CDK8 | ENSG00000132964 | NCBI 1024

Details for: CDK8

Gene ID: 1024

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CDK8

Ensembl ID: ENSG00000132964

Description: cyclin dependent kinase 8

Cell Significance Landscape

Display Count:

Associated with

Adipogenesis
(R-HSA-9843745)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Rsv-host interactions
(R-HSA-9833110)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Ckm complex
(GO:1990508)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
G1/s transition of mitotic cell cycle
(GO:0000082)
Mediator complex
(GO:0016592)
Negative regulation of triglyceride metabolic process
(GO:0090209)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein ubiquitination
(GO:0016567)
Regulation of cell cycle
(GO:0051726)
Rna polymerase ii ctd heptapeptide repeat kinase activity
(GO:0008353)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

VIP GABAergic cortical interneuron CL4023016

CSI 33.78

rCSI 40.35%

PRS 33.61
lamp5 GABAergic cortical interneuron CL4023011

CSI 31.96

rCSI 53.65%

PRS 33.72
sncg GABAergic cortical interneuron CL4023015

CSI 30.15

rCSI 48.48%

PRS 35.84
differentiation-committed oligodendrocyte precursor CL4023059

CSI 25.89

rCSI 47.05%

PRS 43.37
pvalb GABAergic cortical interneuron CL4023018

CSI 25.78

rCSI 32.08%

PRS 32.06
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 19.09

rCSI 33.71%

PRS 32.8
sst GABAergic cortical interneuron CL4023017

CSI 19.03

rCSI 24.53%

PRS 34.77
L6b glutamatergic cortical neuron CL4023038

CSI 17.65

rCSI 55.15%

PRS 35.11
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 17.38

rCSI 54.36%

PRS 37.46
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 17.12

rCSI 41.61%

PRS 32.63
erythroblast CL0000765

CSI 16.26

rCSI 43.16%

PRS 63.71
near-projecting glutamatergic cortical neuron CL4023012

CSI 15.82

rCSI 59.79%

PRS 34.58
retinal ganglion cell CL0000740

CSI 15.55

rCSI 34.35%

PRS 37.9
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 14.89

rCSI 53.57%

PRS 32.49
IgG plasma cell CL0000985

CSI 14.55

rCSI 17.42%

PRS 69.25
retinal cone cell CL0000573

CSI 13.9

rCSI 22.37%

PRS 40.68
stem cell CL0000034

CSI 13.18

rCSI 12.71%

PRS 41
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 11.31

rCSI 16.03%

PRS 46.96
ependymal cell CL0000065

CSI 11.21

rCSI 22.74%

PRS 31.87
retinal rod cell CL0000604

CSI 10.17

rCSI 17.93%

PRS 48.02
amacrine cell CL0000561

CSI 9.77

rCSI 28.31%

PRS 41.13
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 9.73

rCSI 22.18%

PRS 48.24
lung secretory cell CL1000272

CSI 9.58

rCSI 23.71%

PRS 48.3
tendon cell CL0000388

CSI 9.36

rCSI 24.33%

PRS 70.88
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 9.26

rCSI 54.55%

PRS 35.16
adipocyte CL0000136

CSI 8.77

rCSI 11.27%

PRS 44.87
cerebral cortex endothelial cell CL1001602

CSI 8.75

rCSI 15.13%

PRS 40.83
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 8.68

rCSI 10.02%

PRS 44.48
neuron CL0000540

CSI 8.27

rCSI 22.03%

PRS 41.55
interneuron CL0000099

CSI 7.87

rCSI 15.8%

PRS 39.94
Mueller cell CL0000636

CSI 7.64

rCSI 17.44%

PRS 43.26
radial glial cell CL0000681

CSI 7.38

rCSI 10.25%

PRS 49.8
S cone cell CL0003050

CSI 7.32

rCSI 32.15%

PRS 47.58
glioblast CL0000030

CSI 7.21

rCSI 11.5%

PRS 43.95
central nervous system neuron CL2000029

CSI 7.13

rCSI 52.42%

PRS 37.83
erythrocyte CL0000232

CSI 6.95

rCSI 15.77%

PRS 55.68
alveolar macrophage CL0000583

CSI 6.89

rCSI 11.35%

PRS 55.93
rod bipolar cell CL0000751

CSI 6.61

rCSI 11.87%

PRS 43.7
