CDK6 | ENSG00000105810 | NCBI 1021

Details for: CDK6

Gene ID: 1021

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CDK6

Ensembl ID: ENSG00000105810

Description: cyclin dependent kinase 6

Cell Significance Landscape

Display Count:

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin d associated events in g1
(R-HSA-69231)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of cellular response to stress
(R-HSA-9675132)
Diseases of cellular senescence
(R-HSA-9630747)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Evasion of oncogene induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9630794)
Evasion of oncogene induced senescence due to p16ink4a defects
(R-HSA-9630750)
Evasion of oxidative stress induced senescence due to defective p16ink4a binding to cdk4 and cdk6
(R-HSA-9632700)
Evasion of oxidative stress induced senescence due to p16ink4a defects
(R-HSA-9632693)
G1 phase
(R-HSA-69236)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Transcriptional regulation by runx1
(R-HSA-8878171)
Astrocyte development
(GO:0014002)
Atp binding
(GO:0005524)
Cell dedifferentiation
(GO:0043697)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
Cyclin d1-cdk6 complex
(GO:0097131)
Cyclin d2-cdk6 complex
(GO:0097132)
Cyclin d3-cdk6 complex
(GO:0097133)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dentate gyrus development
(GO:0021542)
Fbxo family protein binding
(GO:0098770)
G1/s transition of mitotic cell cycle
(GO:0000082)
Generation of neurons
(GO:0048699)
Gliogenesis
(GO:0042063)
Hematopoietic stem cell differentiation
(GO:0060218)
Lateral ventricle development
(GO:0021670)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of monocyte differentiation
(GO:0045656)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of cell cycle
(GO:0051726)
Regulation of cell motility
(GO:2000145)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of hematopoietic stem cell differentiation
(GO:1902036)
Response to virus
(GO:0009615)
Ruffle
(GO:0001726)
Signal transduction
(GO:0007165)
T cell differentiation in thymus
(GO:0033077)
Type b pancreatic cell development
(GO:0003323)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

