Details for: CDK7

Gene ID: 1022

Symbol: CDK7

Ensembl ID: ENSG00000134058

Description: cyclin dependent kinase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.6010
    Cell Significance Index: -19.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.4639
    Cell Significance Index: -18.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.8795
    Cell Significance Index: -22.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.4300
    Cell Significance Index: -18.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.7396
    Cell Significance Index: -22.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.0837
    Cell Significance Index: -18.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3347
    Cell Significance Index: -20.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4360
    Cell Significance Index: -19.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2483
    Cell Significance Index: -20.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5711
    Cell Significance Index: -14.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5045
    Cell Significance Index: -7.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1667
    Cell Significance Index: 412.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1325
    Cell Significance Index: 56.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1163
    Cell Significance Index: 110.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0623
    Cell Significance Index: 959.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9828
    Cell Significance Index: 13.9900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9089
    Cell Significance Index: 14.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9015
    Cell Significance Index: 12.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8256
    Cell Significance Index: 89.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8226
    Cell Significance Index: 165.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7141
    Cell Significance Index: 116.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6769
    Cell Significance Index: 134.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6565
    Cell Significance Index: 17.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5588
    Cell Significance Index: 29.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4877
    Cell Significance Index: 3.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4524
    Cell Significance Index: 17.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4237
    Cell Significance Index: 11.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4234
    Cell Significance Index: 18.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4146
    Cell Significance Index: 28.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3576
    Cell Significance Index: 7.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3346
    Cell Significance Index: 8.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3098
    Cell Significance Index: 111.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2916
    Cell Significance Index: 159.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2865
    Cell Significance Index: 18.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2858
    Cell Significance Index: 126.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2843
    Cell Significance Index: 6.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2672
    Cell Significance Index: 12.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2591
    Cell Significance Index: 179.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2497
    Cell Significance Index: 11.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2331
    Cell Significance Index: 30.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1795
    Cell Significance Index: 13.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1765
    Cell Significance Index: 21.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1647
    Cell Significance Index: 8.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1508
    Cell Significance Index: 27.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1402
    Cell Significance Index: 10.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1365
    Cell Significance Index: 7.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1223
    Cell Significance Index: 8.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1154
    Cell Significance Index: 5.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0800
    Cell Significance Index: 10.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0696
    Cell Significance Index: 11.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0638
    Cell Significance Index: 7.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0273
    Cell Significance Index: 51.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0231
    Cell Significance Index: 0.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0190
    Cell Significance Index: 29.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0177
    Cell Significance Index: 24.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0152
    Cell Significance Index: 0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0151
    Cell Significance Index: 27.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0139
    Cell Significance Index: 0.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0059
    Cell Significance Index: 0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0058
    Cell Significance Index: 3.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0043
    Cell Significance Index: 0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0176
