Genular: Defining Cellular Identity and Function

Details for: PSMD14

Gene ID: 10213

Symbol: PSMD14

Ensembl ID: ENSG00000115233

Description: proteasome 26S subunit, non-ATPase 14

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.54
Marker Score: 2,647
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.88
Marker Score: 7,384
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.74
Marker Score: 641
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.72
Marker Score: 105,918
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.69
Marker Score: 1,697
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.67
Marker Score: 17,243
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.66
Marker Score: 15,780
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.64
Marker Score: 15,428
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.62
Marker Score: 1,954
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.62
Marker Score: 13,894
Cell Name: neuron (CL0000540)
Fold Change: 1.62
Marker Score: 6,580
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.58
Marker Score: 12,087
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.58
Marker Score: 3,292
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.57
Marker Score: 13,497
Cell Name: osteoclast (CL0000092)
Fold Change: 1.55
Marker Score: 770
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.54
Marker Score: 2,214
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.54
Marker Score: 58,317
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.53
Marker Score: 5,919
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.52
Marker Score: 22,778
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.52
Marker Score: 529
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.51
Marker Score: 5,603
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.51
Marker Score: 4,113
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.5
Marker Score: 29,740
Cell Name: male germ cell (CL0000015)
Fold Change: 1.48
Marker Score: 427
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.48
Marker Score: 54,630
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.48
Marker Score: 37,818
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.48
Marker Score: 6,040
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.46
Marker Score: 991
Cell Name: plasmablast (CL0000980)
Fold Change: 1.46
Marker Score: 1,940
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.45
Marker Score: 1,531
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.45
Marker Score: 1,361
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.44
Marker Score: 2,444
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.41
Marker Score: 5,840
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.4
Marker Score: 2,168
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.39
Marker Score: 3,421
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.39
Marker Score: 493
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.39
Marker Score: 1,481
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.38
Marker Score: 6,771
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.37
Marker Score: 29,327
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.37
Marker Score: 24,299
Cell Name: decidual cell (CL2000002)
Fold Change: 1.37
Marker Score: 5,897
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.35
Marker Score: 566
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.34
Marker Score: 1,977
Cell Name: oocyte (CL0000023)
Fold Change: 1.33
Marker Score: 329
Cell Name: Unknown (CL0000548)
Fold Change: 1.33
Marker Score: 969
Cell Name: kidney cell (CL1000497)
Fold Change: 1.32
Marker Score: 879
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.31
Marker Score: 2,669
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.31
Marker Score: 828
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.31
Marker Score: 721
Cell Name: basal cell (CL0000646)
Fold Change: 1.31
Marker Score: 1,690
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.29
Marker Score: 1,620
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.29
Marker Score: 44,626
Cell Name: erythroblast (CL0000765)
Fold Change: 1.29
Marker Score: 803
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.27
Marker Score: 1,057
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 1.26
Marker Score: 378
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.26
Marker Score: 1,323
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.23
Marker Score: 842
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.23
Marker Score: 644
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.23
Marker Score: 367
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.23
Marker Score: 3,650
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.23
Marker Score: 9,594
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.22
Marker Score: 591
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.22
Marker Score: 2,771
Cell Name: stem cell (CL0000034)
Fold Change: 1.21
Marker Score: 2,877
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.21
Marker Score: 905
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.2
Marker Score: 491
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.2
Marker Score: 287
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.2
Marker Score: 484
Cell Name: stromal cell (CL0000499)
Fold Change: 1.2
Marker Score: 1,404
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.2
Marker Score: 1,926
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.2
Marker Score: 1,345
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2
Marker Score: 40,745
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.19
Marker Score: 1,690
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.19
Marker Score: 7,631
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.19
Marker Score: 13,414
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 1.17
Marker Score: 373
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.16
Marker Score: 2,062
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.16
Marker Score: 1,848
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.16
Marker Score: 729
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.16
Marker Score: 1,066
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.15
Marker Score: 3,124
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.14
Marker Score: 600
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.14
Marker Score: 1,141
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.13
Marker Score: 327
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.13
Marker Score: 583
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.13
Marker Score: 552
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.13
Marker Score: 1,869
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.13
Marker Score: 1,006
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.12
Marker Score: 246
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.12
Marker Score: 1,194
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.11
Marker Score: 2,611
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.11
Marker Score: 631
Cell Name: PP cell (CL0000696)
Fold Change: 1.11
Marker Score: 249
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.1
Marker Score: 312
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.1
Marker Score: 585
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.1
Marker Score: 458
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.09
Marker Score: 2,618
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.09
Marker Score: 2,400
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.09
Marker Score: 256
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.09
Marker Score: 9,460