megakaryocyte-erythroid progenitor cell CL0000050

CSI 56.25

rCSI 50.8%

PRS 34.26
hematopoietic stem cell CL0000037

CSI 54.86

rCSI 36.47%

PRS 41.39
fraction A pre-pro B cell CL0002045

CSI 38.38

rCSI 43.94%

PRS 60.36
hematopoietic precursor cell CL0008001

CSI 37.02

rCSI 38.08%

PRS 54.28
common lymphoid progenitor CL0000051

CSI 33.4

rCSI 44.63%

PRS 59.64
common myeloid progenitor CL0000049

CSI 32.27

rCSI 26.09%

PRS 37.68
pro-B cell CL0000826

CSI 21.36

rCSI 17.69%

PRS 38.05
goblet cell CL0000160

CSI 20.55

rCSI 19.42%

PRS 38.44
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 20.49

rCSI 49.81%

PRS 23.28
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 19.66

rCSI 70.75%

PRS 22.98
lymphoid lineage restricted progenitor cell CL0000838

CSI 19.66

rCSI 76.51%

PRS 56.71
CD4-positive helper T cell CL0000492

CSI 19.48

rCSI 14.74%

PRS 48.56
keratinocyte CL0000312

CSI 19.27

rCSI 16.15%

PRS 42.34
intestinal crypt stem cell of small intestine CL0009017

CSI 19.11

rCSI 51.51%

PRS 46.06
kidney connecting tubule epithelial cell CL1000768

CSI 15.43

rCSI 39.15%

PRS 29.29
renal principal cell CL0005009

CSI 14.83

rCSI 38.53%

PRS 43.35
myeloid lineage restricted progenitor cell CL0000839

CSI 14.64

rCSI 75.6%

PRS 61.07
L6b glutamatergic cortical neuron CL4023038

CSI 14.03

rCSI 43.84%

PRS 25
Kupffer cell CL0000091

CSI 13.8

rCSI 31.57%

PRS 36.66
pvalb GABAergic cortical interneuron CL4023018

CSI 12.47

rCSI 15.51%

PRS 22.67
immature B cell CL0000816

CSI 11.96

rCSI 8.88%

PRS 49.79
cardiac muscle cell CL0000746

CSI 11.56

rCSI 16.59%

PRS 29.92
early lymphoid progenitor CL0000936

CSI 11.15

rCSI 9.8%

PRS 42.02
endothelial cell of placenta CL0009092

CSI 11.07

rCSI 54.57%

PRS 48.02
GABAergic neuron CL0000617

CSI 10.47

rCSI 35.08%

PRS 27.78
near-projecting glutamatergic cortical neuron CL4023012

CSI 10.04

rCSI 37.96%

PRS 24.86
lung secretory cell CL1000272

CSI 10.03

rCSI 24.82%

PRS 35.43
CD1c-positive myeloid dendritic cell CL0002399

CSI 9.7

rCSI 11.72%

PRS 43.91
mucosal invariant T cell CL0000940

CSI 9.35

rCSI 7.55%

PRS 48.61
group 3 innate lymphoid cell CL0001071

CSI 9.29

rCSI 6.98%

PRS 40.06
small pre-B-II cell CL0000954

CSI 8.99

rCSI 8.64%

PRS 61.29
epithelial cell of lung CL0000082

CSI 8.97

rCSI 7.44%

PRS 35.78
intestine goblet cell CL0019031

CSI 8.92

rCSI 7.92%

PRS 36.79
mesenchymal cell CL0008019

CSI 8.52

rCSI 21.65%

PRS 34.62
precursor B cell CL0000817

CSI 8.35

rCSI 7.32%

PRS 46.54
thymocyte CL0000893

CSI 8.29

rCSI 29.48%

PRS 75.13
late pro-B cell CL0002048

CSI 7.69

rCSI 19.28%

PRS 69.22
squamous epithelial cell CL0000076

CSI 7.11

rCSI 16.88%

PRS 43.04
ependymal cell CL0000065

CSI 7.02

rCSI 14.25%

PRS 22.52
neural crest cell CL0011012

CSI 6.98

rCSI 5.52%

PRS 26.69
hematopoietic multipotent progenitor cell CL0000837

CSI 6.88

rCSI 16.56%

PRS 54.02
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 6.6

rCSI 4.45%

PRS 46.16
type B pancreatic cell CL0000169

CSI 6.46

rCSI 14.3%

PRS 34.65
promyelocyte CL0000836

CSI 6.38

rCSI 9.21%

PRS 47.24
perivascular cell CL4033054

CSI 6.34

rCSI 8.67%

PRS 41.58
granulocyte CL0000094

CSI 6.22

rCSI 9.5%

PRS 45.82
erythroid progenitor cell CL0000038

CSI 6.19

rCSI 35.52%

PRS 48.3
blood vessel smooth muscle cell CL0019018

CSI 6.13

rCSI 49.82%

PRS 33.25
inhibitory interneuron CL0000498

CSI 6.06

rCSI 13.99%

PRS 30.73
stem cell CL0000034

CSI 5.96

rCSI 5.74%

PRS 29.05
common dendritic progenitor CL0001029

CSI 5.84

rCSI 7.33%

PRS 46.27
