Details for: ANGPTL7

Gene ID: 10218

Symbol: ANGPTL7

Ensembl ID: ENSG00000171819

Description: angiopoietin like 7

Associated with

  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of vasculature development involved in avascular cornea development in camera-type eye
    (GO:1901346)
  • Protein binding
    (GO:0005515)
  • Regulation of extracellular matrix organization
    (GO:1903053)
  • Response to oxidative stress
    (GO:0006979)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.29
    Marker Score: 15676.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.66
    Marker Score: 30986.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.61
    Marker Score: 7501.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1517
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.55
    Marker Score: 2933
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2563
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15333.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1879
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.74
    Marker Score: 442
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.68
    Marker Score: 157
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.63
    Marker Score: 1373
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 224
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 238
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.48
    Marker Score: 1003
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.42
    Marker Score: 465
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.35
    Marker Score: 142
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.28
    Marker Score: 68
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.22
    Marker Score: 105
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 116
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2
    Marker Score: 2720
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 117
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.18
    Marker Score: 1070
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.18
    Marker Score: 170
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.15
    Marker Score: 53
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 129
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 78
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.14
    Marker Score: 154
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.14
    Marker Score: 165
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 158
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.13
    Marker Score: 154
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.12
    Marker Score: 152
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 144
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.11
    Marker Score: 154
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1
    Marker Score: 409
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 230
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 175
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.09
    Marker Score: 132
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.09
    Marker Score: 229
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.08
    Marker Score: 125
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.08
    Marker Score: 800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.08
    Marker Score: 591
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.07
    Marker Score: 88
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.07
    Marker Score: 172
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.07
    Marker Score: 104.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.06
    Marker Score: 107
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.06
    Marker Score: 123
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 18

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Other Information

**Key characteristics:** * ANGPTL7 is a secreted protein that is expressed in high levels in the cornea, lens, and vitreous humor of the eye. * It is a member of the Angiopoietin family of proteins, which are involved in the regulation of blood vessel formation. * ANGPTL7 is known to interact with a number of proteins involved in the ECM, including collagen, proteoglycans, and fibronectin. * It is also involved in the regulation of cell migration and differentiation. **Pathways and functions:** * ANGPTL7 is involved in the development of the corneal and lens tissue in the eye. * It is essential for the formation of the avascular cornea, which is a clear, dome-shaped structure that covers the front of the eye. * ANGPTL7 is also involved in the maintenance of the ECM in the eye. * It helps to protect the eye from damage by oxidative stress. * It also plays a role in the regulation of blood-brain barrier function. **Clinical significance:** * Mutations in ANGPTL7 have been linked to a number of eye diseases, including corneal dystrophy, glaucoma, and age-related macular degeneration. * Studies of ANGPTL7 knockout mice have shown that they have a number of eye abnormalities, including a clear cornea, a discolored lens, and a high risk of age-related macular degeneration. * Thus, ANGPTL7 is a promising target for the treatment of eye diseases.

Genular Protein ID: 2388351037

Symbol: ANGL7_HUMAN

Name: Angiopoietin-related protein 7

UniProtKB Accession Codes:

O43827 B2R9B2 F1T0A6 Q4ZGK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9727400

Title: Molecular cloning of a new angiopoietin-like factor from the human cornea.

PubMed ID: 9727400

PubMed ID: 11426320

Title: The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.

PubMed ID: 11426320

DOI: 10.1038/sj.gene.6363745

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11682471

Title: The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea.

PubMed ID: 11682471

DOI: 10.1074/jbc.m105746200

PubMed ID: 16541013

Title: Gene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure.

PubMed ID: 16541013

PubMed ID: 21199193

Title: Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma.

PubMed ID: 21199193

DOI: 10.1111/j.1365-2443.2010.01483.x

PubMed ID: 25622036

Title: Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea.

PubMed ID: 25622036

DOI: 10.1371/journal.pone.0116838

Sequence Information:

  • Length: 346
  • Mass: 40018
  • Checksum: AEC0A601CC498B43
  • Sequence:
    • MLKKPLSAVT WLCIFIVAFV SHPAWLQKLS KHKTPAQPQL KAANCCEEVK ELKAQVANLS 
SLLSELNKKQ ERDWVSVVMQ VMELESNSKR MESRLTDAES KYSEMNNQID IMQLQAAQTV 
TQTSADAIYD CSSLYQKNYR ISGVYKLPPD DFLGSPELEV FCDMETSGGG WTIIQRRKSG 
LVSFYRDWKQ YKQGFGSIRG DFWLGNEHIH RLSRQPTRLR VEMEDWEGNL RYAEYSHFVL 
GNELNSYRLF LGNYTGNVGN DALQYHNNTA FSTKDKDNDN CLDKCAQLRK GGYWYNCCTD 
SNLNGVYYRL GEHNKHLDGI TWYGWHGSTY SLKRVEMKIR PEDFKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.