Details for: CDK7

Gene ID: 1022

Symbol: CDK7

Ensembl ID: ENSG00000134058

Description: cyclin dependent kinase 7

Associated with

Other Information

Genular Protein ID: 3578933109

Symbol: CDK7_HUMAN

Name: Cyclin-dependent kinase 7

UniProtKB Accession Codes:

P50613 Q9BS60 Q9UE19

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 4 EMBL 8 EMDB 54 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 20 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 34 RefSeq 5 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929589

Title: Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

PubMed ID: 7929589

DOI: 10.1083/jcb.127.2.467

PubMed ID: 8208544

Title: Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.

PubMed ID: 8208544

PubMed ID: 7936635

Title: Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase.

PubMed ID: 7936635

PubMed ID: 8208556

Title: Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase.

PubMed ID: 8208556

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8069918

Title: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.

PubMed ID: 8069918

DOI: 10.1016/0092-8674(94)90535-5

PubMed ID: 9372954

Title: p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.

PubMed ID: 9372954

DOI: 10.1128/mcb.17.12.7220

PubMed ID: 9832506

Title: The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.

PubMed ID: 9832506

DOI: 10.1101/gad.12.22.3541

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 9840937

Title: Regulation of CAK kinase activity by p53.

PubMed ID: 9840937

DOI: 10.1038/sj.onc.1202504

PubMed ID: 10024882

Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

PubMed ID: 10024882

DOI: 10.1016/s1097-2765(00)80177-x

PubMed ID: 10958787

Title: Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.

PubMed ID: 10958787

DOI: 10.1074/jbc.c000505200

PubMed ID: 10882074

Title: The FBP interacting repressor targets TFIIH to inhibit activated transcription.

PubMed ID: 10882074

DOI: 10.1016/s1097-2765(00)80428-1

PubMed ID: 11113184

Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.

PubMed ID: 11113184

DOI: 10.1128/mcb.21.1.88-99.2001

PubMed ID: 15695176

Title: Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells.

PubMed ID: 15695176

DOI: 10.1016/j.tice.2004.10.004

PubMed ID: 16327805

Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

PubMed ID: 16327805

DOI: 10.1038/nsmb1028

PubMed ID: 17386261

Title: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.

PubMed ID: 17386261

DOI: 10.1016/j.molcel.2007.02.003

PubMed ID: 17373709

Title: Recognition of Cdk2 by Cdk7.

PubMed ID: 17373709

DOI: 10.1002/prot.21370

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 17901130

Title: Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7.

PubMed ID: 17901130

DOI: 10.1210/me.2006-0478

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19450536

Title: TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.

PubMed ID: 19450536

DOI: 10.1016/j.molcel.2009.04.016

PubMed ID: 19015234

Title: SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.

PubMed ID: 19015234

DOI: 10.1128/mcb.00295-08

PubMed ID: 19667075

Title: TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.

PubMed ID: 19667075

DOI: 10.1128/mcb.00637-09

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19136461

Title: Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.

PubMed ID: 19136461

DOI: 10.1093/nar/gkn1061

PubMed ID: 19071173

Title: DNA-Bound peptides control the mRNA transcription through CDK7.

PubMed ID: 19071173

DOI: 10.1016/j.peptides.2008.11.008

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20360007

Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

PubMed ID: 20360007

DOI: 10.1074/jbc.m109.096552

PubMed ID: 19911397

Title: R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis.

PubMed ID: 19911397

DOI: 10.1002/jcb.22400

PubMed ID: 15876871

Title: CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

PubMed ID: 15876871

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21592869

Title: A history of TFIIH: Two decades of molecular biology on a pivotal transcription/repair factor.

PubMed ID: 21592869

DOI: 10.1016/j.dnarep.2011.04.021

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15530371

Title: The crystal structure of human CDK7 and its protein recognition properties.

PubMed ID: 15530371

DOI: 10.1016/j.str.2004.08.013

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 346
  • Mass: 39038
  • Checksum: 0A94BFA7DD416CEB
  • Sequence:
    • MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 
REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 
TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA 
PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 
CSLPDYVTFK SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG 
PTPGCQLPRP NCPVETLKEQ SNPALAIKRK RTEALEQGGL PKKLIF

Genular Protein ID: 1461964437

Symbol: D6RFL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RFL0

Database IDs:

Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 4 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 3 PROSITE-ProRule 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 43
  • Mass: 4945
  • Checksum: 9C40CB3CED87CE53
  • Sequence:
    • MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKV

Genular Protein ID: 3232861602

Symbol: D6R9G1_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6R9G1

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 EPD 1 Ensembl 3 GO 8 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 3 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 5 Rhea 3 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 253
  • Mass: 28502
  • Checksum: 35EFFEE96644F414
  • Sequence:
    • METDLEVIIK DNSLVLTPSH IKAYMLMTLQ GLEYLHQHWI LHRDLKPNNL LLDENGVLKL 
ADFGLAKSFG SPNRAYTHQV VTRWYRAPEL LFGARMYGVG VDMWAVGCIL AELLLRVPFL 
PGDSDLDQLT RIFETLGTPT EEQWPDMCSL PDYVTFKSFP GIPLHHIFSA AGDDLLDLIQ 
GLFLFNPCAR ITATQALKMK YFSNRPGPTP GCQLPRPNCP VETLKEQSNP ALAIKRKRTE 
ALEQGGLPKK LIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.