Bergmann glial cell CL0000644

CSI 5.84

rCSI 7.99%

PRS 35
basophil mast progenitor cell CL0002028

CSI 5.78

rCSI 30.83%

PRS 77.56
central nervous system neuron CL2000029

CSI 5.61

rCSI 41.21%

PRS 26.8
basal cell of prostate epithelium CL0002341

CSI 5.57

rCSI 16.11%

PRS 57.39
naive T cell CL0000898

CSI 5.48

rCSI 3.82%

PRS 49.25
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 5.47

rCSI 9.36%

PRS 58.35
melanocyte CL0000148

CSI 5.44

rCSI 4.03%

PRS 31.98
medium spiny neuron CL1001474

CSI 5.33

rCSI 45.94%

PRS 25.8
myoepithelial cell CL0000185

CSI 5.29

rCSI 13.38%

PRS 44.86
CD14-positive, CD16-positive monocyte CL0002397

CSI 5.25

rCSI 6.87%

PRS 49.94
fibroblast of cardiac tissue CL0002548

CSI 5.23

rCSI 25.08%

PRS 35.37
sst GABAergic cortical interneuron CL4023017

CSI 5.12

rCSI 6.61%

PRS 24.8
transit amplifying cell of small intestine CL0009012

CSI 5.06

rCSI 22.22%

PRS 57.28
parietal epithelial cell CL1000452

CSI 5.05

rCSI 13.51%

PRS 31.58
periportal region hepatocyte CL0019026

CSI 5.03

rCSI 19.57%

PRS 46.69
fallopian tube secretory epithelial cell CL4030006

CSI 4.94

rCSI 4.76%

PRS 37.97
IgA plasma cell CL0000987

CSI 4.94

rCSI 5.06%

PRS 55.99
dendritic cell, human CL0001056

CSI 4.91

rCSI 7.54%

PRS 43.52
tuft cell of colon CL0009041

CSI 4.9

rCSI 11.42%

PRS 56.71
secretory cell CL0000151

CSI 4.88

rCSI 5.09%

PRS 37.86
colon goblet cell CL0009039

CSI 4.86

rCSI 11.56%

PRS 49.89
vascular leptomeningeal cell CL4023051

CSI 4.73

rCSI 8.29%

PRS 30.47
astrocyte of the cerebral cortex CL0002605

CSI 4.68

rCSI 10.49%

PRS 24.5
paneth cell of epithelium of small intestine CL1000343

CSI 4.58

rCSI 12.84%

PRS 52.12
epithelial cell CL0000066

CSI 4.58

rCSI 7.03%

PRS 41.45
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.52

rCSI 3.44%

PRS 47.36
eosinophil CL0000771

CSI 4.5

rCSI 29.55%

PRS 69.32
stromal cell CL0000499

CSI 4.39

rCSI 12.34%

PRS 39.5
ionocyte CL0005006

CSI 4.35

rCSI 4.66%

PRS 35.06
endocardial cell CL0002350

CSI 4.3

rCSI 20.6%

PRS 39.79
CD4-positive, alpha-beta memory T cell CL0000897

CSI 4.28

rCSI 3.08%

PRS 49.01
hepatic stellate cell CL0000632

CSI 4.25

rCSI 15.93%

PRS 31.67
radial glial cell CL0000681

CSI 4.14

rCSI 5.75%

PRS 37.25
large pre-B-II cell CL0000957

CSI 4.08

rCSI 11.66%

PRS 52.34
granulocyte monocyte progenitor cell CL0000557

CSI 4.08

rCSI 3.53%

PRS 40.93
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 4.02

rCSI 18.27%

PRS 74.65
fibroblast of lung CL0002553

CSI 4

rCSI 3.72%

PRS 37.03
lung macrophage CL1001603

CSI 3.99

rCSI 8.91%

PRS 43.14
mesodermal cell CL0000222

CSI 3.94

rCSI 4.73%

PRS 35.63
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 3.93

rCSI 10.17%

PRS 69.15
adipocyte CL0000136

CSI 3.92

rCSI 5.03%

PRS 34.27
cerebral cortex endothelial cell CL1001602

CSI 3.91

rCSI 6.77%

PRS 29.27
peripheral nervous system neuron CL2000032

CSI 3.89

rCSI 5.3%

PRS 32.02
glial cell CL0000125

CSI 3.88

rCSI 14.78%

PRS 32.71
megakaryocyte progenitor cell CL0000553

CSI 3.81

rCSI 69.74%

PRS 73.02
glioblast CL0000030

CSI 3.79

rCSI 6.04%

PRS 32.14
intestinal crypt stem cell of colon CL0009043

CSI 3.78

rCSI 28.39%

PRS 58.04
neuroblast (sensu Vertebrata) CL0000031

CSI 3.78

rCSI 4.85%

PRS 35.58
double negative thymocyte CL0002489

CSI 3.77

rCSI 2.62%

PRS 44.74

mesenchymal stem cell CL0000134

CSI 0.1

rCSI 0.6%

PRS 54.6%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.2%

PRS 49.6%
pre-conventional dendritic cell CL0002010

CSI 0.2

rCSI 2.7%

