Details for: GLYAT

Gene ID: 10249

Symbol: GLYAT

Ensembl ID: ENSG00000149124

Description: glycine-N-acyltransferase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 6.48
    Marker Score: 8,942
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.83
    Marker Score: 2,543
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.52
    Marker Score: 1,052
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.38
    Marker Score: 8,445
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2
    Marker Score: 1,319
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.86
    Marker Score: 5,431
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.69
    Marker Score: 10,839
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.67
    Marker Score: 8,957
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.54
    Marker Score: 6,666
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.52
    Marker Score: 3,575
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.17
    Marker Score: 2,215
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7,304
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.08
    Marker Score: 1,206
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.07
    Marker Score: 1,026
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2,121
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.02
    Marker Score: 494
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,021
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.91
    Marker Score: 7,690
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13,145
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.78
    Marker Score: 295
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.77
    Marker Score: 529
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.71
    Marker Score: 398
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.68
    Marker Score: 723
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.61
    Marker Score: 658
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.6
    Marker Score: 219
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 361
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.59
    Marker Score: 1,936
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.59
    Marker Score: 219
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.47
    Marker Score: 175
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.46
    Marker Score: 957
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 142
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.44
    Marker Score: 295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.44
    Marker Score: 254
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 676
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.42
    Marker Score: 319
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 198
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.41
    Marker Score: 389
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.38
    Marker Score: 209
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.37
    Marker Score: 721
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.37
    Marker Score: 387
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.36
    Marker Score: 84
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.34
    Marker Score: 151
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 199
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.33
    Marker Score: 352
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.32
    Marker Score: 304
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.31
    Marker Score: 434
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.3
    Marker Score: 2,832
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.29
    Marker Score: 322
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.28
    Marker Score: 75
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 123
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.27
    Marker Score: 53
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.27
    Marker Score: 83
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.26
    Marker Score: 53
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.26
    Marker Score: 1,013
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.24
    Marker Score: 210
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.23
    Marker Score: 273
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.23
    Marker Score: 317
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.23
    Marker Score: 282
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 349
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.22
    Marker Score: 2,957
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 167
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.21
    Marker Score: 59
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.21
    Marker Score: 348
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 187
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.21
    Marker Score: 135
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.2
    Marker Score: 47
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2
    Marker Score: 12,041
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2
    Marker Score: 1,678
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.18
    Marker Score: 315
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.18
    Marker Score: 52
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.18
    Marker Score: 111
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 360
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 165
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.16
    Marker Score: 53

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** GLYAT has a broad substrate specificity, accepting various acyl-CoA derivatives, including benzoate, carboxylic acids, and salicylate. 2. **Catalytic mechanism:** The enzyme catalyzes the acylation of glycine with acyl-CoA derivatives, resulting in the formation of glycine-N-acyltransferase conjugates. 3. **Tissue distribution:** GLYAT is widely expressed in various tissues, including the liver, kidney, hematopoietic system, and epithelial cells. 4. **Regulatory mechanisms:** The expression and activity of GLYAT can be regulated by various factors, including transcriptional and post-translational modifications. **Pathways and Functions:** 1. **Glycine metabolism:** GLYAT plays a crucial role in the metabolism of glycine, a non-essential amino acid, by catalyzing the conjugation of glycine with acyl-CoA derivatives. 2. **Xenobiotic conjugation:** The enzyme is involved in the conjugation of various xenobiotics, including benzoate, carboxylic acids, and salicylate, which are commonly encountered as environmental pollutants. 3. **Acyl-CoA metabolic process:** GLYAT is also involved in the acyl-CoA metabolic process, which is essential for the regulation of fatty acid synthesis and degradation. 4. **Biological oxidations:** The enzyme participates in the biological oxidations of various compounds, including xenobiotics and endogenous metabolites. **Clinical Significance:** 1. **Detoxification:** GLYAT plays a crucial role in the detoxification of various xenobiotics, including environmental pollutants and pharmaceuticals. 2. **Gastrointestinal disorders:** Abnormalities in GLYAT expression and activity have been linked to gastrointestinal disorders, such as liver disease and kidney dysfunction. 3. **Cancer:** The enzyme has been implicated in the development and progression of various cancers, including colorectal and breast cancer. 4. **Neurological disorders:** GLYAT has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, GLYAT is a critical enzyme in the metabolism of amino acids and xenobiotics, and its dysregulation has been implicated in various diseases, including gastrointestinal disorders, cancer, and neurological disorders. Further research is necessary to fully elucidate the role of GLYAT in human health and disease.

Genular Protein ID: 112192208

Symbol: GLYAT_HUMAN

Name: Acyl-CoA:glycine N-acyltransferase

UniProtKB Accession Codes:

Q6IB77 H1AE11 O14833 Q96QK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10630424

Title: The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase.

PubMed ID: 10630424

DOI: 10.1002/(sici)1099-0461(2000)14:2<102::aid-jbt6>3.0.co;2-h

PubMed ID: 22475485

Title: Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma.

PubMed ID: 22475485

DOI: 10.1016/j.bbrc.2012.03.099

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7802672

Title: Purification to homogeneity of mitochondrial acyl CoA:glycine N-acyltransferase from human liver.

PubMed ID: 7802672

DOI: 10.1006/bbrc.1994.2817

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 296
  • Mass: 33924
  • Checksum: CB9D63FA48C23FE3
  • Sequence:
    • MMLPLQGAQM LQMLEKSLRK SLPASLKVYG TVFHINHGNP FNLKAVVDKW PDFNTVVVCP 
QEQDMTDDLD HYTNTYQIYS KDPQNCQEFL GSPELINWKQ HLQIQSSQPS LNEAIQNLAA 
IKSFKVKQTQ RILYMAAETA KELTPFLLKS KILSPNGGKP KAINQEMFKL SSMDVTHAHL 
VNKFWHFGGN ERSQRFIERC IQTFPTCCLL GPEGTPVCWD LMDQTGEMRM AGTLPEYRLH 
GLVTYVIYSH AQKLGKLGFP VYSHVDYSNE AMQKMSYTLQ HVPIPRSWNQ WNCVPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.