Details for: CDK9

Gene ID: 1025

Symbol: CDK9

Ensembl ID: ENSG00000136807

Description: cyclin dependent kinase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.3164
    Cell Significance Index: -21.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.0944
    Cell Significance Index: -21.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.1607
    Cell Significance Index: -23.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8490
    Cell Significance Index: -23.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2008
    Cell Significance Index: -19.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9959
    Cell Significance Index: -23.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1897
    Cell Significance Index: -15.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.4960
    Cell Significance Index: 40.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6640
    Cell Significance Index: 107.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4981
    Cell Significance Index: 20.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2716
    Cell Significance Index: 1148.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9614
    Cell Significance Index: 104.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9556
    Cell Significance Index: 57.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8961
    Cell Significance Index: 24.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8452
    Cell Significance Index: 137.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6096
    Cell Significance Index: 60.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5274
    Cell Significance Index: 105.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4703
    Cell Significance Index: 64.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4637
    Cell Significance Index: 13.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4590
    Cell Significance Index: 20.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4074
    Cell Significance Index: 77.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3964
    Cell Significance Index: 216.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3854
    Cell Significance Index: 266.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3849
    Cell Significance Index: 69.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3586
    Cell Significance Index: 7.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3428
    Cell Significance Index: 17.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3305
    Cell Significance Index: 8.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2623
    Cell Significance Index: 115.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2500
    Cell Significance Index: 16.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2499
    Cell Significance Index: 89.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2336
    Cell Significance Index: 28.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2306
    Cell Significance Index: 10.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2055
    Cell Significance Index: 5.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1970
    Cell Significance Index: 13.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1783
    Cell Significance Index: 21.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1688
    Cell Significance Index: 4.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1671
    Cell Significance Index: 4.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1539
    Cell Significance Index: 4.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1308
    Cell Significance Index: 3.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1228
    Cell Significance Index: 24.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1227
    Cell Significance Index: 5.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0971
    Cell Significance Index: 7.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0785
    Cell Significance Index: 10.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0750
    Cell Significance Index: 9.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0681
    Cell Significance Index: 1.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0404
    Cell Significance Index: 1.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0111
    Cell Significance Index: 20.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0102
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0133
    Cell Significance Index: -18.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0136
    Cell Significance Index: -2.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0173
    Cell Significance Index: -13.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0201
    Cell Significance Index: -0.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0258
    Cell Significance Index: -0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0268
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0407
    Cell Significance Index: -5.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0414
    Cell Significance Index: -4.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0418
    Cell Significance Index: -23.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0450
    Cell Significance Index: -28.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0688
    Cell Significance Index: -19.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0698
    Cell Significance Index: -5.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0911
    Cell Significance Index: -5.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1177
    Cell Significance Index: -13.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1191
    Cell Significance Index: -7.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1233
    Cell Significance Index: -3.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1255
    Cell Significance Index: -6.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1297
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1332
    Cell Significance Index: -28.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1406
    Cell Significance Index: -2.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1485
    Cell Significance Index: -17.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1658
    Cell Significance Index: -5.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1734
    Cell Significance Index: -1.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1843
    Cell Significance Index: -3.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2072
    Cell Significance Index: -1.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2090
    Cell Significance Index: -21.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2200
    Cell Significance Index: -6.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2388
    Cell Significance Index: -7.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2600
    Cell Significance Index: -20.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2938
    Cell Significance Index: -6.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3158
    Cell Significance Index: -19.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3422
    Cell Significance Index: -7.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3430
    Cell Significance Index: -15.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3456
    Cell Significance Index: -17.4600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3600
    Cell Significance Index: -5.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3674
    Cell Significance Index: -6.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3729
    Cell Significance Index: -14.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3887
    Cell Significance Index: -8.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4445
    Cell Significance Index: -8.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4550
    Cell Significance Index: -4.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4679
    Cell Significance Index: -15.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4892
    Cell Significance Index: -15.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5107
    Cell Significance Index: -6.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5109
    Cell Significance Index: -18.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5172
    Cell Significance Index: -13.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5325
    Cell Significance Index: -9.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5349
    Cell Significance Index: -18.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDK9 has several key characteristics that make it an essential component of the transcriptional machinery: 1. **Cyclin-dependent kinase activity**: CDK9 is a cyclin-dependent kinase (CDK) that phosphorylates and activates RNAP II, allowing it to transcribe genes more efficiently. 2. **Positive transcription elongation factor b (P-TEFb) complex**: CDK9 is a key component of the P-TEFb complex, which regulates gene expression by phosphorylating and activating RNAP II. 3. **RNA polymerase II (RNAP II) interaction**: CDK9 binds to the CTD of RNAP II, allowing it to transcribe genes more efficiently. 4. **Chromatin binding**: CDK9 can bind to chromatin, allowing it to regulate gene expression by modifying chromatin structure. **Pathways and Functions** CDK9 is involved in various cellular processes, including: 1. **Transcriptional regulation**: CDK9 regulates gene expression by phosphorylating and activating RNAP II, allowing it to transcribe genes more efficiently. 2. **Cell cycle regulation**: CDK9 regulates the cell cycle by phosphorylating and activating proteins involved in cell cycle progression. 3. **DNA repair**: CDK9 regulates DNA repair by phosphorylating and activating proteins involved in DNA repair pathways. 4. **HIV transcription**: CDK9 is essential for the transcription of HIV genes, as it phosphorylates and activates RNAP II, allowing it to transcribe HIV genes more efficiently. **Clinical Significance** CDK9 has significant clinical implications, particularly in the context of: 1. **Cancer**: CDK9 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis. 2. **HIV/AIDS**: CDK9 is essential for the transcription of HIV genes, and its dysregulation can lead to HIV disease progression. 3. **Neurological disorders**: CDK9 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where its dysregulation can lead to disease progression. 4. **Regenerative medicine**: CDK9 has been used as a therapeutic target in regenerative medicine, where its dysregulation can lead to tissue repair and regeneration. In conclusion, CDK9 is a crucial component of the transcriptional machinery, regulating gene expression and involved in various cellular processes. Its dysregulation has significant clinical implications, particularly in the context of cancer, HIV/AIDS, neurological disorders, and regenerative medicine. Further research is needed to fully understand the role of CDK9 in these processes and to explore its therapeutic potential.

