Details for: CDK9

Gene ID: 1025

Symbol: CDK9

Ensembl ID: ENSG00000136807

Description: cyclin dependent kinase 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.55
    Marker Score: 15705
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.14
    Marker Score: 1228
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.07
    Marker Score: 309
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.01
    Marker Score: 1073
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71680
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47904
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.92
    Marker Score: 1943
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.91
    Marker Score: 471
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.91
    Marker Score: 1821
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.9
    Marker Score: 427
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.9
    Marker Score: 1128.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2691
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.89
    Marker Score: 7686
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.88
    Marker Score: 8851.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13484.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5219
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4775
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.82
    Marker Score: 2817
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 489
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.81
    Marker Score: 819
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.8
    Marker Score: 1959
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8
    Marker Score: 1174
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.79
    Marker Score: 27024
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.78
    Marker Score: 7437.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.78
    Marker Score: 270
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.75
    Marker Score: 46192
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.74
    Marker Score: 362
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.74
    Marker Score: 244
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.74
    Marker Score: 4374
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.74
    Marker Score: 444
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.73
    Marker Score: 25227
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.72
    Marker Score: 6274
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.72
    Marker Score: 224
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.71
    Marker Score: 487
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.71
    Marker Score: 249
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.71
    Marker Score: 740
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.71
    Marker Score: 1022
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 367.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 226
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.7
    Marker Score: 1074
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.7
    Marker Score: 257
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.69
    Marker Score: 599
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.69
    Marker Score: 159
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 442
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.68
    Marker Score: 453.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2857
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.68
    Marker Score: 204
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.68
    Marker Score: 2511
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 458
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.67
    Marker Score: 162
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.67
    Marker Score: 251
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.67
    Marker Score: 1824
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.67
    Marker Score: 4347
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.67
    Marker Score: 14256
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.66
    Marker Score: 271
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.66
    Marker Score: 600
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.66
    Marker Score: 320
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.66
    Marker Score: 157.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 599
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.65
    Marker Score: 9773.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.65
    Marker Score: 231
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.65
    Marker Score: 686
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.65
    Marker Score: 613
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.65
    Marker Score: 1768
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 429
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.65
    Marker Score: 2542
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.64
    Marker Score: 243
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.64
    Marker Score: 1773
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.64
    Marker Score: 467
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.64
    Marker Score: 2750.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.64
    Marker Score: 5999
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.63
    Marker Score: 168
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.63
    Marker Score: 677
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.63
    Marker Score: 432
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.63
    Marker Score: 288
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.63
    Marker Score: 426
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.62
    Marker Score: 601
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.62
    Marker Score: 286
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.62
    Marker Score: 23586
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.62
    Marker Score: 1560
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.62
    Marker Score: 1038
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.62
    Marker Score: 463
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1450
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.61
    Marker Score: 605
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.61
    Marker Score: 123.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.61
    Marker Score: 6861
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.61
    Marker Score: 2350
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.61
    Marker Score: 150
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.61
    Marker Score: 385
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.6
    Marker Score: 254
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.6
    Marker Score: 165.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.6
    Marker Score: 492
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.6
    Marker Score: 601

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Other Information

**Key characteristics:** * CDK9 is a serine/threonine kinase with a molecular weight of approximately 130 kDa. * It is a member of the cyclin-dependent kinase family, which also includes CDK6 and CDK15. * CDK9 is highly expressed in proliferating cells and tissues. * It is involved in the regulation of cell cycle progression, cell cycle checkpoints, and apoptosis. * It is also involved in the regulation of cell differentiation, proliferation, and migration. **Pathways and functions:** * CDK9 is involved in the regulation of cell cycle progression through the G1 and S phases. * It is essential for the initiation of cell cycle entry and the progression through G1. * It is also involved in the regulation of cell cycle checkpoints, which prevent cells from entering mitosis when they are not properly synchronized. * CDK9 is also involved in the regulation of cell differentiation, proliferation, and migration. * It is involved in the regulation of immune responses and inflammation. * CDK9 is also involved in viral infection pathways. **Clinical significance:** * Mutations in CDK9 have been linked to a number of human cancers, including breast cancer, lung cancer, and colorectal cancer. * Targeting CDK9 has been investigated as a therapeutic strategy for cancer. * CDK9 inhibitors are currently being evaluated in clinical trials for the treatment of cancer and other diseases. **Additional information:** * CDK9 is a key regulator of cell growth, proliferation, and differentiation. * It is involved in both normal and malignant cell growth. * It is a target for cancer therapy. * Mutations in CDK9 have been linked to a number of human cancers.

Genular Protein ID: 2542068508

Symbol: CDK9_HUMAN

Name: Cyclin-dependent kinase 9

UniProtKB Accession Codes:

P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 DrugCentral 1 EC 3 ELM 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 26 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 15 RefSeq 1 Rhea 12 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8170997

Title: PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.

