Details for: CDK8

Gene ID: 1024

Symbol: CDK8

Ensembl ID: ENSG00000132964

Description: cyclin dependent kinase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 284.2903
    Cell Significance Index: -44.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.1492
    Cell Significance Index: -45.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.3030
    Cell Significance Index: -36.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.9998
    Cell Significance Index: -36.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.2357
    Cell Significance Index: -45.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2569
    Cell Significance Index: -43.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.7561
    Cell Significance Index: -46.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4771
    Cell Significance Index: -22.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.3168
    Cell Significance Index: 142.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1590
    Cell Significance Index: 433.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1508
    Cell Significance Index: 771.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0517
    Cell Significance Index: 115.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.9420
    Cell Significance Index: 33.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8979
    Cell Significance Index: 145.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8828
    Cell Significance Index: 71.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7241
    Cell Significance Index: 76.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6218
    Cell Significance Index: 321.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5891
    Cell Significance Index: 38.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3484
    Cell Significance Index: 82.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3049
    Cell Significance Index: 32.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2569
    Cell Significance Index: 869.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1714
    Cell Significance Index: 1057.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1045
    Cell Significance Index: 28.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0703
    Cell Significance Index: 71.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8002
    Cell Significance Index: 22.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6877
    Cell Significance Index: 19.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6767
    Cell Significance Index: 110.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6444
    Cell Significance Index: 75.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6272
    Cell Significance Index: 68.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5591
    Cell Significance Index: 25.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5292
    Cell Significance Index: 14.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2526
    Cell Significance Index: 24.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2473
    Cell Significance Index: 17.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2275
    Cell Significance Index: 4.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2241
    Cell Significance Index: 42.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1907
    Cell Significance Index: 12.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1885
    Cell Significance Index: 33.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1876
    Cell Significance Index: 353.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1847
    Cell Significance Index: 6.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1838
    Cell Significance Index: 2.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1745
    Cell Significance Index: 268.6000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1713
    Cell Significance Index: 2.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1658
    Cell Significance Index: 305.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1293
    Cell Significance Index: 58.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1198
    Cell Significance Index: 14.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0899
    Cell Significance Index: 49.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0889
    Cell Significance Index: 120.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0839
    Cell Significance Index: 53.2900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0515
    Cell Significance Index: 0.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0501
    Cell Significance Index: 2.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0219
    Cell Significance Index: 0.4800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0049
    Cell Significance Index: -0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0101
    Cell Significance Index: -4.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0238
    Cell Significance Index: -3.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0386
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0438
    Cell Significance Index: -32.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0453
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0492
    Cell Significance Index: -36.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0612
    Cell Significance Index: -46.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0672
    Cell Significance Index: -11.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0711
    Cell Significance Index: -40.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0797
    Cell Significance Index: -49.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1184
    Cell Significance Index: -5.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1350
    Cell Significance Index: -38.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1509
    Cell Significance Index: -20.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1783
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2211
    Cell Significance Index: -46.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2444
    Cell Significance Index: -5.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2581
    Cell Significance Index: -33.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2609
    Cell Significance Index: -26.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2726
    Cell Significance Index: -3.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2860
    Cell Significance Index: -36.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2874
    Cell Significance Index: -6.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2996
    Cell Significance Index: -2.0300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3023
    Cell Significance Index: -3.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3034
    Cell Significance Index: -31.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3115
    Cell Significance Index: -6.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3123
    Cell Significance Index: -4.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3136
    Cell Significance Index: -36.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3353
    Cell Significance Index: -6.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3407
    Cell Significance Index: -6.8400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3416
    Cell Significance Index: -4.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3508
    Cell Significance Index: -7.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3607
    Cell Significance Index: -41.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3692
    Cell Significance Index: -17.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3837
    Cell Significance Index: -19.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3882
    Cell Significance Index: -20.3800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3923
    Cell Significance Index: -2.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4148
    Cell Significance Index: -5.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4167
    Cell Significance Index: -14.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4447
    Cell Significance Index: -14.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4577
    Cell Significance Index: -4.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4686
    Cell Significance Index: -28.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4810
    Cell Significance Index: -35.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4885
    Cell Significance Index: -34.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5064
    Cell Significance Index: -40.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5093
    Cell Significance Index: -16.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5251
    Cell Significance Index: -33.8800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5451
    Cell Significance Index: -6.8800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6225
    Cell Significance Index: -13.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDK8 is a member of the cyclin-dependent kinase (CDK) family, which consists of a group of serine/threonine kinases that regulate cell cycle progression. CDK8 is distinct from other CDKs in its ability to phosphorylate and activate the CTD of RNA polymerase II, a process that is essential for the elongation of transcription. The P-TEFb complex, which contains CDK8, is a heterotrimeric complex consisting of CDK8, Taf15, and TBP (TATA-binding protein). CDK8 is highly expressed in neurons and other cells of the central nervous system, where it plays a critical role in regulating gene expression during development and differentiation. **Pathways and Functions** CDK8 is involved in several key cellular processes, including: 1. **Transcriptional regulation**: CDK8 phosphorylates and activates the CTD of RNA polymerase II, which is essential for the elongation of transcription. 2. **Cell cycle progression**: CDK8 regulates the G2/M phase of the cell cycle by phosphorylating and activating the CTD of RNA polymerase II. 3. **Developmental biology**: CDK8 is essential for the regulation of gene expression during development and differentiation, particularly in neurons and other cells of the central nervous system. 4. **Signaling pathways**: CDK8 is involved in various signaling pathways, including the Notch and TGF-β signaling pathways, which regulate cell growth, differentiation, and survival. **Clinical Significance** Aberrant expression or activity of CDK8 has been implicated in various diseases, including: 1. **Cancer**: CDK8 overexpression or mutations have been linked to tumorigenesis and oncogenesis in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: CDK8 mutations have been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Developmental disorders**: CDK8 mutations have been linked to developmental disorders, such as intellectual disability and epilepsy. In conclusion, CDK8 is a critical component of the P-TEFb complex, which plays a central role in regulating gene expression during the elongation phase of transcription. Aberrant expression or activity of CDK8 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which CDK8 regulates gene expression and the clinical implications of its dysregulation.

Genular Protein ID: 3822939450

Symbol: CDK8_HUMAN

Name: Cyclin-dependent kinase 8

UniProtKB Accession Codes:

P49336 Q5VUF3 Q6ISB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 5 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7568034

Title: Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.

PubMed ID: 7568034

DOI: 10.1073/pnas.92.19.8871

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734358

Title: NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.

PubMed ID: 9734358

DOI: 10.1016/s1097-2765(00)80131-8

PubMed ID: 10024883

Title: A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

PubMed ID: 10024883

DOI: 10.1016/s1097-2765(00)80178-1

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 15546612

Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

PubMed ID: 15546612

DOI: 10.1016/j.molcel.2004.10.014

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 17000779

Title: Mediator modulates Gli3-dependent Sonic hedgehog signaling.

PubMed ID: 17000779

DOI: 10.1128/mcb.00443-06

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 30905399

Title: De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.

PubMed ID: 30905399

DOI: 10.1016/j.ajhg.2019.02.006

PubMed ID: 21806996

Title: The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.

PubMed ID: 21806996

DOI: 10.1016/j.jmb.2011.07.020

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 464
  • Mass: 53284
  • Checksum: 00CBAB6CE354605F
  • Sequence:
    • MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 
MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 
VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 
NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 
IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 
KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLT 
EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP LKKVRVVPPT TTSGGLIMTS 
DYQRSNPHAA YPNPGPSTSQ PQSSMGYSAT SQQPPQYSHQ THRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.