PRS 71.6%
peptic cell CL0000155

CSI 0.2

rCSI 2.3%

PRS 65.9%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.4

rCSI 3.7%

PRS 40.2%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.4

rCSI 2.1%

PRS 47.3%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.4

rCSI 2.4%

PRS 25.2%
primitive red blood cell CL0002355

CSI 0.4

rCSI 2.3%

PRS 52.4%
pancreatic PP cell CL0002275

CSI 0.5

rCSI 1.9%

PRS 53.3%
IgG plasma cell CL0000985

CSI 0.5

rCSI 0.6%

PRS 56.0%
type EC enteroendocrine cell CL0000577

CSI 0.6

rCSI 2.0%

PRS 51.1%
luminal cell of prostate epithelium CL0002340

CSI 0.6

rCSI 3.0%

PRS 53.6%
pancreatic ductal cell CL0002079

CSI 0.6

rCSI 1.2%

PRS 38.8%
mesangial cell CL0000650

CSI 0.6

rCSI 2.5%

PRS 49.3%
epicardial adipocyte CL1000309

CSI 0.6

rCSI 2.0%

PRS 40.1%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.6

rCSI 1.5%

PRS 28.3%
midbrain dopaminergic neuron CL2000097

CSI 0.7

rCSI 4.3%

PRS 45.1%
cardiac blood vessel endothelial cell CL0010006

CSI 0.8

rCSI 5.7%

PRS 33.2%
mature alpha-beta T cell CL0000791

CSI 0.8

rCSI 3.0%

PRS 55.7%
respiratory suprabasal cell CL4033048

CSI 0.8

rCSI 1.1%

PRS 41.7%
mammary gland epithelial cell CL0002327

CSI 0.9

rCSI 3.2%

PRS 53.3%
acinar cell CL0000622

CSI 0.9

rCSI 1.3%

PRS 47.6%
enteroendocrine cell of colon CL0009042

CSI 0.9

rCSI 4.4%

PRS 65.0%
transit amplifying cell CL0009010

CSI 0.9

rCSI 1.4%

PRS 53.6%
erythroblast CL0000765

CSI 0.9

rCSI 2.5%

PRS 50.6%
cholangiocyte CL1000488

CSI 1.0

rCSI 6.1%

PRS 52.5%
dopaminergic neuron CL0000700

CSI 1.0

rCSI 5.7%

PRS 25.5%
regular ventricular cardiac myocyte CL0002131

CSI 1.0

rCSI 6.4%

PRS 30.8%
paneth cell CL0000510

CSI 1.1

rCSI 1.6%

PRS 54.0%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 1.1

rCSI 2.5%

PRS 83.1%
skeletal muscle satellite stem cell CL0008011

CSI 1.1

rCSI 5.0%

PRS 63.3%
contractile cell CL0000183

CSI 1.1

rCSI 3.3%

PRS 36.0%
Hofbauer cell CL3000001

CSI 1.1

rCSI 2.2%

PRS 46.4%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.1

rCSI 3.0%

PRS 34.1%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.2

rCSI 3.9%

PRS 27.8%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.3

rCSI 1.8%

PRS 34.8%
intrahepatic cholangiocyte CL0002538

CSI 1.3

rCSI 3.1%

PRS 54.3%
renal beta-intercalated cell CL0002201

CSI 1.3

rCSI 3.0%

PRS 40.0%
corneal epithelial cell CL0000575

CSI 1.3

rCSI 3.7%

PRS 55.3%
mesothelial cell CL0000077

CSI 1.3

rCSI 5.2%

PRS 16.9%
adventitial cell CL0002503

CSI 1.4

rCSI 3.3%

PRS 48.5%
keratocyte CL0002363

CSI 1.4

rCSI 3.3%

PRS 48.1%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.4

rCSI 12.2%

PRS 40.9%
alveolar macrophage CL0000583

CSI 1.4

rCSI 2.3%

PRS 42.2%
cardiac endothelial cell CL0010008

CSI 1.4

rCSI 5.7%

PRS 36.0%
intestinal tuft cell CL0019032

CSI 1.4

rCSI 2.2%

PRS 41.6%
respiratory basal cell CL0002633

CSI 1.5

rCSI 1.5%

PRS 42.7%
tracheobronchial smooth muscle cell CL0019019

CSI 1.5

rCSI 2.7%

PRS 45.7%
astrocyte CL0000127

CSI 1.5

rCSI 3.2%

PRS 19.6%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.6

rCSI 2.9%

PRS 32.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.6

rCSI 2.8%

PRS 23.1%
duct epithelial cell CL0000068

CSI 1.6

rCSI 2.3%

PRS 39.8%
chondrocyte CL0000138

CSI 1.6

rCSI 2.5%

PRS 31.6%
retinal pigment epithelial cell CL0002586

CSI 1.6

rCSI 3.2%

PRS 37.3%
club cell CL0000158

CSI 1.6

rCSI 2.4%

PRS 38.0%
colon macrophage CL0009038

CSI 1.6

rCSI 7.5%

PRS 60.7%
lung interstitial macrophage CL4033043

CSI 1.6

