CDK8 | ENSG00000132964 | NCBI 1024

Details for: CDK8

Gene ID: 1024

Symbol: CDK8

Ensembl ID: ENSG00000132964

Description: cyclin dependent kinase 8

Associated with

Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Rsv-host interactions
(R-HSA-9833110)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Ckm complex
(GO:1990508)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Mediator complex
(GO:0016592)
Negative regulation of triglyceride metabolic process
(GO:0090209)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein ubiquitination
(GO:0016567)
Regulation of cell cycle
(GO:0051726)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii ctd heptapeptide repeat kinase activity
(GO:0008353)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

Cyclin-dependent kinase 8

Genular Protein ID: 3822939450

Symbol: CDK8_HUMAN

Name: Cyclin-dependent kinase 8

UniProtKB Accession Codes:

P49336 Q5VUF3 Q6ISB5

Database IDs:

Citations:

PubMed ID: 7568034

Title: Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.

PubMed ID: 7568034

DOI: 10.1073/pnas.92.19.8871

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734358

Title: NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.

PubMed ID: 9734358

DOI: 10.1016/s1097-2765(00)80131-8

PubMed ID: 10024883

Title: A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

PubMed ID: 10024883

DOI: 10.1016/s1097-2765(00)80178-1

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 15546612

Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

PubMed ID: 15546612

DOI: 10.1016/j.molcel.2004.10.014

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 17000779

Title: Mediator modulates Gli3-dependent Sonic hedgehog signaling.

PubMed ID: 17000779

DOI: 10.1128/mcb.00443-06

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 30905399

Title: De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.

PubMed ID: 30905399

DOI: 10.1016/j.ajhg.2019.02.006

PubMed ID: 21806996

Title: The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.

PubMed ID: 21806996

DOI: 10.1016/j.jmb.2011.07.020

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 464
Mass: 53284
Checksum: 00CBAB6CE354605F
Sequence:

MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 
MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 
VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 
NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 
IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 
KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLT 
EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP LKKVRVVPPT TTSGGLIMTS 
DYQRSNPHAA YPNPGPSTSQ PQSSMGYSAT SQQPPQYSHQ THRY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDK8

Associated with

Other Information

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. PubMed ID: 7568034

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. PubMed ID: 9734358

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. PubMed ID: 10024883

TFIIH is negatively regulated by cdk8-containing mediator complexes. PubMed ID: 10993082

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. PubMed ID: 15546612

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. PubMed ID: 15175163

MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. PubMed ID: 15989967

Mediator modulates Gli3-dependent Sonic hedgehog signaling. PubMed ID: 17000779

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder. PubMed ID: 30905399

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. PubMed ID: 21806996

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846