Genular Protein ID: 2542068508

Symbol: CDK9_HUMAN

Name: Cyclin-dependent kinase 9

UniProtKB Accession Codes:

P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 DrugCentral 1 EC 3 ELM 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 28 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 15 RefSeq 1 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8170997

Title: PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.

PubMed ID: 8170997

DOI: 10.1073/pnas.91.9.3834

PubMed ID: 7695608

Title: Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells.

PubMed ID: 7695608

DOI: 10.1006/bbrc.1995.1375

PubMed ID: 10903437

Title: Genomic organization and characterization of promoter function of the human CDK9 gene.

PubMed ID: 10903437

DOI: 10.1016/s0378-1119(00)00215-8

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9491887

Title: A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

PubMed ID: 9491887

DOI: 10.1016/s0092-8674(00)80939-3

PubMed ID: 9857195

Title: Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.

PubMed ID: 9857195

DOI: 10.1093/emboj/17.24.7395

PubMed ID: 9499409

Title: Identification of multiple cyclin subunits of human P-TEFb.

PubMed ID: 9499409

DOI: 10.1101/gad.12.5.755

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10574912

Title: Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.

PubMed ID: 10574912

DOI: 10.1074/jbc.274.49.34527

PubMed ID: 10912001

Title: FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

PubMed ID: 10912001

DOI: 10.1016/s1097-2765(00)80272-5

PubMed ID: 10757782

Title: Domains in the SPT5 protein that modulate its transcriptional regulatory properties.

PubMed ID: 10757782

DOI: 10.1128/mcb.20.9.2970-2983.2000

PubMed ID: 10958691

Title: CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.