vascular leptomeningeal cell CL4023051

CSI 6.57

rCSI 11.52%

PRS 42.51
neuroblast (sensu Vertebrata) CL0000031

CSI 6.51

rCSI 8.35%

PRS 48.31
renal principal cell CL0005009

CSI 6.36

rCSI 16.52%

PRS 54.87
melanocyte CL0000148

CSI 6.35

rCSI 4.7%

PRS 43.45
GABAergic amacrine cell CL4030027

CSI 6.3

rCSI 21.58%

PRS 40.73
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 6.22

rCSI 4.37%

PRS 70.9
blood vessel endothelial cell CL0000071

CSI 6.2

rCSI 12.86%

PRS 47.96
neural crest cell CL0011012

CSI 5.95

rCSI 4.7%

PRS 37.75
Kupffer cell CL0000091

CSI 5.88

rCSI 13.45%

PRS 49.8
retinal bipolar neuron CL0000748

CSI 5.84

rCSI 10.94%

PRS 39.59
mesothelial cell CL0000077

CSI 5.62

rCSI 21.97%

PRS 27.11
epithelial cell of proximal tubule CL0002306

CSI 5.55

rCSI 13.55%

PRS 45.32
regular ventricular cardiac myocyte CL0002131

CSI 5.54

rCSI 34.61%

PRS 42.59
renal beta-intercalated cell CL0002201

CSI 5.51

rCSI 13.13%

PRS 51.87
fibroblast of cardiac tissue CL0002548

CSI 5.46

rCSI 26.15%

PRS 49.31
Schwann cell CL0002573

CSI 5.42

rCSI 15.41%

PRS 49.33
brush cell of tracheobronchial tree CL0002075

CSI 5.39

rCSI 16%

PRS 60.99
basal cell CL0000646

CSI 5.22

rCSI 6.97%

PRS 51.66
hepatic stellate cell CL0000632

CSI 5.08

rCSI 19.03%

PRS 42.93
mononuclear phagocyte CL0000113

CSI 5.07

rCSI 11.16%

PRS 54.52
inhibitory interneuron CL0000498

CSI 5.02

rCSI 11.58%

PRS 41
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.85

rCSI 12.53%

PRS 46.08
choroid plexus epithelial cell CL0000706

CSI 4.77

rCSI 7.82%

PRS 40.41
diffuse bipolar 3a cell CL4033029

CSI 4.67

rCSI 31.79%

PRS 47.2
dopaminergic neuron CL0000700

CSI 4.63

rCSI 26.15%

PRS 36.28
colon epithelial cell CL0011108

CSI 4.61

rCSI 4.83%

PRS 47.33
intestinal crypt stem cell of small intestine CL0009017

CSI 4.61

rCSI 12.42%

PRS 58.86
alveolar type 1 fibroblast cell CL4028004

CSI 4.55

rCSI 4.98%

PRS 54.14
pulmonary alveolar type 2 cell CL0002063

CSI 4.52

rCSI 7.02%

PRS 59.3
alveolar adventitial fibroblast CL4028006

CSI 4.33

rCSI 6.83%

PRS 51.64
cardiac neuron CL0010022

CSI 4.29

rCSI 13.73%

PRS 47.08
early lymphoid progenitor CL0000936

CSI 4.21

rCSI 3.7%

PRS 55.78
neuroendocrine cell CL0000165

CSI 4.16

rCSI 16.1%

PRS 67.16
parietal epithelial cell CL1000452

CSI 3.93

rCSI 10.5%

PRS 42.46
mesangial cell CL0000650

CSI 3.88

rCSI 15.81%

PRS 61.59
BEST4+ enteroycte CL4030026

CSI 3.84

rCSI 4.78%

PRS 52.84
cardiac endothelial cell CL0010008

CSI 3.83

rCSI 15.45%

PRS 48.77
double-positive, alpha-beta thymocyte CL0000809

CSI 3.82

rCSI 3.89%

PRS 64.07
astrocyte of the cerebral cortex CL0002605

CSI 3.8

rCSI 8.52%

PRS 34.52
diffuse bipolar 6 cell CL4033032

CSI 3.78

rCSI 19.9%

PRS 46.34
kidney connecting tubule epithelial cell CL1000768

CSI 3.78

rCSI 9.58%

PRS 40.36
skeletal muscle satellite cell CL0000594

CSI 3.76

rCSI 11.01%

PRS 77.07
hepatocyte CL0000182

CSI 3.75

rCSI 6.71%

PRS 48.95
cerebellar granule cell CL0001031

CSI 3.74

rCSI 5.49%

PRS 45.13
tracheobronchial smooth muscle cell CL0019019

CSI 3.66

rCSI 6.46%

PRS 58.74
chondrocyte CL0000138

CSI 3.58

rCSI 5.69%

PRS 43.05
ON parasol ganglion cell CL4033052

CSI 3.37

rCSI 47.8%

PRS 42.14
regular atrial cardiac myocyte CL0002129

CSI 3.26

rCSI 10.48%

PRS 49.25
enteric smooth muscle cell CL0002504

CSI 3.23

rCSI 4.61%

PRS 52.91
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.11

rCSI 8.12%

PRS 49.47
pulmonary alveolar type 1 cell CL0002062

CSI 3.1

rCSI 17.88%

PRS 51.09
lung pericyte CL0009089

CSI 3.1

rCSI 8.18%

PRS 58.63
