COQ7 | ENSG00000167186 | NCBI 10229

Details for: COQ7

Gene ID: 10229

Symbol: COQ7

Ensembl ID: ENSG00000167186

Description: coenzyme Q7, hydroxylase

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of cofactors
(R-HSA-8978934)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Ubiquinol biosynthesis
(R-HSA-2142789)
3-demethoxyubiquinol 3-hydroxylase activity
(GO:0008682)
Chromosome
(GO:0005694)
Determination of adult lifespan
(GO:0008340)
Extrinsic component of mitochondrial inner membrane
(GO:0031314)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
(GO:0016709)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Ubiquinone biosynthesis complex
(GO:0110142)
Ubiquinone biosynthetic process
(GO:0006744)

Other Information

Proteins

COQ7_HUMAN

Genular Protein ID: 1188997841

Symbol: COQ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99807 B2RDA9 Q9BTT7 Q9H0T5 Q9UEW5 Q9UNR5

Database IDs:

Citations:

PubMed ID: 10373327

Title: Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human.

PubMed ID: 10373327

DOI: 10.1006/geno.1999.5838

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10501970

Title: Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging.

PubMed ID: 10501970

DOI: 10.1007/s003359901147

PubMed ID: 9020081

Title: Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.

PubMed ID: 9020081

DOI: 10.1126/science.275.5302.980

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24270420

Title: ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption.

PubMed ID: 24270420

DOI: 10.1172/jci69000

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25339443

Title: Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis.

PubMed ID: 25339443

DOI: 10.1073/pnas.1413128111

PubMed ID: 26084283

Title: Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid.

PubMed ID: 26084283

DOI: 10.1136/jmedgenet-2015-102986

PubMed ID: 25961505

Title: A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

PubMed ID: 25961505

DOI: 10.1038/ncb3170

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 217
Mass: 24277
Checksum: 37BEC3CEA621B77B
Sequence:

MSCAGAAAAP RLWRLRPGAR RSLSAYGRRT SVRFRSSGMT LDNISRAAVD RIIRVDHAGE 
YGANRIYAGQ MAVLGRTSVG PVIQKMWDQE KDHLKKFNEL MVTFRVRPTV LMPLWNVLGF 
ALGAGTALLG KEGAMACTVA VEESIAHHYN NQIRTLMEED PEKYEELLQL IKKFRDEELE 
HHDIGLDHDA ELAPAYAVLK SIIQAGCRVA IYLSERL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: COQ7

Associated with

Other Information

Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human. PubMed ID: 10373327

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. PubMed ID: 10501970

Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. PubMed ID: 9020081

Initial characterization of the human central proteome. PubMed ID: 21269460

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. PubMed ID: 24270420

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. PubMed ID: 25339443

Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid. PubMed ID: 26084283

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. PubMed ID: 25961505

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712