    Cell Significance Index: -13.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0229
    Cell Significance Index: -1.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0290
    Cell Significance Index: -4.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0320
    Cell Significance Index: -18.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0374
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0393
    Cell Significance Index: -24.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0403
    Cell Significance Index: -4.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0440
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0450
    Cell Significance Index: -5.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0735
    Cell Significance Index: -21.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0840
    Cell Significance Index: -9.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0951
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1024
    Cell Significance Index: -21.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1094
    Cell Significance Index: -3.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1341
    Cell Significance Index: -4.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1417
    Cell Significance Index: -2.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1447
    Cell Significance Index: -1.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1730
    Cell Significance Index: -4.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1774
    Cell Significance Index: -18.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1783
    Cell Significance Index: -9.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1931
    Cell Significance Index: -5.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2000
    Cell Significance Index: -5.0000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2137
    Cell Significance Index: -3.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2174
    Cell Significance Index: -2.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2256
    Cell Significance Index: -17.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2498
    Cell Significance Index: -4.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2601
    Cell Significance Index: -7.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2761
    Cell Significance Index: -16.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2764
    Cell Significance Index: -4.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2814
    Cell Significance Index: -6.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2842
    Cell Significance Index: -7.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3053
    Cell Significance Index: -6.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3156
    Cell Significance Index: -10.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3189
    Cell Significance Index: -10.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3531
    Cell Significance Index: -7.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Cycle Regulation:** CDK7 is essential for the G1/S transition and the G2/M transition of the cell cycle. It phosphorylates and activates cyclin-dependent kinases, which in turn drive the cell cycle forward. 2. **DNA Repair:** CDK7 has been shown to regulate the activity of DNA repair enzymes, such as ERCC2, and is involved in the repair of DNA damage. 3. **Transcriptional Regulation:** CDK7 phosphorylates and activates transcription factors, such as TFIIH, which in turn regulate the expression of genes involved in cell cycle progression, DNA repair, and transcription. 4. **Cyclin-Dependent Kinase Activating Kinase (CAK) Complex:** CDK7 is a component of the CAK complex, which phosphorylates and activates CDK2, leading to the progression of the cell cycle. **Pathways and Functions:** 1. **Cell Cycle Regulation:** CDK7 regulates the G1/S transition by phosphorylating and activating cyclin-dependent kinases, leading to the progression of the cell cycle. 2. **DNA Repair:** CDK7 regulates the activity of DNA repair enzymes, such as ERCC2, and is involved in the repair of DNA damage. 3. **Transcriptional Regulation:** CDK7 phosphorylates and activates transcription factors, such as TFIIH, which in turn regulate the expression of genes involved in cell cycle progression, DNA repair, and transcription. 4. **Cyclin-Dependent Kinase Activity:** CDK7 phosphorylates and activates cyclin-dependent kinases, leading to the progression of the cell cycle. **Clinical Significance:** 1. **Cancer:** CDK7 has been implicated in the pathogenesis of various cancers, including breast, lung, and colon cancer, where it is often overexpressed or mutated. 2. **DNA Repair Deficiencies:** CDK7 has been linked to DNA repair deficiencies, such as Xeroderma pigmentosum, where it is essential for the repair of DNA damage. 3. **Transcriptional Dysregulation:** CDK7 dysregulation has been implicated in various transcriptional dysregulation disorders, including cancer and neurodegenerative diseases. 4. **Therapeutic Targeting:** CDK7 has emerged as a promising therapeutic target for the treatment of various diseases, including cancer, where it can be inhibited to prevent cancer cell proliferation. In conclusion, CDK7 is a crucial regulator of the cell cycle, DNA repair, and transcription, and its dysregulation has been linked to various diseases, including cancer. Further research is needed to fully understand the mechanisms by which CDK7 regulates these cellular processes and to develop effective therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 3578933109