GABAergic interneuron CL0011005

CSI 3.09

rCSI 48.73%

PRS 54.95
cardiac muscle cell CL0000746

CSI 3.08

rCSI 4.42%

PRS 41
diffuse bipolar 3b cell CL4033030

CSI 3.05

rCSI 20.22%

PRS 48.36
small intestine goblet cell CL1000495

CSI 2.99

rCSI 6.55%

PRS 59.8
endocardial cell CL0002350

CSI 2.97

rCSI 14.23%

PRS 50.45
renal interstitial pericyte CL1001318

CSI 2.9

rCSI 7.99%

PRS 46.54
fibroblast of lung CL0002553

CSI 2.9

rCSI 2.7%

PRS 50.09
macroglial cell CL0000126

CSI 2.88

rCSI 7.41%

PRS 51.81
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 2.86

rCSI 9.41%

PRS 38.56
retinal blood vessel endothelial cell CL0002585

CSI 2.73

rCSI 4.35%

PRS 54.41

kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.5

rCSI 5.5%

PRS 50.3%
stromal cell CL0000499

CSI 0.5

rCSI 1.5%

PRS 48.9%
Hofbauer cell CL3000001

CSI 0.5

rCSI 1.0%

PRS 60.8%
eye photoreceptor cell CL0000287

CSI 0.6

rCSI 6.5%

PRS 73.4%
enteroglial cell CL4040002

CSI 0.6

rCSI 3.3%

PRS 57.2%
serotonergic neuron CL0000850

CSI 0.7

rCSI 3.0%

PRS 35.6%
diffuse bipolar 4 cell CL4033031

CSI 0.7

rCSI 7.8%

PRS 42.3%
flat midget bipolar cell CL4033033

CSI 0.8

rCSI 5.6%

PRS 45.0%
diffuse bipolar 1 cell CL4033027

CSI 0.8

rCSI 6.0%

PRS 44.6%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.0

rCSI 0.8%

PRS 49.7%
pancreatic A cell CL0000171

CSI 1.1

rCSI 1.1%

PRS 53.7%
extravillous trophoblast CL0008036

CSI 1.1

rCSI 1.3%

PRS 46.2%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.1

rCSI 1.3%

PRS 58.6%
retina horizontal cell CL0000745

CSI 1.1

rCSI 1.7%

PRS 46.9%
neural progenitor cell CL0011020

CSI 1.1

rCSI 5.0%

PRS 42.9%
endothelial cell of placenta CL0009092

CSI 1.1

rCSI 5.6%

PRS 62.1%
paneth cell of epithelium of small intestine CL1000343

CSI 1.2

rCSI 3.3%

PRS 64.2%
type B pancreatic cell CL0000169

CSI 1.2

rCSI 2.7%

PRS 48.0%
lung ciliated cell CL1000271

CSI 1.3

rCSI 1.5%

PRS 40.4%
myoepithelial cell CL0000185

CSI 1.3

rCSI 3.3%

PRS 58.7%
H1 horizontal cell CL0004217

CSI 1.3

rCSI 5.2%

PRS 51.1%
OFFx cell CL4033036

CSI 1.3

rCSI 6.2%

PRS 46.5%
podocyte CL0000653

CSI 1.5

rCSI 6.6%

PRS 49.4%
neuroplacodal cell CL0000032

CSI 1.5

rCSI 13.9%

PRS 65.2%
intestinal tuft cell CL0019032

CSI 1.5

rCSI 2.4%

PRS 55.1%
medium spiny neuron CL1001474

CSI 1.6

rCSI 13.4%

PRS 37.6%
skeletal muscle satellite stem cell CL0008011

CSI 1.7

rCSI 7.3%

PRS 71.2%
enteroendocrine cell of small intestine CL0009006

CSI 1.7

rCSI 3.7%

PRS 64.8%
blood vessel smooth muscle cell CL0019018

CSI 1.8

rCSI 14.3%

PRS 44.2%
midbrain dopaminergic neuron CL2000097

CSI 1.8

rCSI 11.6%

PRS 54.8%
glutamatergic neuron CL0000679

CSI 1.9

rCSI 3.9%

PRS 43.1%
diffuse bipolar 2 cell CL4033028

CSI 2.1

rCSI 16.2%

PRS 47.1%
lung neuroendocrine cell CL1000223

CSI 2.1

rCSI 3.1%

PRS 55.8%
mesodermal cell CL0000222

CSI 2.1

rCSI 2.5%

PRS 48.3%
cerebellar neuron CL1001611

CSI 2.1

rCSI 18.7%

PRS 38.0%
GABAergic neuron CL0000617

CSI 2.2

rCSI 7.3%

PRS 37.4%
basophil CL0000767

CSI 2.2

rCSI 4.6%

PRS 70.4%
cerebral cortex pyramidal neuron CL4023111

CSI 2.2

rCSI 13.5%

PRS 69.3%
mucosal invariant T cell CL0000940

CSI 2.2

rCSI 1.8%

PRS 60.4%
Bergmann glial cell CL0000644

CSI 2.3

rCSI 3.1%

PRS 45.6%
conjunctival epithelial cell CL1000432

CSI 2.3

rCSI 3.5%

PRS 51.1%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 2.3

rCSI 5.5%

PRS 38.9%
bronchus fibroblast of lung CL2000093

CSI 2.3

rCSI 1.9%

PRS 50.9%
CD14-positive monocyte CL0001054

CSI 2.3

rCSI 2.9%

PRS 61.6%
interstitial cell of Cajal CL0002088

CSI 2.3

