Details for: RIDA

Gene ID: 10247

Symbol: RIDA

Ensembl ID: ENSG00000132541

Description: reactive intermediate imine deaminase A homolog

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.19
    Marker Score: 7,773
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.59
    Marker Score: 1,418
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5
    Marker Score: 1,000
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,486
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.29
    Marker Score: 878
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.16
    Marker Score: 273
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.14
    Marker Score: 1,383
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.13
    Marker Score: 1,181
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.13
    Marker Score: 2,657
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.11
    Marker Score: 1,177
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.07
    Marker Score: 5,127
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.02
    Marker Score: 21,875
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.02
    Marker Score: 1,062
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,968
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1,419
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.94
    Marker Score: 12,514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.92
    Marker Score: 2,475
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.92
    Marker Score: 536
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.91
    Marker Score: 2,171
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,181
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.9
    Marker Score: 1,448
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.9
    Marker Score: 1,878
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.89
    Marker Score: 716
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.87
    Marker Score: 253
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,393
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.85
    Marker Score: 784
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.85
    Marker Score: 3,352
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.84
    Marker Score: 242
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.83
    Marker Score: 565
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.82
    Marker Score: 1,738
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.81
    Marker Score: 5,296
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8
    Marker Score: 27,834
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.8
    Marker Score: 988
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.78
    Marker Score: 828
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 971
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.77
    Marker Score: 1,751
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.76
    Marker Score: 2,938
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.75
    Marker Score: 2,357
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.74
    Marker Score: 4,744
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.74
    Marker Score: 801
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.74
    Marker Score: 1,146
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.73
    Marker Score: 354
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.72
    Marker Score: 6,234
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.72
    Marker Score: 993
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 451
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10,983
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.7
    Marker Score: 1,770
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,910
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.68
    Marker Score: 510
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.68
    Marker Score: 912
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.67
    Marker Score: 132
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.67
    Marker Score: 374
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.67
    Marker Score: 5,220
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.66
    Marker Score: 2,705
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.65
    Marker Score: 686
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.65
    Marker Score: 5,561
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.65
    Marker Score: 539
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.64
    Marker Score: 427
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.63
    Marker Score: 262
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.62
    Marker Score: 1,034
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.61
    Marker Score: 306
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.61
    Marker Score: 327
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 531
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.61
    Marker Score: 5,811
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6
    Marker Score: 1,026
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6
    Marker Score: 36,728
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6
    Marker Score: 1,358
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.59
    Marker Score: 2,489
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.59
    Marker Score: 601
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.59
    Marker Score: 325
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.58
    Marker Score: 581
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.58
    Marker Score: 2,141
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.58
    Marker Score: 5,433
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.58
    Marker Score: 552
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.58
    Marker Score: 241
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.57
    Marker Score: 302
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.57
    Marker Score: 5,910
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 749
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.56
    Marker Score: 353
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.56
    Marker Score: 598
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.56
    Marker Score: 884
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.55
    Marker Score: 853
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.55
    Marker Score: 134
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.54
    Marker Score: 832
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.54
    Marker Score: 506

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Deaminase Activity:** RIDA's primary function is to catalyze the removal of amino groups from imine-containing compounds, resulting in the production of ketoacids and ammonia. 2. **Widespread Expression:** RIDA is expressed in various cell types, including epithelial cells of the proximal tubule, extravillous trophoblast, kidney cells, and erythroid progenitor cells. 3. **Cytosolic Localization:** RIDA is primarily localized to the cytosol, where it can interact with various proteins and modulate cellular processes. 4. **Negative Regulation of Translation:** RIDA has been shown to negatively regulate protein synthesis by binding to mRNA and inducing its degradation. **Pathways and Functions:** 1. **Metabolism of Amino Acids and Derivatives:** RIDA plays a crucial role in the catabolism of amino acids, including threonine, by catalyzing its conversion to glycine. 2. **Lipid Metabolic Process:** RIDA is involved in the regulation of lipid metabolism, particularly in the catabolism of fatty acids. 3. **Cytoplasmic Deaminase Activity:** RIDA's deaminase activity is essential for the removal of amino groups from imine-containing compounds, which can have various cellular consequences. 4. **Negative Regulation of Translation:** RIDA's ability to bind to mRNA and induce its degradation provides a mechanism for negative regulation of protein synthesis, which can be beneficial in regulating cellular processes. **Clinical Significance:** 1. **Kidney Disease:** Alterations in RIDA expression have been linked to various kidney diseases, including diabetic nephropathy and chronic kidney disease. 2. **Cancer:** RIDA's involvement in protein synthesis regulation and its expression in erythroid progenitor cells make it a potential biomarker for cancer diagnosis and prognosis. 3. **Neurological Disorders:** RIDA's role in lipid metabolism and its expression in neural cells make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases:** RIDA's deaminase activity and its expression in immune cells make it a potential target for the treatment of infectious diseases, such as tuberculosis and malaria. In conclusion, RIDA is a multifaceted gene with far-reaching implications in human health and disease. Further research is necessary to elucidate the precise mechanisms by which RIDA regulates cellular processes and to explore its potential as a therapeutic target. As an expert immunologist, I am excited to continue studying the intricacies of RIDA and its role in maintaining human health.

Genular Protein ID: 873821173

Symbol: RIDA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P52758 Q6FHU9 Q6IBG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8973653

Title: Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation.

PubMed ID: 8973653

DOI: 10.1111/j.1432-1033.1996.0339r.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9141440

Title: Hrp12, a novel heat-responsive, tissue-specific, phosphorylated protein isolated from mouse liver.

PubMed ID: 9141440

DOI: 10.1002/hep.510250525

PubMed ID: 20817725

Title: Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro.

PubMed ID: 20817725

DOI: 10.1074/jbc.m110.160515

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22094463

Title: The conserved YjgF protein family deaminates enamine/imine intermediates of pyridoxal-5'-phosphate (PLP)-dependent enzyme reactions.

PubMed ID: 22094463

DOI: 10.1074/jbc.m111.304477

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30930054

Title: Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex.

PubMed ID: 30930054

DOI: 10.1016/j.molcel.2019.02.034

PubMed ID: 14997576

Title: Crystal structure of Homo sapiens protein hp14.5.

PubMed ID: 14997576

DOI: 10.1002/prot.10619

Sequence Information:

  • Length: 137
  • Mass: 14494
  • Checksum: DD0740621E8BE6AD
  • Sequence:
    • MSSLIRRVIS TAKAPGAIGP YSQAVLVDRT IYISGQIGMD PSSGQLVSGG VAEEAKQALK 
NMGEILKAAG CDFTNVVKTT VLLADINDFN TVNEIYKQYF KSNFPARAAY QVAALPKGSR 
IEIEAVAIQG PLTTASL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.