Details for: ANGPTL7

Gene ID: 10218

Symbol: ANGPTL7

Ensembl ID: ENSG00000171819

Description: angiopoietin like 7

Associated with

  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of vasculature development involved in avascular cornea development in camera-type eye
    (GO:1901346)
  • Protein binding
    (GO:0005515)
  • Regulation of extracellular matrix organization
    (GO:1903053)
  • Response to oxidative stress
    (GO:0006979)

Other Information

Genular Protein ID: 2388351037

Symbol: ANGL7_HUMAN

Name: Angiopoietin-related protein 7

UniProtKB Accession Codes:

O43827 B2R9B2 F1T0A6 Q4ZGK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9727400

Title: Molecular cloning of a new angiopoietin-like factor from the human cornea.

PubMed ID: 9727400

PubMed ID: 11426320

Title: The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.

PubMed ID: 11426320

DOI: 10.1038/sj.gene.6363745

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11682471

Title: The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea.

PubMed ID: 11682471

DOI: 10.1074/jbc.m105746200

PubMed ID: 16541013

Title: Gene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure.

PubMed ID: 16541013

PubMed ID: 21199193

Title: Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma.

PubMed ID: 21199193

DOI: 10.1111/j.1365-2443.2010.01483.x

PubMed ID: 25622036

Title: Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea.

PubMed ID: 25622036

DOI: 10.1371/journal.pone.0116838

Sequence Information:

  • Length: 346
  • Mass: 40018
  • Checksum: AEC0A601CC498B43
  • Sequence:
    • MLKKPLSAVT WLCIFIVAFV SHPAWLQKLS KHKTPAQPQL KAANCCEEVK ELKAQVANLS 
SLLSELNKKQ ERDWVSVVMQ VMELESNSKR MESRLTDAES KYSEMNNQID IMQLQAAQTV 
TQTSADAIYD CSSLYQKNYR ISGVYKLPPD DFLGSPELEV FCDMETSGGG WTIIQRRKSG 
LVSFYRDWKQ YKQGFGSIRG DFWLGNEHIH RLSRQPTRLR VEMEDWEGNL RYAEYSHFVL 
GNELNSYRLF LGNYTGNVGN DALQYHNNTA FSTKDKDNDN CLDKCAQLRK GGYWYNCCTD 
SNLNGVYYRL GEHNKHLDGI TWYGWHGSTY SLKRVEMKIR PEDFKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.