FLOT1 | ENSG00000137312 | NCBI 10211

Details for: FLOT1

Gene ID: 10211

Symbol: FLOT1

Ensembl ID: ENSG00000137312

Description: flotillin 1

Associated with

Neuronal system
(R-HSA-112316)
Programmed cell death
(R-HSA-5357801)
Protein-protein interactions at synapses
(R-HSA-6794362)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhob gtpase cycle
(R-HSA-9013026)
Rhoc gtpase cycle
(R-HSA-9013106)
Rho gtpase cycle
(R-HSA-9012999)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Synaptic adhesion-like molecules
(R-HSA-8849932)
Adherens junction
(GO:0005912)
Apical plasma membrane
(GO:0016324)
Axonogenesis
(GO:0007409)
Basolateral plasma membrane
(GO:0016323)
Caveola
(GO:0005901)
Cell-cell contact zone
(GO:0044291)
Cell-cell junction
(GO:0005911)
Cellular response to exogenous dsrna
(GO:0071360)
Centriolar satellite
(GO:0034451)
Cop9 signalosome
(GO:0008180)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasmic vesicle
(GO:0031410)
Dopaminergic synapse
(GO:0098691)
Dsrna transport
(GO:0033227)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular matrix disassembly
(GO:0022617)
Flotillin complex
(GO:0016600)
Focal adhesion
(GO:0005925)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Ionotropic glutamate receptor binding
(GO:0035255)
Lamellipodium
(GO:0030027)
Lysosomal membrane
(GO:0005765)
Melanosome
(GO:0042470)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Microtubule organizing center
(GO:0005815)
Plasma membrane
(GO:0005886)
Plasma membrane raft assembly
(GO:0044854)
Plasma membrane raft organization
(GO:0044857)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell-cell adhesion mediated by cadherin
(GO:2000049)
Positive regulation of cell junction assembly
(GO:1901890)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of myoblast fusion
(GO:1901741)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of skeletal muscle tissue development
(GO:0048643)
Positive regulation of synaptic transmission, dopaminergic
(GO:0032226)
Positive regulation of toll-like receptor 3 signaling pathway
(GO:0034141)
Presynaptic active zone
(GO:0048786)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein kinase c signaling
(GO:0070528)
Protein localization to plasma membrane
(GO:0072659)
Protein stabilization
(GO:0050821)
Regulation of neurotransmitter uptake
(GO:0051580)
Regulation of receptor internalization
(GO:0002090)
Regulation of rho protein signal transduction
(GO:0035023)
Regulation of toll-like receptor 4 signaling pathway
(GO:0034143)
Response to endoplasmic reticulum stress
(GO:0034976)
Sarcolemma
(GO:0042383)
Uropod
(GO:0001931)

Other Information

Proteins

Flotillin-1

Genular Protein ID: 1555149171

Symbol: FLOT1_HUMAN

Name: Flotillin-1

UniProtKB Accession Codes:

O75955 B4DVY7 Q969J8 Q9UHW1 Q9UNV8

Database IDs:

Citations:

PubMed ID: 11167132

Title: Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals.

PubMed ID: 11167132

DOI: 10.1016/s1357-2725(00)00069-8

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25893292

Title: Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.

PubMed ID: 25893292

DOI: 10.1038/onc.2015.100

Sequence Information:

Length: 427
Mass: 47355
Checksum: C69E5421E565F53A
Sequence:

MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG 
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI 
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE 
AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL 
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA 
EKSQLIMQAE AEAASVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK 
LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI LTRLPESVER LTGVSISQVN 
HKPLRTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FLOT1

Associated with

Other Information

Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. PubMed ID: 11167132

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. PubMed ID: 10931946

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. PubMed ID: 20682791

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization. PubMed ID: 25893292