Details for: SPRY1

Gene ID: 10252

Symbol: SPRY1

Ensembl ID: ENSG00000164056

Description: sprouty RTK signaling antagonist 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.54
    Marker Score: 2,715
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.09
    Marker Score: 5,476
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.04
    Marker Score: 791
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.98
    Marker Score: 68,693
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.93
    Marker Score: 1,270
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.91
    Marker Score: 2,627
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.86
    Marker Score: 396
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.83
    Marker Score: 2,039
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.81
    Marker Score: 3,070
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.77
    Marker Score: 2,570
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.75
    Marker Score: 3,490
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.6
    Marker Score: 3,334
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.58
    Marker Score: 1,414
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.58
    Marker Score: 506
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.55
    Marker Score: 372
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.51
    Marker Score: 864
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.48
    Marker Score: 344
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,040
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.44
    Marker Score: 619
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.44
    Marker Score: 48,891
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.38
    Marker Score: 1,002
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.37
    Marker Score: 10,216
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.35
    Marker Score: 1,275
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.34
    Marker Score: 1,290
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.31
    Marker Score: 2,019
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.3
    Marker Score: 1,125
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.27
    Marker Score: 439
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.26
    Marker Score: 1,350
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.24
    Marker Score: 1,723
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.22
    Marker Score: 625
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.21
    Marker Score: 3,356
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.19
    Marker Score: 15,706
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.18
    Marker Score: 260
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.16
    Marker Score: 272
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.12
    Marker Score: 1,386
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.12
    Marker Score: 748
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.07
    Marker Score: 963
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.06
    Marker Score: 244
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16,306
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.04
    Marker Score: 976
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,680
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.03
    Marker Score: 827
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.01
    Marker Score: 268
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1
    Marker Score: 254
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,703
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,926
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.98
    Marker Score: 243
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.98
    Marker Score: 401
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.98
    Marker Score: 1,217
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.97
    Marker Score: 640
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.97
    Marker Score: 401
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.96
    Marker Score: 562
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.96
    Marker Score: 413
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.96
    Marker Score: 188
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.95
    Marker Score: 968
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.95
    Marker Score: 1,660
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.95
    Marker Score: 2,573
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.93
    Marker Score: 941
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.92
    Marker Score: 656
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1,871
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.91
    Marker Score: 5,481
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.9
    Marker Score: 270
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.89
    Marker Score: 557
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.88
    Marker Score: 231
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.86
    Marker Score: 7,509
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1,388
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.85
    Marker Score: 198
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1,602
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.84
    Marker Score: 184
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,783
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.83
    Marker Score: 235
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.83
    Marker Score: 215
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.82
    Marker Score: 200
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.82
    Marker Score: 784
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.82
    Marker Score: 963
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.81
    Marker Score: 455
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.81
    Marker Score: 2,996
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.8
    Marker Score: 323
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8
    Marker Score: 971
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.8
    Marker Score: 753
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.8
    Marker Score: 196
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.8
    Marker Score: 330
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.79
    Marker Score: 597
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.78
    Marker Score: 5,090
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1,833
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.78
    Marker Score: 466
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.77
    Marker Score: 227
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.76
    Marker Score: 173
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.76
    Marker Score: 816
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 237
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.75
    Marker Score: 571

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RTK Signaling Antagonist:** SPRY1 is a potent antagonist of receptor tyrosine kinase (RTK) signaling pathways, which are essential for cell proliferation, differentiation, and survival. 2. **Negative Regulation:** SPRY1 exerts its regulatory effects by negatively modulating the activity of multiple RTK signaling pathways, including EGFR, FGFR, and TRK. 3. **Diverse Cellular Expression:** SPRY1 is expressed in various cell types, including skeletal muscle satellite stem cells, fibroblasts, endothelial cells, and intraepithelial lymphocytes. 4. **Signaling Pathway Involvement:** SPRY1 is implicated in multiple signaling pathways, including the Erk1 and Erk2 cascade, mitotic spindle orientation, and fibroblast growth factor receptor signaling pathway. **Pathways and Functions:** 1. **Animal Organ Development:** SPRY1 plays a crucial role in the development of various animal organs, including the lung, heart, and kidney, by regulating cell proliferation and differentiation. 2. **Bud Elongation Involved in Lung Branching:** SPRY1 is essential for the proper elongation of lung buds during development, which is critical for lung morphogenesis. 3. **Cytosol and Golgi Apparatus:** SPRY1 interacts with the cytosol and Golgi apparatus, influencing the regulation of cellular processes such as cell proliferation and differentiation. 4. **Negative Regulation of Cell Population Proliferation:** SPRY1 acts as a negative regulator of cell population proliferation, preventing excessive cell growth and tumor formation. 5. **Negative Regulation of Epithelial to Mesenchymal Transition:** SPRY1 inhibits the epithelial-to-mesenchymal transition (EMT), a process critical in cancer progression and metastasis. **Clinical Significance:** 1. **Cancer Prevention:** SPRY1's negative regulation of RTK signaling pathways makes it a potential target for cancer prevention and therapy. 2. **Regulation of Cell Proliferation:** SPRY1's role in regulating cell population proliferation has significant implications for understanding and treating diseases characterized by excessive cell growth, such as cancer and fibrosis. 3. **Developmental Disorders:** SPRY1's involvement in animal organ development and bud elongation suggests its potential role in developmental disorders, such as congenital heart defects and lung abnormalities. 4. **Inflammation and Immune Response:** SPRY1's expression in intraepithelial lymphocytes and vascular lymphangioblasts highlights its potential role in regulating inflammation and immune responses. In conclusion, the Sprouty RTK signaling antagonist 1 gene plays a multifaceted role in regulating cellular processes, including cell proliferation, differentiation, and survival. Its negative regulation of RTK signaling pathways and involvement in various signaling pathways make it a critical regulator of tissue homeostasis and disease prevention. Further research is needed to fully elucidate the clinical significance of SPRY1 and its potential applications in cancer prevention, developmental disorders, and inflammatory diseases.

Genular Protein ID: 882914870

Symbol: SPY1_HUMAN

Name: Protein sprouty homolog 1

UniProtKB Accession Codes:

O43609 D3DNX6 Q6PNE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14533010

Title: Identification and expression analysis of a novel splice variant of human Sprouty1 gene.

PubMed ID: 14533010

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9458049

Title: Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

PubMed ID: 9458049

DOI: 10.1016/s0092-8674(00)80919-8

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

Sequence Information:

  • Length: 319
  • Mass: 35122
  • Checksum: 40E2D4D12816E057
  • Sequence:
    • MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV 
KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA 
ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI 
CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS 
YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 
NTVYCKLESC PSRGQGKPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.