PubMed ID: 8170997

DOI: 10.1073/pnas.91.9.3834

PubMed ID: 7695608

Title: Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells.

PubMed ID: 7695608

DOI: 10.1006/bbrc.1995.1375

PubMed ID: 10903437

Title: Genomic organization and characterization of promoter function of the human CDK9 gene.

PubMed ID: 10903437

DOI: 10.1016/s0378-1119(00)00215-8

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9491887

Title: A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

PubMed ID: 9491887

DOI: 10.1016/s0092-8674(00)80939-3

PubMed ID: 9857195

Title: Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.

PubMed ID: 9857195

DOI: 10.1093/emboj/17.24.7395

PubMed ID: 9499409

Title: Identification of multiple cyclin subunits of human P-TEFb.

PubMed ID: 9499409

DOI: 10.1101/gad.12.5.755

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10574912

Title: Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.

PubMed ID: 10574912

DOI: 10.1074/jbc.274.49.34527

PubMed ID: 10912001

Title: FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

PubMed ID: 10912001

DOI: 10.1016/s1097-2765(00)80272-5

PubMed ID: 10757782

Title: Domains in the SPT5 protein that modulate its transcriptional regulatory properties.

PubMed ID: 10757782

DOI: 10.1128/mcb.20.9.2970-2983.2000

PubMed ID: 10958691

Title: CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.

PubMed ID: 10958691

DOI: 10.1128/mcb.20.18.6958-6969.2000

PubMed ID: 11145967

Title: Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

PubMed ID: 11145967

DOI: 10.1074/jbc.m010908200

PubMed ID: 11112772

Title: DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.

PubMed ID: 11112772

DOI: 10.1074/jbc.m006130200

PubMed ID: 11575923

Title: The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.

PubMed ID: 11575923

DOI: 10.1006/jmbi.2001.4991

PubMed ID: 11884399

Title: P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.

PubMed ID: 11884399

DOI: 10.1074/jbc.m200117200

PubMed ID: 12065898

Title: MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.

PubMed ID: 12065898

DOI: 10.1007/bf02256070

PubMed ID: 12115727

Title: CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.

PubMed ID: 12115727

DOI: 10.1002/jcp.10130

PubMed ID: 11809800

Title: Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences.

PubMed ID: 11809800

DOI: 10.1128/mcb.22.4.1079-1093.2002

PubMed ID: 12037670

Title: Activation of MyoD-dependent transcription by cdk9/cyclin T2.

PubMed ID: 12037670

DOI: 10.1038/sj.onc.1205493

PubMed ID: 12718890

Title: Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

PubMed ID: 12718890

DOI: 10.1016/s1097-2765(03)00101-1

PubMed ID: 15564463

Title: Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.

PubMed ID: 15564463

DOI: 10.1128/jvi.78.24.13522-13533.2004

PubMed ID: 14701750

Title: Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element.

PubMed ID: 14701750

DOI: 10.1128/mcb.24.2.787-795.2004

PubMed ID: 15965233

Title: Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.

PubMed ID: 15965233

DOI: 10.1074/jbc.m502712200

PubMed ID: 16109376

Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

PubMed ID: 16109376

DOI: 10.1016/j.molcel.2005.06.027

PubMed ID: 16109377

Title: Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

PubMed ID: 16109377

DOI: 10.1016/j.molcel.2005.06.029

PubMed ID: 17956865

Title: The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.

PubMed ID: 17956865

DOI: 10.1074/jbc.m706458200

PubMed ID: 17643375

Title: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

PubMed ID: 17643375

DOI: 10.1016/j.molcel.2007.06.027

PubMed ID: 17452463

Title: Regulation of P-TEFb elongation complex activity by CDK9 acetylation.

PubMed ID: 17452463

DOI: 10.1128/mcb.00857-06

PubMed ID: 18483222

Title: PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.

PubMed ID: 18483222

DOI: 10.1101/gad.1636008

PubMed ID: 18829461

Title: Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop.

PubMed ID: 18829461

DOI: 10.1074/jbc.m807495200

PubMed ID: 18249148

Title: A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.

PubMed ID: 18249148

DOI: 10.1016/j.molcel.2008.01.003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18250157

Title: Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.

PubMed ID: 18250157

DOI: 10.1128/mcb.01557-07

PubMed ID: 18362169

Title: RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes.

PubMed ID: 18362169

DOI: 10.1128/mcb.01152-07

PubMed ID: 19844166

Title: Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.

PubMed ID: 19844166

DOI: 10.4161/cc.8.22.9890

PubMed ID: 19575011

Title: CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.

PubMed ID: 19575011

DOI: 10.1038/embor.2009.108

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20493174

Title: 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.

PubMed ID: 20493174

DOI: 10.1016/j.bbrc.2010.05.092

PubMed ID: 20930849

Title: Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.

