TRIB1 | ENSG00000173334 | NCBI 10221

Details for: TRIB1

Gene ID: 10221

Symbol: TRIB1

Ensembl ID: ENSG00000173334

Description: tribbles pseudokinase 1

Associated with

Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Jnk cascade
(GO:0007254)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031665)
Negative regulation of neutrophil differentiation
(GO:0045659)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Nucleus
(GO:0005634)
Positive regulation of eosinophil differentiation
(GO:0045645)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase inhibitor activity
(GO:0004860)
Protein phosphorylation
(GO:0006468)
Regulation of map kinase activity
(GO:0043405)
Response to lipopolysaccharide
(GO:0032496)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Ubiquitin-protein transferase regulator activity
(GO:0055106)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Tribbles homolog 1

Genular Protein ID: 3790085091

Symbol: TRIB1_HUMAN

Name: Tribbles homolog 1

UniProtKB Accession Codes:

Q96RU8 B4DMM6 C5HU08 O15180 Q9H2Y8

Database IDs:

Citations:

PubMed ID: 15299019

Title: Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.

PubMed ID: 15299019

DOI: 10.1074/jbc.m407732200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9342215

Title: Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.

PubMed ID: 9342215

DOI: 10.1111/j.1432-1033.1997.t01-1-00660.x

PubMed ID: 20410507

Title: Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

PubMed ID: 20410507

DOI: 10.1182/blood-2009-07-229450

PubMed ID: 26455797

Title: Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase.

PubMed ID: 26455797

DOI: 10.1016/j.str.2015.08.017

PubMed ID: 27041596

Title: Structural basis for substrate selectivity of the E3 ligase COP1.

PubMed ID: 27041596

DOI: 10.1016/j.str.2016.03.002

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 372
Mass: 41009
Checksum: 5F54E50924B1365B
Sequence:

MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL SECSSPPDYL 
SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA EREHVSRALC IHTGRELRCK 
VFPIKHYQDK IRPYIQLPSH SNITGIVEVI LGETKAYVFF EKDFGDMHSY VRSRKRLREE 
EAARLFKQIV SAVAHCHQSA IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS 
DKHGCPAYVS PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ 
FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE IGTSDQIVPE 
YQEDSDISSF FC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIB1

Associated with

Other Information

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. PubMed ID: 15299019

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. PubMed ID: 9342215

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. PubMed ID: 20410507

Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase. PubMed ID: 26455797

Structural basis for substrate selectivity of the E3 ligase COP1. PubMed ID: 27041596

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846