Details for: TIMM17B

Gene ID: 10245

Symbol: TIMM17B

Ensembl ID: ENSG00000126768

Description: translocase of inner mitochondrial membrane 17B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.09
    Marker Score: 2,067
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.09
    Marker Score: 2,755
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.61
    Marker Score: 1,584
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.6
    Marker Score: 764
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.51
    Marker Score: 1,769
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.03
    Marker Score: 1,078
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.99
    Marker Score: 2,860
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.89
    Marker Score: 3,951
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.77
    Marker Score: 438
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.75
    Marker Score: 2,900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.75
    Marker Score: 23,480
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.74
    Marker Score: 20,276
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.74
    Marker Score: 1,162
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.71
    Marker Score: 574
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.68
    Marker Score: 1,749
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.64
    Marker Score: 1,655
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.63
    Marker Score: 1,761
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.63
    Marker Score: 6,033
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.63
    Marker Score: 6,392
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.63
    Marker Score: 1,728
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.62
    Marker Score: 1,710
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.61
    Marker Score: 21,222
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.59
    Marker Score: 3,222
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.55
    Marker Score: 854
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.54
    Marker Score: 4,192
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.54
    Marker Score: 1,447
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.54
    Marker Score: 3,873
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.54
    Marker Score: 1,925
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.53
    Marker Score: 845
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.52
    Marker Score: 1,629
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.52
    Marker Score: 3,794
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.49
    Marker Score: 51,620
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.46
    Marker Score: 920
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.46
    Marker Score: 9,337
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.45
    Marker Score: 723
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.45
    Marker Score: 80,930
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.44
    Marker Score: 14,510
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.44
    Marker Score: 10,712
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.44
    Marker Score: 2,035
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.43
    Marker Score: 2,785
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.42
    Marker Score: 531
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.42
    Marker Score: 1,893
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.41
    Marker Score: 936
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.4
    Marker Score: 688
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.4
    Marker Score: 663
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2,065
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.4
    Marker Score: 832
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.4
    Marker Score: 3,806
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.4
    Marker Score: 12,044
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.4
    Marker Score: 3,288
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.39
    Marker Score: 942
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.38
    Marker Score: 324
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.38
    Marker Score: 770
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.35
    Marker Score: 3,196
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.34
    Marker Score: 1,363
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.34
    Marker Score: 546
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.33
    Marker Score: 3,675
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.32
    Marker Score: 5,488
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.32
    Marker Score: 7,809
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.31
    Marker Score: 2,286
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.31
    Marker Score: 2,145
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.3
    Marker Score: 6,248
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.29
    Marker Score: 621
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.27
    Marker Score: 3,779
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.27
    Marker Score: 5,213
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.27
    Marker Score: 452
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.27
    Marker Score: 2,036
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.26
    Marker Score: 599
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.26
    Marker Score: 3,380
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.25
    Marker Score: 1,047
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.25
    Marker Score: 1,310
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.25
    Marker Score: 1,062
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.24
    Marker Score: 1,169
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.22
    Marker Score: 7,944
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.22
    Marker Score: 1,725
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.22
    Marker Score: 491
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.21
    Marker Score: 3,462
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.21
    Marker Score: 3,796
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.2
    Marker Score: 680
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.19
    Marker Score: 416
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.19
    Marker Score: 589
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.19
    Marker Score: 1,437
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.18
    Marker Score: 861
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.17
    Marker Score: 404
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.16
    Marker Score: 466
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.16
    Marker Score: 2,048
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.15
    Marker Score: 1,081
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.14
    Marker Score: 422
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.14
    Marker Score: 497
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.14
    Marker Score: 1,816
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.14
    Marker Score: 9,913
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.14
    Marker Score: 1,209
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.14
    Marker Score: 4,036
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.14
    Marker Score: 598
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.13
    Marker Score: 397
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.13
    Marker Score: 287
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.12
    Marker Score: 579
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.11
    Marker Score: 1,333
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.1
    Marker Score: 313
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.09
    Marker Score: 326

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial protein import:** TIMM17B is a transmembrane protein that facilitates the import of mitochondrial proteins into the mitochondrial matrix. It is a subunit of the Tim23 mitochondrial import inner membrane translocase complex, which is responsible for regulating the biogenesis and function of mitochondria. 2. **Intracellular localization:** TIMM17B is primarily localized to the inner mitochondrial membrane, where it interacts with other components of the Tim23 complex to facilitate protein import. 3. **Cell type-specific expression:** TIMM17B is significantly expressed in various cell types, including skeletal muscle satellite cells, extravillous trophoblasts, myeloid dendritic cells, and enteric neurons, highlighting its importance in maintaining cellular homeostasis across different tissues. **Pathways and Functions:** 1. **Intracellular protein transport:** TIMM17B plays a critical role in the transport of proteins across the inner mitochondrial membrane, regulating the biogenesis and function of mitochondria. 2. **Mitochondrial protein import:** As a subunit of the Tim23 complex, TIMM17B facilitates the import of mitochondrial proteins into the mitochondrial matrix, ensuring the proper assembly and function of the mitochondrial proteome. 3. **Regulation of mitochondrial dynamics:** TIMM17B has been implicated in regulating mitochondrial dynamics, including mitochondrial fission, fusion, and motility, which are essential for maintaining cellular homeostasis. **Clinical Significance:** 1. **Neurodegenerative disorders:** Dysregulation of TIMM17B has been linked to neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, highlighting its potential as a therapeutic target for these conditions. 2. **Metabolic disorders:** TIMM17B has been implicated in metabolic disorders, including type 2 diabetes and metabolic syndrome, suggesting its potential role in regulating glucose and lipid metabolism. 3. **Immune-related conditions:** TIMM17B has been expressed in immune cells, including myeloid dendritic cells and monocytes, highlighting its potential role in regulating immune responses and inflammation. In conclusion, TIMM17B is a crucial gene that plays a pivotal role in mitochondrial protein import and cellular homeostasis. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, metabolic disorders, and immune-related conditions. Further research is needed to fully elucidate the mechanisms by which TIMM17B regulates mitochondrial function and to explore its potential as a therapeutic target for these conditions.

Genular Protein ID: 3943248036

Symbol: TI17B_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim17-B

UniProtKB Accession Codes:

O60830 A8K2E2 J3KPV3 Q9UJV0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 EMBL 9 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10339406

Title: Genetic and structural characterization of the human mitochondrial inner membrane translocase.

PubMed ID: 10339406

DOI: 10.1006/jmbi.1999.2751

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23263864

Title: Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.

PubMed ID: 23263864

DOI: 10.1093/hmg/dds541

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27265872

Title: The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.

PubMed ID: 27265872

DOI: 10.1038/srep27484

Sequence Information:

  • Length: 172
  • Mass: 18273
  • Checksum: 5DF3926F815E835A
  • Sequence:
    • MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGIRHRLRG SANAVRIRAP 
QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSITSGALTG AVLAARSGPL AMVGSAMMGG 
ILLALIEGVG ILLTRYTAQQ FRNAPPFLED PSQLPPKDGT PAPGYPSYQQ YH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.