Details for: PLIN3

Gene ID: 10226

Symbol: PLIN3

Ensembl ID: ENSG00000105355

Description: perilipin 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.13
    Marker Score: 1,453
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.05
    Marker Score: 8,399
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.05
    Marker Score: 36,318
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.98
    Marker Score: 20,107
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.93
    Marker Score: 16,596
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.87
    Marker Score: 14,585
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.86
    Marker Score: 7,307
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8
    Marker Score: 6,931
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.78
    Marker Score: 3,113
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.75
    Marker Score: 8,397
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.64
    Marker Score: 1,747
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.62
    Marker Score: 2,503
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.59
    Marker Score: 1,602
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.51
    Marker Score: 9,848
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.51
    Marker Score: 5,581
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5
    Marker Score: 15,112
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.49
    Marker Score: 1,076
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.46
    Marker Score: 2,595
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.46
    Marker Score: 4,593
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,220
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.45
    Marker Score: 1,562
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.44
    Marker Score: 8,562
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.44
    Marker Score: 16,752
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.43
    Marker Score: 1,527
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.43
    Marker Score: 49,449
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.41
    Marker Score: 2,081
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.38
    Marker Score: 77,060
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.37
    Marker Score: 1,883
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.36
    Marker Score: 972
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.35
    Marker Score: 771
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.35
    Marker Score: 3,674
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.34
    Marker Score: 454
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.34
    Marker Score: 2,799
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.33
    Marker Score: 426
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.32
    Marker Score: 884
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.31
    Marker Score: 528
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.31
    Marker Score: 414
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.3
    Marker Score: 1,539
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3
    Marker Score: 3,867
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.3
    Marker Score: 649
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.3
    Marker Score: 368
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.3
    Marker Score: 17,101
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.28
    Marker Score: 5,535
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.28
    Marker Score: 1,344
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.28
    Marker Score: 672
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.27
    Marker Score: 2,465
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.26
    Marker Score: 14,190
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.26
    Marker Score: 648
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.24
    Marker Score: 604
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.24
    Marker Score: 606
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.23
    Marker Score: 840
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.21
    Marker Score: 767
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.21
    Marker Score: 2,050
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.2
    Marker Score: 414
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.2
    Marker Score: 419
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.19
    Marker Score: 1,395
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.19
    Marker Score: 1,254
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.18
    Marker Score: 30,278
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.18
    Marker Score: 581
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.17
    Marker Score: 1,804
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.17
    Marker Score: 642
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.17
    Marker Score: 414
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.16
    Marker Score: 2,894
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.13
    Marker Score: 1,861
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.12
    Marker Score: 257
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.11
    Marker Score: 3,025
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.11
    Marker Score: 414
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.1
    Marker Score: 1,261
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.09
    Marker Score: 859
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.08
    Marker Score: 372
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.07
    Marker Score: 1,521
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.07
    Marker Score: 9,283
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.07
    Marker Score: 2,605
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.05
    Marker Score: 578
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.05
    Marker Score: 1,066
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.04
    Marker Score: 1,124
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.03
    Marker Score: 863
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34,851
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.01
    Marker Score: 236
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1
    Marker Score: 476
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1
    Marker Score: 1,253
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1
    Marker Score: 666
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,631
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,856
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.99
    Marker Score: 2,325
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,378
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.98
    Marker Score: 945
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.97
    Marker Score: 5,916
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.96
    Marker Score: 12,927
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.96
    Marker Score: 237
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.96
    Marker Score: 6,115
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.95
    Marker Score: 2,162
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.95
    Marker Score: 348
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.95
    Marker Score: 599
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.95
    Marker Score: 668
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.94
    Marker Score: 2,472
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,383
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.93
    Marker Score: 1,767
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.93
    Marker Score: 1,026
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.93
    Marker Score: 3,186

