Details for: SLC17A2

Gene ID: 10246

Symbol: SLC17A2

Ensembl ID: ENSG00000112337

Description: solute carrier family 17 member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 6.14
    Marker Score: 8,479
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.72
    Marker Score: 3,249
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.81
    Marker Score: 2,535
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.52
    Marker Score: 1,053
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2,223
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.87
    Marker Score: 1,234
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1,194
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.06
    Marker Score: 723
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.05
    Marker Score: 2,176
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.91
    Marker Score: 5,529
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.89
    Marker Score: 3,828
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.84
    Marker Score: 5,379
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.81
    Marker Score: 2,649
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.72
    Marker Score: 3,845
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1,131
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 529
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.63
    Marker Score: 366
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.53
    Marker Score: 1,012
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.49
    Marker Score: 183
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.43
    Marker Score: 332
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 858
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5,366
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.33
    Marker Score: 330
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 192
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.29
    Marker Score: 314
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.28
    Marker Score: 486
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 636
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.26
    Marker Score: 98
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.21
    Marker Score: 218
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.18
    Marker Score: 177
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 194
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.08
    Marker Score: 151
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 418
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 53
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.06
    Marker Score: 205
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.02
    Marker Score: 112
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.01
    Marker Score: 195
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.01
    Marker Score: 28

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SLC17A2 protein exhibits several key characteristics that make it an important player in phosphate homeostasis: 1. **Sodium-dependent transport**: SLC17A2 is a sodium-dependent transporter, meaning that it uses sodium ions to facilitate the transport of phosphate across cell membranes. 2. **High affinity for phosphate**: The protein has a high affinity for phosphate, allowing it to efficiently transport phosphate ions across cell membranes. 3. **Transmembrane localization**: SLC17A2 is a transmembrane protein, with both N- and C-termini located on the extracellular side of the plasma membrane. 4. **Expression in multiple cell types**: The protein is significantly expressed in various cell types, including hematopoietic stem cells, megakaryocytes, and plasma cells. **Pathways and Functions** SLC17A2 is involved in several key pathways and functions, including: 1. **Phosphate homeostasis**: The protein plays a crucial role in maintaining phosphate homeostasis in the body by regulating phosphate levels in various tissues and cells. 2. **Bone metabolism**: SLC17A2 is involved in the regulation of bone metabolism, with phosphate homeostasis being essential for bone mineralization and density. 3. **Energy production**: The protein is also involved in energy production, with phosphate being a critical component of ATP synthesis. 4. **Ion balance regulation**: SLC17A2 helps to regulate ion balances in various tissues and cells, including the kidney and plasma cells. **Clinical Significance** Dysregulation of SLC17A2 has been implicated in several diseases, including: 1. **Hypophosphatemia**: A condition characterized by low phosphate levels in the blood, which can lead to muscle weakness, fatigue, and other complications. 2. **Hyperphosphatemia**: A condition characterized by high phosphate levels in the blood, which can lead to kidney damage and other complications. 3. **Bone disorders**: SLC17A2 dysregulation has been implicated in various bone disorders, including osteoporosis and rickets. In conclusion, SLC17A2 is a critical regulator of phosphate homeostasis, with a high affinity for sodium ions and a transmembrane localization. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining proper ion balances and regulating phosphate levels in the body.

Genular Protein ID: 333231270

Symbol: NPT3_HUMAN

Name: Sodium-dependent phosphate transport protein 3

UniProtKB Accession Codes:

O00624 A6NK81 A6NLD6 Q5TB84 Q76P85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 5 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9149941

Title: A 1.1-Mb transcript map of the hereditary hemochromatosis locus.

PubMed ID: 9149941

DOI: 10.1101/gr.7.5.441

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 439
  • Mass: 47277
  • Checksum: 67494C6E00EABB54
  • Sequence:
    • MDGKPATRKG PDFCSLRYGL ALIMHFSNFT MITQRVSLSI AIIAMVNTTQ QQGLSNASTE 
GPVADAFNNS SISIKEFDTK ASVYQWSPET QGIIFSSINY GIILTLIPSG YLAGIFGAKK 
MLGAGLLISS LLTLFTPLAA DFGVILVIMV RTVQGMAQGM AWTGQFTIWA KWAPPLERSK 
LTTIAGSGSA FGSFIILCVG GLISQALSWP FIFYIFGSTG CVCCLLWFTV IYDDPMHHPC 
ISVREKEHIL SSLAQQPSSP GRAVPIKAMV TCLPLWAIFL GFFSHFWLCT IILTYLPTYI 
STLLHVNIRD SGVLSSLPFI AAASCTILGG QLADFLLSRN LLRLITVRKL FSSLGLLLPS 
ICAVALPFVA SSYVITIILL ILIPGTSNLC DSGFIINTLD IAPRYASFLM GISRGFGLIA 
GIISSTATGF LISQVGPVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.