rCSI 3.0%

PRS 56.2%
glycinergic amacrine cell CL4030028

CSI 2.3

rCSI 6.1%

PRS 49.1%
retinal pigment epithelial cell CL0002586

CSI 2.4

rCSI 4.7%

PRS 48.9%
myeloid dendritic cell CL0000782

CSI 2.4

rCSI 3.5%

PRS 66.9%
H2 horizontal cell CL0004218

CSI 2.4

rCSI 12.0%

PRS 48.9%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 2.5

rCSI 2.2%

PRS 65.2%
epithelial cell of lower respiratory tract CL0002632

CSI 2.5

rCSI 2.0%

PRS 51.1%
invaginating midget bipolar cell CL4033034

CSI 2.5

rCSI 15.0%

PRS 46.7%
glial cell CL0000125

CSI 2.6

rCSI 9.7%

PRS 42.6%
tuft cell of colon CL0009041

CSI 2.6

rCSI 6.0%

PRS 66.5%
OFF midget ganglion cell CL4033047

CSI 2.6

rCSI 52.9%

PRS 43.4%
common myeloid progenitor CL0000049

CSI 2.6

rCSI 2.1%

PRS 51.3%
naive B cell CL0000788

CSI 2.6

rCSI 2.3%

PRS 58.2%
ON-bipolar cell CL0000749

CSI 2.7

rCSI 3.9%

PRS 52.6%
epicardial adipocyte CL1000309

CSI 2.7

rCSI 8.6%

PRS 51.8%
indirect pathway medium spiny neuron CL4023029

CSI 2.7

rCSI 64.4%

PRS 34.1%
direct pathway medium spiny neuron CL4023026

CSI 2.7

rCSI 64.8%

PRS 33.2%
mature T cell CL0002419

CSI 2.7

rCSI 2.1%

PRS 68.4%
retinal blood vessel endothelial cell CL0002585

CSI 2.7

rCSI 4.4%

PRS 54.4%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 2.9

rCSI 9.4%

PRS 38.6%
macroglial cell CL0000126

CSI 2.9

rCSI 7.4%

PRS 51.8%
fibroblast of lung CL0002553

CSI 2.9

rCSI 2.7%

PRS 50.1%
renal interstitial pericyte CL1001318

CSI 2.9

rCSI 8.0%

PRS 46.5%
endocardial cell CL0002350

CSI 3.0

rCSI 14.2%

PRS 50.5%
small intestine goblet cell CL1000495

CSI 3.0

rCSI 6.6%

PRS 59.8%
diffuse bipolar 3b cell CL4033030

CSI 3.1

rCSI 20.2%

PRS 48.4%
cardiac muscle cell CL0000746

CSI 3.1

rCSI 4.4%

PRS 41.0%
GABAergic interneuron CL0011005

CSI 3.1

rCSI 48.7%

PRS 55.0%
lung pericyte CL0009089

CSI 3.1

rCSI 8.2%

PRS 58.6%
pulmonary alveolar type 1 cell CL0002062

CSI 3.1

rCSI 17.9%

PRS 51.1%
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.1

rCSI 8.1%

PRS 49.5%
enteric smooth muscle cell CL0002504

CSI 3.2

rCSI 4.6%

PRS 52.9%
regular atrial cardiac myocyte CL0002129

CSI 3.3

rCSI 10.5%

PRS 49.3%
ON parasol ganglion cell CL4033052

CSI 3.4

rCSI 47.8%

PRS 42.1%
chondrocyte CL0000138

CSI 3.6

rCSI 5.7%

PRS 43.1%
tracheobronchial smooth muscle cell CL0019019

CSI 3.7

rCSI 6.5%

PRS 58.7%
cerebellar granule cell CL0001031

CSI 3.7

rCSI 5.5%

PRS 45.1%
hepatocyte CL0000182

CSI 3.8

rCSI 6.7%

PRS 49.0%
skeletal muscle satellite cell CL0000594

CSI 3.8

rCSI 11.0%

PRS 77.1%
kidney connecting tubule epithelial cell CL1000768

CSI 3.8

rCSI 9.6%

PRS 40.4%
diffuse bipolar 6 cell CL4033032

CSI 3.8

rCSI 19.9%

PRS 46.3%
astrocyte of the cerebral cortex CL0002605

CSI 3.8

rCSI 8.5%

PRS 34.5%
double-positive, alpha-beta thymocyte CL0000809

CSI 3.8

rCSI 3.9%

PRS 64.1%
cardiac endothelial cell CL0010008

CSI 3.8

rCSI 15.5%

PRS 48.8%
BEST4+ enteroycte CL4030026

CSI 3.8

rCSI 4.8%

PRS 52.8%
mesangial cell CL0000650

CSI 3.9

rCSI 15.8%

PRS 61.6%
parietal epithelial cell CL1000452

CSI 3.9

rCSI 10.5%

PRS 42.5%
neuroendocrine cell CL0000165

CSI 4.2

rCSI 16.1%

PRS 67.2%
early lymphoid progenitor CL0000936

CSI 4.2

rCSI 3.7%

PRS 55.8%
cardiac neuron CL0010022

CSI 4.3

rCSI 13.7%

PRS 47.1%
alveolar adventitial fibroblast CL4028006

CSI 4.3

rCSI 6.8%

PRS 51.6%
pulmonary alveolar type 2 cell CL0002063

CSI 4.5

rCSI 7.0%

PRS 59.3%
alveolar type 1 fibroblast cell CL4028004

CSI 4.6

rCSI 5.0%

PRS 54.1%
intestinal crypt stem cell of small intestine CL0009017

CSI 4.6

rCSI 12.4%