PubMed ID: 10958691

DOI: 10.1128/mcb.20.18.6958-6969.2000

PubMed ID: 11145967

Title: Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

PubMed ID: 11145967

DOI: 10.1074/jbc.m010908200

PubMed ID: 11112772

Title: DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.

PubMed ID: 11112772

DOI: 10.1074/jbc.m006130200

PubMed ID: 11575923

Title: The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.

PubMed ID: 11575923

DOI: 10.1006/jmbi.2001.4991

PubMed ID: 11884399

Title: P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.

PubMed ID: 11884399

DOI: 10.1074/jbc.m200117200

PubMed ID: 12065898

Title: MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.

PubMed ID: 12065898

DOI: 10.1007/bf02256070

PubMed ID: 12115727

Title: CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.

PubMed ID: 12115727

DOI: 10.1002/jcp.10130

PubMed ID: 11809800

Title: Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences.

PubMed ID: 11809800

DOI: 10.1128/mcb.22.4.1079-1093.2002

PubMed ID: 12037670

Title: Activation of MyoD-dependent transcription by cdk9/cyclin T2.

PubMed ID: 12037670

DOI: 10.1038/sj.onc.1205493

PubMed ID: 12718890

Title: Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

PubMed ID: 12718890

DOI: 10.1016/s1097-2765(03)00101-1

PubMed ID: 15564463

Title: Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.

PubMed ID: 15564463

DOI: 10.1128/jvi.78.24.13522-13533.2004

PubMed ID: 14701750

Title: Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element.

PubMed ID: 14701750

DOI: 10.1128/mcb.24.2.787-795.2004

PubMed ID: 15965233

Title: Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.

PubMed ID: 15965233

DOI: 10.1074/jbc.m502712200

PubMed ID: 16109376

Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

PubMed ID: 16109376

DOI: 10.1016/j.molcel.2005.06.027

PubMed ID: 16109377

Title: Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

PubMed ID: 16109377

DOI: 10.1016/j.molcel.2005.06.029

PubMed ID: 17956865

Title: The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.

PubMed ID: 17956865

DOI: 10.1074/jbc.m706458200

PubMed ID: 17643375

Title: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

PubMed ID: 17643375

DOI: 10.1016/j.molcel.2007.06.027

PubMed ID: 17452463

Title: Regulation of P-TEFb elongation complex activity by CDK9 acetylation.

PubMed ID: 17452463

DOI: 10.1128/mcb.00857-06

PubMed ID: 18483222

Title: PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.

PubMed ID: 18483222

DOI: 10.1101/gad.1636008

PubMed ID: 18829461

Title: Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop.

PubMed ID: 18829461

DOI: 10.1074/jbc.m807495200

PubMed ID: 18249148

Title: A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.

PubMed ID: 18249148

DOI: 10.1016/j.molcel.2008.01.003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18250157

Title: Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.

PubMed ID: 18250157

DOI: 10.1128/mcb.01557-07

PubMed ID: 18362169

Title: RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes.

PubMed ID: 18362169

DOI: 10.1128/mcb.01152-07

PubMed ID: 19844166

Title: Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.

PubMed ID: 19844166

DOI: 10.4161/cc.8.22.9890

PubMed ID: 19575011

Title: CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.

PubMed ID: 19575011

DOI: 10.1038/embor.2009.108

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20493174

Title: 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.

PubMed ID: 20493174

DOI: 10.1016/j.bbrc.2010.05.092

PubMed ID: 20930849

Title: Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.

PubMed ID: 20930849

DOI: 10.1038/embor.2010.153

PubMed ID: 20081228

Title: Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.

PubMed ID: 20081228

DOI: 10.1074/jbc.m109.070458

PubMed ID: 20471948

Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

PubMed ID: 20471948

DOI: 10.1016/j.molcel.2010.04.013

PubMed ID: 20159561

Title: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

PubMed ID: 20159561

DOI: 10.1016/j.molcel.2010.01.026

PubMed ID: 20980437

Title: CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.

PubMed ID: 20980437

DOI: 10.1210/me.2010-0238

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22195968

Title: The little elongation complex regulates small nuclear RNA transcription.

