CDK6 | ENSG00000105810 | NCBI 1021

Details for: CDK6

Gene ID: 1021

Symbol: CDK6

Ensembl ID: ENSG00000105810

Description: cyclin dependent kinase 6

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin d associated events in g1
(R-HSA-69231)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of cellular response to stress
(R-HSA-9675132)
Diseases of cellular senescence
(R-HSA-9630747)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9630794)
Evasion of oncogene induced senescence due to p16ink4a defects
(R-HSA-9630750)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9632700)
Evasion of oxidative stress induced senescence due to p16ink4a defects
(R-HSA-9632693)
G1 phase
(R-HSA-69236)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Transcriptional regulation by runx1
(R-HSA-8878171)
Astrocyte development
(GO:0014002)
Atp binding
(GO:0005524)
Cell dedifferentiation
(GO:0043697)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
Cyclin d2-cdk6 complex
(GO:0097132)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dentate gyrus development
(GO:0021542)
Fbxo family protein binding
(GO:0098770)
G1/s transition of mitotic cell cycle
(GO:0000082)
Generation of neurons
(GO:0048699)
Gliogenesis
(GO:0042063)
Hematopoietic stem cell differentiation
(GO:0060218)
Lateral ventricle development
(GO:0021670)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of monocyte differentiation
(GO:0045656)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of cell cycle
(GO:0051726)
Regulation of cell motility
(GO:2000145)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of hematopoietic stem cell differentiation
(GO:1902036)
Response to organic substance
(GO:0010033)
Response to virus
(GO:0009615)
Ruffle
(GO:0001726)
Signal transduction
(GO:0007165)
T cell differentiation in thymus
(GO:0033077)
Type b pancreatic cell development
(GO:0003323)

Other Information

Proteins

Cyclin-dependent kinase 6

Genular Protein ID: 3603685081

Symbol: CDK6_HUMAN

Name: Cyclin-dependent kinase 6

UniProtKB Accession Codes:

Q00534 A4D1G0

Database IDs:

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 9482106

Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.

PubMed ID: 9482106

DOI: 10.1038/sj.onc.1201570

PubMed ID: 12833137

Title: CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells.

PubMed ID: 12833137

DOI: 10.1038/sj.onc.1206484

PubMed ID: 14985467

Title: Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.

PubMed ID: 14985467

PubMed ID: 15254224

Title: Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6.

PubMed ID: 15254224

DOI: 10.1128/mcb.24.15.6560-6568.2004

PubMed ID: 16096642

Title: Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

PubMed ID: 16096642

DOI: 10.1038/sj.emboj.7600775

PubMed ID: 15809340

Title: Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro.

PubMed ID: 15809340

DOI: 10.1093/jb/mvi050

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 17431401

Title: Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.

PubMed ID: 17431401

DOI: 10.1038/sj.emboj.7601675

PubMed ID: 17420273

Title: CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.

PubMed ID: 17420273

DOI: 10.1128/mcb.02286-06

PubMed ID: 19139263

Title: A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

PubMed ID: 19139263

DOI: 10.1083/jcb.200801009

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20668294

Title: Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.

PubMed ID: 20668294

DOI: 10.2337/db09-1776

PubMed ID: 20333249

Title: Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

PubMed ID: 20333249

DOI: 10.1371/journal.ppat.1000818

PubMed ID: 16294322

Title: Beyond the cell cycle: a new role for Cdk6 in differentiation.

PubMed ID: 16294322

DOI: 10.1002/jcb.20712

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23918663

Title: CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.

PubMed ID: 23918663

DOI: 10.1093/hmg/ddt374

PubMed ID: 9751050

Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

PubMed ID: 9751050

DOI: 10.1038/26155

PubMed ID: 11124804

Title: Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.

PubMed ID: 11124804

DOI: 10.1101/gad.851100

PubMed ID: 11828325

Title: Structural basis for CDK6 activation by a virus-encoded cyclin.

PubMed ID: 11828325

DOI: 10.1038/nsb756

PubMed ID: 15689157

Title: Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

PubMed ID: 15689157

DOI: 10.1021/jm049353p

PubMed ID: 16789739

Title: Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.

PubMed ID: 16789739

DOI: 10.1021/jm0600388

PubMed ID: 21038853

Title: 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.

PubMed ID: 21038853

DOI: 10.1021/jm100571n

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 326
Mass: 36938
Checksum: 571733EE6BE7FD4A
Sequence:

MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR 
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 
EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF 
QDLERCKENL DSHLPPSQNT SELNTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDK6

Associated with

Other Information

A family of human cdc2-related protein kinases. PubMed ID: 1639063

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. PubMed ID: 9482106

CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. PubMed ID: 12833137

Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. PubMed ID: 14985467

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. PubMed ID: 15254224

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. PubMed ID: 16096642

Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro. PubMed ID: 15809340

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. PubMed ID: 17431401

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. PubMed ID: 17420273

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. PubMed ID: 19139263

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. PubMed ID: 20668294

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PubMed ID: 20333249

Beyond the cell cycle: a new role for Cdk6 in differentiation. PubMed ID: 16294322

Cell cycle, CDKs and cancer: a changing paradigm. PubMed ID: 19238148

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. PubMed ID: 23918663

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. PubMed ID: 9751050

Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. PubMed ID: 11124804

Structural basis for CDK6 activation by a virus-encoded cyclin. PubMed ID: 11828325

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. PubMed ID: 15689157

Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. PubMed ID: 16789739

4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. PubMed ID: 21038853

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846