PRS 58.9%
colon epithelial cell CL0011108

CSI 4.6

rCSI 4.8%

PRS 47.3%
dopaminergic neuron CL0000700

CSI 4.6

rCSI 26.2%

PRS 36.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Cyclin-dependent kinase 8 ([CDK8](/details-gene/1024)) is a protein-coding gene located on chromosome 13q12.13 that encodes a serine/threonine kinase. As a component of the Cdk8-kinase module (CKM) within the larger Mediator complex ([GO:0016592](https://www.ebi.ac.uk/QuickGO/term/GO:0016592)), [CDK8](/details-gene/1024) acts as a critical transcriptional co-regulator, primarily involved in the positive regulation of transcription by RNA polymerase II ([GO:0045944](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)). Expression data indicates that **Overall**, [CDK8](/details-gene/1024) is most significantly expressed in the central nervous system, particularly within distinct subtypes of inhibitory neurons, such as [VIP GABAergic cortical interneuron](/details-cell/CL4023016) and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011), suggesting a key role in establishing or maintaining specialized neuronal identities. Its function is pleiotropic, extending to cell cycle regulation, protein phosphorylation, and involvement in critical signaling pathways like Notch and TGF-beta. Missense substitutions in [CDK8](/details-gene/1024) have been associated with a syndromic developmental disorder [Link](https://doi.org/10.1016/j.ajhg.2019.02.006). ## Cellular Roles and Expression Landscape The expression profile of [CDK8](/details-gene/1024) highlights its prominent role in the central nervous system. **Overall**, the gene shows the highest significance in various subtypes of cortical interneurons, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 33.78), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 31.96), and [sncg GABAergic cortical interneuron](/details-cell/CL4023015) (CSI: 30.15). Its significance extends to other neuronal populations like [L6b glutamatergic cortical neuron](/details-cell/CL4023038) and [retinal ganglion cell](/details-cell/CL0000740), reinforcing its importance in diverse neuronal functions. Beyond mature neurons, [CDK8](/details-gene/1024) is also a significant marker in [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) cells (CSI: 25.89), suggesting a role in glial cell development and myelination. Its expression is not restricted to the nervous system; notable significance is also observed in hematopoietic lineages such as [erythroblast](/details-cell/CL0000765) (CSI: 16.26) and terminally differentiated [IgG plasma cell](/details-cell/CL0000985) (CSI: 14.55). This broad but specific expression pattern suggests that [CDK8](/details-gene/1024) acts as a fundamental transcriptional regulator in the terminal differentiation and functional specification of multiple distinct cell lineages. ## Pathways and Molecular Function Functionally, [CDK8](/details-gene/1024) operates as a cyclin-dependent protein serine/threonine kinase ([GO:0004693](https://www.ebi.ac.uk/QuickGO/term/GO:0004693)), primarily within the nucleus ([GO:0005634](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)) as part of the Mediator complex. Its kinase activity is crucial for phosphorylating the C-terminal domain of RNA polymerase II, thereby modulating transcriptional initiation and elongation ([R-HSA-73857](https://reactome.org/content/detail/R-HSA-73857)). The gene is deeply integrated into fundamental developmental and signaling pathways. Its involvement in [Signaling by notch](https://reactome.org/content/detail/R-HSA-157118) and [Signaling by tgf-beta receptor complex](https://reactome.org/content/detail/R-HSA-170834) is consistent with its high expression in developing neural cells and its role in cell fate decisions. For example, Mastermind-like proteins can recruit a CycC:[CDK8](/details-gene/1024) complex to phosphorylate the Notch intracellular domain, coordinating transcriptional activation with protein turnover [Link](https://doi.org/10.1016/j.molcel.2004.10.014). Furthermore, [CDK8](/details-gene/1024) is implicated in metabolic regulation, particularly through pathways like [Adipogenesis](https://reactome.org/content/detail/R-HSA-9843745) and [Regulation of lipid metabolism by pparalpha](https://reactome.org/content/detail/R-HSA-400206), indicating a role in linking transcriptional control to cellular metabolic state. ## Research Directions The specific and high-level expression of [CDK8](/details-gene/1024) in distinct neuronal subtypes, coupled with its role as a core transcriptional regulator, suggests it is a linchpin in defining neural cell identity and function. Future research should focus on elucidating its context-specific roles in both development and disease. **Proposed Hypotheses:** 1. Given its high significance in specific subtypes of inhibitory interneurons ([VIP GABAergic cortical interneuron](/details-cell/CL4023016), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011)), [CDK8](/details-gene/1024) is essential for the transcriptional programming that establishes and maintains the unique functional properties of these neuronal circuits. Its disruption could lead to imbalances in cortical excitation-inhibition, a hallmark of several neurological disorders. 2. The high significance of [CDK8](/details-gene/1024) in [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) cells, combined with its role in Notch signaling, suggests it is a critical mediator of oligodendrocyte differentiation and subsequent myelination. **Experimental Approach:** To test the first hypothesis, a conditional knockout mouse model could be generated using a Cre-LoxP system to specifically delete [CDK8](/details-gene/1024) in VIP-expressing interneurons (e.g., VIP-Cre driver line). The consequences of this deletion could be assessed using a combination of single-cell RNA sequencing to identify changes in the cellular transcriptome and identity, and ex vivo slice electrophysiology to measure alterations in the firing properties and synaptic connectivity of the affected neurons. This would directly test the role of [CDK8](/details-gene/1024) in maintaining the functional identity of this crucial interneuron population. **Therapeutic Potential:** As a protein kinase, [CDK8](/details-gene/1024) represents a druggable target. Its role in transcriptional regulation and cell cycle control has made it a target of interest in oncology, particularly in cancers where transcriptional addiction is a key dependency. Small molecule inhibitors of [CDK8](/details-gene/1024) are already in development. However, its high expression in essential cell types like neurons presents a potential challenge for systemic therapy due to on-target central nervous system toxicities. The development of next-generation inhibitors with improved specificity or targeted delivery mechanisms may be required. Given its association with developmental disorders, therapeutic strategies would likely focus on inhibition rather than activation, aiming to correct aberrant transcriptional programs.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-dependent kinase 8

