CDK6 | ENSG00000105810 | NCBI 1021

Details for: CDK6

Gene ID: 1021

Symbol: CDK6

Ensembl ID: ENSG00000105810

Description: cyclin dependent kinase 6

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin d associated events in g1
(R-HSA-69231)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of cellular response to stress
(R-HSA-9675132)
Diseases of cellular senescence
(R-HSA-9630747)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9630794)
Evasion of oncogene induced senescence due to p16ink4a defects
(R-HSA-9630750)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9632700)
Evasion of oxidative stress induced senescence due to p16ink4a defects
(R-HSA-9632693)
G1 phase
(R-HSA-69236)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Transcriptional regulation by runx1
(R-HSA-8878171)
Astrocyte development
(GO:0014002)
Atp binding
(GO:0005524)
Cell dedifferentiation
(GO:0043697)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
Cyclin d1-cdk6 complex
(GO:0097131)
Cyclin d2-cdk6 complex
(GO:0097132)
Cyclin d3-cdk6 complex
(GO:0097133)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dentate gyrus development
(GO:0021542)
Fbxo family protein binding
(GO:0098770)
G1/s transition of mitotic cell cycle
(GO:0000082)
Generation of neurons
(GO:0048699)
Gliogenesis
(GO:0042063)
Hematopoietic stem cell differentiation
(GO:0060218)
Lateral ventricle development
(GO:0021670)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of monocyte differentiation
(GO:0045656)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of cell cycle
(GO:0051726)
Regulation of cell motility
(GO:2000145)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of hematopoietic stem cell differentiation
(GO:1902036)
Response to virus
(GO:0009615)
Ruffle
(GO:0001726)
Signal transduction
(GO:0007165)
T cell differentiation in thymus
(GO:0033077)
Type b pancreatic cell development
(GO:0003323)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 252.2739
Cell Significance Index: -39.2400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 113.4125
Cell Significance Index: -46.7200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 100.7154
Cell Significance Index: -47.5500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 99.4813
Cell Significance Index: -40.4200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 89.6215
Cell Significance Index: -46.1000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 71.0409
Cell Significance Index: -47.6700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 55.4716
Cell Significance Index: -14.0700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 42.5926
Cell Significance Index: -40.6700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.3865
Cell Significance Index: -43.6300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.4884
Cell Significance Index: -44.1700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.7552
Cell Significance Index: -45.3200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.4659
Cell Significance Index: -31.6600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.5407
Cell Significance Index: -45.5400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 6.5549
Cell Significance Index: 175.6400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 5.6600
Cell Significance Index: 365.1600
Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.0786
Cell Significance Index: 32.4200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 5.0375
Cell Significance Index: 282.6800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 4.3265
Cell Significance Index: 115.7300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.9365
Cell Significance Index: 105.1100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.7052
Cell Significance Index: 256.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.5621
Cell Significance Index: 157.5600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.3171
Cell Significance Index: 125.6100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.2466
Cell Significance Index: 46.7000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.1594
Cell Significance Index: 626.9900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.9354
Cell Significance Index: 40.0500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.5073
Cell Significance Index: 192.4100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.1859
Cell Significance Index: 131.2300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.1131
Cell Significance Index: 423.8900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.5594
Cell Significance Index: 44.5000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.9732
Cell Significance Index: 10.5800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.9388
Cell Significance Index: 26.2400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8507
Cell Significance Index: 588.3800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7323
Cell Significance Index: 38.1500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.6731
Cell Significance Index: 45.2600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6083
Cell Significance Index: 43.0200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6004
Cell Significance Index: 265.4400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5825
Cell Significance Index: 208.9200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.5743
Cell Significance Index: 3.4700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.5709
Cell Significance Index: 878.9000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4930
Cell Significance Index: 14.2100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4775
Cell Significance Index: 260.7700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4651
Cell Significance Index: 13.6600
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.4381
Cell Significance Index: 4.4200
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.4330
Cell Significance Index: 8.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4121
Cell Significance Index: 18.6800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3422
Cell Significance Index: 309.0200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3166
Cell Significance Index: 38.9300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2802
Cell Significance Index: 50.5200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2238
Cell Significance Index: 10.5200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2135
Cell Significance Index: 290.2400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.2120
Cell Significance Index: 3.1300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1740
Cell Significance Index: 20.5200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1603
Cell Significance Index: 30.5100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1319