rCSI 3.7%

PRS 58.2%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.7

rCSI 2.8%

PRS 24.0%
mature B cell CL0000785

CSI 1.7

rCSI 1.5%

PRS 45.6%
T follicular helper cell CL0002038

CSI 1.8

rCSI 1.3%

PRS 51.5%
regular atrial cardiac myocyte CL0002129

CSI 1.8

rCSI 5.8%

PRS 37.2%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.8

rCSI 2.2%

PRS 56.8%
erythroid lineage cell CL0000764

CSI 1.8

rCSI 11.8%

PRS 60.4%
enterocyte of epithelium of large intestine CL0002071

CSI 1.8

rCSI 9.7%

PRS 53.2%
innate lymphoid cell CL0001065

CSI 1.9

rCSI 3.8%

PRS 45.5%
M cell of gut CL0000682

CSI 1.9

rCSI 2.1%

PRS 53.2%
bronchus fibroblast of lung CL2000093

CSI 1.9

rCSI 1.6%

PRS 38.2%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.0

rCSI 5.6%

PRS 53.4%
mucous neck cell CL0000651

CSI 2.0

rCSI 2.8%

PRS 51.1%
cerebral cortex neuron CL0010012

CSI 2.0

rCSI 8.0%

PRS 36.3%
hepatocyte CL0000182

CSI 2.0

rCSI 3.5%

PRS 35.6%
renal interstitial pericyte CL1001318

CSI 2.0

rCSI 5.5%

PRS 34.8%
Langerhans cell CL0000453

CSI 2.0

rCSI 3.1%

PRS 54.7%
mature microglial cell CL0002629

CSI 2.1

rCSI 8.6%

PRS 39.9%
enteric smooth muscle cell CL0002504

CSI 2.1

rCSI 3.0%

PRS 40.0%
intestinal epithelial cell CL0002563

CSI 2.1

rCSI 2.2%

PRS 37.3%
mucus secreting cell CL0000319

CSI 2.2

rCSI 3.4%

PRS 46.8%
lung neuroendocrine cell CL1000223

CSI 2.2

rCSI 3.2%

PRS 41.6%
colon epithelial cell CL0011108

CSI 2.2

rCSI 2.3%

PRS 35.0%
pancreatic A cell CL0000171

CSI 2.2

rCSI 2.3%

PRS 39.5%
pulmonary artery endothelial cell CL1001568

CSI 2.2

rCSI 3.0%

PRS 49.9%
microcirculation associated smooth muscle cell CL0008035

CSI 2.2

rCSI 6.4%

PRS 40.0%
small intestine goblet cell CL1000495

CSI 2.2

rCSI 4.9%

PRS 47.0%
interstitial cell of Cajal CL0002088

CSI 2.3

rCSI 2.9%

PRS 42.0%
intermediate monocyte CL0002393

CSI 2.3

rCSI 3.4%

PRS 38.7%
erythrocyte CL0000232

CSI 2.3

rCSI 5.2%

PRS 43.4%
Schwann cell CL0002573

CSI 2.3

rCSI 6.6%

PRS 37.9%
intraepithelial lymphocyte CL0002496

CSI 2.3

rCSI 6.3%

PRS 77.9%
skeletal muscle satellite cell CL0000594

CSI 2.5

rCSI 7.2%

PRS 70.2%
activated CD8-positive, alpha-beta T cell CL0000906

CSI 2.5

rCSI 2.5%

PRS 66.8%
transit amplifying cell of colon CL0009011

CSI 2.5

rCSI 3.0%

PRS 41.0%
pancreatic acinar cell CL0002064

CSI 2.6

rCSI 3.4%

PRS 41.3%
cerebellar granule cell CL0001031

CSI 2.6

rCSI 3.8%

PRS 34.3%
choroid plexus epithelial cell CL0000706

CSI 2.6

rCSI 4.2%

PRS 29.4%
myeloid dendritic cell CL0000782

CSI 2.6

rCSI 3.8%

PRS 52.6%
placental villous trophoblast CL2000060

CSI 2.6

rCSI 4.0%

PRS 35.4%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.7

rCSI 1.6%

PRS 50.7%
microglial cell CL0000129

CSI 2.7

rCSI 10.7%

PRS 50.8%
alveolar type 1 fibroblast cell CL4028004

CSI 2.7

rCSI 3.0%

PRS 41.0%
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.7

rCSI 7.2%

PRS 36.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CDK6](/details-gene/1021) (Cyclin Dependent Kinase 6) is a protein-coding gene located on chromosome 7q21.2. It encodes a catalytic subunit of the cyclin-dependent protein kinase family, which plays a crucial role in regulating the cell cycle, specifically the G1/S phase transition. As a serine/threonine kinase, [CDK6](/details-gene/1021) forms active complexes with D-type cyclins to phosphorylate and inactivate the retinoblastoma protein (RB1), thereby enabling cell cycle progression. **Overall**, expression data reveals that [CDK6](/details-gene/1021) is a highly significant