Details for: RABEPK

Gene ID: 10244

Symbol: RABEPK

Ensembl ID: ENSG00000136933

Description: Rab9 effector protein with kelch motifs

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.48
    Marker Score: 927
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,231
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.21
    Marker Score: 44,608
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.2
    Marker Score: 11,405
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.18
    Marker Score: 11,107
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.15
    Marker Score: 11,910
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.14
    Marker Score: 1,756
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68,073
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.1
    Marker Score: 9,406
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.05
    Marker Score: 1,126
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,732
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,955
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Marker Score: 4,050
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.99
    Marker Score: 14,760
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.97
    Marker Score: 911
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.96
    Marker Score: 403
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.96
    Marker Score: 19,045
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.93
    Marker Score: 5,966
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.92
    Marker Score: 3,833
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.91
    Marker Score: 3,588
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,709
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.9
    Marker Score: 1,201
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.88
    Marker Score: 33,518
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.87
    Marker Score: 3,775
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,893
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.85
    Marker Score: 244
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.84
    Marker Score: 6,436
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.82
    Marker Score: 3,187
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8
    Marker Score: 858
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.78
    Marker Score: 719
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.78
    Marker Score: 377
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.77
    Marker Score: 525
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.76
    Marker Score: 958
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.76
    Marker Score: 4,068
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.74
    Marker Score: 202
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,025
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.72
    Marker Score: 204
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.72
    Marker Score: 763
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.72
    Marker Score: 349
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.71
    Marker Score: 487
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.69
    Marker Score: 14,627
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10,624
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.68
    Marker Score: 4,407
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.67
    Marker Score: 2,760
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.67
    Marker Score: 703
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.67
    Marker Score: 763
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.67
    Marker Score: 234
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.67
    Marker Score: 332
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.66
    Marker Score: 945
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.65
    Marker Score: 1,326
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.64
    Marker Score: 1,517
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.64
    Marker Score: 1,736
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.63
    Marker Score: 8,327
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 416
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.62
    Marker Score: 450
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.61
    Marker Score: 320
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.61
    Marker Score: 750
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.6
    Marker Score: 748
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.6
    Marker Score: 2,788
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.6
    Marker Score: 4,453
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.6
    Marker Score: 179
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.59
    Marker Score: 3,793
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.59
    Marker Score: 716
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 191
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.58
    Marker Score: 616
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.58
    Marker Score: 623
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.58
    Marker Score: 368
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.58
    Marker Score: 308
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1,360
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.57
    Marker Score: 2,466
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 492
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 426
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.57
    Marker Score: 402
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.56
    Marker Score: 545
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.56
    Marker Score: 6,495
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.56
    Marker Score: 312
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.56
    Marker Score: 496
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.55
    Marker Score: 605
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.55
    Marker Score: 1,291
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.55
    Marker Score: 302
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1,107
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.54
    Marker Score: 610
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.54
    Marker Score: 544
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.54
    Marker Score: 220
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.54
    Marker Score: 1,842

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Kelch Motifs**: The RABEPK protein features kelch motifs, which are crucial for its interaction with other proteins and membranes. 2. **Rab9 Effector Protein**: RABEPK is a specific effector protein of the Rab9 GTPase, which regulates membrane trafficking and vesicle-mediated transport. 3. **Membrane Trafficking**: RABEPK is involved in various membrane trafficking processes, including endocytosis, exocytosis, and retrograde transport within the Golgi apparatus. **Pathways and Functions** 1. **Intra-Golgi and Retrograde Golgi-to-Er Trafficking**: RABEPK regulates the transport of vesicles within the Golgi apparatus, facilitating the movement of proteins and lipids towards the endoplasmic reticulum. 2. **Protein Binding**: RABEPK interacts with various proteins, including Rab9, to regulate membrane trafficking and vesicle-mediated transport. 3. **Retrograde Transport at the Trans-Golgi Network**: RABEPK plays a crucial role in regulating retrograde transport within the trans-Golgi network, ensuring the proper sorting and targeting of proteins and lipids. 4. **Vesicle Docking Involved in Exocytosis**: RABEPK is involved in the docking of vesicles with the plasma membrane, facilitating the release of neurotransmitters and hormones. **Clinical Significance** 1. **Neurological Disorders**: Alterations in RABEPK expression have been linked to various neurological disorders, including neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Cancer**: RABEPK has been implicated in cancer progression, with its overexpression contributing to tumor growth and metastasis. 3. **Neurodevelopmental Disorders**: RABEPK has been shown to play a critical role in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, the RABEPK gene is a vital component of the endosomal and Golgi apparatus pathways, regulating membrane trafficking and vesicle-mediated transport. Its dysregulation has been linked to various neurological and cancerous disorders, highlighting the importance of further research into the mechanisms underlying RABEPK function.

Genular Protein ID: 301140480

Symbol: RABEK_HUMAN

Name: 40 kDa Rab9 effector protein

UniProtKB Accession Codes:

Q7Z6M1 A8K403 O00568 Q69YR2 Q6FHA4 Q6IBG7 Q6P092 Q86Y76 Q9BWB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9230071

Title: A novel Rab9 effector required for endosome-to-TGN transport.

PubMed ID: 9230071

DOI: 10.1083/jcb.138.2.283

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14530284

Title: Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.

PubMed ID: 14530284

DOI: 10.1074/jbc.m307260200

PubMed ID: 16769818

Title: TIP47 is a key effector for Rab9 localization.

PubMed ID: 16769818

DOI: 10.1083/jcb.200510010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 372
  • Mass: 40565
  • Checksum: FBB17B9C6260C62E
  • Sequence:
    • MKQLPVLEPG DKPRKATWYT LTVPGDSPCA RVGHSCSYLP PVGNAKRGKV FIVGGANPNR 
SFSDVHTMDL GKHQWDLDTC KGLLPRYEHA SFIPSCTPDR IWVFGGANQS GNRNCLQVLN 
PETRTWTTPE VTSPPPSPRT FHTSSAAIGN QLYVFGGGER GAQPVQDTKL HVFDANTLTW 
SQPETLGNPP SPRHGHVMVA AGTKLFIHGG LAGDRFYDDL HCIDISDMKW QKLNPTGAAP 
AGCAAHSAVA MGKHVYIFGG MTPAGALDTM YQYHTEEQHW TLLKFDTLLP PGRLDHSMCI 
IPWPVTCASE KEDSNSLTLN HEAEKEDSAD KVMSHSGDSH EESQTATLLC LVFGGMNTEG 
EIYDDCIVTV VD

Genular Protein ID: 299399972

Symbol: A0A0S2Z4Z5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4Z5

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 321
  • Mass: 34841
  • Checksum: 92ACDAAD554F818F
  • Sequence:
    • MKQLPVLEPG DKPRKATWYT LTVPGDSPCA RVGHSCSYLP PVGNAKRGKV FIVGGANPNR 
SFSDVHTMDL ETRTWTTPEV TSPPPSPRTF HTSSAAIGNQ LYVFGGGERG AQPVQDTKLH 
VFDANTLTWS QPETLGNPPS PRHGHVMVAA GTKLFIHGGL AGDRFYDDLH CIDISDMKWQ 
KLNPTGAAPA GCAAHSAVAM GKHVYIFGGM TPAGALDTMY QYHTEEQHWT LLKFDTLLPP 
GRLDHSMCII PWPVTCASEK EDSNSLTLNH EAEKEDSADK VMSHSGDSHE ESQTATLLCL 
VFGGMNTEGE IYDDCIVTVV D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.