Details for: MSLN

Gene ID: 10232

Symbol: MSLN

Ensembl ID: ENSG00000102854

Description: mesothelin

Associated with

Other Information

Genular Protein ID: 940401937

Symbol: MSLN_HUMAN

Name: Mesothelin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7665620

Title: Molecular cloning and expression of megakaryocyte potentiating factor cDNA.

PubMed ID: 7665620

DOI: 10.1074/jbc.270.37.21984

PubMed ID: 8552591

Title: Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.

PubMed ID: 8552591

DOI: 10.1073/pnas.93.1.136

PubMed ID: 15140265

Title: Characterization of human mesothelin transcripts in ovarian and pancreatic cancer.

PubMed ID: 15140265

DOI: 10.1186/1471-2407-4-19

PubMed ID: 15897581

Title: Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients.

PubMed ID: 15897581

DOI: 10.1158/1078-0432.ccr-04-2304

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8288629

Title: A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5.

PubMed ID: 8288629

DOI: 10.1016/s0021-9258(17)42180-6

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 10500211

Title: Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma.

PubMed ID: 10500211

DOI: 10.1073/pnas.96.20.11531

PubMed ID: 14676194

Title: Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion.

PubMed ID: 14676194

DOI: 10.1074/jbc.m312372200

PubMed ID: 16857795

Title: Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma.

PubMed ID: 16857795

DOI: 10.1158/1078-0432.ccr-06-0472

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 22787150

Title: Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights.

PubMed ID: 22787150

DOI: 10.1074/jbc.m112.381756

Sequence Information:

  • Length: 630
  • Mass: 68986
  • Checksum: FA17E3609B6CC9CA
  • Sequence:
  • MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS 
    LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL 
    DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA 
    DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW 
    SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT 
    ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY 
    PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ APRRPLPQVA 
    TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ 
    LDVLYPKARL AFQNMNGSEY FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL 
    PLTVAEVQKL LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS 
    MQEALSGTPC LLGPGPVLTV LALLLASTLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.