marker for undifferentiated, proliferative cell populations, particularly within the hematopoietic system, where it is prominently expressed in [hematopoietic stem cell](/details-cell/CL0000037) and various progenitor lineages. Its function is not only tied to proliferation but also to the inhibition of cellular differentiation, a role implicated in both normal development and oncogenesis. ## Cellular Roles and Expression Landscape The expression profile of [CDK6](/details-gene/1021) underscores its fundamental role in maintaining progenitor cell states and driving proliferation. **Overall**, the gene exhibits its highest significance in early hematopoietic lineages, including [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 56.25), [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 54.86), and both lymphoid and myeloid progenitors such as [fraction A pre-pro B cell](/details-cell/CL0002045) (CSI: 38.38) and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 32.27). This pattern is consistent with its established role in blocking differentiation in hematopoietic cells, for instance by interfering with the function of key transcription factors like RUNX1 ([Link](https://doi.org/10.1038/sj.emboj.7601675)). Beyond hematopoiesis, [CDK6](/details-gene/1021) is also significantly expressed in other highly proliferative or developing tissues. Notable examples include epithelial stem and progenitor cells like [intestinal crypt stem cell of small intestine](/details-cell/CL0009017) (CSI: 19.11) and [keratinocyte](/details-cell/CL0000312) (CSI: 19.27), as well as certain neuronal populations, such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 20.49). This broader expression suggests a conserved function in controlling proliferation and development across diverse tissues. The consistent and high significance of [CDK6](/details-gene/1021) in these progenitor populations establishes it as a key regulator of cell fate decisions, coupling cell cycle progression with the maintenance of an undifferentiated state ([Link](https://doi.org/10.1038/sj.onc.1206484)). ## Pathways and Molecular Function The molecular function of [CDK6](/details-gene/1021) is centered on its [Cyclin-dependent protein serine/threonine kinase activity](/details-go/GO:0004693). Upon binding to D-type cyclins, it forms active holoenzyme complexes such as the [Cyclin d1-cdk6 complex](/details-go/GO:0097131), which are predominantly located in the [nucleus](/details-go/GO:0005634) ([Link](https://doi.org/10.1038/sj.onc.1201570)). These complexes are central to the [Mitotic g1 phase and g1/s transition](/details-reactome/R-HSA-453279) of the [Cell cycle](/details-reactome/R-HSA-1640170). A primary substrate of the active CDK6/cyclin-D complex is the retinoblastoma tumor suppressor protein (RB1), and its phosphorylation is a key event that releases E2F transcription factors to drive the expression of genes required for S-phase entry. This core function is implicated in a wide range of biological processes. Its role in hematopoiesis is highlighted by its involvement in [Hematopoietic stem cell differentiation](/details-go/GO:0060218) and the [Negative regulation of myeloid cell differentiation](/details-go/GO:0045638). Mechanistically, [CDK6](/details-gene/1021) can interfere with the DNA-binding activity of RUNX1, a master regulator of hematopoiesis, thereby blocking myeloid differentiation ([Link](https://doi.org/10.1038/sj.emboj.7601675)). Similarly, its involvement in [Negative regulation of osteoblast