Symbol: CDK7_HUMAN

Name: Cyclin-dependent kinase 7

UniProtKB Accession Codes:

P50613 Q9BS60 Q9UE19

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 4 EMBL 8 EMDB 74 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 34 RefSeq 5 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929589

Title: Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

PubMed ID: 7929589

DOI: 10.1083/jcb.127.2.467

PubMed ID: 8208544

Title: Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.

PubMed ID: 8208544

PubMed ID: 7936635

Title: Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase.

PubMed ID: 7936635

PubMed ID: 8208556

Title: Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase.

PubMed ID: 8208556

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8069918

Title: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.

PubMed ID: 8069918

DOI: 10.1016/0092-8674(94)90535-5

PubMed ID: 9372954

Title: p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.

PubMed ID: 9372954

DOI: 10.1128/mcb.17.12.7220

PubMed ID: 9832506

Title: The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.

PubMed ID: 9832506

DOI: 10.1101/gad.12.22.3541

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 9840937

Title: Regulation of CAK kinase activity by p53.

PubMed ID: 9840937

DOI: 10.1038/sj.onc.1202504

PubMed ID: 10024882

Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

PubMed ID: 10024882

DOI: 10.1016/s1097-2765(00)80177-x

PubMed ID: 10958787

Title: Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.

PubMed ID: 10958787

DOI: 10.1074/jbc.c000505200

PubMed ID: 10882074

Title: The FBP interacting repressor targets TFIIH to inhibit activated transcription.

PubMed ID: 10882074

DOI: 10.1016/s1097-2765(00)80428-1

PubMed ID: 11113184

Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.

PubMed ID: 11113184

DOI: 10.1128/mcb.21.1.88-99.2001

PubMed ID: 15695176

Title: Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells.

PubMed ID: 15695176

DOI: 10.1016/j.tice.2004.10.004

PubMed ID: 16327805

Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

PubMed ID: 16327805

DOI: 10.1038/nsmb1028

PubMed ID: 17386261

Title: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.

PubMed ID: 17386261

DOI: 10.1016/j.molcel.2007.02.003

PubMed ID: 17373709

Title: Recognition of Cdk2 by Cdk7.

PubMed ID: 17373709

DOI: 10.1002/prot.21370

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 17901130

Title: Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7.

PubMed ID: 17901130

DOI: 10.1210/me.2006-0478

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19450536

Title: TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.

PubMed ID: 19450536

DOI: 10.1016/j.molcel.2009.04.016

PubMed ID: 19015234

Title: SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.

PubMed ID: 19015234

DOI: 10.1128/mcb.00295-08

PubMed ID: 19667075

Title: TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.

PubMed ID: 19667075

DOI: 10.1128/mcb.00637-09

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19136461

Title: Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.

PubMed ID: 19136461

DOI: 10.1093/nar/gkn1061

PubMed ID: 19071173

Title: DNA-Bound peptides control the mRNA transcription through CDK7.

PubMed ID: 19071173

DOI: 10.1016/j.peptides.2008.11.008

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20360007

Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

PubMed ID: 20360007

DOI: 10.1074/jbc.m109.096552

PubMed ID: 19911397

Title: R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis.

PubMed ID: 19911397

DOI: 10.1002/jcb.22400

PubMed ID: 15876871

Title: CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

PubMed ID: 15876871

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21592869

Title: A history of TFIIH: Two decades of molecular biology on a pivotal transcription/repair factor.

PubMed ID: 21592869

DOI: 10.1016/j.dnarep.2011.04.021

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15530371

Title: The crystal structure of human CDK7 and its protein recognition properties.

PubMed ID: 15530371

DOI: 10.1016/j.str.2004.08.013

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 346
  • Mass: 39038
  • Checksum: 0A94BFA7DD416CEB
  • Sequence:
    • MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 
REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 
TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA 
PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 
CSLPDYVTFK SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG 
PTPGCQLPRP NCPVETLKEQ SNPALAIKRK RTEALEQGGL PKKLIF

Genular Protein ID: 3232861602

Symbol: D6R9G1_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6R9G1

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 3 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 5 Rhea 3 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 253
  • Mass: 28502
  • Checksum: 35EFFEE96644F414
  • Sequence:
    • METDLEVIIK DNSLVLTPSH IKAYMLMTLQ GLEYLHQHWI LHRDLKPNNL LLDENGVLKL 
ADFGLAKSFG SPNRAYTHQV VTRWYRAPEL LFGARMYGVG VDMWAVGCIL AELLLRVPFL 
PGDSDLDQLT RIFETLGTPT EEQWPDMCSL PDYVTFKSFP GIPLHHIFSA AGDDLLDLIQ 
GLFLFNPCAR ITATQALKMK YFSNRPGPTP GCQLPRPNCP VETLKEQSNP ALAIKRKRTE 
ALEQGGLPKK LIF

Genular Protein ID: 1461964437

Symbol: D6RFL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RFL0

Database IDs:

Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 2 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 43
  • Mass: 4945
  • Checksum: 9C40CB3CED87CE53
  • Sequence:
    • MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.