Details for: LRRC17

Gene ID: 10234

Symbol: LRRC17

Ensembl ID: ENSG00000128606

Description: leucine rich repeat containing 17

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.86
    Marker Score: 24,555
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.71
    Marker Score: 6,319
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.56
    Marker Score: 10,137
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.47
    Marker Score: 1,563
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.35
    Marker Score: 564
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.22
    Marker Score: 883
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.21
    Marker Score: 866
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.15
    Marker Score: 326
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11,122
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,802
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.03
    Marker Score: 1,268
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,044
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 409
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.98
    Marker Score: 1,052
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,312
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.91
    Marker Score: 1,247
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 657
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.84
    Marker Score: 1,287
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,106
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.71
    Marker Score: 10,576
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.69
    Marker Score: 1,524
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.63
    Marker Score: 1,722
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.62
    Marker Score: 1,634
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3,625
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.6
    Marker Score: 580
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.59
    Marker Score: 709
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.59
    Marker Score: 145
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.58
    Marker Score: 4,414
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 459
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.55
    Marker Score: 309
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.54
    Marker Score: 518
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.52
    Marker Score: 800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.51
    Marker Score: 4,840
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.48
    Marker Score: 16,452
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 230
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.48
    Marker Score: 1,849
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.48
    Marker Score: 4,086
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.47
    Marker Score: 17,870
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.46
    Marker Score: 28,291
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.46
    Marker Score: 158
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.44
    Marker Score: 310
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.43
    Marker Score: 4,061
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 819
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.4
    Marker Score: 14,738
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.4
    Marker Score: 463
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.38
    Marker Score: 628
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.38
    Marker Score: 896
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.38
    Marker Score: 153
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.37
    Marker Score: 344
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.37
    Marker Score: 105
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.37
    Marker Score: 83
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.37
    Marker Score: 348
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.37
    Marker Score: 1,527
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.36
    Marker Score: 7,244
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 95
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.34
    Marker Score: 158
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 545
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.33
    Marker Score: 81
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 5,023
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.32
    Marker Score: 1,302
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.32
    Marker Score: 83
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 282
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.31
    Marker Score: 272
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.31
    Marker Score: 116
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3
    Marker Score: 206
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3
    Marker Score: 69
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 508
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.3
    Marker Score: 112
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.29
    Marker Score: 566
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.29
    Marker Score: 83
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.29
    Marker Score: 3,263
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.29
    Marker Score: 503
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.28
    Marker Score: 692
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.28
    Marker Score: 287
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.28
    Marker Score: 126
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.26
    Marker Score: 1,093
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.26
    Marker Score: 288
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.26
    Marker Score: 137
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.25
    Marker Score: 110
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.25
    Marker Score: 2,559
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.25
    Marker Score: 265

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Leucine-rich repeat domains**: The protein encoded by LRRC17 possesses multiple leucine-rich repeat domains, which are known to be involved in protein-protein interactions and recognition of specific ligands. 2. **Osteoblast differentiation regulation**: LRRC17 has been implicated in the regulation of osteoblast differentiation, a process critical for bone formation and remodeling. 3. **Negative regulation of osteoclast differentiation**: The gene also plays a role in inhibiting osteoclast differentiation, thereby maintaining bone homeostasis and preventing excessive bone resorption. 4. **Expression in various cell types**: LRRC17 is expressed in a range of cell types, including mesodermal cells, cortical thymic epithelial cells, and granulosa cells, highlighting its broad functional significance. **Pathways and Functions:** 1. **Bone marrow development**: LRRC17 is likely involved in regulating the development and differentiation of osteoblasts and osteoclasts within the bone marrow, influencing bone formation and resorption. 2. **Extracellular matrix**: The protein may interact with extracellular matrix components, modulating cell adhesion, migration, and signaling. 3. **Extracellular space**: LRRC17 may also influence the regulation of extracellular space, affecting the balance between bone formation and resorption. 4. **Osteoblast proliferation**: The gene's role in regulating osteoblast proliferation is critical for bone growth and repair. **Clinical Significance:** 1. **Bone disorders**: Alterations in LRRC17 expression or function may contribute to bone disorders such as osteoporosis, osteopenia, or osteomalacia. 2. **Cancer**: The gene's involvement in osteoblast differentiation and regulation may also have implications for cancer, particularly those affecting bone tissue, such as osteosarcoma. 3. **Reproductive health**: LRRC17's expression in granulosa cells suggests a potential role in reproductive health, particularly in the regulation of follicular development and ovulation. 4. **Thyroid disorders**: The gene's expression in cortical thymic epithelial cells may also be relevant to thyroid disorders, such as goiter or thyroid cancer. In conclusion, LRRC17 is a multifaceted gene with significant implications for bone development, osteoblast differentiation, and regulation of the extracellular matrix. Further research is necessary to fully elucidate the gene's functions and clinical significance, particularly in the context of bone disorders and cancer.

Genular Protein ID: 1015424500

Symbol: LRC17_HUMAN

Name: Leucine-rich repeat-containing protein 17

UniProtKB Accession Codes:

Q8N6Y2 Q13288 Q6UWA7 Q75MG5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8982252

Title: A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR) protein, p37NB, isolated from S-type neuroblastoma cell has a differential tissue distribution.

PubMed ID: 8982252

DOI: 10.1016/s0167-4781(96)00158-3

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19336404

Title: Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.

PubMed ID: 19336404

DOI: 10.1074/jbc.m807722200

Sequence Information:

  • Length: 441
  • Mass: 51800
  • Checksum: F629666C807A4254
  • Sequence:
    • MRVVTIVILL CFCKAAELRK ASPGSVRSRV NHGRAGGGRR GSNPVKRYAP GLPCDVYTYL 
HEKYLDCQER KLVYVLPGWP QDLLHMLLAR NKIRTLKNNM FSKFKKLKSL DLQQNEISKI 
ESEAFFGLNK LTTLLLQHNQ IKVLTEEVFI YTPLLSYLRL YDNPWHCTCE IETLISMLQI 
PRNRNLGNYA KCESPQEQKN KKLRQIKSEQ LCNEEEKEQL DPKPQVSGRP PVIKPEVDST 
FCHNYVFPIQ TLDCKRKELK KVPNNIPPDI VKLDLSYNKI NQLRPKEFED VHELKKLNLS 
SNGIEFIDPA AFLGLTHLEE LDLSNNSLQN FDYGVLEDLY FLKLLWLRDN PWRCDYNIHY 
LYYWLKHHYN VHFNGLECKT PEEYKGWSVG KYIRSYYEEC PKDKLPAYPE SFDQDTEDDE 
WEKKHRDHTA KKQSVIITIV G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.