Details for: SPRY3

Gene ID: 10251

Symbol: SPRY3

Ensembl ID: ENSG00000168939

Description: sprouty RTK signaling antagonist 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.38
    Marker Score: 6,836
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,995
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.37
    Marker Score: 434
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.31
    Marker Score: 767
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.17
    Marker Score: 851
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,816
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,630
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 659
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,267
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 373
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.87
    Marker Score: 1,808
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.75
    Marker Score: 219
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.72
    Marker Score: 1,574
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 557
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.58
    Marker Score: 642
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 367
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.54
    Marker Score: 2,213
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.51
    Marker Score: 2,149
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.42
    Marker Score: 504
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.39
    Marker Score: 141
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.39
    Marker Score: 357
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.38
    Marker Score: 154
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.38
    Marker Score: 579
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.36
    Marker Score: 1,514
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.35
    Marker Score: 3,314
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.34
    Marker Score: 3,552
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.34
    Marker Score: 489
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.34
    Marker Score: 2,905
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.32
    Marker Score: 425
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.31
    Marker Score: 108
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.31
    Marker Score: 447
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3
    Marker Score: 103
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 169
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.28
    Marker Score: 296
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.26
    Marker Score: 3,853
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.26
    Marker Score: 2,410
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.25
    Marker Score: 15,283
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.24
    Marker Score: 111
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.24
    Marker Score: 294
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.23
    Marker Score: 650
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.23
    Marker Score: 880
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.22
    Marker Score: 8,244
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.22
    Marker Score: 137
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 180
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.19
    Marker Score: 311
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.19
    Marker Score: 7,114
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.19
    Marker Score: 233
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.17
    Marker Score: 725
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.17
    Marker Score: 67
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.17
    Marker Score: 85
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.17
    Marker Score: 3,390
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.17
    Marker Score: 3,635
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.17
    Marker Score: 869
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.15
    Marker Score: 1,179
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.15
    Marker Score: 53
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 355
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.14
    Marker Score: 343
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.14
    Marker Score: 341
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.14
    Marker Score: 740
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.13
    Marker Score: 379
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.13
    Marker Score: 122
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.13
    Marker Score: 948
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.12
    Marker Score: 159
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.12
    Marker Score: 541
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.11
    Marker Score: 191
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.11
    Marker Score: 209
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 127

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RTK Signaling Antagonist:** SPRY3 acts as a potent antagonist to receptor tyrosine kinases (RTKs), which are essential for cell signaling and proliferation. 2. **Negative Regulation:** SPRY3 exerts its regulatory effects by negatively modulating various signaling pathways, including the Erk1/2, fibroblast growth factor receptor (FGFR), MAPK, and Ras protein signal transduction cascades. 3. **Tissue-Specific Expression:** SPRY3 is significantly expressed in specific cell types, including retinal cone cells, enterocytes, lens fibers, and GABAergic interneurons, highlighting its importance in development and tissue homeostasis. 4. **Protein Binding:** SPRY3 interacts with various proteins, including other SPRY family members, which may contribute to its regulatory functions. **Pathways and Functions:** 1. **Negative Regulation of Erk1/2 Cascade:** SPRY3 inhibits the activation of the Erk1/2 MAPK pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Negative Regulation of FGFR Signaling:** SPRY3 antagonizes FGFR signaling, which is crucial for cell growth, migration, and angiogenesis. 3. **Negative Regulation of MAPK Cascade:** SPRY3 suppresses the activation of the MAPK pathway, which is involved in cell proliferation, differentiation, and apoptosis. 4. **Negative Regulation of Ras Protein Signal Transduction:** SPRY3 inhibits the activation of the Ras protein signaling pathway, which is involved in cell growth, differentiation, and survival. 5. **Regulation of Neuron Projection Arborization:** SPRY3 plays a role in regulating the development and morphology of neurons, including the formation of axonal projections. **Clinical Significance:** 1. **Cancer Therapy:** SPRY3's ability to regulate RTK signaling pathways makes it a potential target for cancer therapy, particularly in tumors with aberrant RTK activity. 2. **Neurological Disorders:** SPRY3's involvement in neuronal development and function suggests its potential role in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. 3. **Developmental Disorders:** SPRY3's expression in specific cell types during development highlights its potential role in developmental disorders, such as retinal degeneration and gastrointestinal disorders. 4. **Immunological Disorders:** SPRY3's interaction with other proteins may contribute to its regulatory functions in immune cells, potentially impacting immunological disorders, such as autoimmune diseases. In conclusion, SPRY3 is a multifaceted gene involved in regulating various cellular processes, including cell signaling, development, and survival. Its clinical significance is vast, and further research is needed to fully elucidate its role in different diseases and disorders.

Genular Protein ID: 3023606928

Symbol: SPY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43610 A8K0H8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10655549

Title: Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region.

PubMed ID: 10655549

DOI: 10.1093/hmg/9.3.395

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9458049

Title: Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

PubMed ID: 9458049

DOI: 10.1016/s0092-8674(00)80919-8

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 26089202

Title: Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.

PubMed ID: 26089202

DOI: 10.1093/hmg/ddv231

PubMed ID: 29293652

Title: USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.

PubMed ID: 29293652

DOI: 10.1371/journal.pone.0190513

PubMed ID: 30878395

Title: MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.

PubMed ID: 30878395

DOI: 10.1016/j.yjmcc.2019.03.005

Sequence Information:

  • Length: 288
  • Mass: 31222
  • Checksum: 62C59F5E897D99B8
  • Sequence:
    • MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK SDWSLATMPT 
SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL ASITPSPSGQ SIIRTQPGAG 
VHPKADGALK GEAEQSAGHP SEHLFICEEC GRCKCVPCTA ARPLPSCWLC NQRCLCSAES 
LLDYGTCLCC VKGLFYHCST DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP 
TRGCLHLCQQ GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV

Genular Protein ID: 1284634698

Symbol: Q6ZUP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZUP3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 2

Sequence Information:

  • Length: 125
  • Mass: 13335
  • Checksum: C9C25D301AFCA7C1
  • Sequence:
    • MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK SDWSLATMPT 
SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASSTTAP LMMKTTVLMS PALVGLVLAL 
SAGQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.