PubMed ID: 22195968

DOI: 10.1016/j.molcel.2011.12.008

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21484792

Title: CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.

PubMed ID: 21484792

DOI: 10.1002/ijc.26127

PubMed ID: 21127351

Title: Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

PubMed ID: 21127351

DOI: 10.1074/jbc.m110.176628

PubMed ID: 21448926

Title: Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway.

PubMed ID: 21448926

DOI: 10.1002/jcp.22760

PubMed ID: 21533037

Title: Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.

PubMed ID: 21533037

DOI: 10.1371/journal.pone.0018985

PubMed ID: 16885020

Title: Controlling the elongation phase of transcription with P-TEFb.

PubMed ID: 16885020

DOI: 10.1016/j.molcel.2006.06.014

PubMed ID: 18728388

Title: Expanding role of cyclin dependent kinases in cytokine inducible gene expression.

PubMed ID: 18728388

DOI: 10.4161/cc.7.17.6594

PubMed ID: 19029809

Title: Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases.

PubMed ID: 19029809

DOI: 10.4161/cc.7.23.7122

PubMed ID: 18423896

Title: Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology.

PubMed ID: 18423896

DOI: 10.1016/j.tips.2008.03.003

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 19757441

Title: Pharmacological targeting of CDK9 in cardiac hypertrophy.

PubMed ID: 19757441

DOI: 10.1002/med.20172

PubMed ID: 21200140

Title: A role for cdk9-cyclin k in maintaining genome integrity.

PubMed ID: 21200140

DOI: 10.4161/cc.10.1.14364

PubMed ID: 23029222

Title: Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb.

PubMed ID: 23029222

DOI: 10.1371/journal.pone.0045749

PubMed ID: 24360279

Title: Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

PubMed ID: 24360279

DOI: 10.1016/j.cell.2013.10.056

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25233083

Title: Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation.

PubMed ID: 25233083

DOI: 10.1371/journal.pone.0107654

PubMed ID: 27189267

Title: Heat shock factor 1 mediates latent HIV reactivation.

PubMed ID: 27189267

DOI: 10.1038/srep26294

PubMed ID: 28426094

Title: SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription.

PubMed ID: 28426094

DOI: 10.1093/nar/gkx053

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 29335245

Title: CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery.

PubMed ID: 29335245

DOI: 10.15252/embr.201744311

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 20535204

Title: Crystal structure of HIV-1 Tat complexed with human P-TEFb.

PubMed ID: 20535204

DOI: 10.1038/nature09131

PubMed ID: 18566585

Title: The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

PubMed ID: 18566585

DOI: 10.1038/emboj.2008.121

PubMed ID: 20851342

Title: Halogen bonds form the basis for selective P-TEFb inhibition by DRB.

PubMed ID: 20851342

DOI: 10.1016/j.chembiol.2010.07.012

PubMed ID: 21779453

Title: CDK inhibitors roscovitine and CR8 trigger Mcl-1 down-regulation and apoptotic cell death in neuroblastoma cells.

PubMed ID: 21779453

DOI: 10.1177/1947601910369817

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 372
  • Mass: 42778
  • Checksum: 69E851CC6F7A0388
  • Sequence:
    • MAKQYDSVEC PFCDEVSKYE KLAKIGQGTF GEVFKARHRK TGQKVALKKV LMENEKEGFP 
ITALREIKIL QLLKHENVVN LIEICRTKAS PYNRCKGSIY LVFDFCEHDL AGLLSNVLVK 
FTLSEIKRVM QMLLNGLYYI HRNKILHRDM KAANVLITRD GVLKLADFGL ARAFSLAKNS 
QPNRYTNRVV TLWYRPPELL LGERDYGPPI DLWGAGCIMA EMWTRSPIMQ GNTEQHQLAL 
ISQLCGSITP EVWPNVDNYE LYEKLELVKG QKRKVKDRLK AYVRDPYALD LIDKLLVLDP 
AQRIDSDDAL NHDFFWSDPM PSDLKGMLST HLTSMFEYLA PPRRKGSQIT QQSTNQSRNP 
ATTNQTEFER VF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.