polarity and the establishment of a pro-inflammatory environment. PATJ's role in maintaining cell polarity makes it a potential target for therapeutic interventions in SARS-CoV-2 infections. Furthermore, PATJ's dysregulation has been implicated in other diseases, including cancer, where it has been found to play a role in the establishment and maintenance of epithelial cell polarity. Its dysregulation has also been implicated in various cardiovascular diseases, including heart failure and cardiac arrhythmias. In conclusion, PATJ is a crucial component of the apical junction complex, playing a pivotal role in maintaining cell polarity and regulating various cellular processes. Its dysregulation has been implicated in several diseases, including those caused by SARS-CoV-2, making it a potential target for therapeutic interventions. Further research is needed to fully elucidate PATJ's role in maintaining cell polarity and its implications in infectious diseases. **Recommendations:** 1. Further research is needed to elucidate PATJ's role in maintaining cell polarity and its implications in infectious diseases. 2. PATJ's potential as a therapeutic target in SARS-CoV-2 infections should be further explored. 3. The role of PATJ in other diseases, including cancer and cardiovascular diseases, should be further investigated. **Limitations:** 1. The current understanding of PATJ's role in cell polarity is limited, and further research is needed to fully elucidate its functions. 2. The clinical significance of PATJ's dysregulation in infectious diseases is still being investigated. 3. The potential therapeutic targets of PATJ in SARS-CoV-2 infections are still being explored. **Future Directions:** 1. Further research is needed to elucidate PATJ's role in maintaining cell polarity and its implications in infectious diseases. 2. The development of therapeutic interventions targeting PATJ's function in cell polarity should be further explored. 3. The role of PATJ in other diseases, including cancer and cardiovascular diseases, should be further investigated.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.