Cell Significance Index: 243.3400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1195
Cell Significance Index: 20.4100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1168
Cell Significance Index: 219.8400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1139
Cell Significance Index: 11.2700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1075
Cell Significance Index: 68.2500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0697
Cell Significance Index: 2.4500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0432
Cell Significance Index: 5.9300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0305
Cell Significance Index: 0.8300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0157
Cell Significance Index: 0.3400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0145
Cell Significance Index: -0.3800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0165
Cell Significance Index: -12.2200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0169
Cell Significance Index: -7.6900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0199
Cell Significance Index: -12.4600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0306
Cell Significance Index: -4.4600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0319
Cell Significance Index: -3.4700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0338
Cell Significance Index: -24.7500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0565
Cell Significance Index: -31.8900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0584
Cell Significance Index: -44.2300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1087
Cell Significance Index: -1.8200
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.1093
Cell Significance Index: -0.9700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1205
Cell Significance Index: -2.0700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1343
Cell Significance Index: -38.6500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1385
Cell Significance Index: -29.1800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1414
Cell Significance Index: -14.4400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1421
Cell Significance Index: -18.3600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1491
Cell Significance Index: -17.3800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1507
Cell Significance Index: -3.8500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1830
Cell Significance Index: -8.5300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1934
Cell Significance Index: -22.1600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2153
Cell Significance Index: -6.9000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2432
Cell Significance Index: -5.0900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2852
Cell Significance Index: -32.5500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3094
Cell Significance Index: -19.0200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.3434
Cell Significance Index: -44.0200
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: -0.3867
Cell Significance Index: -2.7800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3972
Cell Significance Index: -41.3600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4281
Cell Significance Index: -22.2400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4352
Cell Significance Index: -10.8800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5455
Cell Significance Index: -43.2100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5843
Cell Significance Index: -43.5500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5906
Cell Significance Index: -16.9300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6287
Cell Significance Index: -10.5900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6332
Cell Significance Index: -13.4400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6466
Cell Significance Index: -39.6500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.7285
Cell Significance Index: -9.3300
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.8265
Cell Significance Index: -11.0300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8388
Cell Significance Index: -44.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CDK6 is a member of the cyclin-dependent kinase family, which is characterized by their ability to bind to cyclins and drive the cell cycle forward. CDK6 is specifically known for its ability to form a complex with cyclin D2, which is essential for the G1/S transition. CDK6 is also known for its ability to phosphorylate and activate various downstream targets, including transcription factors and other kinases. **Pathways and Functions** CDK6 is involved in several key pathways, including: 1. **Cell Cycle Regulation**: CDK6 is a key regulator of the cell cycle, particularly during the G1/S transition. It forms a complex with cyclin D2 to drive the cell cycle forward, promoting cell proliferation and growth. 2. **Cell Differentiation**: CDK6 is involved in the regulation of cell differentiation, particularly in the development of neural and hematopoietic cells. 3. **Apoptosis**: CDK6 can also induce apoptosis in certain cell types, particularly when overexpressed. 4. **Transcriptional Regulation**: CDK6 can phosphorylate and activate various transcription factors, including E2F1, to regulate gene expression. **Clinical Significance** CDK6 has been implicated in several diseases, including: 1. **Cancer**: CDK6 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. CDK6 can contribute to uncontrolled cell proliferation and tumorigenesis. 2. **Neurological Disorders**: CDK6 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Hematological Disorders**: CDK6 has been implicated in the development of hematological disorders, including leukemia and lymphoma. In conclusion, CDK6 is a critical regulator of the cell cycle and development, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which CDK6 regulates cell cycle and development, and to explore its potential as a therapeutic target for various diseases. **Significantly Expressed Cells** CDK6 is significantly expressed in various cell types, including: 1. Cortical cells of the adrenal gland 2. Chromaffin cells 3. Early promyelocytes 4. Skeletal muscle satellite cells 5. Neuron-associated cells 6. Epithelial cells of the lower respiratory tract 7. Early pro-B cells 8. Lens epithelial cells 9. Syncytiotrophoblast cells 10. Pro-T cells **Proteins** CDK6 is encoded by the CDK6 gene, which is also known as Cyclin-dependent kinase 6.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-dependent kinase 6

Genular Protein ID: 3603685081

Symbol: CDK6_HUMAN

Name: Cyclin-dependent kinase 6

UniProtKB Accession Codes:

Q00534 A4D1G0

Database IDs:

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 9482106

Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.