Genular Protein ID: 3822939450

Symbol: CDK8_HUMAN

Name: Cyclin-dependent kinase 8

UniProtKB Accession Codes:

P49336 Q5VUF3 Q6ISB5

Database IDs:

Citations:

PubMed ID: 7568034

Title: Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.

PubMed ID: 7568034

DOI: 10.1073/pnas.92.19.8871

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734358

Title: NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.

PubMed ID: 9734358

DOI: 10.1016/s1097-2765(00)80131-8

PubMed ID: 10024883

Title: A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

PubMed ID: 10024883

DOI: 10.1016/s1097-2765(00)80178-1

PubMed ID: 10993082

Title: TFIIH is negatively regulated by cdk8-containing mediator complexes.

PubMed ID: 10993082

DOI: 10.1038/35024111

PubMed ID: 15546612

Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

PubMed ID: 15546612

DOI: 10.1016/j.molcel.2004.10.014

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 17000779

Title: Mediator modulates Gli3-dependent Sonic hedgehog signaling.

PubMed ID: 17000779

DOI: 10.1128/mcb.00443-06

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 30905399

Title: De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.

PubMed ID: 30905399

DOI: 10.1016/j.ajhg.2019.02.006

PubMed ID: 21806996

Title: The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.

PubMed ID: 21806996

DOI: 10.1016/j.jmb.2011.07.020

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 464
Mass: 53284
Checksum: 00CBAB6CE354605F
Sequence:

MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 
MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 
VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 
NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 
IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 
KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLT 
EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP LKKVRVVPPT TTSGGLIMTS 
DYQRSNPHAA YPNPGPSTSQ PQSSMGYSAT SQQPPQYSHQ THRY

Details for: CDK8

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. PubMed ID: 7568034

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. PubMed ID: 9734358

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. PubMed ID: 10024883

TFIIH is negatively regulated by cdk8-containing mediator complexes. PubMed ID: 10993082

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. PubMed ID: 15546612

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. PubMed ID: 15175163

MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. PubMed ID: 15989967

Mediator modulates Gli3-dependent Sonic hedgehog signaling. PubMed ID: 17000779

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder. PubMed ID: 30905399

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. PubMed ID: 21806996

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846