PubMed ID: 20930849

DOI: 10.1038/embor.2010.153

PubMed ID: 20081228

Title: Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.

PubMed ID: 20081228

DOI: 10.1074/jbc.m109.070458

PubMed ID: 20471948

Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

PubMed ID: 20471948

DOI: 10.1016/j.molcel.2010.04.013

PubMed ID: 20159561

Title: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

PubMed ID: 20159561

DOI: 10.1016/j.molcel.2010.01.026

PubMed ID: 20980437

Title: CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.

PubMed ID: 20980437

DOI: 10.1210/me.2010-0238

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22195968

Title: The little elongation complex regulates small nuclear RNA transcription.

PubMed ID: 22195968

DOI: 10.1016/j.molcel.2011.12.008

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21484792

Title: CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.

PubMed ID: 21484792

DOI: 10.1002/ijc.26127

PubMed ID: 21127351

Title: Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

PubMed ID: 21127351

DOI: 10.1074/jbc.m110.176628

PubMed ID: 21448926

Title: Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway.

PubMed ID: 21448926

DOI: 10.1002/jcp.22760

PubMed ID: 21533037

Title: Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.

PubMed ID: 21533037

DOI: 10.1371/journal.pone.0018985

PubMed ID: 16885020

Title: Controlling the elongation phase of transcription with P-TEFb.

PubMed ID: 16885020

DOI: 10.1016/j.molcel.2006.06.014

PubMed ID: 18728388

Title: Expanding role of cyclin dependent kinases in cytokine inducible gene expression.

PubMed ID: 18728388

DOI: 10.4161/cc.7.17.6594

PubMed ID: 19029809

Title: Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases.

PubMed ID: 19029809

DOI: 10.4161/cc.7.23.7122

PubMed ID: 18423896

Title: Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology.

PubMed ID: 18423896

DOI: 10.1016/j.tips.2008.03.003

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 19757441

Title: Pharmacological targeting of CDK9 in cardiac hypertrophy.

PubMed ID: 19757441

DOI: 10.1002/med.20172

PubMed ID: 21200140

Title: A role for cdk9-cyclin k in maintaining genome integrity.

PubMed ID: 21200140

DOI: 10.4161/cc.10.1.14364

PubMed ID: 23029222

Title: Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb.

PubMed ID: 23029222

DOI: 10.1371/journal.pone.0045749

PubMed ID: 24360279

Title: Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

PubMed ID: 24360279

DOI: 10.1016/j.cell.2013.10.056

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25233083

Title: Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation.

PubMed ID: 25233083

DOI: 10.1371/journal.pone.0107654

PubMed ID: 27189267

Title: Heat shock factor 1 mediates latent HIV reactivation.

PubMed ID: 27189267

DOI: 10.1038/srep26294

PubMed ID: 28426094

Title: SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription.

PubMed ID: 28426094

DOI: 10.1093/nar/gkx053

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 29335245

Title: CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery.

PubMed ID: 29335245

DOI: 10.15252/embr.201744311

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 20535204

Title: Crystal structure of HIV-1 Tat complexed with human P-TEFb.

PubMed ID: 20535204

DOI: 10.1038/nature09131

PubMed ID: 18566585

Title: The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

PubMed ID: 18566585

DOI: 10.1038/emboj.2008.121

PubMed ID: 20851342

Title: Halogen bonds form the basis for selective P-TEFb inhibition by DRB.

PubMed ID: 20851342

DOI: 10.1016/j.chembiol.2010.07.012

PubMed ID: 21779453

Title: CDK inhibitors roscovitine and CR8 trigger Mcl-1 down-regulation and apoptotic cell death in neuroblastoma cells.

PubMed ID: 21779453

DOI: 10.1177/1947601910369817

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 372
  • Mass: 42778
  • Checksum: 69E851CC6F7A0388
  • Sequence:
    • MAKQYDSVEC PFCDEVSKYE KLAKIGQGTF GEVFKARHRK TGQKVALKKV LMENEKEGFP 
ITALREIKIL QLLKHENVVN LIEICRTKAS PYNRCKGSIY LVFDFCEHDL AGLLSNVLVK 
FTLSEIKRVM QMLLNGLYYI HRNKILHRDM KAANVLITRD GVLKLADFGL ARAFSLAKNS 
QPNRYTNRVV TLWYRPPELL LGERDYGPPI DLWGAGCIMA EMWTRSPIMQ GNTEQHQLAL 
ISQLCGSITP EVWPNVDNYE LYEKLELVKG QKRKVKDRLK AYVRDPYALD LIDKLLVLDP 
AQRIDSDDAL NHDFFWSDPM PSDLKGMLST HLTSMFEYLA PPRRKGSQIT QQSTNQSRNP 
ATTNQTEFER VF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.