differentiation](/details-go/GO:0045668) has been shown to be mediated via Smad signaling pathways ([Link](https://doi.org/10.1128/mcb.24.15.6560-6568.2004)). Due to its central role in cell cycle control, dysregulation of [CDK6](/details-gene/1021) activity is a hallmark of many cancers, as reflected in pathways such as [Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects](/details-reactome/R-HSA-9659787) and [Oncogene induced senescence](/details-reactome/R-HSA-2559585). ## Research Directions The function of [CDK6](/details-gene/1021) as a nexus between cell proliferation and differentiation presents several avenues for future research, particularly in oncology and developmental biology. ### Proposed Hypotheses: 1. **Overcoming Differentiation Block in Leukemia:** Given that [CDK6](/details-gene/1021) is highly expressed in hematopoietic stem and progenitor cells and is known to block myeloid differentiation by inhibiting RUNX1 ([Link](https://doi.org/10.1038/sj.emboj.7601675)), it is hypothesized that targeted pharmacological inhibition of [CDK6](/details-gene/1021) in acute myeloid leukemia (AML) blasts will restore RUNX1 activity, lift the differentiation block, and induce terminal maturation of leukemic cells, thereby providing a non-cytotoxic therapeutic strategy. 2. **Role in Neurodevelopment and Glioma Pathogenesis:** The significant expression of [CDK6](/details-gene/1021) in specific neuronal populations and its annotation in processes like [Astrocyte development](/details-go/GO:0014002) suggest a role in regulating the proliferation of neural progenitors. It is hypothesized that aberrant re-activation or overexpression of [CDK6](/details-gene/1021) in glial progenitor cells is a key event in the pathogenesis of certain brain tumors, such as glioblastoma, by promoting uncontrolled proliferation and preventing differentiation. ### Key Experiment: To test the first hypothesis, primary AML patient samples, particularly those with known RUNX1 mutations or alterations, could be cultured *ex vivo* and treated with a highly specific CDK6 inhibitor (e.g., Palbociclib). The effects on cell fate could be assessed by measuring the expression of myeloid differentiation markers (e.g., CD11b, CD14, MPO) using flow cytometry and quantitative PCR. Concurrently, RNA-sequencing would be performed to confirm the reactivation of the RUNX1 transcriptional program and identify downstream gene expression changes associated with induced differentiation. ### Therapeutic Potential: [CDK6](/details-gene/1021) is a well-validated therapeutic target. Its function as a critical driver of the G1/S transition makes its **inhibition** a highly attractive strategy for treating hyperproliferative diseases, especially cancers. The development of small molecule inhibitors that target the ATP-binding pocket of [CDK6](/details-gene/1021) and its homolog CDK4 has led to several FDA-approved drugs for hormone receptor-positive breast cancer. The data suggest that the utility of these inhibitors could be expanded to hematological malignancies where a differentiation block is a key pathogenic feature, positioning [CDK6](/details-gene/1021) as a prime target for differentiation-based therapies.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-dependent kinase 6

Genular Protein ID: 3603685081

Symbol: CDK6_HUMAN

Name: Cyclin-dependent kinase 6

UniProtKB Accession Codes:

Q00534 A4D1G0

Database IDs:

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 9482106

Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.

