Details for: RASGRP2
Associated with
Other Information
Genular Protein ID: 153085798
Symbol: GRP2_HUMAN
Name: RAS guanyl-releasing protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9341881
Title: The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13.
PubMed ID: 9341881
PubMed ID: 9789079
Title: A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.
PubMed ID: 9789079
PubMed ID: 10918068
Title: Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.
PubMed ID: 10918068
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11278453
Title: Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia.
PubMed ID: 11278453
PubMed ID: 14702343
Title: Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1.
PubMed ID: 14702343
PubMed ID: 14988412
Title: F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.
PubMed ID: 14988412
PubMed ID: 17702895
Title: Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.
PubMed ID: 17702895
PubMed ID: 17576779
Title: A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
PubMed ID: 17576779
DOI: 10.1084/jem.20070058
PubMed ID: 19064721
Title: LAD-1/variant syndrome is caused by mutations in FERMT3.
PubMed ID: 19064721
PubMed ID: 19234463
Title: Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
PubMed ID: 19234463
DOI: 10.1038/nm.1931
PubMed ID: 19234460
Title: A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.
PubMed ID: 19234460
DOI: 10.1038/nm.1917
PubMed ID: 24958846
Title: Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.
PubMed ID: 24958846
DOI: 10.1084/jem.20130477
PubMed ID: 27235135
Title: Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.
PubMed ID: 27235135
PubMed ID: 23908768
Title: Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
PubMed ID: 23908768
DOI: 10.7554/elife.00813
PubMed ID: 28726538
Title: Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).
PubMed ID: 28726538
PubMed ID: 28762304
Title: Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.
PubMed ID: 28762304
Sequence Information:
- Length: 609
- Mass: 69248
- Checksum: 8B1321F864D24BC7
- Sequence:
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID IDSVPTYKWK RQVTQRNPVG QKKRKMSLLF DHLEPMELAE HLTYLEYRSF CKILFQDYHS FVTHGCTVDN PVLERFISLF NSVSQWVQLM ILSKPTAPQR ALVITHFVHV AEKLLQLQNF NTLMAVVGGL SHSSISRLKE THSHVSPETI KLWEGLTELV TATGNYGNYR RRLAACVGFR FPILGVHLKD LVALQLALPD WLDPARTRLN GAKMKQLFSI LEELAMVTSL RPPVQANPDL LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP PPRPPVLEEW TSAAKPKLDQ ALVVEHIEKM VESVFRNFDV DGDGHISQEE FQIIRGNFPY LSAFGDLDQN QDGCISREEM VSYFLRSSSV LGGRMGFVHN FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC KDRLSVECRR RAQSVSLEGS APSPSPMHSH HHRAFSFSLP RPGRRGSRPP EIREEEVQTV EDGVFDIHL
Genular Protein ID: 1664044266
Symbol: B3KV60_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 464
- Mass: 52440
- Checksum: 81AD21A494745C13
- Sequence:
MSLLFDHLEP MELAEHLTYL EYRSFCKILF QDYHSFVTHG CTVDNPVLER FISLFNSVSQ WVQLMILSKP TAPQRALVIT HFVHVAEKLL QLQNFNTLMA VVGGLSHSSI SRLKETHSHV SPETIKLWEG LTELVTATGN YGNYRRRLAA CVGFRFPILG VHLKDLVALQ LALPDWLDPA RTRLNGAKMK QLFSILEELA MVTSLRPPVQ ANPDLLSLLT VSLDQYQTED ELYQLSLQRE PRSKSSPTSP TSCTPPPRPP VLEEWTSAAK PKLDQALVVE HIEKMVESVF RNFDVDGDGH ISQEEFQIIR GNFPYLSAFG DLDQNQDGCI SREEMVSYFL RSSSVLGGRM GFVHNFQESN SLRPVACRHC KALILGIYKQ GLKCRACGVN CHKQCNDRLS VECRRRAQSV SLEGSAPSPS PMHSHHHRAF SFSLPRPGRR GSRPPEIREE EVQTVEDGVF DIHL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.