PubMed ID: 9482106

DOI: 10.1038/sj.onc.1201570

PubMed ID: 12833137

Title: CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells.

PubMed ID: 12833137

DOI: 10.1038/sj.onc.1206484

PubMed ID: 14985467

Title: Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.

PubMed ID: 14985467

PubMed ID: 15254224

Title: Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6.

PubMed ID: 15254224

DOI: 10.1128/mcb.24.15.6560-6568.2004

PubMed ID: 16096642

Title: Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

PubMed ID: 16096642

DOI: 10.1038/sj.emboj.7600775

PubMed ID: 15809340

Title: Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro.

PubMed ID: 15809340

DOI: 10.1093/jb/mvi050

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 17431401

Title: Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.

PubMed ID: 17431401

DOI: 10.1038/sj.emboj.7601675

PubMed ID: 17420273

Title: CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.

PubMed ID: 17420273

DOI: 10.1128/mcb.02286-06

PubMed ID: 19139263

Title: A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

PubMed ID: 19139263

DOI: 10.1083/jcb.200801009

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20668294

Title: Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.

PubMed ID: 20668294

DOI: 10.2337/db09-1776

PubMed ID: 20333249

Title: Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

PubMed ID: 20333249

DOI: 10.1371/journal.ppat.1000818

PubMed ID: 16294322

Title: Beyond the cell cycle: a new role for Cdk6 in differentiation.

PubMed ID: 16294322

DOI: 10.1002/jcb.20712

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23918663

Title: CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.

PubMed ID: 23918663

DOI: 10.1093/hmg/ddt374

PubMed ID: 9751050

Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

PubMed ID: 9751050

DOI: 10.1038/26155

PubMed ID: 11124804

Title: Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.

PubMed ID: 11124804

DOI: 10.1101/gad.851100

PubMed ID: 11828325

Title: Structural basis for CDK6 activation by a virus-encoded cyclin.

PubMed ID: 11828325

DOI: 10.1038/nsb756

PubMed ID: 15689157

Title: Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

PubMed ID: 15689157

DOI: 10.1021/jm049353p

PubMed ID: 16789739

Title: Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.

PubMed ID: 16789739

DOI: 10.1021/jm0600388

PubMed ID: 21038853

Title: 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.

PubMed ID: 21038853

DOI: 10.1021/jm100571n

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 326
Mass: 36938
Checksum: 571733EE6BE7FD4A
Sequence:

MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR 
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 
EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF 
QDLERCKENL DSHLPPSQNT SELNTA

Database document:

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Details for: CDK6

Associated with

Cells (max top 100)

Other Information

A family of human cdc2-related protein kinases. PubMed ID: 1639063

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. PubMed ID: 9482106

CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. PubMed ID: 12833137

Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. PubMed ID: 14985467

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. PubMed ID: 15254224

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. PubMed ID: 16096642

Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro. PubMed ID: 15809340

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. PubMed ID: 17431401

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. PubMed ID: 17420273

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. PubMed ID: 19139263

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. PubMed ID: 20668294

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PubMed ID: 20333249

Beyond the cell cycle: a new role for Cdk6 in differentiation. PubMed ID: 16294322

Cell cycle, CDKs and cancer: a changing paradigm. PubMed ID: 19238148

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. PubMed ID: 23918663

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. PubMed ID: 9751050

Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. PubMed ID: 11124804

Structural basis for CDK6 activation by a virus-encoded cyclin. PubMed ID: 11828325

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. PubMed ID: 15689157

Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. PubMed ID: 16789739

4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. PubMed ID: 21038853

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846