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** 1. **Proteasome subunit**: PSMD14 is a non-ATPase subunit of the 26S proteasome, which is composed of two subunits: the 19S regulatory subunit and the 20S catalytic subunit. 2. **Degradation of proteins**: PSMD14 is involved in the degradation of proteins that are marked for degradation by ubiquitin, a small protein that tags proteins for proteasomal degradation. 3. **Antigen processing**: The 26S proteasome, including PSMD14, plays a crucial role in the processing of antigens for presentation to the immune system. 4. **Cell cycle regulation**: The proteasome, including PSMD14, regulates the cell cycle by degrading proteins that promote cell cycle progression. **Pathways and Functions** 1. **Protein degradation**: PSMD14 is involved in the degradation of proteins that are marked for degradation by ubiquitin. 2. **Antigen processing**: The 26S proteasome, including PSMD14, processes antigens for presentation to the immune system. 3. **Cell cycle regulation**: The proteasome, including PSMD14, regulates the cell cycle by degrading proteins that promote cell cycle progression. 4. **Apoptosis**: The proteasome, including PSMD14, is involved in the regulation of apoptosis (programmed cell death) by degrading proteins that promote cell survival. 5. **Immune system**: PSMD14 is involved in the regulation of the immune system by processing antigens for presentation to T-cells. **Clinical Significance** 1. **Cancer**: Mutations in the PSMD14 gene have been associated with various types of cancer, including leukemia and lymphoma. 2. **Immunodeficiency**: Defects in the PSMD14 gene have been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 3. **Neurological disorders**: PSMD14 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: The proteasome, including PSMD14, plays a critical role in the regulation of the immune response to viral infections. In conclusion, PSMD14 is a critical component of the 26S proteasome, playing a central role in various cellular processes, including protein degradation, antigen processing, and cell cycle regulation. Its dysregulation has been implicated in various diseases, including cancer, immunodeficiency, and neurological disorders. Further research is needed to fully understand the role of PSMD14 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 14

Genular Protein ID: 3310672622

Symbol: PSDE_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 14

UniProtKB Accession Codes:

O00487 B3KNW2 O00176

Database IDs:

Citations:

PubMed ID: 9374539

Title: Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit.

PubMed ID: 9374539

DOI: 10.1074/jbc.272.48.30470

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 19214193

Title: K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.

PubMed ID: 19214193

DOI: 10.1038/emboj.2009.27

PubMed ID: 19349277

Title: Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome.

PubMed ID: 19349277

DOI: 10.1074/jbc.m900016200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22909820

Title: The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

PubMed ID: 22909820

DOI: 10.1038/emboj.2012.232

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 310
Mass: 34577
Checksum: 18ACE876C7682039
Sequence:

MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP MEVMGLMLGE 
FVDDYTVRVI DVFAMPQSGT GVSVEAVDPV FQAKMLDMLK QTGRPEMVVG WYHSHPGFGC 
WLSGVDINTQ QSFEALSERA VAVVVDPIQS VKGKVVIDAF RLINANMMVL GHEPRQTTSN 
LGHLNKPSIQ ALIHGLNRHY YSITINYRKN ELEQKMLLNL HKKSWMEGLT LQDYSEHCKH 
NESVVKEMLE LAKNYNKAVE EEDKMTPEQL AIKNVGKQDP KRHLEEHVDV LMTSNIVQCL 
AAMLDTVVFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMD14

Associated with

Cells (max top 100)

Other Information

Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. PubMed ID: 9374539

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. PubMed ID: 17693683

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. PubMed ID: 19214193

Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. PubMed ID: 19349277

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response. PubMed ID: 22909820

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858