PubMed ID: 9482106

DOI: 10.1038/sj.onc.1201570

PubMed ID: 12833137

Title: CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells.

PubMed ID: 12833137

DOI: 10.1038/sj.onc.1206484

PubMed ID: 14985467

Title: Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.

PubMed ID: 14985467

PubMed ID: 15254224

Title: Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6.

PubMed ID: 15254224

DOI: 10.1128/mcb.24.15.6560-6568.2004

PubMed ID: 16096642

Title: Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

PubMed ID: 16096642

DOI: 10.1038/sj.emboj.7600775

PubMed ID: 15809340

Title: Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro.

PubMed ID: 15809340

DOI: 10.1093/jb/mvi050

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 17431401

Title: Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.

PubMed ID: 17431401

DOI: 10.1038/sj.emboj.7601675

PubMed ID: 17420273

Title: CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.

PubMed ID: 17420273

DOI: 10.1128/mcb.02286-06

PubMed ID: 19139263

Title: A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

PubMed ID: 19139263

DOI: 10.1083/jcb.200801009

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20668294

Title: Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.

PubMed ID: 20668294

DOI: 10.2337/db09-1776

PubMed ID: 20333249

Title: Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

PubMed ID: 20333249

DOI: 10.1371/journal.ppat.1000818

PubMed ID: 16294322

Title: Beyond the cell cycle: a new role for Cdk6 in differentiation.

PubMed ID: 16294322

DOI: 10.1002/jcb.20712

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23918663

Title: CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.

PubMed ID: 23918663

DOI: 10.1093/hmg/ddt374

PubMed ID: 9751050

Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

PubMed ID: 9751050

DOI: 10.1038/26155

PubMed ID: 11124804

Title: Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.

PubMed ID: 11124804

DOI: 10.1101/gad.851100

PubMed ID: 11828325

Title: Structural basis for CDK6 activation by a virus-encoded cyclin.

PubMed ID: 11828325

DOI: 10.1038/nsb756

PubMed ID: 15689157

Title: Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

PubMed ID: 15689157

DOI: 10.1021/jm049353p

PubMed ID: 16789739

Title: Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.

PubMed ID: 16789739

DOI: 10.1021/jm0600388

PubMed ID: 21038853

Title: 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.

PubMed ID: 21038853

DOI: 10.1021/jm100571n

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 326
Mass: 36938
Checksum: 571733EE6BE7FD4A
Sequence:

MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR 
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 
EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF 
QDLERCKENL DSHLPPSQNT SELNTA

Details for: CDK6

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

A family of human cdc2-related protein kinases. PubMed ID: 1639063

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. PubMed ID: 9482106

CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. PubMed ID: 12833137

Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. PubMed ID: 14985467

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. PubMed ID: 15254224

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. PubMed ID: 16096642

Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro. PubMed ID: 15809340

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. PubMed ID: 17431401

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. PubMed ID: 17420273

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. PubMed ID: 19139263

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. PubMed ID: 20668294

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PubMed ID: 20333249

Beyond the cell cycle: a new role for Cdk6 in differentiation. PubMed ID: 16294322

Cell cycle, CDKs and cancer: a changing paradigm. PubMed ID: 19238148

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. PubMed ID: 23918663

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. PubMed ID: 9751050

Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. PubMed ID: 11124804

Structural basis for CDK6 activation by a virus-encoded cyclin. PubMed ID: 11828325

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. PubMed ID: 15689157

Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. PubMed ID: 16789739

4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. PubMed ID: 21038853

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846