Details for: SSX3

Gene ID: 10214

Symbol: SSX3

Ensembl ID: ENSG00000165584

Description: SSX family member 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.14
    Marker Score: 3,692
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.97
    Marker Score: 2,196
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,213
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.97
    Marker Score: 311
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,334
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.92
    Marker Score: 537
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1,458
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.83
    Marker Score: 381
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 703
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 549
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 185
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.59
    Marker Score: 185
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.57
    Marker Score: 182
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.5
    Marker Score: 182
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.49
    Marker Score: 182
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 910
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.46
    Marker Score: 133
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 388
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.42
    Marker Score: 170
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 762
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.35
    Marker Score: 239
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.31
    Marker Score: 163
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.3
    Marker Score: 183
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3
    Marker Score: 385
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.29
    Marker Score: 184
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.28
    Marker Score: 187
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.27
    Marker Score: 184
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.27
    Marker Score: 184
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 123
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.23
    Marker Score: 177
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.22
    Marker Score: 3,455
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.21
    Marker Score: 184
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 240
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.17
    Marker Score: 185
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.17
    Marker Score: 174
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.15
    Marker Score: 157
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.14
    Marker Score: 850
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.14
    Marker Score: 179
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 151
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.14
    Marker Score: 170
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.13
    Marker Score: 180
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.11
    Marker Score: 385
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 453
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.11
    Marker Score: 155
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1
    Marker Score: 181
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.1
    Marker Score: 164
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1
    Marker Score: 349
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.1
    Marker Score: 237
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 185
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.09
    Marker Score: 183
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.07
    Marker Score: 179
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 118
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 150
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.06
    Marker Score: 173
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.06
    Marker Score: 240
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.05
    Marker Score: 141
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.05
    Marker Score: 182
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.04
    Marker Score: 176
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.04
    Marker Score: 389
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.04
    Marker Score: 184
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.03
    Marker Score: 185
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.02
    Marker Score: 292
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.02
    Marker Score: 182
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.02
    Marker Score: 183
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.02
    Marker Score: 182
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.01
    Marker Score: 185
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.01
    Marker Score: 181
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.01
    Marker Score: 175
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 185
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 175
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 220
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 163
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 95
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 185

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSX3 is a transcriptional regulator that belongs to the SSX family of genes, which are known to be involved in the regulation of cellular development and differentiation. The gene is characterized by its ability to bind to specific DNA sequences and regulate the expression of target genes involved in transcriptional processes. SSX3 has been shown to interact with various proteins, including transcription factors and chromatin-modifying enzymes, to regulate gene expression. The gene's expression in multiple cell types suggests its role in cellular differentiation and development. **Pathways and Functions:** SSX3 is involved in several key pathways, including: 1. **Regulation of DNA-templated transcription**: SSX3 regulates the expression of genes involved in transcriptional processes, including the regulation of chromatin structure and the recruitment of transcriptional machinery. 2. **Protein binding**: SSX3 interacts with various proteins, including transcription factors and chromatin-modifying enzymes, to regulate gene expression. 3. **Nucleus-related processes**: SSX3 is involved in the regulation of nuclear processes, including DNA replication and repair, and the maintenance of genome stability. **Clinical Significance:** The SSX3 gene has been implicated in various pathologies, including: 1. **Cancer**: SSX3 has been identified as a tumor suppressor gene in several types of cancer, including leukemia and lymphoma. 2. **Autoimmune diseases**: SSX3 has been implicated in autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, where it is thought to play a role in the regulation of immune cell function. 3. **Genetic disorders**: SSX3 has been associated with genetic disorders, including cancer and autoimmune diseases, where it is thought to play a role in the regulation of cellular development and differentiation. In conclusion, SSX3 is a critical gene involved in the regulation of immune cell function and development. Its expression in multiple cell types and its involvement in various pathways, including transcriptional regulation and protein binding, suggest its role in maintaining genome stability and preventing disease. Further research is needed to fully understand the function of SSX3 and its role in human disease.

Genular Protein ID: 3088231256

Symbol: SSX3_HUMAN

Name: Protein SSX3

UniProtKB Accession Codes:

Q99909 O60223 Q5JQZ3 Q9BRW7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8697803

Title: A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas.

PubMed ID: 8697803

DOI: 10.1159/000134334

PubMed ID: 9378559

Title: SSX: a multigene family with several members transcribed in normal testis and human cancer.

PubMed ID: 9378559

DOI: 10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12007189

Title: The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.

PubMed ID: 12007189

DOI: 10.1002/gcc.10073

Sequence Information:

  • Length: 188
  • Mass: 21697
  • Checksum: 988294793159C36E
  • Sequence:
    • MNGDDTFARR PTVGAQIPEK IQKAFDDIAK YFSKEEWEKM KVSEKIVYVY MKRKYEAMTK 
LGFKAILPSF MRNKRVTDFQ GNDFDNDPNR GNQVQRPQMT FGRLQGIFPK IMPKKPAEEG 
NVSKEVPEAS GPQNDGKQLC PPGKPTTSEK INMISGPKRG EHAWTHRLRE RKQLVIYEEI 
SDPEEDDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.