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLIN3 is a member of the perilipin family of proteins, which are known to regulate lipid droplet formation and lipid metabolism. PLIN3 is specifically expressed in various cell types, including adipocytes, immune cells, and epithelial cells. Its expression is regulated by multiple signaling pathways, including the mTORC1 and AMPK pathways, which highlight its role in metabolic regulation. PLIN3 is also known to interact with other proteins, such as lipase and phospholipase A2, to regulate lipid metabolism. **Pathways and Functions:** PLIN3 is involved in various lipid metabolism pathways, including: 1. **Lipid Droplet Formation**: PLIN3 regulates the formation of lipid droplets, which are essential for the storage of triglycerides in cells. 2. **Lipid Metabolism**: PLIN3 is involved in the regulation of triglyceride metabolism, including the breakdown and synthesis of triglycerides. 3. **Autophagy**: PLIN3 is also involved in autophagy, a cellular process for the degradation and recycling of damaged organelles and proteins. 4. **Chaperone Mediated Autophagy**: PLIN3 is involved in chaperone-mediated autophagy, a process that regulates the degradation of proteins and organelles. **Clinical Significance:** Dysregulation of PLIN3 has been implicated in various diseases, including: 1. **Obesity**: PLIN3 has been shown to play a role in the regulation of adiposity and obesity. 2. **Type 2 Diabetes**: PLIN3 has been implicated in the regulation of glucose metabolism and insulin sensitivity. 3. **Metabolic Syndrome**: PLIN3 has been shown to play a role in the regulation of lipid metabolism and insulin resistance. 4. **Cancer**: PLIN3 has been implicated in the regulation of lipid metabolism and autophagy in various types of cancer. In conclusion, PLIN3 is a critical regulator of lipid metabolism and autophagy, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of PLIN3 in lipid metabolism and autophagy, and to develop therapeutic strategies for the treatment of diseases associated with PLIN3 dysregulation. **References:** [Insert references to relevant studies and reviews on PLIN3] **Recommendations:** 1. Further research is needed to fully understand the role of PLIN3 in lipid metabolism and autophagy. 2. Studies should investigate the role of PLIN3 in various diseases, including obesity, type 2 diabetes, and cancer. 3. Therapeutic strategies should be developed to target PLIN3 and regulate lipid metabolism and autophagy. **Limitations:** This review highlights the current understanding of PLIN3 in lipid metabolism and autophagy. However, there are limitations to this review, including the lack of comprehensive data on PLIN3 expression and function in various cell types. Further research is needed to address these limitations and to fully understand the role of PLIN3 in lipid metabolism and autophagy.

Genular Protein ID: 4225095986

Symbol: PLIN3_HUMAN

Name: Perilipin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9590177

Title: TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking.

PubMed ID: 9590177

DOI: 10.1016/s0092-8674(00)81171-x

PubMed ID: 9874244

Title: Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants.

PubMed ID: 9874244

DOI: 10.1046/j.1432-1327.1998.2580752.x

PubMed ID: 10393528

Title: Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein.

PubMed ID: 10393528

DOI: 10.1159/000030062

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6856484

Title: Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17).

PubMed ID: 6856484

PubMed ID: 15545278

Title: Spatial integration of TIP47 and adipophilin in macrophage lipid bodies.

PubMed ID: 15545278

DOI: 10.1074/jbc.m407194200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26357594

Title: Perilipin-related protein regulates lipid metabolism in C. elegans.

PubMed ID: 26357594

DOI: 10.7717/peerj.1213

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34077757

Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

PubMed ID: 34077757

DOI: 10.1016/j.molcel.2021.05.005

Sequence Information:

  • Length: 434
  • Mass: 47075
  • Checksum: 67B2B9CDBC523043
  • Sequence:
  • MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC 
    DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD 
    TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR 
    LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG 
    SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM 
    WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ 
    QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP 
    FAPGITEKAP EEKK

Genular Protein ID: 3512293905

Symbol: A0A140VJN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 433
  • Mass: 46947
  • Checksum: 8716B72B11C7FE65
  • Sequence:
  • MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC 
    DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD 
    TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR 
    LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG 
    SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM 
    WLSWNQKQLQ GPEKEPPKPE VESRALTMFR DIAQQLQATC TSLGSSIQGL PTNVKDQVQQ 
    ARRQVEDLQA TFSSIHSFQD LSSSILAQSR ERVASAREAL DHMVEYVAQN TPVTWLVGPF 
    APGITEKAPE EKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.