Details for: POP7

Gene ID: 10248

Symbol: POP7

Ensembl ID: ENSG00000172336

Description: POP7 homolog, ribonuclease P/MRP subunit

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.32
    Marker Score: 4,888
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.08
    Marker Score: 2,174
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.92
    Marker Score: 7,537
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.66
    Marker Score: 1,129
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.44
    Marker Score: 2,923
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.4
    Marker Score: 12,066
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.39
    Marker Score: 1,678
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.31
    Marker Score: 1,646
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.3
    Marker Score: 1,225
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.29
    Marker Score: 1,447
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.25
    Marker Score: 43,201
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.25
    Marker Score: 1,317
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.22
    Marker Score: 1,149
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.21
    Marker Score: 4,480
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.21
    Marker Score: 906
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.21
    Marker Score: 2,518
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.2
    Marker Score: 9,333
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.18
    Marker Score: 744
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.17
    Marker Score: 1,560
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.17
    Marker Score: 4,795
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.17
    Marker Score: 5,754
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.16
    Marker Score: 2,750
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.14
    Marker Score: 1,930
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.14
    Marker Score: 801
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.12
    Marker Score: 1,806
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.12
    Marker Score: 1,197
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1
    Marker Score: 4,257
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.09
    Marker Score: 1,179
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.09
    Marker Score: 5,233
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.07
    Marker Score: 891
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.06
    Marker Score: 2,617
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.06
    Marker Score: 4,561
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.06
    Marker Score: 355
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.04
    Marker Score: 574
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.04
    Marker Score: 2,826
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.03
    Marker Score: 754
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.03
    Marker Score: 293
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.03
    Marker Score: 2,356
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.03
    Marker Score: 1,512
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.02
    Marker Score: 525
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.02
    Marker Score: 345
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1
    Marker Score: 670
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,665
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,889
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.99
    Marker Score: 1,000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.98
    Marker Score: 2,919
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,387
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.96
    Marker Score: 545
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.95
    Marker Score: 7,065
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.95
    Marker Score: 10,665
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.95
    Marker Score: 1,677
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,389
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.94
    Marker Score: 467
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.94
    Marker Score: 1,489
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.93
    Marker Score: 459
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.93
    Marker Score: 329
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.92
    Marker Score: 445
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.92
    Marker Score: 1,528
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.92
    Marker Score: 578
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.91
    Marker Score: 342
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,177
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,698
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.9
    Marker Score: 2,119
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.89
    Marker Score: 256
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.89
    Marker Score: 226
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.89
    Marker Score: 5,662
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.89
    Marker Score: 10,301
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.87
    Marker Score: 197
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.87
    Marker Score: 584
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.87
    Marker Score: 22,340
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,212
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.86
    Marker Score: 1,950
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.85
    Marker Score: 805
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.85
    Marker Score: 2,325
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.85
    Marker Score: 1,396
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.85
    Marker Score: 466
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.85
    Marker Score: 755
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.84
    Marker Score: 5,378
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.84
    Marker Score: 750
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.83
    Marker Score: 10,933
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.82
    Marker Score: 439
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.82
    Marker Score: 5,331
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.82
    Marker Score: 785
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.82
    Marker Score: 386
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.81
    Marker Score: 191
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.81
    Marker Score: 7,070
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.81
    Marker Score: 1,169
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.81
    Marker Score: 337
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.81
    Marker Score: 862
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.81
    Marker Score: 2,543
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.8
    Marker Score: 815
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.8
    Marker Score: 834
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.8
    Marker Score: 180
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.8
    Marker Score: 1,500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.8
    Marker Score: 458

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribonuclease P/MRP Complex**: The POP7 gene is part of the ribonuclease P/MRP complex, which consists of two subunits: the POP7 protein subunit (p20) and the RNU14 protein subunit. The complex is responsible for the processing of precursor RNAs in the nucleus. 2. **RNA Processing**: The POP7 gene is involved in the processing of tRNA, 5S rRNA, and other small RNAs, ensuring proper translation and gene expression. 3. **Cellular Expression**: The POP7 gene is significantly expressed in various cell types, including pancreatic acinar cells, erythroid progenitor cells, and neurons. 4. **Multifunctional Role**: The POP7 gene plays a multifunctional role in cellular processes, including RNA processing, translation, and gene expression. **Pathways and Functions:** 1. **Metabolism of RNA**: The POP7 gene is involved in the metabolism of RNA, specifically in the processing of precursor RNAs. 2. **Multimeric Ribonuclease P Complex**: The POP7 gene is part of the multimeric ribonuclease P complex, which consists of multiple subunits working together to process precursor RNAs. 3. **Nucleolar Ribonuclease P Complex**: The POP7 gene is also part of the nucleolar ribonuclease P complex, which is responsible for the processing of 5S rRNA. 4. **Protein Binding**: The POP7 gene interacts with various proteins, including RNU14 and other subunits of the ribonuclease P/MRP complex. **Clinical Significance:** The POP7 gene has significant implications in various diseases, including: 1. **Cancer**: Alterations in the POP7 gene have been linked to various types of cancer, including pancreatic cancer and leukemia. 2. **Neurological Disorders**: The POP7 gene is involved in the processing of tRNA and other small RNAs, which are essential for proper neuronal function. Alterations in the POP7 gene have been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Genetic Disorders**: The POP7 gene is involved in the processing of precursor RNAs, which are essential for proper gene expression. Alterations in the POP7 gene have been linked to genetic disorders, including inherited forms of cancer and neurological disorders. In conclusion, the POP7 gene plays a crucial role in the processing of precursor RNAs, ensuring proper translation and gene expression. Its significance extends to various diseases, including cancer, neurological disorders, and genetic disorders. Further research is needed to fully elucidate the molecular mechanisms of the POP7 gene and its implications in human disease.

Genular Protein ID: 2564845594

Symbol: POP7_HUMAN

Name: Ribonuclease P protein subunit p20

UniProtKB Accession Codes:

O75817 A4D2E0 Q9BV74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ComplexPortal 2 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 EMDB 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9630247

Title: Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.

PubMed ID: 9630247

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15096576

Title: Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.

PubMed ID: 15096576

DOI: 10.1093/nar/gkh539

PubMed ID: 14715275

Title: Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress.

PubMed ID: 14715275

DOI: 10.1016/j.bbrc.2003.12.084

PubMed ID: 16723659

Title: Differential association of protein subunits with the human RNase MRP and RNase P complexes.

PubMed ID: 16723659

DOI: 10.1261/rna.2293906

PubMed ID: 20215441

Title: Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.

PubMed ID: 20215441

DOI: 10.1093/nar/gkq141

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28115465

Title: Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.

PubMed ID: 28115465

DOI: 10.1101/gad.286963.116

PubMed ID: 30454648

Title: Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.

PubMed ID: 30454648

DOI: 10.1016/j.cell.2018.10.003

PubMed ID: 29625199

Title: Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding.

PubMed ID: 29625199

DOI: 10.1016/j.jmb.2018.03.029

Sequence Information:

  • Length: 140
  • Mass: 15651
  • Checksum: CA380F7D273A64B3
  • Sequence:
    • MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA RCQKLLDGGA 
RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA NTSTVELVDE LEPETDTREP 
LTRIRNNSAI HIRVFRVTPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.